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21. 发明申请

US20080166815A1 Ozone gas sensing element, detection apparatus, and measurement method 失效
公开(公告)号：US20080166815A1
公开(公告)日：2008-07-10
申请号：US12075638
申请日：2008-03-13
申请人： Yasuko Maruo , Shigeo Ogawa , Seizou Sakata , Tohru Tanaka
发明人： Yasuko Maruo , Shigeo Ogawa , Seizou Sakata , Tohru Tanaka
IPC分类号： G01N21/77
CPC分类号： G01N31/225 , G01N33/0039 , Y02A50/247 , Y10T436/206664
摘要： A sensing element in which a dye that changes in the light absorption characteristic of the visible region upon reaction with ozone gas is deposited in the pores of a porous material is prepared. A change in dye before and after exposing the sensing element to a measurement environment for a predetermined time is measured. The ozone gas amount in measurement target air is measured on the basis of the change in dye.

22. 发明申请

US20070203027A1 5-Aminolevulinic Acid Salt, Process For Producing The Same And Use Thereof 有权
标题翻译： 5-氨基乙酰丙酸盐，其生产方法和用途
公开(公告)号：US20070203027A1
公开(公告)日：2007-08-30
申请号：US10594923
申请日：2005-03-28
申请人： Naohisa Tachiya , Seiji Nishikawa , Mai Higo , Tohru Tanaka , Masahiro Ishizuka , Hideki Okada
发明人： Naohisa Tachiya , Seiji Nishikawa , Mai Higo , Tohru Tanaka , Masahiro Ishizuka , Hideki Okada
IPC分类号： A01N57/00 , A61K31/66 , C07F9/02
CPC分类号： A01N37/44 , A61K41/0061 , A61K49/0021 , C07C227/00 , C07C229/22 , C07C309/30 , C07F9/11
摘要： A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.
摘要翻译：可用于微生物，发酵，动物，药物，植物等领域的5-氨基乙酰丙酸盐; 其制造方法; 包含其的医药组合物; 和包含其的植物活化剂组合物。

23. 发明授权

US07149165B2 Controller for data recorder 有权
标题翻译：数据记录器控制器
公开(公告)号：US07149165B2
公开(公告)日：2006-12-12
申请号：US09748509
申请日：2000-12-26
申请人： Koji Hayashi , Akira Tsukihashi , Yasushi Hanamoto , Tohru Tanaka
发明人： Koji Hayashi , Akira Tsukihashi , Yasushi Hanamoto , Tohru Tanaka
IPC分类号： G11B5/09
CPC分类号： G11B27/24 , G11B19/04 , G11B20/10527 , G11B27/3027 , G11B27/3063 , G11B2020/10814 , G11B2220/216 , G11B2220/218 , G11B2220/2529 , G11B2220/2545
摘要： A controller for a data recorder for recording data that records data in a continuous manner regardless of interruptions. An encoder encodes data that is to be written to a recording medium. A synchronizing circuit synchronizes the data read from the recording medium with the encoded data when the writing of data to the recording medium is interrupted. A first retry determination circuit determines whether an address of the data read from the recording medium and an address of the data provided to the encoder match. A second retry determination circuit determines whether the timing for reading data from recording medium and the timing for encoding data match. A restart circuit restarts the writing of data to the recording medium based on the determinations of the first and second retry determination circuits.
摘要翻译：用于记录以连续方式记录数据的数据的数据记录器的控制器，而不管中断。编码器对要写入记录介质的数据进行编码。当将记录介质写入中断时，同步电路将从记录介质读取的数据与编码数据同步。第一重试确定电路确定从记录介质读取的数据的地址和提供给编码器的数据的地址是否匹配。第二重试确定电路确定从记录介质读取数据的定时和编码数据的定时是否匹配。基于第一和第二重试确定电路的确定，重新启动电路重新开始将数据写入记录介质。

