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21. 发明申请

WO2006047311A3 CLONING OF THE RETINOIC ACID INDUCIBLE GENE-1 PROMOTER AND USES THEREOF 审中-公开
标题翻译：赖氨酸诱导基因-1启动子及其用途的克隆
公开(公告)号：WO2006047311A3
公开(公告)日：2006-09-14
申请号：PCT/US2005037950
申请日：2005-10-19
申请人： UNIV COLUMBIA , FISHER PAUL B , SU ZAO-ZHONG
发明人： FISHER PAUL B , SU ZAO-ZHONG
IPC分类号： C07H21/04 , A01K67/00 , C12N15/00 , C12Q1/02
CPC分类号： C07K14/47
摘要： The present invention relates to the human Retinoic Acid Inducible Gene-1 (hereafter, "RIG-1") promoter. The present invention provides for the promoter itself which is inducible by interferon, virus infection, retinoic acid and double-stranded RNA. A further embodiment includes expression constructs comprising the RIG-1 promoter operatively linked to a gene of interest, which may be a reporter gene or a therapeutic gene. It also provides for cells and non-human transgenic animals comprising such expression constructs. In addition, the present invention provides for methods of screening agents for anti-viral activity using RIG-1 promoter activation or inhibition as the basis of the screening system.
摘要翻译：本发明涉及人视黄酸诱导基因-1（以下称为“RIG-1”）启动子。本发明提供可由干扰素，病毒感染，视黄酸和双链RNA诱导的启动子本身。另一个实施方案包括包含可操作地连接到目的基因的RIG-1启动子的表达构建体，其可以是报道基因或治疗基因。它还提供包含这种表达构建体的细胞和非人转基因动物。此外，本发明提供了使用RIG-1启动子活化或抑制作为筛选系统的基础筛选抗病毒活性物质的方法。

22. 发明申请

WO2006060680A2 MDA-7 PROTEIN VARIANTS HAVING ANTIPROLIFERATIVE ACTIVITY 审中-公开
标题翻译：具有抗增殖活性的MDA-7蛋白变体
公开(公告)号：WO2006060680A2
公开(公告)日：2006-06-08
申请号：PCT/US2005043673
申请日：2005-12-02
申请人： UNIV COLUMBIA , FISHER PAUL B , GUPTA PANKAJ
发明人： FISHER PAUL B , GUPTA PANKAJ
IPC分类号： A61K38/17 , C07K14/82
CPC分类号： G01N33/5011 , A61K38/00 , A61K45/06 , A61K48/005 , C07K14/47 , C07K14/52 , C07K14/54 , C07K16/244 , C12N15/86 , C12N2710/10343
摘要： The invention relates to the mda-7 gene, its encoded protein and fragments of the proteins. Several of these fragments of the MDA-7 protein exhibit antiproliferative activity and/or inhibited the activity of intact MDA-7. Accordingly, the invention provides, among other things, for methods and compositions that may be used in the treatment of disorders of cell proliferation, including cancer.
摘要翻译：本发明涉及mda-7基因，其编码的蛋白质和蛋白质的片段。 MDA-7蛋白的这些片段中的几个表现出抗增殖活性和/或抑制完整MDA-7的活性。因此，本发明尤其提供了可用于治疗细胞增殖障碍（包括癌症）的方法和组合物。

