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21. 发明授权

US09101616B2 Aryl substituted carboxamide derivatives as calcium or sodium channel blockers 有权
标题翻译：芳基取代的甲酰胺衍生物作为钙或钠通道阻断剂
公开(公告)号：US09101616B2
公开(公告)日：2015-08-11
申请号：US13375117
申请日：2010-05-31
申请人： Tadashi Inoue , Shuzo Watanabe , Tatsuya Yamagishi , Yoshimasa Arano , Mikio Morita , Kaoru Shimada
发明人： Tadashi Inoue , Shuzo Watanabe , Tatsuya Yamagishi , Yoshimasa Arano , Mikio Morita , Kaoru Shimada
IPC分类号： A61K31/498 , C07D401/12 , C07D213/65 , C07D241/18 , A61K31/497 , A61K31/444 , A61K31/44 , A61K31/4965 , A61K31/4439 , A61K31/4709 , C07D413/12 , A61K31/4725 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4706 , A61K31/506 , C07D215/40 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4706 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/506 , C07D213/65 , C07D215/40 , C07D241/18 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.
摘要翻译：本发明涉及式（I）的芳基取代的甲酰胺衍生物或其药学上可接受的盐，其具有作为河豚毒素敏感型（TTX-S）阻滞剂如NaV1的T型钙通道或电压门控钠通道的阻断活性 3和NaV1.7，其可用于治疗或预防其中涉及T型钙通道或电压门控钠通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道或电压门控钠通道的疾病中的用途。

22. 发明授权

US08999974B2 Acyl piperazine derivatives as TTX-S blockers 有权
标题翻译：酰基哌嗪衍生物作为TTX-S阻断剂
公开(公告)号：US08999974B2
公开(公告)日：2015-04-07
申请号：US13814716
申请日：2011-08-09
申请人： Mikiko Morita , Shuzo Watanabe
发明人： Mikiko Morita , Shuzo Watanabe
IPC分类号： C07D403/12 , A61K31/506 , C07D239/47 , A61K45/06 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/517 , A61K31/538 , C07D401/12 , C07D403/04 , C07D417/14 , C07D471/04 , C07D487/08 , C07D495/04
CPC分类号： C07D239/47 , A61K31/506 , A61K31/517 , A61K31/538 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/08 , C07D495/04 , A61K2300/00
摘要： The present invention relates to acyl piperazine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.
摘要翻译：本发明涉及具有电压门控钠通道作为TTX-S通道的阻断活性的酰基哌嗪衍生物，其可用于治疗或预防涉及电压门控钠通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病中的用途。

23. 发明授权

US06978710B2 Pneumatic booster 有权
标题翻译：气动助力器
公开(公告)号：US06978710B2
公开(公告)日：2005-12-27
申请号：US10900688
申请日：2004-07-28
申请人： Toshio Takayama , Mitsuhiro Endo , Shuzo Watanabe
发明人： Toshio Takayama , Mitsuhiro Endo , Shuzo Watanabe
IPC分类号： B60T13/573 , B60T13/57 , B60T13/575 , B60T13/52
CPC分类号： B60T13/57 , B60T13/575
摘要： An elastic member is interposed between a reaction disk and a plunger. By moving the plunger to open a poppet seal such that atmospheric air is introduced into the variable pressure chambers, a pressure differential is created between the variable pressure chambers and constant pressure chambers (negative pressure). As a result, servo power is applied to an output rod, and a resulting reaction force is partly transmitted back to an input rod through the reaction disk. During a rapid braking operation, a piston is caused to retract by a pin, thus pushing the elastic member into an outer peripheral groove formed on the piston so that the elastic member is axially compressed. As a result, the movement amount of the plunger can be increased without receiving a reaction force, enabling the rapid development of servo power.
摘要翻译：弹性构件介于反作用盘和柱塞之间。通过移动柱塞来打开提升阀密封，使得大气空气被引入到可变压力室中，在可变压力室和恒定压力室之间产生压力差（负压）。结果，伺服电源被施加到输出杆，并且所产生的反作用力部分地通过反作用盘传递回输入杆。在快速制动操作期间，通过销使活塞缩回，从而将弹性构件推入形成在活塞上的外周槽，使得弹性构件被轴向压缩。结果，可以在不接收到反作用力的情况下增加柱塞的移动量，从而能够快速发展伺服电力。

