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21. 发明申请

US20090189065A1 Method of mass spectrometry and mass spectrometer 有权
标题翻译：质谱法和质谱仪
公开(公告)号：US20090189065A1
公开(公告)日：2009-07-30
申请号：US11631033
申请日：2006-03-08
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： B01D59/44
CPC分类号： H01J49/427 , H01J49/067 , H01J49/4225
摘要： In a mass spectrometer introducing ions produced at an ion source, and including quadrupole rods which have an inlet and an outlet and to which a radio-frequency voltage is applied, the mass spectrometer, i.e., a mass spectrometry device implemented by a linear trap which exhibits high ejection efficiency, high mass resolution, and low ejection energy, executes the following steps: Trapping at least part of the ions by a trap potential generated on the central axis of a quadrupole field, oscillating part of the trapped ions in an intermediate direction between the mutually-adjacent quadrupole rods, ejecting the oscillated ions by an extraction field, and detecting the ejected ions or introducing the ejected ions into another detection process.
摘要翻译：在质谱仪中引入在离子源处产生的离子，并且包括具有入口和出口的四极棒，并且施加射频电压，质谱仪即通过线性捕获器实现的质谱装置表现出高喷射效率，高质量分辨率和低喷射能量，执行以下步骤：通过在四极场的中心轴上产生的捕获电位捕获至少一部分离子，在中间方向上振荡部分捕获的离子在相邻的四极棒之间，通过提取场喷射振荡的离子，并检测喷出的离子或将喷出的离子引入另一检测过程。

22. 发明申请

US20080073508A1 REACTION CELL AND MASS SPECTROMETER 有权
标题翻译：反应池和质谱仪
公开(公告)号：US20080073508A1
公开(公告)日：2008-03-27
申请号：US11671562
申请日：2007-02-06
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4295 , H01J49/005 , H01J49/0054
摘要： An ion trap in which highly accurate isolation, ECD, and CID can be efficiently performed. A reaction cell and a mass spectrometer of the present invention include an ion-trap which has a plurality of rod electrodes and creates a multipole field, a means for generating a magnetic field in the axial direction of the ion-trap, a means for creating a DC harmonic potential in the axial direction of the ion-trap, and an electron source for introducing electrons into the central axis of the ion-trap. The identification ability is greatly improved compared with the prior art.
摘要翻译：可以有效地执行高精度隔离，ECD和CID的离子阱。本发明的反应池和质谱仪包括具有多个棒电极并产生多极场的离子阱，用于在离子阱的轴向产生磁场的装置，用于产生在离子阱的轴向上的DC谐波电位和用于将电子引入离子阱的中心轴的电子源。与现有技术相比，识别能力大大提高。

23. 发明申请

US20060284072A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20060284072A1
公开(公告)日：2006-12-21
申请号：US11495534
申请日：2006-07-31
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/401
摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.
摘要翻译：能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围离子从第一线性捕集器喷射到第二线性阱。

24. 发明授权

US06888134B2 Mass spectrometer and mass spectrometric method 失效
标题翻译：质谱仪和质谱法
公开(公告)号：US06888134B2
公开(公告)日：2005-05-03
申请号：US10608263
申请日：2003-06-30
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： G01N27/62 , H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/424 , H01J49/0481
摘要： There is provided an ion trap mass spectrometer which can detect fragment ions having a low mass and enables high-sensitivity measurement. A mass spectrometer has an ion source generating sample ions; an ion trap having a pair of and endcap electrodes and a ring electrode and accumulating ions generated by the ion source and isolating precursor ions from the accumulated ion and dissociating the isolated precursor ions and ejecting the dissociated ions from the ion trap. A gas introduction hole is arranged in the endcap electrode or the ring electrode for introducing in intermittently-introduced bath gas therethrough into the ion trap. A detector detects the ions ejected from the ion trap. The center axis of the gas introduction hole is arranged so as to pass through a region near the center of gravity of the ion trap.
摘要翻译：提供了一种离子阱质谱仪，可以检测低质量的碎片离子，并实现高灵敏度测量。质谱仪具有产生样品离子的离子源; 具有一对和端盖电极和环形电极的离子阱，并且积聚由离子源产生的离子并且从累积的离子中分离前体离子并解离分离的前体离子并将离解的离子从离子阱中排出。在端盖电极或环形电极中布置有气体导入孔，用于将间歇导入的浴气引入到离子阱中。检测器检测从离子阱排出的离子。气体导入孔的中心轴配置成通过离子阱重心附近的区域。