23. 发明申请

WO0216419A9 PROGRESSION SUPPRESSED GENE 13 (PSGEN 13) AND USES THEREOF 审中-公开
标题翻译：进行抑制基因13（PSGEN 13）及其用途
公开(公告)号：WO0216419A9
公开(公告)日：2003-03-27
申请号：PCT/US0126795
申请日：2001-08-27
申请人： UNIV COLUMBIA , FISHER PAUL B , KANG DONG-CHUL , SU ZAO-ZHONG
发明人： FISHER PAUL B , KANG DONG-CHUL , SU ZAO-ZHONG
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P9/00 , A61P35/00 , A61P35/02 , C07K14/47 , C07K16/18 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/68 , G01N33/566 , G01N33/574 , C12N15/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention provides for isolated nucleic acids encoding Progression Suppressed Gene 13 (PS Gen 13) proteins, vectors comprising said nucleic acids, isolated PSGen 13 proteins, and methods of using such molecules to prevent the growth of cancer cells and/or new blood vessels and accordingly to treat patients suffering from cancer. It is based, at least in part, on the characterization of the complete cDNAs encoding rat and human PSGen 13, and on the discovery that increased levels of PSGen 13 expression can suppress the transformed phenotype and inhibit the activities of promoter elements associated with cancer progression and angiogenesis. In various embodiments, the present invention provides a method for inhibiting growth of a cancer cell which comprises contacting the cancer cell with a nucleic acid encoding a PSGen 13 protein, a PSGen 13 protein or a PSGen 13 activator compound in a sufficient amount so as to inhibit growth of the cancer cell. The invention also provides a method for treating cancer in a subject which comprises contacting a cell of the subject with a nucleic acid encoding a PSGen 13 protein in a sufficient amount so as to cause the cell to express the PSGen 13 protein, thereby treating cancer in the subject.
摘要翻译：本发明提供了编码进展抑制基因13（PS Gen 13）蛋白的分离核酸，包含所述核酸的载体，分离的PSGen 13蛋白，以及使用这些分子来防止癌细胞和/或新血管生长的方法，以及因此治疗癌症患者。至少部分基于编码大鼠和人类PSGen13的完整cDNAs的表征，并且发现增加的PSGen13表达水平可以抑制转化的表型并抑制与癌症进展相关的启动子元件的活性和血管发生。在各种实施方案中，本发明提供了抑制癌细胞生长的方法，其包括将足够量的癌细胞与编码PSGen13蛋白，PSGen13蛋白或PSGen13激活剂化合物的核酸接触，以便抑制癌细胞的生长。本发明还提供了一种治疗受试者的癌症的方法，其包括将受试者的细胞与编码PSGen 13蛋白的核酸充分接触，以使细胞表达PSGen13蛋白，从而治疗癌症主题。

24. 发明申请

WO0046391A9 GENES DISPLAYING ENHANCED EXPRESSION DURING CELLULAR SENESCENCE AND TERMINAL CELL DIFFERENTIATION AND USES THEREOF 审中-公开
标题翻译：在细胞感染和终末细胞分化期间显示增强表达的基因及其用途
公开(公告)号：WO0046391A9
公开(公告)日：2001-08-02
申请号：PCT/US0002920
申请日：2000-02-02
申请人： UNIV COLUMBIA , FISHER PAUL B , LESZCZYNIECKA MAGDALENA
发明人： FISHER PAUL B , LESZCZYNIECKA MAGDALENA
IPC分类号： G01N33/50 , A61K31/7105 , A61K31/711 , A61K35/76 , A61K38/00 , A61K45/00 , A61K48/00 , A61P9/14 , A61P17/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P43/00 , C07K14/315 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/74 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K1/00 , C07H21/04 , C07K14/00 , C12N5/00 , C12N5/06 , C12N15/63 , C12N15/85 , C12N15/86 , C12N15/87 , C12N15/88 , C12P21/00 , C12Q1/00
CPC分类号： C07K14/47 , C07K14/315 , C07K14/82 , C12N15/746
摘要： This invention provides isolated nucleic acid molecules encoding an OLD-35 protein, OLD-64 protein, OLD-137 protein, OLD-139 protein, OLD-142 protein or OLD-175 protein. This invention further provides a purified OLD-35 protein, OLD-64, OLD-137, OLD-139, OLD-142 and OLD-175. Finally, this invention provides different uses of the nucleic acids and proteins.
摘要翻译：本发明提供编码OLD-35蛋白，OLD-64蛋白，OLD-137蛋白，OLD-139蛋白，OLD-142蛋白或OLD-175蛋白的分离的核酸分子。本发明还提供了纯化的OLD-35蛋白，OLD-64，OLD-137，OLD-139，OLD-142和OLD-175。最后，本发明提供了核酸和蛋白质的不同用途。

25. 发明申请

WO2008063773A9 COMBINATORIAL TREATMENT WITH EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR MOLECULES AND MELANOMA DIFFERENTIATION ASSOCIATED GENE-7 审中-公开
标题翻译：与EPIDERMAL生长因子受体抑制剂分子和MELANOMA差异相关的基因组7的组合治疗
公开(公告)号：WO2008063773A9
公开(公告)日：2008-08-14
申请号：PCT/US2007080962
申请日：2007-10-10
申请人： UNIV COLUMBIA , SETTLEMAN JEFFREY , FISHER PAUL B , EMDAD LUNI
发明人： SETTLEMAN JEFFREY , FISHER PAUL B , EMDAD LUNI
IPC分类号： A61K48/00
CPC分类号： A61K31/7088 , A61K38/179 , A61K38/20 , A61K45/06 , A61K48/00 , C12N15/86 , C12N2710/10343 , A61K2300/00
摘要： The present invention relates to methods of treating a cancer associated with aberrant EGFR-activity comprising administering, to a subject in need of such treatment, an effective amount of a combination of an EGFR inhibitor and a MD A-7 molecule. The combined use of these agents allows effective therapy of cancers that may be relatively resistant to either agent alone.
摘要翻译：本发明涉及治疗与异常EGFR活性相关的癌症的方法，包括向需要这种治疗的受试者施用有效量的EGFR抑制剂和MDA-7分子的组合。这些药物的组合使用可以有效治疗可能相对单独使用任一药物的癌症。

