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21. 发明授权

US10488393B2 Device and method for self-referenced confidence test 有权
公开(公告)号：US10488393B2
公开(公告)日：2019-11-26
申请号：US12895361
申请日：2010-09-30
申请人： Sam Kavusi , Christoph Lang
发明人： Sam Kavusi , Christoph Lang
IPC分类号： G01N33/48 , G01N33/487 , G06G7/58
CPC分类号： G01N33/48707
摘要： A system and method of providing a confidence test in one embodiment includes determining a first quality metric based upon a first and a second test environment wherein the second test environment is different from the first test environment, exposing a sample to a plurality of test sites, establishing the first test environment at a first of the plurality of test sites, establishing the second test environment at a second test site, obtaining a first detection signal associated with the first of the plurality of test sites exposed to the sample and at the first test environment, obtaining a second detection signal associated with the second of the plurality of test sites exposed to the sample and at the second test environment, determining a second quality metric based upon the first detection signal and the second detection signal, and comparing the second quality metric with the first quality metric.

22. 发明授权

US09946836B2 Biomarker monitoring device and method 有权
公开(公告)号：US09946836B2
公开(公告)日：2018-04-17
申请号：US13017391
申请日：2011-01-31
申请人： Sam Kavusi , Christoph Lang
发明人： Sam Kavusi , Christoph Lang
IPC分类号： G01N33/48 , G06F19/28 , G06F19/00
CPC分类号： G06F19/28 , G16H10/40 , G16H15/00 , G16H50/30
摘要： A biomarker monitoring method and system in one embodiment includes a communications network, a portable wellness device configured to form a communication link with the communications network, the portable wellness device including a detector configured to detect at least one biomarker in a biologic sample, a first memory, a plurality of program instructions stored in the first memory, and a processing circuit operably connected to the first memory and configured to execute the program instructions to generate wellness data based upon detection of the at least one biomarker in the biologic sample, and a remote user interface operably connected to the communications network and configured to render the wellness data.

23. 发明授权

US09927435B2 Multisite biosensor and associated method 有权
公开(公告)号：US09927435B2
公开(公告)日：2018-03-27
申请号：US12580113
申请日：2009-10-15
申请人： Sam Kavusi , Daniel Roser , Christoph Lang , AmirAli Haj Hossein Talasaz
发明人： Sam Kavusi , Daniel Roser , Christoph Lang , AmirAli Haj Hossein Talasaz
IPC分类号： G01N33/00 , G01N33/543 , G01N29/32 , G01N33/53
CPC分类号： G01N33/54393 , G01N29/32 , G01N33/53 , G01N33/543 , G01N33/54366
摘要： A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.

24. 发明授权

US09063138B2 Device and method for indirect electronic condition control in biomolecule detection platforms 有权
标题翻译：生物分子检测平台间接电子状态控制的装置和方法
公开(公告)号：US09063138B2
公开(公告)日：2015-06-23
申请号：US13348727
申请日：2012-01-12
申请人： Michael Chen , Vincent Chen , Sam Kavusi , Christoph Lang
发明人： Michael Chen , Vincent Chen , Sam Kavusi , Christoph Lang
IPC分类号： G01N33/53 , G01N33/543 , C08F20/56
CPC分类号： G01N33/54393 , C08F20/56 , G01N33/5306 , Y10T436/11 , Y10T436/115831
摘要： A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a hydrogel composition loaded with a chemical factor at the test site, providing an actuator configured to activate the hydrogel composition to release a chemical factor at the test site, controlling the actuator to activate the hydrogel composition to release a chemical factor at the test site, and modifying the local chemical environment at the test site with the chemical factor.
摘要翻译：在一个实施方案中间接改变测试部位的环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供装载有化学因子的水凝胶组合物，提供构造成将水凝胶组合物活化的致动器在试验现场释放化学因子，控制致动器激活水凝胶组合物以释放在试验部位的化学因子，并用化学因子改变试验部位的局部化学环境。

