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21. 发明授权

US06268353B1 Method for inhibiting the formation of volatile aldehydes including their related compounds and/or the decomposition of fatty acids including their related compounds, and uses thereof 有权
标题翻译：包括其相关化合物在内的抑制挥发性醛的形成和/或其相关化合物的脂肪酸分解的方法及其用途
公开(公告)号：US06268353B1
公开(公告)日：2001-07-31
申请号：US09387520
申请日：1999-09-01
申请人： Hiroto Chaen , Kazuyuki Oku , Yukio Uchida , Toshio Miyake
发明人： Hiroto Chaen , Kazuyuki Oku , Yukio Uchida , Toshio Miyake
IPC分类号： A61K3170
CPC分类号： A23G9/34 , A21D2/16 , A21D2/181 , A23B4/033 , A23B4/20 , A23B5/025 , A23B7/154 , A23B9/26 , A23D9/007 , A23F3/163 , A23G9/52 , A23G2200/06 , A23K20/163 , A23K30/00 , A23L3/349 , A23L3/3544 , A23L3/3562 , A23L5/00 , A23L7/00 , A23L7/196 , A23L7/198 , A23L9/00 , A23L13/428 , A23L15/30 , A23L19/03 , A23L19/18 , A23L19/20 , A23L21/00 , A23L25/10 , A23L25/20 , A23L29/10 , A23L29/30 , A23L29/37 , A23L33/125 , A61K8/361 , A61K8/365 , A61K8/37 , A61K8/60 , A61Q15/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C11B1/04 , C11B3/001 , C11B5/0021
摘要： A method for inhibiting the formation of volatile aldehydes including their related compounds and/or the decomposition of fatty acids including their related compounds by incorporating trehalose and/or maltitol. Using the method, compositions such as foods, cosmetics, and pharmaceuticals comprising fatty acids can be prepared and stably stored for a relatively-long period of time without fear of forming volatile aldehydes and/or decomposing the fatty acids.
摘要翻译：一种通过掺入海藻糖和/或麦芽糖醇抑制挥发性醛的形成的方法，包括其相关化合物和/或包括其相关化合物在内的脂肪酸的分解。使用该方法，可以制备并稳定地储存包含脂肪酸的食品，化妆品和药物等组合物相当长的时间，而不用担心形成挥发性醛和/或分解脂肪酸。

22. 发明授权

US06197282B1 Fine ultraviolet screening particles, process for preparing the same, and cosmetic preparation 有权
标题翻译：精细的紫外线筛选颗粒，其制备方法和化妆品制备
公开(公告)号：US06197282B1
公开(公告)日：2001-03-06
申请号：US09194199
申请日：1998-11-20
申请人： Kentaro Oshima , Shunji Kozaki , Yoshinobu Imaizumi , Toshio Miyake , Keiichi Tsuto , Kazuhiro Yamaki , Satoshi Sugawara
发明人： Kentaro Oshima , Shunji Kozaki , Yoshinobu Imaizumi , Toshio Miyake , Keiichi Tsuto , Kazuhiro Yamaki , Satoshi Sugawara
IPC分类号： A61K742
CPC分类号： C01G23/047 , A61K8/0241 , A61K8/27 , A61K8/29 , A61K2800/412 , A61K2800/624 , A61Q17/04 , C01G9/02 , C01P2004/62 , C09C1/3684
摘要： The present invention provides a method for producing a material dispersed with ultraviolet shielding fine particles, characterized by subjecting a starting material liquid mixture comprising particles comprising one or more inorganic substances having shielding abilities against ultraviolet light, one or more silicone dispersants selected from modified silicones and reactive silicones, and a silicone oil to a mill treatment and/or a high-pressure dispersion treatment; and ultraviolet shielding fine particles or a material dispersed therewith, characterized by being produced by the above method. Also, the present invention provides a method of producing a powdery product of ultraviolet shielding fine particles, characterized by drying the material dispersed with ultraviolet shielding fine particles obtainable by the above method. Further, the present invention provides cosmetics comprising a material dispersed with ultraviolet shielding fine particles or a powdery product of the ultraviolet shielding fine particles. The material dispersed with ultraviolet shielding fine particles of the present invention is characterized in that the ultraviolet shielding fine particles comprise particles comprising one or more inorganic substances having shielding abilities against ultraviolet light, surfaces thereof being coated with one or more silicone dispersants selected from modified silicones and reactive silicones, and that at least a part of the ultraviolet shielding fine particles is dispersed in a silicone oil as aggregated particles of the particles comprising inorganic substances.
摘要翻译：本发明提供一种分散有紫外线屏蔽微粒的材料的制造方法，其特征在于，将包含一种或多种具有屏蔽能力的无机物质的紫外线的原料液体混合物，一种或多种选自改性硅酮的有机硅分散剂和反应性硅氧烷和硅油进行研磨处理和/或高压分散处理; 和紫外线屏蔽微粒或其分散的材料，其特征在于通过上述方法制备。另外，本发明提供一种紫外线屏蔽微粒的粉末状制品的制造方法，其特征在于，使用通过上述方法得到的紫外线屏蔽微粒分散的材料进行干燥。此外，本发明提供了包含分散有紫外线屏蔽微粒的材料或紫外线屏蔽微粒的粉末状产品的化妆品。用本发明的紫外线屏蔽微粒分散的材料的特征在于，紫外线屏蔽微粒包括包含一种或多种具有对紫外线的屏蔽能力的无机物质的颗粒，其表面涂覆有一种或多种选自改性有机硅的硅氧烷分散剂和反应性硅氧烷，并且至少一部分紫外线屏蔽细颗粒作为包含无机物质的颗粒的凝集颗粒分散在硅油中。

