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21. 发明申请

WO1995021249A1 A CASSETTE TO ACCUMULATE MULTIPLE PROTEINS THROUGH SYNTHESIS OF A SELF-PROCESSING POLYPEPTIDE 审中-公开
标题翻译：通过合成多自由基聚合物来累积多种蛋白质的CASSETTE
公开(公告)号：WO1995021249A1
公开(公告)日：1995-08-10
申请号：PCT/US1995001495
申请日：1995-02-03
申请人： THE SCRIPPS RESEARCH INSTITUTE
发明人： THE SCRIPPS RESEARCH INSTITUTE , BEACHY, Roger, N. , MARCOS, Jose, F.
IPC分类号： C12N15/00
CPC分类号： C07K14/005 , C12N9/506 , C12N15/62 , C12N15/8216 , C12N15/8241 , C12N2770/34022
摘要： A cassette for simultaneous expression of two or more heterogenous peptides in equimolar amounts and based upon the nuclear inclusion (NIa) protease from tobacco etch potyvirus. The heterogenous peptides are translated and incorporated into a polypeptide that also includes the protease which releases the heterologous proteins post translationally by autoproteolytic reaction.
摘要翻译：用于以等摩尔量同时表达两种或更多种异源肽并基于来自烟草蚀刻法病毒的核包涵体（NIa）蛋白酶的盒。将异源肽翻译并掺入多肽中，该多肽还包括通过自身蛋白水解反应翻译后释放异源蛋白质的蛋白酶。

22. 发明申请

WO1995014081A1 METHOD FOR DETECTION OF INFLAMMATORY AGENTS 审中-公开
标题翻译：检测炎症因子的方法
公开(公告)号：WO1995014081A1
公开(公告)日：1995-05-26
申请号：PCT/US1994013236
申请日：1994-11-18
申请人： THE SCRIPPS RESEARCH INSTITUTE
发明人： THE SCRIPPS RESEARCH INSTITUTE , PUGIN, Jerome , ULEVITCH, Richard , TOBIAS, Peter, S.
IPC分类号： C12N05/08
CPC分类号： G01N33/56972 , G01N33/5005 , G01N33/6863 , G01N2333/525 , G01N2333/54 , G01N2333/70596 , G01N2400/50
摘要： An improved method for detection of agents in an analyte sample from a mammal, which agents will stimulate mononuclear cells to release factors for endothelial cell activation. The method is based on the discovery that an indirect pathway for endothelial cell activation mediated by mononuclear blood cells is substantially more efficient in stimulating the production of cytokines and cell adhesion molecules by endothelial cells than a direct, serum-dependent pathway. The method of the invention therefore utilizes the indirect pathway to activate cultured endothelial cells by exposing them to an amplification mixture comprising the analyte sample and mononuclear blood cells. Activation, if any, of the cultured endothelial cells is then determined by described detection means. Using this improved method, mononuclear cell stimulatory agents (such as inflammatory agents) can be detected in an analyte sample at picomolar or greater concentrations.
摘要翻译：用于检测来自哺乳动物的分析物样品中的试剂的改进方法，所述试剂将刺激单核细胞释放内皮细胞活化因子。该方法基于以下发现：由单核血细胞介导的内皮细胞活化的间接途径在内皮细胞刺激细胞因子和细胞粘附分子的产生方面比直接的血清依赖性途径更有效。因此，本发明的方法利用间接途径将培养的内皮细胞暴露于包含分析物样品和单核血细胞的扩增混合物中。然后通过描述的检测手段确定培养的内皮细胞的活化（如果有的话）。使用这种改进的方法，可以在皮摩尔浓度或更高浓度的分析物样品中检测单核细胞刺激剂（如炎症剂）。