24. 发明授权

US06905671B1 Diagnostic agents and remedies for malignant tumors 有权
标题翻译：恶性肿瘤的诊断剂和治疗方法
公开(公告)号：US06905671B1
公开(公告)日：2005-06-14
申请号：US09445963
申请日：1998-06-16
申请人： Tohru Tanaka , Hiroshi Sasaki
发明人： Tohru Tanaka , Hiroshi Sasaki
IPC分类号： A61K51/00 , A61K31/195 , A61K41/00 , A61K49/00 , A61K51/04 , A61P35/00
CPC分类号： A61K41/0061 , A61K51/0402
摘要： An agent for diagnosing or photokinetically treating malignant tumors, comprising as an active ingredient a compound in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, or an ester, amide, salt, hydrate or solvate of the compound.
摘要翻译：一种用于诊断或光动力治疗恶性肿瘤的药剂，其中含有5-氨基乙酰丙酸的至少一个碳原子是其氨基上的碳同位素和/或氮原子的化合物是氮同位素作为活性成分，或作为活性成分，或酯，酰胺，盐，水合物或溶剂化物。

25. 发明授权

US06461581B1 Clathrate compounds and manufacturing method thereof 有权
标题翻译：包合物及其制造方法
公开(公告)号：US06461581B1
公开(公告)日：2002-10-08
申请号：US09631176
申请日：2000-08-02
申请人： Haruki Eguchi , Akihiko Suzuki , Satoshi Takahashi , Kaoru Miyahara , Tohru Tanaka , Shigemitsu Kihara , Kazuo Tsumuraya
发明人： Haruki Eguchi , Akihiko Suzuki , Satoshi Takahashi , Kaoru Miyahara , Tohru Tanaka , Shigemitsu Kihara , Kazuo Tsumuraya
IPC分类号： C01B3100
CPC分类号： H01L35/14 , C01B33/06 , Y02P20/129 , Y02P20/13
摘要： The present invention provides a clathrate compound which can be used as a thermoelectric material, a hard material, or a semiconductor material. Silicon or carbon are formed into a clathrate lattice, and a clathrate compound is then formed in which specified doping atoms are encapsulated within the clathrate lattice, and a portion of the atoms of the clathrate lattice are substituted with specified substitution atoms. The clathrate lattice is, for example, a silicon clathrate 34 (Si34) mixed lattice of a Si20 cluster including a dodecahedron of Si atoms, and a Si28 cluster including a hexahedron of Si atoms. Suitable doping atoms are atoms from group 1A, group 2A, group 3A, group 1B, group 2B, group 3B, group 4A, group 5A, group 6A, and group 8, and suitable substitution atoms are atoms from group 1A, group 2A, group 3A, group 1B, group 2B, group 3B, group 5A, group 6A, group 7A, group 5B, group 6B, group 7B, and group 8 of the periodic table. Suitable manufacturing methods include melt methods and sintering methods, and moreover intercalant intercalation compounds or the like may also be used as raw materials.
摘要翻译：本发明提供可用作热电材料，硬质材料或半导体材料的包合物。硅或碳形成包合物晶格，然后形成包合物化合物，其中特定的掺杂原子被包封在包合物晶格内，并且包合物晶格的一部分原子被指定的取代原子取代。包合物晶格是例如包含Si原子的十二面体的Si 20簇的硅包合物34（Si34）混合晶格和包含Si原子的六面体的Si28簇。合适的掺杂原子是1A组，2A组，3A组，1B组，2B组，3B组，4A组，5A组，6A组和8组的原子，合适的取代原子是来自1A组，2A组， 3A组，1B组，2B组，3B组，5A组，6A组，7A组，5B组，6B组，7B组和8周期。合适的制造方法包括熔融法和烧结方法，而且插入剂插层化合物等也可以用作原料。