26. 发明申请

WO2004066915A3 OLD-35, A GENE ASSOCIATED WITH SENESCENCE AND TERMINAL CELL DIFFERENTIATION, AND USES THEREOF 审中-公开
标题翻译： OLD-35，与感染和终末细胞分化相关的基因及其用途
公开(公告)号：WO2004066915A3
公开(公告)日：2005-11-03
申请号：PCT/US0318382
申请日：2003-06-09
申请人： UNIV COLUMBIA , FISHER PAUL B , LESZCZYNIECKA MAGDALENA , KANG DONG-CHUL , SARKAR DEVANAND
发明人： FISHER PAUL B , LESZCZYNIECKA MAGDALENA , KANG DONG-CHUL , SARKAR DEVANAND
IPC分类号： A61K20060101 , C07H5/04 , C07H5/06 , C07H21/02 , C07H21/04 , C07K14/47 , C08B37/00
CPC分类号： C07K14/47
摘要： The present invention relates to the old-35 gene, its encoded protein, and its promoter sequence. The old-35 gene is associated with terminal differentiation and senescence of cells, and as such the gene and its related molecules may be used in the control of cell proliferation and in the modulation.
摘要翻译：本发明涉及老35基因，其编码蛋白及其启动子序列。老35基因与细胞的终末分化和衰老相关，因此基因及其相关分子可用于控制细胞增殖和调节。

27. 发明申请

WO2004072253A9 HUMAN EXCITATORY AMINO ACID TRANSPORTER-2 GENE PROMOTER AND USES THEREOF 审中-公开
标题翻译：人类兴奋氨基酸转运蛋白-2基因启动子及其用途
公开(公告)号：WO2004072253A9
公开(公告)日：2004-10-14
申请号：PCT/US2004003700
申请日：2004-02-09
申请人： UNIV COLUMBIA , FISHER PAUL B , SU ZAO-ZHONG
发明人： FISHER PAUL B , SU ZAO-ZHONG
IPC分类号： A61K31/711 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/705 , C12N20060101 , C12N5/10 , C12N15/63 , C12N15/85 , C12Q1/02 , C12Q1/68 , C12N
CPC分类号： C07K14/705
摘要： The nucleic acid sequence of the human Excitatory Amino Acid Transporter-2 Gene (hEAAT2) promoter, a nucleic acid sequence that hybridizes to the hEAAT2 promoter nucleic acid sequence under stringent hybridization conditions, and a nucleic acid sequence that is functionally equivalent to the hEAAT2 promoter sequence are provided, as are vectors containing these nucleic acid sequences. In addition, methods for the use of these nucleic acids to achieve tissue- or cell-specific gene expression are provided, as are methods for the use of these hEAAT2 promoter nucleic acids to identify agents that can modulate glutamate transport or the activity of the glutamate promoter. Such agents may be useful in the prevention, palliation or treatment of neurodegenerative and/or cerebrovascular diseases.
摘要翻译：人兴奋性氨基酸转运蛋白-2基因（hEAAT2）启动子的核酸序列，在严格杂交条件下与hEAAT2启动子核酸序列杂交的核酸序列，以及与hEAAT2启动子功能等同的核酸序列序列，含有这些核酸序列的载体也是如此。另外，提供了使用这些核酸实现组织或细胞特异性基因表达的方法，以及使用这些hEAAT2启动子核酸鉴定可调节谷氨酸转运或谷氨酸活性的试剂的方法子。这些药物可用于预防，减轻或治疗神经变性和/或脑血管疾病。