23. 发明授权

US6159529A Method for enhancing the salty-taste and/or delicious-taste of food products 失效
标题翻译：提高食品的咸味和/或美味的方法
公开(公告)号：US6159529A
公开(公告)日：2000-12-12
申请号：US879318
申请日：1997-06-19
申请人： Yukio Uchida , Satoshi Iritani , Toshio Miyake
发明人： Yukio Uchida , Satoshi Iritani , Toshio Miyake
IPC分类号： A23B4/033 , A23L1/03 , A23L1/202 , A23L1/22 , A23L1/236 , A23L1/237 , A23L1/238 , A23L1/30 , A23L1/325 , A23L1/39 , C07H3/04 , C12J1/00
CPC分类号： A23L27/50 , A23L27/30 , A23L27/40
摘要： A method for enhancing the salty-taste and/or delicious-taste of food products and materials thereof, containing sodium chloride, by using trehalose without imparting any unsatisfactory taste and flavor. The content of trehalose to be incorporated is usually in the range of about 1.5-12% to the food products and materials thereof, on a dry solid basis. The method can reduce the content of sodium chloride used in conventional salty food products without losing their satisfactory salty-taste.
摘要翻译：通过使用海藻糖而不赋予不令人满意的味道和味道的方法来提高含有氯化钠的食品及其食品的咸味和/或美味。待干燥固体的海藻糖含量通常在食品及其材料的约1.5-12％的范围内。该方法可以降低常规咸食品中氯化钠的含量，而不会失去其令人满意的咸味。

24. 发明授权

US06140487A DNA encoding kojibiose phosphorylase obtainable from thermoanaerobium, ' its preparation and uses 有权
标题翻译：编码由热酵母获得的曲霉糖磷酸化酶的DNA，其制备和用途
公开(公告)号：US06140487A
公开(公告)日：2000-10-31
申请号：US188404
申请日：1998-11-10
申请人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tomoyuki Nishimoto , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K8/60 , A61K38/00 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C07H21/04 , C12N9/12
CPC分类号： A61K8/60 , A61Q11/00 , A61Q17/04 , A61Q19/02 , C12N9/1051 , C12P19/18 , A61K38/00
摘要： A kojibiose phosphorylase which hydrolyzes kojibiose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid, forms kojibiose and an inorganic phosphoric acid from .beta.-D-glucose-1-phosphoric acid, and catalyzes the transfer reaction of glucosyl group to other saccharides using .beta.-D-glucose-1-phosphoric acid as a saccharide donor. The enzyme is obtainable from natural sources such as microorganisms of the genus Thermoanaerobium, and obtainable by recombinant technology.
摘要翻译：在无机磷酸存在下水解曲霉糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸的曲霉糖磷酸化酶，从β-D-葡萄糖-1-磷酸形成曲酸和无机磷酸，并使用β-D-葡萄糖-1-磷酸作为糖供体催化葡糖基转移到其他糖类上。该酶可从天然来源例如Thermoanaerobium属的微生物获得，可通过重组技术获得。