26. 发明授权

US5733770A 5-aminolevulinic acid producing microorganism and process for producing 5-aminolevulinic acid 失效
标题翻译： 5-氨基乙酰丙酸生产微生物和生产5-氨基乙酰丙酸的方法
公开(公告)号：US5733770A
公开(公告)日：1998-03-31
申请号：US575818
申请日：1995-12-20
申请人： Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
发明人： Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
IPC分类号： C12P13/00 , C12N1/20
CPC分类号： C12P13/005 , C12R1/01 , C12R1/19 , C12R1/38 , C12R1/85 , Y10S435/822
摘要： A microorganism that produces 5-aminolevulinic acid, wherein the microorganism has a 5-aminolevulinic acid dehydratase variant having a reduced inhibitor constant for a 5-aminolevulinic acid dehydratate inhibitor. A microorganism that produces 5-aminolevulinic acid, wherein the microorganism is a photosynthetic bacterium that produces 5-aminolevulinic acid without light irradiation. A progess for producing 5-aminolevulinic acid comprising the step of culturing a microorganism that produces 5-aminolevulinic acid in a culture medium under at least one condition selected from the group consisting of (a) less than 1 ppm of dissolved oxygen concentration in the culture medium, (b) from -180 to 50 mV of oxidation-reduction potential in the culture medium, and (c) from 5.times.10.sup.-9 to (KrM-2.times.10.sup.-8) (mol of O.sub.2 /ml.multidot.min.multidot.cell) of cellular respiration rate, wherein KrM represents the maximum cellular respiration rate when oxygen is supplied in an excess quantity.
摘要翻译：一种产生5-氨基乙酰丙酸的微生物，其中微生物具有5-氨基乙酰丙酸脱水抑制剂的抑制剂常数降低的5-氨基乙酰丙酸脱水酶变体。产生5-氨基乙酰丙酸的微生物，其中所述微生物是不照射光而产生5-氨基乙酰丙酸的光合细菌。一种用于生产5-氨基乙酰丙酸的方法，包括在选自以下的至少一种条件下培养在培养基中产生5-氨基乙酰丙酸的微生物的步骤：（a）在培养物中小于1ppm的溶解氧浓度培养基中，（b）在培养基中的-180至50mV的氧化还原电位，和（c）5×10 -9至（KrM-2×10 -8）（摩尔的O 2 / ml×Min×细胞）的细胞呼吸速率，其中当以超量供给氧气时，KrM表示最大的细胞呼吸速率。

27. 发明授权

US5489572A Methods for reducing nitrate nitrogen and oxalic acids contents nin plants 失效
标题翻译：减少植物硝酸盐氮和草酸含量的方法
公开(公告)号：US5489572A
公开(公告)日：1996-02-06
申请号：US292024
申请日：1994-08-18
申请人： Ryuji Yoshida , Tohru Tanaka , Yasushi Hotta
发明人： Ryuji Yoshida , Tohru Tanaka , Yasushi Hotta
IPC分类号： A01N37/44
CPC分类号： A01N37/44 , Y02P60/218
摘要： Methods for reducing nitrate nitrogen and oxalic acid contents in plants, each of which comprises applying 5-aminolevulinic acid, a salt thereof or a mixture thereof. Nitrate nitrogen and oxalic acid contents in plants having high nitrate nitrogen and oxalic acid contents can be reduced effectively and easily.
摘要翻译：减少植物中硝酸盐氮和草酸含量的方法，每种方法包括施用5-氨基乙酰丙酸，其盐或其混合物。硝酸盐氮和草酸含量高的植物中的氮和草酸含量可以有效降低。

28. 发明授权

US09340490B2 Diagnostic agent for tumor 有权
标题翻译：肿瘤诊断剂
公开(公告)号：US09340490B2
公开(公告)日：2016-05-17
申请号：US11664065
申请日：2005-09-22
申请人： Ichiro Okura , Toshiaki Kamachi , Shunichiro Ogura , Masahiro Ishizuka , Tohru Tanaka
发明人： Ichiro Okura , Toshiaki Kamachi , Shunichiro Ogura , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K31/197 , A61P43/00 , C07C229/22 , A61K49/00 , G01N33/574
CPC分类号： C07C229/22 , A61K49/0021 , G01N33/574
摘要： According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising δ-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof: R2R1NCH2COCH2CH2COR3 (I) wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.
摘要翻译：根据本发明，进行早期检测，所有肿瘤的治疗效果和预后诊断的肿瘤诊断剂本发明的肿瘤诊断剂是包含由式（I）表示的δ-氨基乙酰丙酸的肿瘤诊断剂），其衍生物及其盐：R2R1NCH2COCH2CH2COR3（I）其中R1和R2各自独立地表示氢，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，其用于通过在给药后从身体内部或外部收集的样品中的卟啉测量来诊断。