23. 发明申请

WO1995014039A1 MONOCLONAL ANTIBODIES IMMUNOREACTIVE WITH LIPOPOLYSACCHARIDE BINDING PROTEIN (LBP) AND METHODS OF THEIR USE 审中-公开
标题翻译：单克隆抗体与脂多糖结合蛋白（LBP）的免疫反应及其使用方法
公开(公告)号：WO1995014039A1
公开(公告)日：1995-05-26
申请号：PCT/US1994013199
申请日：1994-11-15
申请人： THE SCRIPPS RESEARCH INSTITUTE
发明人： THE SCRIPPS RESEARCH INSTITUTE , KIRKLAND, Theo , TOBIAS, Peter , ULEVITCH, Richard , MORIARTY, Ann , LETURCQ, Didier
IPC分类号： C07K16/18
CPC分类号： A61K49/0058 , A61K38/00 , A61K49/0043 , A61K51/1018 , C07K16/18 , Y10S436/804
摘要： The present invention concerns a method of treating LBP-mediated LPS-induced myeloid cell activation comprising administering a therapeutically effective amount of an anti-LBP monoclonal antibody molecule. A therapeutic composition comprising anti-LBP antibody molecules in a pharmaceutically acceptable excipient is also contemplated.
摘要翻译：本发明涉及治疗LBP介导的LPS诱导的骨髓细胞活化的方法，包括给予治疗有效量的抗LBP单克隆抗体分子。还考虑了在药学上可接受的赋形剂中包含抗LBP抗体分子的治疗组合物。

24. 发明申请

WO1995004543A1 TEMPLATE ASSEMBLED SYNTHETIC PROTEIN 审中-公开
标题翻译：模板组装合成蛋白
公开(公告)号：WO1995004543A1
公开(公告)日：1995-02-16
申请号：PCT/US1994009165
申请日：1994-08-11
申请人： THE SCRIPPS RESEARCH INSTITUTE , DAWSON, Philip, E. , KENT, Stephen, B., H.
发明人： THE SCRIPPS RESEARCH INSTITUTE
IPC分类号： A61K38/00
CPC分类号： C07K7/02 , C07K1/1077
摘要： A chemoselective ligation approach to the preparation of complex peptides is employed in a simple, convenient synthesis of template-assembled synthetic protein (TASP) molecules. Reaction of readily prepared synthetic pro-helical peptide- alpha COSH molecules, in unprotected form, with a synthetic (BrAc)4template peptide molecule, also in unprotected form, proceeds rapidly in aqueous solution to give a uniform product in high yield. The resulting TASP molecule may be simply purified to homogeneity. Structural homogeneity may be demonstrated by ionspray mass spectrometry. The chemoselective ligation of unprotected peptides represents a general approach to the synthesis of TASP molecules.
摘要翻译：用于制备复合肽的化学选择性连接方法用于简单，方便地合成模板组装的合成蛋白（TASP）分子。容易制备的未保护形式的合成前螺旋肽-αCOSH分子与未保护形式的合成（BrAc）4模板肽分子的反应在水溶液中快速进行，以高产率得到均匀的产物。所得到的TASP分子可以简单地纯化至均匀。结构均匀性可以通过离子喷射质谱法来证明。未保护肽的化学选择性连接代表TASP分子合成的一般方法。

25. 发明申请

WO1994019011A1 PEPTIDES FOR INDUCING CYTOTOXIC T LYMPHOCYTE RESPONSES TO HEPATITIS B VIRUS 审中-公开
标题翻译：诱导细胞因子T淋巴细胞因子诱发乙型肝炎病毒的药物
公开(公告)号：WO1994019011A1
公开(公告)日：1994-09-01
申请号：PCT/US1994002195
申请日：1994-02-25
申请人： THE SCRIPPS RESEARCH INSTITUTE , CHISARI, Francis, V.
发明人： THE SCRIPPS RESEARCH INSTITUTE
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/292 , C12N2710/24143 , C12N2730/10122 , C12N2730/10134 , Y10S930/223
摘要： Peptides are used to define epitopes that stimulate HLA-restricted cytotoxic T lymphocyte activity against hepatitis B virus antigens. The peptides are derived from regions of HBV envelope, and are particularly useful in treating or preventing HBV infection, including methods for stimulating the immune response of chronically infected individuals to respond to HBV antigens.
摘要翻译：肽用于限定刺激针对乙型肝炎病毒抗原的HLA限制性细胞毒性T淋巴细胞活性的表位。肽源自HBV包膜区，特别可用于治疗或预防HBV感染，包括刺激慢性感染个体对HBV抗原应答的免疫应答的方法。

