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21. 发明申请

US20110178385A1 PHOTOACOUSTIC MEASURING APPARATUS WITH MOVABLE DETECTOR ARRAY 审中-公开
标题翻译：具有可移动探测器阵列的光电测量设备
公开(公告)号：US20110178385A1
公开(公告)日：2011-07-21
申请号：US13121899
申请日：2009-10-01
申请人： Kazuhiko Fukutani , Takao Nakajima
发明人： Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B6/00
CPC分类号： G01S15/8945 , A61B5/0059 , A61B5/0095 , A61B8/4281 , A61B8/4494 , A61B8/54 , G01N21/1702 , G01N29/2418 , G01N29/265 , G01N2291/106 , G01S15/8925 , G01S15/8997
摘要： A measuring apparatus includes an acoustic transducer with a plurality of elements, each element detecting an acoustic wave generated from a sample and converting the wave into an electric signal; a movement control unit which moves the acoustic transducer from a first position to a second position; and a processing unit which generates image data on the basis of the electric signal. The acoustic transducer has a gap in the arrangement of the elements. The acoustic transducer detects an acoustic wave at the first position, is moved by the movement control unit such that the position of the gap at the first position corresponds to the position of the element at the second position, and then detects an acoustic wave at the second position. The processing unit generates image data on the basis of electric signals obtained at the first and second positions.
摘要翻译：测量装置包括具有多个元件的声换能器，每个元件检测从样本产生的声波并将波转换成电信号; 移动控制单元，其将所述声换能器从第一位置移动到第二位置; 以及处理单元，其基于电信号生成图像数据。声换能器在元件的布置上具有间隙。声换能器检测在第一位置处的声波，由移动控制单元移动，使得在第一位置处的间隙的位置对应于元件在第二位置处的位置，然后检测在该声波处的声波第二名处理单元基于在第一和第二位置处获得的电信号来生成图像数据。

22. 发明申请

US20110112391A1 PHOTOACOUSTIC MEASUREMENT APPARATUS 审中-公开
标题翻译：光电测量设备
公开(公告)号：US20110112391A1
公开(公告)日：2011-05-12
申请号：US13003503
申请日：2009-07-09
申请人： Hiroshi Nishihara , Kazuhiko Fukutani , Takao Nakajima
发明人： Hiroshi Nishihara , Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B5/05
CPC分类号： G01N21/1702 , A61B5/0059 , A61B5/0091 , A61B5/0095 , A61B5/14546 , A61B5/4312 , G01N2021/1706
摘要： A measurement apparatus capable of measuring a position and a size of an absorber with high accuracy, which includes: a light source unit for emitting a pulse beam; an illumination optical unit for leading the pulse beam emitted by the light source unit to an inside of an inspection object; and an acoustic signal detection unit for detecting a photoacoustic signal generated by the pulse beam in which the illumination optical unit includes a first and second illumination optical units that are arranged so that the inspection object is irradiated with the pulse beam from both sides thereof opposingly; and the acoustic signal detection unit is provided so that a detection surface of the acoustic signal detection unit is positioned on the same side as that of one of irradiation surfaces of the inspection object which the first and second illumination optical units irradiate with the pulse beam.
摘要翻译：一种测量装置，其能够高精度地测量吸收体的位置和尺寸，该测量装置包括：用于发射脉冲光束的光源单元; 照明光学单元，用于将由光源单元发射的脉冲光束引导到检查对象的内部; 以及声学信号检测单元，用于检测由脉冲束产生的光声信号，其中照明光学单元包括第一和第二照明光学单元，其布置成使得检查对象从其两侧的脉冲光束相对照射; 提供声信号检测单元，使得声信号检测单元的检测表面位于与第一和第二照明光学单元用脉冲光束照射的检查对象的照射面中的一个的相同侧。