24. 发明申请

US20050061142A1 Pneumatic booster 有权
公开(公告)号：US20050061142A1
公开(公告)日：2005-03-24
申请号：US10900688
申请日：2004-07-28
申请人： Toshio Takayama , Mitsuhiro Endo , Shuzo Watanabe
发明人： Toshio Takayama , Mitsuhiro Endo , Shuzo Watanabe
IPC分类号： B60T13/573 , B60T13/57 , B60T13/575 , F15B9/10
CPC分类号： B60T13/57 , B60T13/575
摘要： An elastic member is interposed between a reaction disk and a plunger. By moving the plunger to open a poppet seal such that atmospheric air is introduced into the variable pressure chambers, a pressure differential is created between the variable pressure chambers and constant pressure chambers (negative pressure). As a result, servo power is applied to an output rod, and a resulting reaction force is partly transmitted back to an input rod through the reaction disk. During a rapid braking operation, a piston is caused to retract by a pin, thus pushing the elastic member into an outer peripheral groove formed on the piston so that the elastic member is axially compressed. As a result, the movement amount of the plunger can be increased without receiving a reaction force, enabling the rapid development of servo power.

25. 发明授权

US06637838B2 Pneumatic booster 有权
标题翻译：气动助力器
公开(公告)号：US06637838B2
公开(公告)日：2003-10-28
申请号：US10132417
申请日：2002-04-26
申请人： Shuzo Watanabe
发明人： Shuzo Watanabe
IPC分类号： B60T844
CPC分类号： B60T13/567
摘要： A tandem pneumatic booster includes a front shell having a relatively long cylindrical portion and a rear shell having a relatively short cylindrical portion. The cylindrical portions of the front and rear shells are joined together to form a shell body. An opening edge of a cylindrical portion of a center shell is disposed in the joint between the front and rear shells, together with an outer peripheral bead of a diaphragm of a rear power piston. The cylindrical portion of each of the front, rear and center shells has a frusto-conical shape gradually increasing in diameter toward the opening edge thereof. Thus, when front shells, rear shells and center shells are stacked on one another, respectively, as constituent parts before assembly, the depth of fitting between each pair of adjacent shell elements is increased sufficiently to stably maintain the stacked conditions of the shell elements.
摘要翻译：串联气动助力器包括具有相对长的圆柱形部分的前壳和具有相对短的圆柱形部分的后壳。前壳和后壳的圆柱形部分连接在一起以形成壳体。中心壳的圆柱形部分的开口边缘与后活塞活塞的隔膜的外周边珠缘一起设置在前壳和后壳之间的接合处。前，后和中心壳体的每个的圆柱形部分具有朝其开口边缘逐渐增大的截头圆锥形状。因此，当前壳，后壳和中心壳分别堆叠在组装之前的组成部分时，每对相邻的壳单元之间的配合深度被充分增加以稳定地保持壳单元的堆叠状态。

