专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US06942868B2 Aerodynamically light particles for pulmonary drug delivery 失效
标题翻译：用于肺部药物递送的空气动力学轻微颗粒
公开(公告)号：US06942868B2
公开(公告)日：2005-09-13
申请号：US10441948
申请日：2003-05-20
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdellaziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K47/32 , A61K49/00 , A61L15/00
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.
摘要翻译：提供用于向肺系统输送药物的空气动力学轻微颗粒，以及用于其合成和给药的方法。在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且具有小于0.4g / cm 3的振实密度和5μm和30μm之间的质量平均直径。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的聚（氨基酸）侧链组成集团在聚酯骨干。在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻微颗粒可用于增强治疗剂递送至肺的肺泡区域。掺入治疗剂的空气动力学轻微颗粒可以被有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。

22. 发明授权

US06749835B1 Formulation for spray-drying large porous particles 有权
公开(公告)号：US06749835B1
公开(公告)日：2004-06-15
申请号：US09644105
申请日：2000-08-23
申请人： Michael W. Lipp , Richard P. Batycky , Giovanni Caponetti
发明人： Michael W. Lipp , Richard P. Batycky , Giovanni Caponetti
IPC分类号： A61K912
CPC分类号： A61K9/0073 , A61K9/1611 , A61K9/1617
摘要： Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.

23. 发明授权

US06740310B2 Porous particles comprising excipients for deep lung delivery 有权
公开(公告)号：US06740310B2
公开(公告)日：2004-05-25
申请号：US10209654
申请日：2002-07-30
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
IPC分类号： A61K912
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137 , Y10S514/826 , Y10S514/851
摘要： Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear a-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The porous particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

24. 发明授权

US06254854B1 Porous particles for deep lung delivery 有权
公开(公告)号：US06254854B1
公开(公告)日：2001-07-03
申请号：US09569153
申请日：2000-05-11
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
IPC分类号： A61K912
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137 , Y10S514/826 , Y10S514/851
摘要： Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The porous particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

25. 发明申请

US20110237681A1 INHALABLE EPINEPHRINE 有权
标题翻译：可吸入的EPINEPHRINE
公开(公告)号：US20110237681A1
公开(公告)日：2011-09-29
申请号：US13082626
申请日：2011-04-08
申请人： Richard P. Batycky , Giovanni Caponetti , Mariko Childs , Elliot Ehrich , Karen Fu , Jeffrey S. Hrkach , Wen-I Li , Michael M. Liip , Mei-Ling Pan , Jason Summa
发明人： Richard P. Batycky , Giovanni Caponetti , Mariko Childs , Elliot Ehrich , Karen Fu , Jeffrey S. Hrkach , Wen-I Li , Michael M. Liip , Mei-Ling Pan , Jason Summa
IPC分类号： A61K31/138 , A61P25/00 , A61P37/08
CPC分类号： A61K31/137 , A61K9/0073 , A61K9/0075 , A61K9/1617 , A61K31/135 , A61M15/0091 , A61M2202/06
摘要： The present invention is directed toward particles for delivery of epinephrine to the respiratory system and methods for treating a patient in need of epinephrine. The particles and respirable compositions comprising the particles of the present invention described herein comprise the bioactive agent epinephrine, or a salt thereof, as a therapeutic agent. The particles are preferably formed by spray drying. Preferably, the particles and the respirable compositions are substantially dry and are substantially free of propellents. In a preferred embodiment, the particles have aerodynamic characteristics that permit targeted delivery of epinephrine to the site(s) of action.
摘要翻译：本发明涉及将肾上腺素递送至呼吸系统的颗粒和用于治疗需要肾上腺素的患者的方法。包含本文所述的本发明的颗粒的颗粒和可呼吸组合物包含作为治疗剂的生物活性剂肾上腺素或其盐。颗粒优选通过喷雾干燥形成。优选地，颗粒和可呼吸组合物基本上是干燥的并且基本上不含推进剂。在优选的实施方案中，颗粒具有允许将肾上腺素靶向递送至作用部位的空气动力特性。