23. 发明申请

US20100331662A1 PHOTOACOUSTIC IMAGING APPARATUS AND PHOTOACOUSTIC IMAGING METHOD 有权
标题翻译：摄影成像设备和摄影成像方法
公开(公告)号：US20100331662A1
公开(公告)日：2010-12-30
申请号：US12816556
申请日：2010-06-16
申请人： Kazuhiko Fukutani , Takao Nakajima
发明人： Kazuhiko Fukutani , Takao Nakajima
IPC分类号： A61B5/05
CPC分类号： A61B5/0059 , A61B5/0073 , A61B5/0095 , G01N21/1702
摘要： A photoacoustic wave detector detects a photoacoustic wave generated inside a specimen by light irradiated thereto. A signal processing device: forms first volume data from a first signal, the first signal being the detection signal acquired from the detector or a signal obtained by adjusting an amplitude of the detection signal; forms second volume data from a second signal, the second signal being a signal obtained by changing a phase of the first signal; forms third volume data from the first and second volume data; and generates and outputs image data representing information on an interior of the specimen from the third volume data.
摘要翻译：光声波检测器通过照射到其上的光检测检测体内的光声波。信号处理装置：从第一信号形成第一体积数据，第一信号是从检测器获取的检测信号或通过调整检测信号的幅度而获得的信号; 从第二信号形成第二音量数据，第二信号是通过改变第一信号的相位而获得的信号; 从第一和第二卷数据形成第三卷数据; 并从第三体积数据生成并输出表示样本内部的信息的图像数据。

24. 发明申请

US20110172513A1 BIOLOGICAL INFORMATION IMAGING APPARATUS 审中-公开
标题翻译：生物信息成像装置
公开(公告)号：US20110172513A1
公开(公告)日：2011-07-14
申请号：US13063703
申请日：2009-11-09
申请人： Takao Nakajima , Kazuhiko Fukutani
发明人： Takao Nakajima , Kazuhiko Fukutani
IPC分类号： A61B5/05
CPC分类号： G01N21/1702 , A61B5/0059 , A61B5/0095 , A61B5/02007 , G01N2201/0662
摘要： The biological information imaging apparatus includes an acoustic wave detector 107 that detects an acoustic wave that is generated from a light absorber 105 and converts it to a first electrical signal; a photo-detector 110 that detects intensities of the light corresponding to a plurality of propagation distances of the light which propagates through the specimen 110 and converts it to a second electrical signal; a signal processing apparatus 111 that derives an average effective attenuation coefficient μeff of the specimen 110 based on the second electrical signal and derives an optical absorption coefficient μa of the specimen 110 based on the first electrical signal and the average effective attenuation coefficient μeff; and an image constructing apparatus 111 that constructs an image of the distribution of the optical absorption coefficient μa based on the distribution of the optical absorption coefficient μa.
摘要翻译：生物信息成像装置包括声波检测器107，其检测从光吸收体105产生的声波并将其转换为第一电信号; 光检测器110，其检测与通过样本110传播的光的多个传播距离相对应的光的强度，并将其转换为第二电信号; 信号处理装置111，其基于第二电信号导出样本110的平均有效衰减系数μeff，并根据第一电信号和平均有效衰减系数μeff导出样本110的光吸收系数μa; 以及基于光吸收系数μa的分布构建光吸收系数μa的分布的图像的图像构造装置111。

25. 发明申请

US20120243369A1 SUBJECT INFORMATION ACQUISITION APPARATUS AND SUBJECT INFORMATION ACQUISITION METHOD 审中-公开
标题翻译：主体信息获取装置和主体信息获取方法
公开(公告)号：US20120243369A1
公开(公告)日：2012-09-27
申请号：US13513341
申请日：2011-01-26
申请人： Yoshiaki Sudo , Kazuhiko Fukutani , Takao Nakajima , Yoshitaka Baba
发明人： Yoshiaki Sudo , Kazuhiko Fukutani , Takao Nakajima , Yoshitaka Baba
IPC分类号： H04B17/00
CPC分类号： A61B5/0095 , A61B5/0059 , A61B8/0825 , A61B8/0833 , G01N21/1702 , G01N29/0663 , G01N29/2418 , G01N2021/1706 , G01N2291/02475
摘要： A subject information acquisition apparatus includes: an acoustic wave detector which detects an acoustic wave which is generated from a subject by irradiating light and outputs a detection signal; an amplifier which amplifies the detection signal which is output from the acoustic wave detector; a gain control unit which changes a gain of the amplifier as time elapses, according to a gain control table, in order to correct a drop in intensity of the acoustic wave caused by attenuation of fluence inside the subject; and a signal processing unit which obtains information inside the subject based on the signal amplified by the amplifier. Measurement under a plurality of measurement conditions, where at least fluence distribution inside the subject or a position of the acoustic wave detector differs, is possible, and the gain control unit changes the gain control table according to the measurement conditions.
摘要翻译：对象信息获取装置包括：声波检测器，其通过照射光检测从对象产生的声波并输出检测信号; 放大器，其放大从声波检测器输出的检测信号; 增益控制单元，用于根据增益控制表改变放大器的增益随时间的变化，以便校正由对象内的注量衰减引起的声波强度的下降; 以及信号处理单元，其基于由放大器放大的信号来获取对象内的信息。在多个测量条件下进行测量，其中至少对象内的注量分布或声波检测器的位置不同，并且增益控制单元根据测量条件改变增益控制表。