26. 发明授权

US5743167A Pneumatic booster 失效
标题翻译：气动助力器
公开(公告)号：US5743167A
公开(公告)日：1998-04-28
申请号：US715894
申请日：1996-09-19
申请人： Shuzo Watanabe , Mitsuhiro Endo , Hiromi Ando
发明人： Shuzo Watanabe , Mitsuhiro Endo , Hiromi Ando
IPC分类号： B60T13/563 , B60T13/567 , B60T13/569 , F01B19/00 , F15B11/00
CPC分类号： B60T13/567 , B60T13/563 , B60T13/569
摘要： A tandem pneumatic booster having a shell body, the inside of which is divided into two, front and rear, chambers by a center shell. Each chamber includes a negative pressure chamber and a working pressure chamber. A valve body is slidably fitted in the shell body and the center shell with seal members therebetween. The valve body is provided with an air passage for communication between the front and rear working pressure chambers. A valve mechanism is actuated in association with an input shaft to introduce atmospheric air into the front and rear working pressure chambers through the air passage so as to apply thrust to front and rear power pistons. The diaphragm of the front power piston has a bead on an inner periphery thereof. The valve body has a groove on an outer periphery thereof. A portion of the air passage which leads to the front working pressure chamber has a main passage portion extending axially in the valve body, and a bypass extending radially outward from the main passage portion. A communicating port leading to the front working pressure chamber extends axially from the bypass. The bypass opens into the groove, and the radially outer end of the bypass is sealed with the bead.
摘要翻译：一种串联式气动助力器，其具有壳体，其壳体通过中心壳体分成两个，前后腔。每个室包括负压室和工作压力室。阀体可滑动地装配在壳体和中心壳体之间，其间具有密封构件。阀体设置有用于在前后工作压力室之间连通的空气通道。阀门机构与输入轴相关联地致动，以将空气通过空气通道引入前后工作压力室，从而将推力施加到前后动力活塞。前功率活塞的隔膜在其内周上具有凸缘。阀体的外周具有槽。通向前工作压力室的空气通道的一部分具有在阀体中轴向延伸的主通道部分和从主通道部分径向向外延伸的旁路。通向前工作压力室的连通口从旁路轴向延伸。旁路通向槽中，旁路的径向外端用珠密封。

27. 发明授权

US07543553B2 Circulating fluidized bed boiler 有权
标题翻译：循环流化床锅炉
公开(公告)号：US07543553B2
公开(公告)日：2009-06-09
申请号：US10980916
申请日：2004-11-04
申请人： Shuzo Watanabe
发明人： Shuzo Watanabe
IPC分类号： F27B15/08
CPC分类号： F23G5/48 , F23C10/10 , F23C2206/103 , F23G5/30 , F23G2203/501
摘要： A circulating fluidized bed boiler has reduced corrosion in the exchanging tube in an external heat exchanger. The circulating fluidized bed boiler has a furnace which combusts a fuel which is fluidized together with a bed material, a cyclone dust collector into which an flue gas which is generated by the combustion in the furnace is introduced and which catches particles in the flue gas, a separation loop, in a seal box, which separates corrosive components from the particles so as not to introduce the corrosive components to the external heat exchanger which is arranged downstream of the seal box.
摘要翻译：循环流化床锅炉在外部热交换器中的交换管中减少了腐蚀。循环流化床锅炉具有燃烧与床料一起流化的燃料的炉，其中引入由炉内燃烧产生的烟道气并且在烟气中捕获颗粒的旋风除尘器，在密封箱中的分离回路，其将腐蚀性成分与颗粒分离，以便不将腐蚀性成分引入布置在密封箱下游的外部热交换器。