28. 发明申请

WO0231205A3 METHOD FOR RAPID SUBTRACTION HYBRIDIZATION TO ISOLATE A GENE WHICH IS DIFFERENTIALLY EXPRESSED BETWEEN TWO POPULATIONS OF CELLS 审中-公开
标题翻译：用于快速分离杂交以分离在两个细胞群体之间差异显着的基因的方法
公开(公告)号：WO0231205A3
公开(公告)日：2003-05-08
申请号：PCT/US0131811
申请日：2001-10-11
申请人： UNIV COLUMBIA , FISHER PAUL B , JIANG HONGPING
发明人： FISHER PAUL B , JIANG HONGPING
IPC分类号： C12Q1/68 , C12N9/50
CPC分类号： C12Q1/6809 , C12Q2539/101
摘要： The present invention provides for methods for rapid subtraction hybridization of two pools of double-stranded cDNA to isolate a differentially expressed gene which comprises: isolating RNA from a first and a second population of cells; producing a first and second double-stranded cDNA pool; admixing the first and second pools of cDNA separately with a first restriction enzyme; admixing the digested first pool and second pool of cDNA with an appropriate amount of a double-stranded oligonucleotide; wherein the oligonucleotide sequence comprises (i) an internal recognition site for a second restriction enzyme and (ii) a ligatable cohesive end at one end which is capable of hybridizing with a ligatable cohesive end resulting from digestion of the first pool of cDNA with the first restriction enzyme; performing two separate polymerase chain reactions (PCR) using an aliquot of the ligation mixture (tester cDNA or driver cDNA) admixed with a PCR primer; digesting the PCR products of the tester cDNA with the second restriction enzyme under appropriate digestion conditions; admixing an aliquot of the digestion product (tester cDNA) with an excess of driver cDNA PCR products under hybridization conditions, so as to isolate a differentially expressed gene from among the two pools of double-stranded DNA.
摘要翻译：本发明提供了两个双链cDNA集合进行快速减法杂交以分离差异表达基因的方法，其包括：从第一和第二细胞群分离RNA; 产生第一和第二双链cDNA库; 将第一和第二组cDNA与第一限制酶分开混合; 用合适量的双链寡核苷酸混合消化的第一个池和第二个cDNA库; 其中所述寡核苷酸序列包含（i）第二限制性内切酶的内部识别位点和（ii）一端的可连接的粘性末端，其能够与第一个cDNA融合产生的可连接的粘性末端杂交，限制酶; 使用与PCR引物混合的连接混合物的等分试样（测试cDNA或驱动cDNA）进行两个单独的聚合酶链反应（PCR）; 在适当的消化条件下用第二限制酶消化测试cDNA的PCR产物; 在杂交条件下将消化产物（测试cDNA）的等分试样与过量的驱动cDNA PCR产物混合，以从两个双链DNA的两个库中分离出差异表达的基因。

29. 发明公开

EP3294748A1 NOVEL METHYLATION SITE REGULATING EXPRESSION OF MDA-9/SYNTENIN 无效
公开(公告)号：EP3294748A1
公开(公告)日：2018-03-21
申请号：EP16797024
申请日：2016-05-13
申请人： UNIV VIRGINIA COMMONWEALTH
发明人： FISHER PAUL B , BACOLOD MANNY
IPC分类号： C07H21/00 , C12Q1/68 , G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/154 , G01N33/57496 , G01N2440/12 , G01N2800/52
摘要： Methods of prognosing the outcome of cancer and/or cancer treatment are provided. The methods involve qiiantitating the level of methylation at a site that regulates expression of the mda-9/Syntenin gene, site cgl 7197774. High levels of methylation indicate a good prognosis whereas low levels of methylation indicate a poor prognosis and determination of these levels permits risk stratification of patients with cancer.

30. 发明公开

EP3004153A4 RECOMBINANT CANCER THERAPEUTIC CYTOKINE 有权
标题翻译：克罗地亚州克罗地亚州FÜREINE KREBSTHERAPIE
公开(公告)号：EP3004153A4
公开(公告)日：2016-12-21
申请号：EP14807031
申请日：2014-06-04
申请人： UNIV VIRGINIA COMMONWEALTH
发明人： FISHER PAUL B , BHOOPATHI PRAVEEN , DAS SWADESH K , EMDAD LUNI , SARKAR DEVANAND , SOKHI UPNEET
IPC分类号： C07K14/54 , A61K38/20 , C12N15/24 , C12N15/62
CPC分类号： C07K14/5428 , A61K38/00 , C07K14/54 , C07K2319/055
摘要： Recombinant therapeutic cytokines (“therakines”) for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24 (“M4”) not normally found in nature that has anti-cancer activity and a secretory signal which causes secretion of the therakine from plasmid/virus transduced normal and cancer cells and interaction of the therakine to MDA-7/IL-24 receptors on adjacent, neighboring and distant cancer cells. Therakine interaction results in bystander killing of the target cancer cell as well as adjacent, neighboring and distant cancer cells.
摘要翻译：提供了用于治疗癌症的重组治疗细胞因子（“治疗”）。重组方法包括自然界中通常没有发现具有抗癌活性的MDA-7 / TL-24（“M4”）的截短区域，以及分泌信号，其导致质粒/病毒转导的正常和癌细胞的分泌以及相邻的，相邻的和远处的癌细胞上的热休克蛋白与MDA-7 / IL-24受体的相互作用。治疗相互作用导致旁观者杀死靶癌细胞以及相邻，相邻和远处的癌细胞。

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