26. 发明申请

US20110257530A1 BIOLOGICAL INFORMATION ACQUISITION APPARATUS 有权
标题翻译：生物信息采集装置
公开(公告)号：US20110257530A1
公开(公告)日：2011-10-20
申请号：US13140866
申请日：2009-12-16
申请人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
发明人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
IPC分类号： A61B6/00 , A61B8/13
CPC分类号： A61B8/0825 , A61B5/0091 , A61B5/0095 , A61B5/4312
摘要： When a subject is pressed by a plate and an acoustic wave is received by a probe via the plate, the acoustic wave is refracted because of the difference between a sound velocity in the subject and a sound velocity in the plate. When the refraction is not considered, a reduction in resolution occurs. A correction table or a correction formula for correcting image distortion associated with refraction is provided. After image information is acquired, new image information is acquired in accordance with the correction table or the correction formula, and is displayed.
摘要翻译：当受试者被板按压并且通过探针经由板接收声波时，由于被检体中的声速和板中的声速之间的差异，声波被折射。当不考虑折射时，会发生分辨率降低。提供了用于校正与折射相关联的图像失真的校正表或校正公式。在获取图像信息之后，根据校正表或校正公式获取新的图像信息，并且显示。

27. 发明申请

US20110251475A1 BIOLOGICAL INFORMATION ACQUISITION APPARATUS AND BIOLOGICAL INFORMATION ACQUISITION METHOD 有权
标题翻译：生物信息获取装置和生物信息获取方法
公开(公告)号：US20110251475A1
公开(公告)日：2011-10-13
申请号：US13140816
申请日：2009-12-16
申请人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
发明人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
IPC分类号： A61B6/00
CPC分类号： A61B5/0095 , A61B5/0091 , A61B5/4312 , A61B8/0825 , A61B8/5207
摘要： When a subject is pressed by a plate and an acoustic wave is received by a probe via the plate, the acoustic wave is refracted because of the difference between a sound velocity in the subject and a sound velocity in the plate. When the refraction is not considered, a reduction in resolution occurs. Weights for signals or virtual wavefronts corresponding to the signals to be added to one another are determined using a thickness of the plate, the sound velocity in the plate, the sound velocity in the subject, positions of image elements (pixels or voxels) for image information, and arrival times of the acoustic wave from an object that is a sound source. The signals or the virtual wavefronts corresponding to the signals are added to one another, thereby acquiring the image information.
摘要翻译：当受试者被板按压并且通过探针经由板接收声波时，由于被检体中的声速和板中的声速之间的差异，声波被折射。当不考虑折射时，会发生分辨率降低。使用板的厚度，板中的声速，对象中的声速，图像的像素（像素或体素）的位置来确定与要添加到彼此的信号相对应的信号或虚拟波前的权重信息和来自作为声源的物体的声波的到达时间。对应于信号的信号或虚拟波前相互添加，从而获取图像信息。