26. 发明申请

WO1994018232A1 METHODS FOR GENERATING BROADLY NEUTRALIZING ANTI-HIV ANTIBODIES AND ANTIGENS CAPABLE OF ELICITING SAME 审中-公开
标题翻译：用于产生广泛抗中性抗体抗体的抗生素和抗精子抗体的方法
公开(公告)号：WO1994018232A1
公开(公告)日：1994-08-18
申请号：PCT/US1994001458
申请日：1994-02-09
申请人： REPLIGEN CORPORATION , THE SCRIPPS RESEARCH INSTITUTE
发明人： REPLIGEN CORPORATION , THE SCRIPPS RESEARCH INSTITUTE , PROFY, Albert, T. , WILSON, Ian, A.
IPC分类号： C07K07/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/1045 , C12N2740/16122 , G01N33/56988
摘要： This invention features methods for identifying molecules which will act as antigens capable of eliciting broadly neutralizing anti-HIV antibodies, and methods for producing recombinant, broadly neutralizing anti-HIV antibodies.
摘要翻译：本发明的特征在于鉴定能够起到广泛中和抗HIV抗体的抗原的分子的方法以及用于产生重组的，广泛中和的抗HIV抗体的方法。

27. 发明申请

WO1994011029A1 HUMAN TISSUE FACTOR RELATED DNA SEGMENTS, POLYPEPTIDES AND ANTIBODIES 审中-公开
标题翻译：人体组织因子相关DNA部分，多肽和抗体
公开(公告)号：WO1994011029A1
公开(公告)日：1994-05-26
申请号：PCT/US1993011239
申请日：1993-11-16
申请人： THE SCRIPPS RESEARCH INSTITUTE , TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEMS OF ...
发明人： THE SCRIPPS RESEARCH INSTITUTE , TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEMS OF ... , EDGINGTON, Thomas, S. , COLMAN, Robert, W. , KAPPELMAYER, Janos , EDMUNDS, L., Henry, Jr. , BERNABEI, Alvise
IPC分类号： A61K39/395
CPC分类号： C07H21/00 , A61K38/00 , A61K2039/505 , C07K14/745 , C07K16/36 , G01N33/86 , G01N2333/745
摘要： DNA segments that include DNA sequences defining a structural gene coding for a human tissue factor heavy chain protein and a precursor form of that protein are disclosed. Recombinant DNA molecules capable of expressing a human tissue factor heavy chain protein are also disclosed. Further disclosed are human tissue factor heavy chain binding site polypeptide analogs as well as methods for their use. Also disclosed is a method of inhibiting coagulation in extracorporeal circulation.
摘要翻译：公开了包括限定编码人组织因子重链蛋白的结构基因的DNA序列和该蛋白质的前体形式的DNA片段。还公开了能够表达人组织因子重链蛋白的重组DNA分子。进一步公开的是人组织因子重链结合位点多肽类似物及其使用方法。还公开了抑制体外循环中的凝血的方法。