25. 发明授权

US06126962A Crystalline powdery saccharide, its preparation and uses 有权
标题翻译：结晶性粉末糖，其制备及用途
公开(公告)号：US06126962A
公开(公告)日：2000-10-03
申请号：US219368
申请日：1998-12-23
申请人： Hiroto Chaen , Kazuhisa Mukai , Toshio Miyake
发明人： Hiroto Chaen , Kazuhisa Mukai , Toshio Miyake
IPC分类号： A23G1/30 , A21D2/10 , A21D2/18 , A23B7/10 , A23G1/00 , A23G1/40 , A23G1/56 , A23G3/34 , A23G4/00 , A23G4/10 , A23L1/00 , A23L1/09 , A23L1/164 , A23L1/187 , A23L1/19 , A23L1/218 , A23L1/22 , A23L1/314 , A23L2/38 , A23L2/39 , A23L2/60 , A61K8/00 , A61K8/02 , A61K8/34 , A61K8/60 , A61K8/73 , A61K8/90 , A61K9/00 , A61K9/28 , A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K47/26 , A61P17/00 , A61Q11/00 , A61Q19/00 , C07H3/02 , C07H3/04 , C07H3/06 , C12N9/24 , C12P19/12 , C13B30/02 , C13B50/00 , A61K7/00
CPC分类号： C12P19/12 , A21D2/181 , A23G1/305 , A23G1/40 , A23G1/56 , A23G3/343 , A23G3/346 , A23G4/10 , A23L13/428 , A23L19/20 , A23L2/39 , A23L2/60 , A23L5/00 , A23L7/117 , A23L9/12 , A23L9/22 , A61K47/26 , A61K8/02 , A61K8/0216 , A61K8/60 , A61K9/0014 , A61K9/2826 , A61Q11/00 , A61Q19/00 , C07H3/04 , A23G2200/06 , Y10S514/97
摘要： A stable crystalline powdery saccharide having a crystallinity of 40% or more, less hygroscopicity, satisfactory fluidity, and beneficial handleability, which is obtainable from an aqueous solution, containing trehalose and a different saccharide(s) crystallizable in the presence of trehalose, by crystallizing the trehalose along with the different saccharide(s).
摘要翻译：结晶度为40％以上，稳定的结晶性粉末糖，吸湿性，令人满意的流动性和有益的操作性，可从包含在海藻糖存在下可结晶的海藻糖和不同糖的水溶液获得，通过结晶海藻糖以及不同的糖类。

26. 发明授权

US6005100A Trehalose composition for prolonging product shelf life 失效
标题翻译：海藻糖组合物延长产品保质期
公开(公告)号：US6005100A
公开(公告)日：1999-12-21
申请号：US874736
申请日：1997-06-13
申请人： Takahiko Mandai , Takashi Shibuya , Toshiyuki Sugimoto , Toshio Miyake
发明人： Takahiko Mandai , Takashi Shibuya , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23C9/123 , A23L3/3427 , A23L3/3562 , A23L3/42 , A23L15/00 , A61K8/60 , A61Q5/00 , A61Q7/00 , A61Q19/00 , B01J20/22 , C07H1/00
CPC分类号： B01J20/22 , A23C9/1232 , A23L15/20 , A23L3/3427 , A23L3/3562 , A23L3/42 , A61K8/60 , A61Q19/00 , A61Q11/00 , A61Q5/00 , A61Q7/00
摘要： Disclosed are a novel desiccant containing a non-reducing anhydrous trehalose as an effective ingredient; a dehydration of hydrous matters, e.g. food products, pharmaceuticals and cosmetics, therewith; and dehydrated products obtained by the dehydration. Such hydrous matters are dehydrated without causing alteration or deterioration by incorporating anhydrous trehalose into the hydrous matters to convert the anhydrous trehalose into hydrous crystalline trehalose. The anhydrous trehalose are anhydrous crystalline trehalose and hydrous amorphous trehalose.
摘要翻译：公开了含有非还原性无水海藻糖作为有效成分的新型干燥剂; 水合物的脱水，例如食品，药品和化妆品; 脱水得到的脱水产物。这些含水物质通过将无水海藻糖掺入含水物质中而不引起改变或劣化，将无水海藻糖转化成含水结晶海藻糖而脱水。无水海藻糖是无水结晶海藻糖和含水无定形海藻糖。

