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21. 发明申请

US20080027517A1 LIGHT GENERATING DEVICE FOR INTRAVASCULAR USE 有权
标题翻译：光生成装置用于静脉内使用
公开(公告)号：US20080027517A1
公开(公告)日：2008-01-31
申请号：US11773555
申请日：2007-07-05
申请人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , Zihong Guo , Jennifer Matson , Steven Daly , David Shine , Gary Lichttenegger , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B2018/2261 , A61N5/062 , A61N2005/0602 , A61N2005/0652 , A61N2005/1003
摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
摘要翻译：用于照射血管组织部分的光产生装置，以进行光动力疗法。在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。光纤可选地将来自光源的光引导到漫射元件。光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。线性光源元件特别适用于处理容器中组织的细长部分。旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

22. 发明申请

US20070260295A1 Light transmission system for photoreactive therapy 有权
标题翻译：用于光反应治疗的光传输系统
公开(公告)号：US20070260295A1
公开(公告)日：2007-11-08
申请号：US11416783
申请日：2006-05-03
申请人： James Chen , Steven Daly , Zihong Guo , Llew Keltner , Jeffrey Storm
发明人： James Chen , Steven Daly , Zihong Guo , Llew Keltner , Jeffrey Storm
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

23. 发明申请

US20120149986A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES 有权
标题翻译：使用灵活的轻型结构的医疗设备
公开(公告)号：US20120149986A1
公开(公告)日：2012-06-14
申请号：US13401747
申请日：2012-02-21
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichtlenegger , Jennifer K. Matson , Jean Bishop , Nick YEO , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

24. 发明申请

US20110281837A1 3-SUBSTITUTED-6-ARYL PYRIDINES 审中-公开
标题翻译： 3-取代的6-芳基吡啶
公开(公告)号：US20110281837A1
公开(公告)日：2011-11-17
申请号：US12983661
申请日：2011-01-03
申请人： Alan J. Hutchinson , Jun Yuan , Kyungae Lee , George D. Maynard , Bertrand L. Chenard , Nian Liu , Qin Guo , Zihong Guo , Peter Hrnciar
发明人： Alan J. Hutchinson , Jun Yuan , Kyungae Lee , George D. Maynard , Bertrand L. Chenard , Nian Liu , Qin Guo , Zihong Guo , Peter Hrnciar
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/4439 , A61K31/4709 , C12N5/078 , A61P19/02 , A61P17/06 , A61P9/00 , A61P11/06 , C12N5/071 , A61K31/4418 , A61K31/4545
CPC分类号： C07D213/30 , C07B2200/05 , C07D213/38 , C07D213/42 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/84 , C07D213/89 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , C40B40/00
摘要： 3-substituted-6-aryl pyridines of Formula I are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.
摘要翻译：提供式I的3-取代-6-芳基吡啶：其中R1，R2，R3，R8，R9，A和Ar如本文所定义。这些化合物是C5a受体的配体。优选的式I化合物以高亲和力结合C5a受体，并在C5a受体上呈现中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗各种炎性，心血管和免疫系统疾病中的用途。此外，本发明提供标记的3-取代-6-芳基吡啶，其可用作C5a受体定位的探针。

25. 发明授权

US08057464B2 Light transmission system for photoreactive therapy 有权
标题翻译：用于光反应治疗的光传输系统
公开(公告)号：US08057464B2
公开(公告)日：2011-11-15
申请号：US11416783
申请日：2006-05-03
申请人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
发明人： James C. Chen , Steven R. Daly , Zihong Guo , Llew Keltner , Jeffrey R. Storm
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，以将光传送到患者体内的靶细胞。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程，以允许用户灵活地为特定患者或病症定制治疗。防止重用的功能之一是控制模块缺少对电源进行再充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

26. 发明申请

US20110077464A1 MEDICAL APPARATUS EMPLOYING FLEXIBLE LIGHT STRUCTURES AND METHODS FOR MANUFACTURING SAME 审中-公开
标题翻译：采用柔性光结构的医疗设备及其制造方法
公开(公告)号：US20110077464A1
公开(公告)日：2011-03-31
申请号：US12890480
申请日：2010-09-24
申请人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
发明人： Phillip Burwell , James C. Chen , Zihong Guo , Steven R. Daly , David B. Shine , Gary Lichttenegger , Jennifer K. Matson , Jean Bishop , Nick Yeo , Hugh Narciso
IPC分类号： A61B1/06
CPC分类号： A61N5/062 , A61N2005/0652
摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
摘要翻译：一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

27. 发明申请

US20090143351A1 SUBSTITUTED AZETIDINONES 审中-公开
标题翻译：取代的AZETIDINONES
公开(公告)号：US20090143351A1
公开(公告)日：2009-06-04
申请号：US12359490
申请日：2009-01-26
申请人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
发明人： Thomas Bannister , Cassandra Celatka , Nizal S. Chandrakumar , Hongfeng Deng , Zihong Guo , Lei Jin , Tsvetelina Lazarova , Jian Lin , Scott T. Moe , Pamela Nagafuji , Manuel Navia , Amy Ripka , Michael J. Rynkiewicz , Kerry L. Spear , James E. Stickler , Roger Xie
IPC分类号： A61K31/397 , C07D401/06 , C07D205/08 , A61P7/00 , C07D401/04 , A61K31/4427
CPC分类号： C07D405/06 , C07D205/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/14
摘要： Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.
摘要翻译：提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa，因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

