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21. 发明授权

US07829008B2 Fabricating a stent from a blow molded tube 有权
标题翻译：从吹塑管制造支架
公开(公告)号：US07829008B2
公开(公告)日：2010-11-09
申请号：US11809011
申请日：2007-05-30
申请人： Vincent J. Gueriguian , David C. Gale , Bin Huang
发明人： Vincent J. Gueriguian , David C. Gale , Bin Huang
IPC分类号： H05B6/00
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/825 , A61F2002/91575
摘要： Disclosed is a method for fabricating a stent, the method comprising: positioning a polymeric tube inside a mold, wherein a high thermally conductive element covers at least a portion of the outer surface of the mold, the high thermally conductive element having a thermal conductivity that is greater than that of the mold; heating at least a portion of the mold; radially expanding the tube against the mold; and fabricating a stent from the radially expanded tube.
摘要翻译：公开了一种用于制造支架的方法，所述方法包括：将聚合物管定位在模具内，其中高导热元件覆盖模具的外表面的至少一部分，高导热元件具有导热性，大于模具; 加热模具的至少一部分; 将管径向膨胀以抵靠模具; 并从径向膨胀的管制造支架。

22. 发明授权

US07794776B1 Modification of polymer stents with radiation 有权
标题翻译：用辐射改性聚合物支架
公开(公告)号：US07794776B1
公开(公告)日：2010-09-14
申请号：US11478974
申请日：2006-06-29
申请人： Timothy A. Limon , David C. Gale , Syed Faiyaz Ahmed Hossainy , Fuh-Wei Tang
发明人： Timothy A. Limon , David C. Gale , Syed Faiyaz Ahmed Hossainy , Fuh-Wei Tang
IPC分类号： B05D3/06 , C08F2/46 , C08F2/54 , C08J7/18 , B29C71/04 , A61F2/06
CPC分类号： B05D3/068 , A61F2/91 , A61F2250/003 , B05D3/061 , B05D5/00 , B29C71/04 , C08J7/123
摘要： Methods of modifying properties such as degradation rate and drug release rate of polymer stents with radiation are disclosed.
摘要翻译：公开了使用辐射改性聚合物支架的降解速率和药物释放速率等性能的方法。

23. 发明申请

US20090220571A1 SELF-EXPANDING DEVICES AND METHODS THEREFOR 有权
标题翻译：自扩展设备及其方法
公开(公告)号：US20090220571A1
公开(公告)日：2009-09-03
申请号：US12334373
申请日：2008-12-12
申请人： Donald J. Eaton , Bin Huang , Anthony J. Abbate , Gail M. Zaler , David C. Gale
发明人： Donald J. Eaton , Bin Huang , Anthony J. Abbate , Gail M. Zaler , David C. Gale
IPC分类号： A61L27/54 , A61K31/58 , A61P27/00 , A61M31/00
CPC分类号： A61L31/022 , A61B17/24 , A61B17/3468 , A61B17/3478 , A61B2017/3454 , A61F2/04 , A61F2/18 , A61F2/186 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/95 , A61F5/08 , A61F2002/048 , A61F2002/91508 , A61F2002/9522 , A61F2210/0004 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2230/0091 , A61F2240/001 , A61F2250/003 , A61F2250/006 , A61F2250/0067 , A61K9/70 , A61L31/10 , A61L31/148 , A61L31/16 , A61M29/00
摘要： Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
摘要翻译：这里描述了用于将一个或多个植入物递送到身体的递送装置以及使用方法。输送装置可以将植入物递送到身体内的各种位置，用于多种不同的用途。在一些变型中，递送装置具有带有一个或多个弯曲部分的套管。在一些变型中，可以使用推动器来从套管释放一个或多个植入物。在一些变型中，一个或多个释放的植入物可以是自扩张装置。这里还描述了将植入物递送到一个或多个窦腔的方法。