27. 发明授权

US5922580A Non-reducing saccharide-forming enzyme, its preparation and uses 失效
公开(公告)号：US5922580A
公开(公告)日：1999-07-13
申请号：US941553
申请日：1997-09-30
申请人： Kazuhiko Maruta , Michio Kubota , Toshiyuki Sugimoto , Toshio Miyake
发明人： Kazuhiko Maruta , Michio Kubota , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： A23L1/236 , A21D2/18 , A23C9/13 , A23C9/152 , A23G3/00 , A23G3/34 , A23G3/42 , A23G3/48 , A23G4/00 , A23G4/10 , A23J3/16 , A23L1/09 , A23L1/31 , A23L1/314 , A23L1/32 , A23L2/60 , A61K8/00 , A61K8/60 , A61K8/66 , A61K8/73 , A61K9/36 , A61K31/00 , A61K31/02 , A61K38/21 , A61K47/26 , A61Q11/00 , A61Q17/04 , A61Q19/00 , C07H20060101 , C07H1/00 , C07H1/06 , C07H3/00 , C07H3/04 , C07H3/06 , C07K7/00 , C08B37/00 , C12N1/20 , C12N9/24 , C12N9/26 , C12N9/90 , C12P19/00 , C12P19/12 , C12P19/14 , C12P19/24 , C12R1/41 , C13K20060101 , C13K13/00 , C07H3/02
CPC分类号： C13K13/00 , A23G3/343 , A23G3/346 , A23G3/42 , A23G4/10 , A23L13/428 , A23L15/20 , A23L27/33 , A61K8/60 , A61K8/66 , A61Q11/00 , A61Q19/00 , C07H1/00 , C07H3/04 , C12N9/90 , C12P19/12 , A23G2200/06 , A61Q17/04 , A61Q19/02 , A61Q7/00
摘要： Disclosed are novel non-reducing saccharide-forming enzyme, and its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Rhizobium sp. M-11 (FERM BP 4130) and Arthrobacter sp. Q36 (FERM BP-4316), and capable of forming non-reducing saccharides having a trehalose structure when allowed to act on reducing partial starch hydrolysates. Glucoamylase and .alpha.-glucosidase readily yield trehalose when allowed to act on the non-reducing saccharides. These non-reducing saccharides and trehalose are extensively useful in food products, cosmetics and pharmaceuticals.

28. 发明授权

US5885969A Enzyme-treated hesperidin, process for producing the same and method of using enzyme-treated hesperidin 失效
标题翻译：酶处理的橙皮苷，其制备方法和使用酶处理的橙皮苷的方法
公开(公告)号：US5885969A
公开(公告)日：1999-03-23
申请号：US881056
申请日：1997-06-24
申请人： Toshio Miyake , Takashi Yumoto
发明人： Toshio Miyake , Takashi Yumoto
IPC分类号： A23L2/02 , A23B7/154 , A23L1/272 , A23L1/275 , A23L2/44 , A23L2/58 , A23L2/70 , A23L3/3544 , C07H17/07 , C09B67/00 , C12P19/14 , C12P19/60 , A61K31/70
CPC分类号： C12P19/605 , A23B7/154 , A23L2/44 , A23L2/58 , A23L3/3544 , A23L5/41 , C07H17/07
摘要： An enzyme-treated hesperidin, comprising alpha-glucosyl hesperidin, hesperidin and beta-monoglucosyl hesperetin, wherein the content of hesperidin is 0.1 part or less by weight; and that of beta-monoglucosyl hesperetin, 0.1 to 0.5 part by weight, on the basis of 1 part by weight of alpha-glucosyl hesperidin. The present invention also provides a process to produce enzyme-treated hesperidin, which comprises subjecting a solution containing alpha-glucosyl hesperidin and intact hesperidin to alpha-L-rhamnosidase to convert the intact hesperidin into beta-monoglucosyl hesperetin. The enzyme-treated hesperidin, which is excellent in water solubility and is free from crystal precipitation (clouding) even if stored for a prolonged period of time, can be produced from a material containing alpha-glucosylhesperidin and hesperidin by conducting the above simple treatment of material. The present invention further provides a method of using the enzyme-treated hesperidin. The enzyme-treated hesperidin can be used in the prevention of clouding of a canned tangerine and prevention of fading of natural coloring matter.
摘要翻译：一种酶处理的橙皮苷，其包含α-葡糖基橙皮苷，橙皮苷和β-单葡萄糖基橙皮素，其中橙皮苷的含量为0.1重量份或更少; 基于1重量份的α-葡萄糖基橙皮苷的β-葡萄糖基橙皮素0.1〜0.5重量份。本发明还提供了一种生产酶处理的橙皮苷的方法，其包括将含有α-葡糖基橙皮苷和完整的橙皮苷的溶液经受α-L-鼠李糖苷酶将完整的橙皮苷转化成β-单葡糖基橙皮素。通过进行上述简单的处理，可以通过含有α-葡萄糖苷基和橙皮苷的材料来生产即使长时间贮存也具有优异的水溶性并且没有晶体沉淀（混浊）的酶处理橙皮苷材料。本发明还提供了使用酶处理的橙皮苷的方法。酶处理的橙皮苷可用于防止罐装橘子的混浊和防止天然色素的褪色。