28. 发明授权

US06660003B1 Percutaneous myocardial revascularization basket delivery system and radiofrequency therapeutic device 失效
标题翻译：经皮心肌血运重建篮输送系统及射频治疗仪
公开(公告)号：US06660003B1
公开(公告)日：2003-12-09
申请号：US09544348
申请日：2000-04-06
申请人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
发明人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
IPC分类号： A61B1814
CPC分类号： A61F2/2493 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002 , A61M2025/009
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.
摘要翻译：血管内装置和在心室壁中同时形成多个经皮心肌血运重建（PMR）孔的方法。一个装置包括由其长度上承载切割探针的柔性臂形成的篮。筐臂向外弯曲偏置，以便在无约束时呈现向外弯曲的弓形形状。该装置包括一个远离固定在篮子的近端部分并可滑动地设置在外轴内的内轴。内轴和塌缩的筐可以缩回到外轴内，血管内递送到左心室，并且向远侧前进，迫使篮筐呈现弓形。提供给电切割探头的射频电流将孔插入心室壁和心肌。一个实施例具有高压流体射流切割装置。另一个实施例使用篮子作为锚定器来定位可操纵的切割探针。另一个实施例包括由多个弓形的向外张开的电极形成的电刷，其可以一旦从约束外轴向远侧远端接触心室壁。

29. 发明授权

US06638222B2 RF ablation and ultrasound catheter for crossing chronic total occlusions 有权
标题翻译：射频消融和超声导管横穿慢性全闭塞
公开(公告)号：US06638222B2
公开(公告)日：2003-10-28
申请号：US10072064
申请日：2002-02-08
申请人： Chandru V. Chandrasekaran , Zihong Guo , Anthony J. Pantages , Donald Masters , Ryan Kaveckis
发明人： Chandru V. Chandrasekaran , Zihong Guo , Anthony J. Pantages , Donald Masters , Ryan Kaveckis
IPC分类号： A61B800
CPC分类号： A61B8/4461 , A61B8/12 , A61B8/445 , A61B18/1492 , A61B2017/003 , A61B2018/00208 , A61B2018/00351 , A61B2018/0041 , A61B2018/00541 , A61B2018/144 , A61B2018/1861 , A61B2090/3782 , A61F9/0079
摘要： A combination catheter includes an ultrasound transducer and RF ablation electrode. The ultrasound transducer transmits ultrasound signals into and receives echo signals from a vessel. The echo signals are processed and used to produce an image of the tissue surrounding the catheter. A driveshaft rotates the ultrasound transducer to obtain a 360° view of the vessel wall. At the distal end of the driveshaft is an electrode. An RF generator is electrically coupled to the driveshaft to deliver RF energy to the electrode at the distal end of the driveshaft to ablate occluding material in the vessel. The electrode may have a variety of tip shapes including concave, roughened, or expandable configurations, depending on the size of the vessel and composition of the occluding material to be ablated.
摘要翻译：组合导管包括超声换能器和RF消融电极。超声波传感器将超声波信号发送到容器中并从容器接收回波信号。回波信号被处理并用于产生围绕导管的组织的图像。驱动轴旋转超声换能器以获得血管壁的360°视图。在驱动轴的远端是电极。 RF发生器电耦合到驱动轴以将RF能量传递到驱动轴的远端处的电极以消除容器中的封闭材料。取决于容器的尺寸和待烧蚀的封闭材料的组成，电极可以具有各种尖端形状，包括凹形，粗糙化或可膨胀构型。

30. 发明授权

US06544220B2 Fluid jet PMR 失效
标题翻译：流体喷射PMR
公开(公告)号：US06544220B2
公开(公告)日：2003-04-08
申请号：US09780698
申请日：2001-02-14
申请人： Brandon J. Shuman , Tim Johnson , Joseph Pearce , Zihong Guo
发明人： Brandon J. Shuman , Tim Johnson , Joseph Pearce , Zihong Guo
IPC分类号： A61M2900
CPC分类号： A61B17/32037 , A61B2017/00247 , A61B2018/00392
摘要： A system for performing fluid jet myocardial revascularization includes a catheter having a proximal region, a distal region, a lumen extending therethrough and a valve disposed in the lumen for allowing the passage of fluids in the lumen to create holes in the myocardium. A valve control means extends through the proximal region of the catheter to open and close the valve. In one embodiment, the valve also includes a biasing mechanism for biasing the valve in a closed position. The valve may be controlled using an electrically actuated device that is heated with an electrical current to open and close the valve. In one embodiment of the invention, the catheter has a wall that can be expanded within a guide catheter to anchor the catheter during revascularization.
摘要翻译：用于进行流体射流心肌血运重建的系统包括具有近端区域，远端区域，延伸穿过其中的腔的导管和设置在内腔中的阀，用于允许腔内的流体通过以在心肌中产生孔。阀控制装置延伸穿过导管的近端区域以打开和关闭阀。在一个实施例中，阀还包括用于将阀偏置在关闭位置的偏置机构。可以使用电动致动装置来控制阀，该电驱动装置用电流加热以打开和关闭阀。在本发明的一个实施例中，导管具有可以在引导导管内扩张以在血运重建期间锚定导管的壁。

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