24. 发明申请

US20090198179A1 DELIVERY DEVICES AND METHODS 审中-公开
标题翻译：交付设备和方法
公开(公告)号：US20090198179A1
公开(公告)日：2009-08-06
申请号：US12334395
申请日：2008-12-12
申请人： Anthony J. Abbate , Bin Huang , David C. Gale , Gail M. Zaler , Richard E. Kaufman
发明人： Anthony J. Abbate , Bin Huang , David C. Gale , Gail M. Zaler , Richard E. Kaufman
IPC分类号： A61M29/02
CPC分类号： A61L31/022 , A61B17/24 , A61B17/3468 , A61B17/3478 , A61B2017/3454 , A61F2/04 , A61F2/18 , A61F2/186 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/95 , A61F5/08 , A61F2002/048 , A61F2002/91508 , A61F2002/9522 , A61F2210/0004 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , A61F2230/0091 , A61F2240/001 , A61F2250/003 , A61F2250/006 , A61F2250/0067 , A61K9/70 , A61L31/10 , A61L31/148 , A61L31/16 , A61M29/00
摘要： Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
摘要翻译：这里描述了用于将一个或多个植入物递送到身体的递送装置以及使用方法。输送装置可以将植入物递送到身体内的各种位置，用于多种不同的用途。在一些变型中，递送装置具有带有一个或多个弯曲部分的套管。在一些变型中，可以使用推动器来从套管释放一个或多个植入物。在一些变型中，一个或多个释放的植入物可以是自扩张装置。这里还描述了将植入物递送到一个或多个窦腔的方法。

25. 发明申请

US20090001633A1 Method Of Manufacturing A Stent From A Polymer Tube 有权
标题翻译：从聚合物管制造支架的方法
公开(公告)号：US20090001633A1
公开(公告)日：2009-01-01
申请号：US11771967
申请日：2007-06-29
申请人： Timothy A. Limon , Daniel A. Castro , David C. Gale
发明人： Timothy A. Limon , Daniel A. Castro , David C. Gale
IPC分类号： B29C35/06
CPC分类号： B29B13/024 , A61F2/91 , B29C35/041 , B29C49/68 , B29C2049/0089 , B29K2105/258 , B29L2031/7532 , B29L2031/7542
摘要： A blow molding apparatus for expanding a polymer tube and a method for fabricating a stent using the apparatus is disclosed. The polymer tube is disposed within a tubular mold, over which a heated ring is made of a material having thermal conductivity greater than the tubular mold is translated. The ring is heated with heated fluid streams applied directly onto an outer surface of the ring, or heated fluid circulated within the ring, or an electrically resistive coil within the ring, or combinations thereof. The heated ring uniformly heats a circumference of the tubular mold that, in turn, uniformly heats a circumferential band of the polymer tube. The heated polymer tube is progressively expanded radially and axially while the ring is translated longitudinally over the polymer tube. The expanded polymer tube can be heat set and cooled prior to removal from the tubular mold.
摘要翻译：公开了一种用于膨胀聚合物管的吹塑设备和使用该设备制造支架的方法。聚合物管设置在管状模具内，加热的环由热导率大于管状模具的材料制成。环被加热的流体流直接施加到环的外表面上，或在环内循环的加热流体，或环内的电阻线圈或其组合。加热环均匀地加热管状模具的圆周，这又使得聚合物管的周向带均匀地加热。加热的聚合物管在径向和轴向上逐渐扩大，同时环在聚合物管上纵向平移。膨胀聚合物管可以在从管状模具移除之前进行热定形和冷却。

26. 发明申请

US20080081063A1 Polymer blend-bioceramic composite implantable medical devices 有权
标题翻译：聚合物混合 - 生物陶瓷复合植入式医疗器械
公开(公告)号：US20080081063A1
公开(公告)日：2008-04-03
申请号：US11529996
申请日：2006-09-29
申请人： Yunbing Wang , David C. Gale
发明人： Yunbing Wang , David C. Gale
IPC分类号： A61F2/02
CPC分类号： A61L31/148 , A61L31/128 , Y10S525/931 , C08L67/04
摘要： Methods and devices relating to polymer blend/bioceramic composite implantable medical devices are disclosed.
摘要翻译：公开了与聚合物共混物/生物陶瓷复合植入式医疗装置有关的方法和装置。