29. 发明授权

US5883243A Non-reducing saccharides, their preparations and uses 失效
标题翻译：非还原糖，其制备和用途
公开(公告)号：US5883243A
公开(公告)日：1999-03-16
申请号：US797248
申请日：1997-02-07
申请人： Tomoyuki Nishimoto , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
发明人： Tomoyuki Nishimoto , Hiroto Chaen , Toshiyuki Sugimoto , Toshio Miyake
IPC分类号： C07H3/06 , C12P19/04 , C07H1/00 , C12P19/00
CPC分类号： C07H3/06 , C12P19/04
摘要： .alpha.-Isomaltosyl .alpha.-isomaltoside represented by O-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-.alpha.-D-glucopyranosyl O-.alpha.-D-glucopyranosyl-(1.fwdarw.6)-.alpha.-D-glucopyranoside is a novel non-reducing saccharide which promotes the growth of bifid bacteria, has an anti-caries activity, and promotes the mineral absorption. Similarly as the non-reducing saccharide, .alpha.-isomaltosyl .alpha.-glucoside and .alpha.-isomaltotriosyl .alpha.-glucoside can be also used to prevent caries and promote the growth of bifid bacteria and the mineral absorption. These saccharides can be used alone or in combination in a variety of foods, cosmetics and pharmaceuticals.
摘要翻译：由α-α-D-吡喃葡萄糖基 - （1-> 6）-β-D-吡喃葡萄糖基O-α-D-吡喃葡萄糖基 - （1-> 6）-β-D-吡喃葡萄糖苷代表的α-异麦角糖型α-异麦芽糖苷是促进双歧杆菌生长的新型非还原性糖类具有抗龋齿活性，促进矿物质吸收。类似地，作为非还原性糖，α-异麦芽糖基α-葡萄糖苷和α-异麦芽糖基α-葡糖苷也可用于预防龋齿并促进双歧杆菌的生长和矿物质吸收。这些糖类可以单独使用，也可以组合使用于各种食品，化妆品，药品等。

30. 发明授权

US5876975A Trehalose phosphorylase its preparation and uses 失效
标题翻译：海藻糖磷酸酶的制备及用途
公开(公告)号：US5876975A
公开(公告)日：1999-03-02
申请号：US103509
申请日：1998-06-24
申请人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
发明人： Tetsuya Nakada , Michio Kubota , Hiroto Chaen , Toshio Miyake
IPC分类号： A61K38/00 , C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18 , C12P19/44 , C07K1/00 , C12P21/06
CPC分类号： C12N9/1051 , C12P19/18 , A61K38/00
摘要： A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and .beta.-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with .beta.-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.
摘要翻译：一种热稳定的海藻糖磷酸化酶，其可从Thermoanaerobium属的微生物获得，并且在无机磷酸存在下水解海藻糖以形成D-葡萄糖和β-D-葡萄糖-1-磷酸。海藻糖磷酸化酶也可以通过重组DNA技术制备。当酶在其他糖类存在下与β-D-葡萄糖-1-磷酸作为糖供体接触时，通常已知但几乎不可获得的包括葡糖基-D-半乳糖苷的葡糖基转移的糖可以是以工业规模生产，成本相对较低。

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