29. 发明授权

US09314443B2 Enhancer of survival of transplanted organ 有权
标题翻译：移植器官生存增强
公开(公告)号：US09314443B2
公开(公告)日：2016-04-19
申请号：US14350488
申请日：2012-09-12
申请人： Ko Rii , Kiwamu Takahashi , Naomi Haga , Fuminori Abe , Tohru Tanaka , Motowo Nakajima , Hidenori Ito
发明人： Ko Rii , Kiwamu Takahashi , Naomi Haga , Fuminori Abe , Tohru Tanaka , Motowo Nakajima , Hidenori Ito
IPC分类号： A61K31/195 , A61K31/265 , A61K31/197 , A61K33/26 , A61K31/22 , A61K31/295 , A61K45/06
CPC分类号： A61K31/197 , A01N1/0226 , A61K31/22 , A61K31/295 , A61K33/26 , A61K35/17 , A61K45/06 , A61K2035/122 , A61K2035/124 , A61K2300/00
摘要： The present invention provides an agent for promoting graft survival which can suppress rejection without use of existing immunosuppressants, an organ preservation solution capable of maintaining the freshness of an organ excised from a donor, and the like. An agent for promoting graft survival or an organ preservation solution is prepared, which comprises 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of ALA or the derivative and an iron compound as active ingredients. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.
摘要翻译：本发明提供了一种用于促进移植物存活的药剂，其可以抑制不使用现有的免疫抑制剂的排斥反应，能够保持从供体排出的器官的新鲜度的器官保存溶液等。制备促进移植物存活的药剂或器官保存溶液，其包含5-氨基乙酰丙酸（ALA）或其衍生物，或ALA或其衍生物和铁化合物的盐作为活性成分。 ALA的优选实例可以包括ALA和各种酯，例如ALA的甲酯，乙酯，丙酯，丁酯和戊酯，以及它们的盐酸盐，磷酸盐和硫酸盐。铁化合物的优选实例可包括柠檬酸亚铁钠。

30. 发明授权

US08927532B2 Therapeutic agent and diagnostic agent for mitochondrial dysfunction brain diseases 有权
标题翻译：线粒体功能障碍脑疾病的治疗剂和诊断剂
公开(公告)号：US08927532B2
公开(公告)日：2015-01-06
申请号：US13613565
申请日：2012-09-13
申请人： Toshihiko Kuroiwa , Yoshinaga Kajimoto , Takahiro Masubuchi , Masahiro Ishizuka , Tohru Tanaka
发明人： Toshihiko Kuroiwa , Yoshinaga Kajimoto , Takahiro Masubuchi , Masahiro Ishizuka , Tohru Tanaka
IPC分类号： A61K31/555 , A61K31/195 , A61K31/295 , A61K31/197 , A61K31/198 , A61K33/26 , A61K45/06 , A61K49/00
CPC分类号： A61K31/295 , A61K31/197 , A61K31/198 , A61K33/26 , A61K45/06 , A61K49/0008 , A61K2300/00
摘要： To provide a therapeutic agent and a diagnostic agent for mitochondrial dysfunction brain diseases including cerebral infarction as a representative.A therapeutic agent for a mitochondrial dysfunction brain disease, which comprises (A) δ-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof and (B) an iron compound in combination. R2R1NCH2COCH2CH2COR3 (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.
摘要翻译：提供治疗剂和用于线粒体功能障碍脑疾病（包括脑梗死代表）的诊断剂。线粒体功能障碍性脑病的治疗剂，其包含（A）由式（1）表示的δ-氨基乙酰丙酸，其衍生物或其盐和（B）铁化合物的组合。 R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基。

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