25. 发明授权

US07329862B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07329862B2
公开(公告)日：2008-02-12
申请号：US11495534
申请日：2006-07-31
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/401
摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.
摘要翻译：能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围离子从第一线性捕集器喷射到第二线性阱。

26. 发明授权

US06967323B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06967323B2
公开(公告)日：2005-11-22
申请号：US10868933
申请日：2004-06-17
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： G01N27/62 , G01N27/64 , H01J49/00 , H01J49/40 , H01J49/42
CPC分类号： H01J49/063 , H01J49/004 , H01J49/0481
摘要： An ion mass spectrometer comprising an ionization source for generating ions, a linear trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time, and having a collision damping region introduced with a buffer gas for reducing the kinetic energy of ions ejected from the linear trap region and converting the ion packet into continuous beam and provided with plural electrodes for generating multipole electric fields in the inside between the linear trap region and the time-of-flight mass spectrometer, and having an ion transmission control mechanism for allowing or inhibiting incidence of ion from the linear trap region to the collision damping region between the linear trap region and the collision damping region.
摘要翻译：一种离子质谱仪，包括用于产生离子的电离源，用于离子的聚集和离解的线性捕获区域，以及用于基于飞行时间的离子质谱的飞行时间质谱仪，并且具有引入的碰撞阻尼区域使用缓冲气体，用于降低从线性捕获区域排出的离子的动能，并将离子包转换为连续光束，并设置有多个电极，用于在线性捕获区域和飞行时间之间的内部产生多极电场并且具有用于允许或抑制从线性捕获区域到线性捕获区域和碰撞阻尼区域之间的碰撞阻尼区域的入射的离子传输控制机构。

27. 发明授权

US06566651B2 Ion trap mass spectrometry and apparatus 失效
标题翻译：离子阱质谱和仪器
公开(公告)号：US06566651B2
公开(公告)日：2003-05-20
申请号：US10215014
申请日：2002-08-12
申请人： Takashi Baba , Izumi Waki , Dongbing Wang
发明人： Takashi Baba , Izumi Waki , Dongbing Wang
IPC分类号： H01J4942
CPC分类号： G01N21/6404 , H01J49/42
摘要： A laser-cooled fluorescence mass spectrometry apparatus includes an ion trap for trapping sample ions, laser-cooled ions, and probe ions therein; a first irradiating device for irradiating the sample ions, the laser-cooled ions, and the probe ions in the ion trap with a first laser beam for cooling the ions; a second irradiating device for irradiating the sample ions, the laser-cooled ions, and the probe ions in the ion trap with a second laser beam for detecting temperature changes in the ions; a detecting device for detecting the temperature changes in the ions; a first ion source for the sample ions; a second ion source for the laser-cooled ions; and a third ion source for the probe ions. The probe ions may be different ions than the laser-cooled ions, or the probe ions may be the same ions as the laser-cooled ions.
摘要翻译：激光冷却荧光质谱仪包括用于捕获样品离子，激光冷却离子和探针离子的离子阱; 第一照射装置，用于用用于冷却离子的第一激光束照射离子阱中的样品离子，激光冷却离子和探针离子; 第二照射装置，用于用用于检测离子温度变化的第二激光束照射离子阱中的样品离子，激光冷却离子和探针离子; 用于检测离子温度变化的检测装置; 用于样品离子的第一离子源; 用于激光冷却离子的第二离子源; 和用于探针离子的第三离子源。探针离子可能是与激光冷却离子不同的离子，或探针离子可能与激光冷却离子相同的离子。