25. 发明授权

US08648016B2 Array with extended dynamic range and associated method 有权
标题翻译：具有扩展动态范围和关联方法的数组
公开(公告)号：US08648016B2
公开(公告)日：2014-02-11
申请号：US12701712
申请日：2010-02-08
申请人： Sam Kavusi , Michaela Laupheimer , Christoph Lang
发明人： Sam Kavusi , Michaela Laupheimer , Christoph Lang
IPC分类号： C40B30/04
CPC分类号： G01N33/54306 , G01N33/558
摘要： A system and method of quantitating the concentration of a molecule of interest in one embodiment includes establishing a plurality of test environments at a plurality of test sites, each of the plurality of test environments associated with one of a plurality of response curves, each of the plurality of response curves different from the other of the plurality of response curves, storing a combined response curve resulting from a summation of the plurality of response curves, exposing the plurality of test sites to a sample having a concentration of a molecule of interest, obtaining a plurality of quantitation signals, each of the plurality of quantitation signals associated with one of the plurality of test sites, associating a summation of the plurality of quantitation signals with the stored combined response curve, and generating a signal related to the concentration of the molecule of interest based upon the association.
摘要翻译：在一个实施方案中定量感兴趣的分子的浓度的系统和方法包括在多个测试位置建立多个测试环境，所述多个测试环境中的每一个与多个响应曲线之一相关联，每个测试环境多个响应曲线不同于多个响应曲线中的另一个响应曲线，存储由多个响应曲线的总和产生的组合响应曲线，将多个测试位置暴露于具有感兴趣分子浓度的样本，获得多个定量信号，所述多个定量信号中的每一个与所述多个测试点之一相关联，将所述多个定量信号的总和与所存储的组合响应曲线相关联，并产生与所述分子的浓度相关的信号基于协会的兴趣。

26. 发明申请

US20110278258A1 Device and Method for Indirect Modulation of Detection Environment 有权
标题翻译：用于间接调制检测环境的设备和方法
公开(公告)号：US20110278258A1
公开(公告)日：2011-11-17
申请号：US12779687
申请日：2010-05-13
申请人： Sam Kavusi , Yi Wei Chen , Michael Chen , Christoph Lang
发明人： Sam Kavusi , Yi Wei Chen , Michael Chen , Christoph Lang
IPC分类号： C23F1/00 , G06F17/00 , G05B15/02 , G01N1/00 , B01J19/00
CPC分类号： G01N33/54306 , G01N33/54366 , G01N33/54393 , Y10T436/25
摘要： A system and method of indirectly modifying an environmental condition at a test site in one embodiment includes providing a test site on a substrate, providing a first activatable stimulant at the test site, providing an actuator configured to activate the first activatable stimulant at the test site, controlling the actuator to activate the first activatable stimulant, and modifying the local chemical environment at the test site with the first activated stimulant.
摘要翻译：在一个实施方案中间接改变测试部位环境条件的系统和方法包括在基底上提供测试部位，在测试部位提供第一可激活的刺激剂，提供构造成在测试部位激活第一可活化刺激物的致动器控制致动器来激活第一可激活的兴奋剂，以及用第一个激活的兴奋剂改变测试部位的局部化学环境。

27. 发明授权

US07492400B2 Adaptive pixel for high dynamic range and disturbance detection and correction 失效
标题翻译：自适应像素用于高动态范围和干扰检测和校正
公开(公告)号：US07492400B2
公开(公告)日：2009-02-17
申请号：US10858944
申请日：2004-06-01
申请人： Abbas El Gamal , Sam Kavusi
发明人： Abbas El Gamal , Sam Kavusi
IPC分类号： H04N3/14 , H04N5/335
CPC分类号： H04N5/3535 , H04N5/2351 , H04N5/2353 , H04N5/33
摘要： A new adaptive pixel architecture, folded-multiple-capture (FMC), integrates synchronous self-reset and multiple capture schemes and advantageously eliminates the requirement of a high-frame-rate sensor array, which is essential for conventional image sensors with high dynamic range. The FMC comprises a per-pixel analog-front-end (AFE), a fine analog-digital convertor (ADC) stage, and a digital-signal-processor/controller (DSPC) stage. The AFE performs programmable gain control, synchronous self-reset, sample-and-hold, and enables disturbance detection. In the AFE, a comparator compares an integrator output with a threshold voltage and produces a binary sequence accordingly. The ADC utilizes the binary sequence and the folded multiple capture signals to estimate photocurrent. An image sensor embodying the present invention adapts integration time to signal level, has minimal per-pixel hardware requirement, provides a very high dynamic range, about 120 dB or more, at high speed, about 1,000 frames/s or more, detects and corrects subframe disturbances, and consumes significantly less power.
摘要翻译：一种新的自适应像素架构，折叠多重捕获（FMC），集成了同步自复位和多重捕获方案，有利地消除了高帧率传感器阵列的需求，这对于具有高动态范围的传统图像传感器至关重要。 FMC包括每像素模拟前端（AFE），精细模拟数字转换器（ADC）级和数字信号处理器/控制器（DSPC）级。 AFE执行可编程增益控制，同步自复位，采样保持和启用干扰检测。在AFE中，比较器将积分器输出与阈值电压进行比较，并相应地产生二进制序列。 ADC利用二进制序列和折叠的多个捕获信号来估计光电流。体现本发明的图像传感器将积分时间适应于信号电平，具有最小的每像素硬件要求，以高速，约1,000帧/秒以上提供约120dB或更大的非常高的动态范围，检测和校正子帧干扰，并消耗明显较少的功率。