28. 发明申请

US20050115400A1 Pneumatic booster 有权
标题翻译：气动助力器
公开(公告)号：US20050115400A1
公开(公告)日：2005-06-02
申请号：US10992817
申请日：2004-11-22
申请人： Mitsuhiro Endo , Shuzo Watanabe
发明人： Mitsuhiro Endo , Shuzo Watanabe
IPC分类号： B60T13/52 , B60T13/56 , B60T13/563 , F16B39/12
CPC分类号： B60T13/567
摘要： In a pneumatic booster, a front shell and a rear shell are connected by means of a rod. A stud bolt on one end of the rod extends through the front shell to the outside, and a support plate fitted around the stud bolt is engaged with the rod and abutted against an inner surface of the front shell. A seal member is provided in an annular groove formed in the support plate. A projection is formed in the support plate. When the support plate is reversely mounted on the stud bolt, the projection is abutted against the front shell, and the seal member is unable to provide a seal between the stud bolt and the front shell. In a leak inspection, air is flowed into a constant-pressure chamber through a cut portion formed in a distal end of the projection, to thereby detect reverse mounting of the support plate.
摘要翻译：在气动助力器中，前壳和后壳通过杆连接。杆的一端上的双头螺栓穿过前壳延伸到外部，并且围绕双头螺栓安装的支撑板与杆接合并抵靠在前壳的内表面上。密封构件设置在形成在支撑板中的环形槽中。在支撑板上形成突起。当支撑板反向安装在双头螺栓上时，突起抵靠前壳，密封件不能在双头螺栓和前壳之间提供密封。在泄漏检查中，空气通过形成在突起的远端的切割部分流入恒压室，从而检测支撑板的反向安装。

29. 发明申请

US20050064357A1 Circulating fluidized bed boiler 有权
标题翻译：循环流化床锅炉
公开(公告)号：US20050064357A1
公开(公告)日：2005-03-24
申请号：US10980916
申请日：2004-11-04
申请人： Shuzo Watanabe
发明人： Shuzo Watanabe
IPC分类号： F23G5/30 , F22B1/02 , F23C10/08 , F23C10/10 , F23C10/18 , F23G5/48 , F27B15/00
CPC分类号： F23G5/48 , F23C10/10 , F23C2206/103 , F23G5/30 , F23G2203/501
摘要： A circulating fluidized bed boiler has reduced corrosion in the exchanging tube in an external heat exchanger. The circulating fluidized bed boiler has a furnace which combusts a fuel which is fluidized together with a bed material, a cyclone dust collector into which an flue gas which is generated by the combustion in the furnace is introduced and which catches particles in the flue gas, a separation loop, in a seal box, which separates corrosive components from the particles so as not to introduce the corrosive components to the external heat exchanger which is arranged downstream of the seal box.
摘要翻译：循环流化床锅炉在外部热交换器中的交换管中减少了腐蚀。循环流化床锅炉具有燃烧与床料一起流化的燃料的炉，其中引入由炉内燃烧产生的烟道气并且在烟气中捕获颗粒的旋风除尘器，在密封箱中的分离回路，其将腐蚀性成分与颗粒分离，以便不将腐蚀性成分引入布置在密封箱下游的外部热交换器。

30. 发明授权

US4168565A Method for manufacturing thermionic cathode 失效
标题翻译：热离子阴极的制造方法
公开(公告)号：US4168565A
公开(公告)日：1979-09-25
申请号：US898401
申请日：1978-04-20
申请人： Masaji Ishii , Shuzo Watanabe , Akira Miyai , Hideo Hiraoka
发明人： Masaji Ishii , Shuzo Watanabe , Akira Miyai , Hideo Hiraoka
IPC分类号： H01J1/13 , H01J9/04
CPC分类号： H01J9/04 , H01J1/13
摘要： A method for manufacturing a thermionic cathode is provided which comprises cutting a bar from a multi-layer structure having a first layer of thermoelectron emissive compound and a third layer of metal of high melting point, a second layer of reaction barrier being interposed between said first and third layers, the bar being cut in a direction substantially perpendicular to that of the layers, sharpening the end of the first layer of the bar and then providing current terminals with the third layer of the bar. According to the method of the invention, a thermionic cathode capable of emitting stable electron beams of high intensity for a long period of time can be manufactured.
摘要翻译：提供一种用于制造热离子阴极的方法，其包括从具有第一层热电子发射化合物层和第三层高熔点金属的多层结构切割条，第二层反应阻挡层插入在所述第一层和第三层，所述条在基本上垂直于所述层的方向上切割，使所述条的所述第一层的末端锐化，然后向所述条的第三层提供电流端子。根据本发明的方法，可以制造能够长时间发射高强度电子束的热离子阴极。

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