27. 发明申请

US20080058916A1 Method of fabricating polymeric self-expandable stent 审中-公开
标题翻译：制造聚合物自扩张支架的方法
公开(公告)号：US20080058916A1
公开(公告)日：2008-03-06
申请号：US11444843
申请日：2006-05-31
申请人： Bin Huang , David C. Gale
发明人： Bin Huang , David C. Gale
IPC分类号： A61F2/06 , B05D1/12
CPC分类号： A61F2/90 , A61F2210/0004
摘要： A method of manufacturing a radially expandable an implantable medical device, the method comprising: providing a plurality of fibers, the fibers comprising a polymer; disposing the plurality of fibers on a cylindrical support element to form a tubular structure, the tubular structure having an initial diameter; heat setting the tubular structure such that the temperature of the tubular structure is between Tg to Tm of the polymer while heat setting, wherein the tubular structure is maintained at a heat set diameter which is equal to or substantially equal to the initial diameter; and fabricating an implantable medical device from the tubular structure.
摘要翻译：一种制造可径向扩张的可植入医疗装置的方法，所述方法包括：提供多根纤维，所述纤维包括聚合物; 将所述多个纤维布置在圆柱形支撑元件上以形成管状结构，所述管状结构具有初始直径; 热定形管状结构，使得管状结构的温度在热定形时在聚合物的Tg至Tm之间，其中管状结构保持在等于或基本等于初始直径的热定形直径; 以及从所述管状结构制造可植入医疗装置。

28. 发明申请

US20080021307A1 Radio frequency identification monitoring of stents 有权
标题翻译：射频识别监测支架
公开(公告)号：US20080021307A1
公开(公告)日：2008-01-24
申请号：US11486688
申请日：2006-07-13
申请人： Abigail Freeman , David C. Gale , Bin Huang , Daniel Castro
发明人： Abigail Freeman , David C. Gale , Bin Huang , Daniel Castro
IPC分类号： A61B5/05
CPC分类号： G01N25/72 , A61B90/90 , A61B90/98 , A61F2/06 , A61F2/82 , A61F2250/0085 , A61L2/081 , A61L2/082 , A61L2/085 , A61L2/087 , A61L2/10 , A61L2202/14
摘要： A method and system of monitoring environmental exposure of stents using radiofrequency identification is disclosed.
摘要翻译：公开了使用射频识别来监测支架的环境暴露的方法和系统。

29. 发明申请

US20080009938A1 Stent with a radiopaque marker and method for making the same 审中-公开
标题翻译：支架用不透射线的标记和方法制作相同
公开(公告)号：US20080009938A1
公开(公告)日：2008-01-10
申请号：US11483040
申请日：2006-07-07
申请人： Bin Huang , David C. Gale
发明人： Bin Huang , David C. Gale
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91566 , A61F2230/0013 , A61F2250/0098
摘要： A stent includes a marker that has a biodegradable body and a plurality of radiopaque nanoparticles dispersed in the body. The marker is disposed in a hole on a biodegradable structural element of the stent, and the marker and the hole have substantially the same configuration. A method for making a stent includes mixing radiopaque nanoparticles with a biodegradable material to form a stent marker, forming a hole on a structural element of a biodegradable stent for accommodating the stent marker, wherein the stent marker and hole have substantially the same configuration, and disposing the stent marker in the hole.
摘要翻译：支架包括具有可生物降解的身体和分散在体内的多个不透射线的纳米颗粒的标记物。标记物设置在支架的可生物降解的结构元件的孔中，并且标记和孔具有基本相同的构造。制造支架的方法包括将不透射线的纳米颗粒与可生物降解材料混合以形成支架标记，在用于容纳支架标记的可生物降解支架的结构元件上形成孔，其中支架标记和孔具有基本相同的构造，以及将支架标记物放置在孔中。

30. 发明申请

US20070282435A1 Implantable medical devices fabricated from branched polymers 有权
标题翻译：由分支聚合物制成的可植入医疗器械
公开(公告)号：US20070282435A1
公开(公告)日：2007-12-06
申请号：US11784886
申请日：2007-04-09
申请人： Yunbing Wang , David C. Gale , Bin Huang , Mikael O. Trollsas , Thierry Glauser , Florian Ludwig
发明人： Yunbing Wang , David C. Gale , Bin Huang , Mikael O. Trollsas , Thierry Glauser , Florian Ludwig
IPC分类号： A61F2/82 , A61F2/02
CPC分类号： A61L27/14 , A61L27/18 , A61L31/06 , C08L67/04
摘要： Implantable medical devices fabricated from branched polymers are disclosed.
摘要翻译：公开了由支化聚合物制造的可植入医疗器械。

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