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21. 发明申请

US20060121564A1 Novel expression vector suitable for expression of recombinant protein at low temperature 审中-公开
标题翻译：适用于低温表达重组蛋白的新型表达载体
公开(公告)号：US20060121564A1
公开(公告)日：2006-06-08
申请号：US10524193
申请日：2003-08-11
申请人： Nobutaka Nakashima , Tomohiro Tamura
发明人： Nobutaka Nakashima , Tomohiro Tamura
IPC分类号： C12P21/06 , C12N1/20 , C12N15/74 , C07K14/195
CPC分类号： C12Q1/18 , C12N15/67 , C12N15/74
摘要： An inducible expression vector which can express a protein at low temperature and a method for expressing a protein at low temperature using this vector are provided. The inducible expression vector can express a gene encoding a protein whose expression product, inhibits proliferation of the host cell under medium to high temperature conditions exceeding about 15° C. in a host cell which can proliferate under low temperature conditions.
摘要翻译：提供了可以在低温下表达蛋白质的诱导型表达载体和使用该载体在低温下表达蛋白质的方法。可诱导表达载体可以表达编码其表达产物的蛋白质的基因，其在低温条件下可以增殖的宿主细胞中在高于约15℃的中等至高温条件下抑制宿主细胞的增殖。

22. 发明申请

US20140163008A1 DIBENZOOXEPIN DERIVATIVE 有权
标题翻译： DIBENZOOXEPIN衍生物
公开(公告)号：US20140163008A1
公开(公告)日：2014-06-12
申请号：US14236545
申请日：2011-08-03
申请人： Keisuke Yamamoto , Tomohiro Tamura , Rina Nakamura , Kimihisa Ueno , Shintaro Hosoe
发明人： Keisuke Yamamoto , Tomohiro Tamura , Rina Nakamura , Kimihisa Ueno , Shintaro Hosoe
IPC分类号： C07D495/04 , C07D471/04 , C07D487/04 , C07D413/14
CPC分类号： C07D495/04 , A61K31/335 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D413/14 , C07D471/04 , C07D487/04
摘要： A dibenzoxepin derivative represented by the following general formula (I) wherein Y is a hydrogen atom and the like, RA is a hydrogen atom and the like, X is the formula (b3) wherein RB is a hydrogen atom and the like, and the like, A is the formula (a18) wherein R1 is a hydrogen atom and the like, and RC and RD are the same or different and each is a hydrogen atom and the like, and the like, which has a PPARγ agonist activity and the like, and useful as a therapeutic agent and/or prophylaxis agent and the like for type 2 diabetes and the like, or a pharmaceutically acceptable salt thereof and the like is provided.
摘要翻译：由以下通式（I）表示的二苯并氧杂环己烷衍生物，其中Y为氢原子等，RA为氢原子等，X为式（b3），其中RB为氢原子等， A是式（a18），其中R1是氢原子等，RC和RD相同或不同，各自是具有PPARγ激动剂活性的氢原子等，以及作为2型糖尿病等的治疗剂和/或预防剂等，或其药学上可接受的盐等有用。

23. 发明申请

US20070004004A1 Process for producing recombinant protein in bacterium belonging to the genus rhodococcus 有权
标题翻译：在属于红球菌属的细菌中产生重组蛋白的方法
公开(公告)号：US20070004004A1
公开(公告)日：2007-01-04
申请号：US10553979
申请日：2004-04-19
申请人： Nobutaka Nakashima , Tomohiro Tamura
发明人： Nobutaka Nakashima , Tomohiro Tamura
IPC分类号： C07K14/195 , C07H21/04 , C12P21/06 , C12N1/21 , C12N15/74
CPC分类号： C12P21/02 , C12N15/74
摘要： Provided is an expression vector capable of constitutive expression of a foreign gene in a bacterium belonging to the genus Rhodococcus. The vector is a constitutive expression vector for a bacterium belonging to the genus Rhodococcus comprising: DNA comprising a nucleotide sequence of a mutated TipA gene promoter where a mutation is incorporated into a −10 region sequence of a TipA gene promoter, the mutated TipA gene promoter being capable of thiostrepton-independent and constitutive expression of a gene located downstream thereof; a promoter sequence for the constitutive expression of a foreign gene, the promoter sequence being a nucleotide sequence of DNA claimed in any one of claim 1 to claim 3; a ribosome-binding site sequence located downstream of the promoter sequence; and a multiple-cloning site sequence capable of incorporating a foreign gene therein, located downstream of the ribosome-binding site sequence.
摘要翻译：本发明提供能够在属于红球菌属的细菌中外源基因组成型表达的表达载体。载体是属于红球菌属的细菌的组成型表达载体，其包含：包含突变的TipA基因启动子的核苷酸序列的DNA，其中突变被并入到TipA基因启动子的-10个区域序列中，所述突变的TipA基因启动子能够位于其下游的基因的硫链螺旋体非依赖性和组成型表达; 3.一种外源基因的组成型表达的启动子序列，所述启动子序列是权利要求1至3中任一项所述的DNA的核苷酸序列; 位于启动子序列下游的核糖体结合位点序列; 以及位于核糖体结合位点序列下游的能够掺入外源基因的多重克隆位点序列。

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