28. 发明申请

WO1994011003A1 CANCEROUS B CELL TREATMENT USING SUBSTITUTED NUCLEOSIDE DERIVATIVES 审中-公开
标题翻译：使用取代的核苷衍生物的CANCEROUS B细胞处理
公开(公告)号：WO1994011003A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010898
申请日：1993-11-12
申请人： THE SCRIPPS RESEARCH INSTITUTE
发明人： THE SCRIPPS RESEARCH INSTITUTE , GOODMAN, Michael, G. , PIRO, Lawrence, D.
IPC分类号： A61K31/56
CPC分类号： A61K31/70 , A61K38/164 , A61K47/6425 , A61K2300/00
摘要： Uses and processes for the killing of cancerous B cells, and particularly peripheral chronic lymphocytic leukemia (CLL) cells are disclosed. In one process, cancerous B cells that do not proliferate when contacted wtih an immune response-enhancing agent are contacted with an amount of such an agent sufficient to cause peripheral CLL cells to undergo blast transformation and proliferation. The contacted cells are then maintained for a time period sufficient for them to die from that contact. Further contacting of those cells with a cytotoxic amount of an anti-cancer drug enhances the death of those cancer cells. In another process, peripheral CLL cells that proliferate on contact with an immune response-enhancing agent are contacted with a proliferation-inducing amount of such an agent. The contacted cells are maintained for a time period sufficient to undergo blast transformation and proliferation, and the blasts are then contacted with a cytotoxic amount of an anti-cancer drug and maintained.
摘要翻译：公开了杀死癌性B细胞，特别是外周慢性淋巴细胞性白血病（CLL）细胞的用途和方法。在一个过程中，与免疫应答增强剂接触时不增殖的癌性B细胞与足以引起外周CLL细胞经历blast转化和增殖的量的这种试剂接触。然后将接触的细胞保持足以使它们从该接触死亡的时间段。这些细胞与细胞毒性量的抗癌药物的进一步接触增强了这些癌细胞的死亡。在另一个过程中，与免疫应答增强剂接触时增殖的外周CLL细胞与增殖诱导量的这种药物接触。将接触的细胞保持足以进行细胞转化和增殖的时间段，然后使细胞与细胞毒性量的抗癌药物接触并保持。

29. 发明申请

WO1993018185A1 RECEPTOR INTERNALIZATION SIGNALS 审中-公开
标题翻译：受体内在信号
公开(公告)号：WO1993018185A1
公开(公告)日：1993-09-16
申请号：PCT/US1993001669
申请日：1993-03-01
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , THE SCRIPPS RESEARCH INSTITUTE
发明人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , THE SCRIPPS RESEARCH INSTITUTE , TROWBRIDGE, Ian, S. , COLLAWN, James, F. , TAINER, John, A. , KUHN, Leslie, A.
IPC分类号： C12Q01/68
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07K5/1016 , C07K14/705 , C07K2319/06 , C12N15/625 , C12N2310/3513 , C12Q1/68
摘要： Internalization signals and their use in modulating cell surface receptor endocytosis.
摘要翻译：内化信号及其在调节细胞表面受体内吞作用中的应用。

30. 发明申请

WO1993009134A1 PHOSPHONAMIDATE ESTER-CONTAINING PSEUDOPEPTIDES 审中-公开
标题翻译：含有PHOSPHONAMIDATE ESTER的PSEUDOPEPTIDES
公开(公告)号：WO1993009134A1
公开(公告)日：1993-05-13
申请号：PCT/US1992009834
申请日：1992-11-06
申请人： THE SCRIPPS RESEARCH INSTITUTE , JANDA, Kim , WIRSHING, Peter
发明人： THE SCRIPPS RESEARCH INSTITUTE
IPC分类号： C07K05/02
CPC分类号： C07K5/0207 , A61K38/00 , C07K7/02 , C07K7/14
摘要： A "capped" phosphonamide C1-C6 alkyl ester linkage unit for joining peptides is disclosed. The linkage unit is substantially isosteric and isocoulombic as compared to conventional peptide backbone structures. The "capping" of the phosphonamide by the C1-C6 alkyl ester causes the linkage unit to be acid stable. When incorporated into a peptide, the phosphonamide C1-C6 alkyl ester linkage unit becomes resistant to cleavage by aspartic proteinase. Accordingly, the phosphonamide C1-C6 alkyl ester linkage unit enhances and/or facilitates the aspartic proteinase inhibition activity of peptides into which it is incorporated.
摘要翻译：公开了一种用于连接肽的“封端”膦酰胺C1-C6烷基酯连接单元。与常规肽骨架结构相比，连接单元基本上是等排的和异构的。通过C1-C6烷基酯对膦酰胺的“封端”使得连接单元是酸稳定的。当加入到肽中时，膦酰胺C1-C6烷基酯连接单元变得耐天冬氨酸蛋白酶切割。因此，膦酰胺C1-C6烷基酯连接单元增强和/或促进其掺入其中的肽的天冬氨酸蛋白酶抑制活性。

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