28. 发明授权

US6075244A Mass spectrometer 失效
标题翻译：质谱仪
公开(公告)号：US6075244A
公开(公告)日：2000-06-13
申请号：US983212
申请日：1998-01-05
申请人： Takashi Baba , Izumi Waki
发明人： Takashi Baba , Izumi Waki
IPC分类号： H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/423 , H01J49/4215
摘要： A method of performing a high sensitivity mass analysis is described wherein a plurality of linear quadrupole radio frequency electrodes are aligned, and operated as a mass filter or an ion trap mass analyzer. A background ion removal filter having a linear quadrupole electrode structure may also be connected in cascade to this mass analyzer if necessary. The background ion removal filter powerfully removes background ions so as to improve analytical sensitivity. This mass spectrometer also makes it possible to prevent losses of minute amounts of sample ions in the ion trap, prevent destruction of minute amounts of ions and reduce contamination of the ion trap electrodes.
摘要翻译： PCT No.PCT / JP95 / 01322 Sec。 371日期：1998年1月5日 102（e）1998年1月5日PCT PCT 1995年7月3日PCT公布。公开号WO97 / 02591 日期1997年1月23日描述了一种进行高灵敏度质量分析的方法，其中多个线性四极杆射频电极对准，并作为质量过滤器或离子阱质量分析仪进行操作。如果需要，具有线性四极电极结构的背景离子去除过滤器也可以与该质量分析器级联连接。背景离子去除过滤器有力地去除背景离子，以提高分析灵敏度。该质谱仪还能够防止离子阱中的微量离子的损失，防止微量离子的破坏，减少离子阱电极的污染。

29. 发明授权

US5783824A Ion trapping mass spectrometry apparatus 失效
标题翻译：离子捕集质谱仪
公开(公告)号：US5783824A
公开(公告)日：1998-07-21
申请号：US886359
申请日：1997-07-01
申请人： Takashi Baba , Izumi Waki
发明人： Takashi Baba , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/423
摘要： A mass spectrometry apparatus having a constitution for attaining analysis with high sensitivity and high resolving power comprising a linear radio-frequency quadrupole ion trap and means for avoiding degradation of analysis performance due to field disturbance caused by an end electrode thereof, where said purpose is achieved by means for forming a harmonic potential in the central axis thereof in whose potential ions are resonantly oscillated to be ejected outside of the ion trap for detection along the axis, or by means to eliminate undesirably- degraded signals originating near the ion trap portions that are disturbed by the end electrodes.
摘要翻译：一种质谱装置，具有用于实现具有高灵敏度和高分辨能力的分析的结构，其包括线性射频四极离子阱和用于避免由于其端电极引起的场干扰导致的分析性能劣化的装置，其中实现了目的通过在其中心轴上形成谐波电位的装置，其中电位离子被共振振荡以被排出离子阱外部，以便沿轴线检测，或者通过消除源自离子阱部分附近的不期望的劣化信号，被末端电极扰乱。

30. 发明授权

US07589321B2 Reaction cell and mass spectrometer 有权
标题翻译：反应池和质谱仪
公开(公告)号：US07589321B2
公开(公告)日：2009-09-15
申请号：US11671562
申请日：2007-02-06
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Takashi Baba , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/4295 , H01J49/005 , H01J49/0054
摘要： An ion trap in which highly accurate isolation, ECD, and CID can be efficiently performed. A reaction cell and a mass spectrometer of the present invention include an ion-trap which has a plurality of rod electrodes and creates a multipole field, a means for generating a magnetic field in the axial direction of the ion-trap, a means for creating a DC harmonic potential in the axial direction of the ion-trap, and an electron source for introducing electrons into the central axis of the ion-trap. The identification ability is greatly improved compared with the prior art.
摘要翻译：可以有效地执行高精度隔离，ECD和CID的离子阱。本发明的反应池和质谱仪包括具有多个棒电极并产生多极场的离子阱，用于在离子阱的轴向产生磁场的装置，用于产生在离子阱的轴向上的DC谐波电位和用于将电子引入离子阱的中心轴的电子源。与现有技术相比，识别能力大大提高。

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