28. 发明授权

US08876717B2 Biological information acquisition apparatus 有权
标题翻译：生物信息采集仪
公开(公告)号：US08876717B2
公开(公告)日：2014-11-04
申请号：US13140866
申请日：2009-12-16
申请人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
发明人： Toshinobu Tokita , Kazuhiko Fukutani , Takao Nakajima , Katsumi Nakagawa
IPC分类号： A61B8/00 , A61B8/14 , A61B5/00 , A61B8/08
CPC分类号： A61B8/0825 , A61B5/0091 , A61B5/0095 , A61B5/4312
摘要： When a subject is pressed by a plate and an acoustic wave is received by a probe via the plate, the acoustic wave is refracted because of the difference between a sound velocity in the subject and a sound velocity in the plate. When the refraction is not considered, a reduction in resolution occurs. A correction table or a correction formula for correcting image distortion associated with refraction is provided. After image information is acquired, new image information is acquired in accordance with the correction table or the correction formula, and is displayed.
摘要翻译：当受试者被板按压并且通过探针经由板接收声波时，由于被检体中的声速和板中的声速之间的差异，声波被折射。当不考虑折射时，会发生分辨率降低。提供了用于校正与折射相关联的图像失真的校正表或校正公式。在获取图像信息之后，根据校正表或校正公式获取新的图像信息，并且显示。

29. 发明申请

US20100191109A1 BIOLOGICAL INFORMATION PROCESSING APPARATUS AND BIOLOGICAL INFORMATION PROCESSING METHOD 审中-公开
标题翻译：生物信息处理设备和生物信息处理方法
公开(公告)号：US20100191109A1
公开(公告)日：2010-07-29
申请号：US12750836
申请日：2010-03-31
申请人： Kazuhiko Fukutani , Takao Nakajima , Yoshitaka Baba
发明人： Kazuhiko Fukutani , Takao Nakajima , Yoshitaka Baba
IPC分类号： A61B8/00
CPC分类号： A61B5/0059 , A61B5/0095 , A61B8/00 , A61B8/0833 , G01N21/1702 , G01N2021/1706
摘要： A biological information processing apparatus includes: a light source 11 that irradiates light 12 to a light irradiation region 13A on a test object 13; an acoustic wave detector 17 that detects an acoustic wave 16 generated by a light absorber 15 in the test object upon its absorption of the light, and outputs a detection signal; and an electronic control system 18 having an amplifier that amplifies the detection signal outputted from the acoustic wave detector 17. The electronic control system controls a gain of the amplifier in such a manner that a gain for a detection signal of an acoustic wave generated at a first location in the test object becomes larger as compared with a gain for a detection signal of an acoustic wave generated at a second location which exists nearer to the light irradiation region than the first location does.
摘要翻译：一种生物信息处理设备包括：将光12照射到测试对象13上的光照射区域13A的光源11; 声波检测器17，其在吸收光时检测由被测物中的光吸收体15产生的声波16，并输出检测信号; 以及具有放大从声波检测器17输出的检测信号的放大器的电子控制系统18.电子控制系统以这样的方式控制放大器的增益，使得在与在比第一位置更靠近光照射区域的第二位置处产生的声波的检测信号的增益相比，测试对象中的第一位置变大。

30. 发明授权

US09615751B2 Object information acquiring apparatus and object information acquiring method 有权
公开(公告)号：US09615751B2
公开(公告)日：2017-04-11
申请号：US14007386
申请日：2012-04-09
申请人： Kazuhiko Fukutani
发明人： Kazuhiko Fukutani
IPC分类号： A61B5/00 , A61B8/00 , G01N21/17
CPC分类号： A61B5/0095 , A61B5/7203 , A61B8/0825 , A61B8/4281 , A61B8/429 , A61B2576/00 , G01N21/1702 , G01N2021/1706
摘要： An object information acquiring apparatus, comprising: a plurality of detecting elements which detect an acoustic wave generated from an object irradiated with light and convert the acoustic wave into detection signals; a signal determining unit which determines a detection signal detected by a detecting element which is not in acoustic contact with the object, of the plurality of detecting elements; a signal acquisition unit which generates a corrected detection signal by deleting at least a region which is not based on an acoustic wave generated from the interior of the object, from the determined detection signal; and an image processor which forms image data of the object from a detection signal detected by a detecting element which is in acoustic contact with the object and from the corrected detection signal.

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