28. 发明申请

US20080316347A1 ADAPTIVE PIXEL FOR HIGH DYNAMIC RANGE AND DISTURBANCE DETECTION AND CORRECTION 失效
标题翻译：用于高动态范围和干扰检测和校正的自适应像素
公开(公告)号：US20080316347A1
公开(公告)日：2008-12-25
申请号：US10858944
申请日：2004-06-01
申请人： Abbas El Gamal , Sam Kavusi
发明人： Abbas El Gamal , Sam Kavusi
IPC分类号： H04N3/14
CPC分类号： H04N5/3535 , H04N5/2351 , H04N5/2353 , H04N5/33
摘要： A new adaptive pixel architecture, folded-multiple-capture (FMC), integrates synchronous self-reset and multiple capture schemes and advantageously eliminates the requirement of a high-frame-rate sensor array, which is essential for conventional image sensors with high dynamic range. The FMC comprises a per-pixel analog-front-end (AFE), a fine analog-digital convertor (ADC) stage, and a digital-signal-processor/controller (DSPC) stage. The AFE performs programmable gain control, synchronous self-reset, sample-and-hold, and enables disturbance detection. In the AFE, a comparator compares an integrator output with a threshold voltage and produces a binary sequence accordingly. The ADC utilizes the binary sequence and the folded multiple capture signals to estimate photocurrent. An image sensor embodying the present invention adapts integration time to signal level, has minimal per-pixel hardware requirement, provides a very high dynamic range, about 120 dB or more, at high speed, about 1,000 frames/s or more, detects and corrects subframe disturbances, and consumes significantly less power.
摘要翻译：一种新的自适应像素架构，折叠多重捕获（FMC），集成了同步自复位和多重捕获方案，有利地消除了高帧率传感器阵列的需求，这对于具有高动态范围的传统图像传感器至关重要。 FMC包括每像素模拟前端（AFE），精细模拟数字转换器（ADC）级和数字信号处理器/控制器（DSPC）级。 AFE执行可编程增益控制，同步自复位，采样保持和启用干扰检测。在AFE中，比较器将积分器输出与阈值电压进行比较，并相应地产生二进制序列。 ADC利用二进制序列和折叠的多个捕获信号来估计光电流。体现本发明的图像传感器将积分时间适应于信号电平，具有最小的每像素硬件要求，以高速，约1,000帧/秒以上提供约120dB或更大的非常高的动态范围，检测和校正子帧干扰，并消耗明显较少的功率。

29. 发明授权

US09075041B2 Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions 有权
标题翻译：用于在电极表面附近产生用于调节生物分子相互作用的pH /离子浓度梯度的方法
公开(公告)号：US09075041B2
公开(公告)日：2015-07-07
申请号：US13543300
申请日：2012-07-06
申请人： Sam Kavusi , Rajan Gangadharan , Christopher Johnson , Aldrich N. K. Lau , Piyush Verma
发明人： Sam Kavusi , Rajan Gangadharan , Christopher Johnson , Aldrich N. K. Lau , Piyush Verma
IPC分类号： G01N33/50 , G01N27/327 , G01N33/53
CPC分类号： G01N33/50 , G01N27/3275 , G01N33/5306
摘要： Methods of modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological sample in a biosensor having a multisite array of test sites. In particular, the methods modulate the pH or ionic concentration gradient near the electrodes in such biosensor. The methods of modulating the binding interactions provide a biosensor and analytic methods for more accurately measuring an analyte of interest in a biological sample.
摘要翻译：在生物传感器中调节生物样品中生物分子探针或检测剂与目的分析物之间的结合相互作用的方法，该生物传感器具有多个测试位点阵列。特别地，该方法调节这种生物传感器中电极附近的pH或离子浓度梯度。调节结合相互作用的方法提供了生物传感器和分析方法，用于更精确地测量生物样品中感兴趣的分析物。

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