26. 发明申请

US20110123574A1 INHALABLE SUSTAINED THERAPEUTIC FORMULATIONS 审中-公开
标题翻译：可持续的持续治疗方案
公开(公告)号：US20110123574A1
公开(公告)日：2011-05-26
申请号：US12907584
申请日：2010-10-19
申请人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
发明人： Sujit K. Basu , Giovanni Caponetti , Robert Clarke , Katharina J. Elbert
IPC分类号： A61K9/00 , A61K31/137 , A61K31/46 , A61P11/08 , A61P11/00
CPC分类号： A61K31/46 , A61K9/0075 , A61K9/1617 , A61K31/137 , A61K31/40 , A61M11/00 , A61M15/003 , A61M15/0045 , A61M15/009 , A61M15/0091 , A61M2202/064
摘要： The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties.
摘要翻译：本发明部分地基于意想不到的发现，即用于肺部递送包含磷脂和足够量的亮氨酸的治疗性，预防性或诊断剂的颗粒可以产生药剂的持久作用。具体地，用于肺部递送含有磷脂或磷脂组合的治疗性预防或诊断剂的颗粒，其中磷脂或磷脂组合以约1至46重量％的量存在于颗粒中; 和亮氨酸，其中亮氨酸以至少46重量％的量存在于颗粒中，可有助于药剂的持续作用。包含至少46重量百分比的亮氨酸但不含磷脂的颗粒不具有这些相同的持续作用特性。

27. 发明授权

US07807200B2 Formulations for spray-drying large porous particles 有权
标题翻译：喷雾干燥大型多孔颗粒的配方
公开(公告)号：US07807200B2
公开(公告)日：2010-10-05
申请号：US11867254
申请日：2007-10-04
申请人： Michael M. Lipp , Richard P. Batycky , Giovanni Caponetti
发明人： Michael M. Lipp , Richard P. Batycky , Giovanni Caponetti
IPC分类号： A61K9/12 , A61K9/14
CPC分类号： A61K9/0073 , A61K9/1611 , A61K9/1617
摘要： Particles having a tap density less than about 0.4 g/cm3 are formed by spray drying from a colloidal solution including a carboxylic acid or salt thereof, a phospholipid, a divalent salt and a solvent such as an aqueous-organic solvent. The colloidal solution can also include a therapeutic, prophylactic or diagnostic agent. Preferred carboxylic acids include at least two carboxyl groups. Preferred phospholipids include phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols, phophstidylserines, phosphatidylinositols and combinations thereof. The particles are suitable for pulmonary delivery.
摘要翻译：通过从包含羧酸或其盐，磷脂，二价盐和溶剂如水 - 有机溶剂的胶体溶液喷雾干燥，形成振实密度小于约0.4g / cm 3的颗粒。胶体溶液还可以包括治疗剂，预防剂或诊断剂。优选的羧酸包括至少两个羧基。优选的磷脂包括磷脂酰胆碱，磷脂酰乙醇胺，磷脂酰甘油，磷脂酰丝氨酸，磷脂酰肌醇及其组合。这些颗粒适用于肺部输送。

28. 发明申请

US20080226736A1 Inhalatory Pharmaceutical Compositions in Form of Dry Powders, Solutions or Suspensions Obtained From the Same and Process for their Preparation 有权
标题翻译：干粉，溶液或悬浮液形式的吸入药物组合物及其制备方法
公开(公告)号：US20080226736A1
公开(公告)日：2008-09-18
申请号：US12090899
申请日：2006-10-20
申请人： Giovanni Caponetti , Loretta Maggi , Laura Zanellotti , Cristina Veneziani
发明人： Giovanni Caponetti , Loretta Maggi , Laura Zanellotti , Cristina Veneziani
IPC分类号： A61K9/72 , A61K31/137 , A61K31/138 , A61K31/546 , A61M15/00 , A61K31/58
CPC分类号： A61K9/0078 , A61K9/0075 , A61K45/06
摘要： Inhalatory pharmaceutical composition comprising a drug, a soluble excipient and a surfactant, characterized by: said soluble excipient is present in an amount between 10% and less than 100% by weight; —the weight ratio between said surfactant and said drug is between 0.01 and 10; —the particle size of at least 50% of the particles of said powder is below 5 μm; —the bulk density db of said powder is between 0.1 and 0.3 g/cc; —the tapped density dt of said powder is between 0.15 and 0.7 g/cc; —the ratio db/dt is between 0.2 and 0.65.
摘要翻译：包含药物，可溶性赋形剂和表面活性剂的吸入药物组合物，其特征在于：所述可溶性赋形剂以10重量％至小于100重量％的量存在; 所述表面活性剂与所述药物之间的重量比为0.01至10; - 所述粉末的至少50％的颗粒的粒径小于5μm; - 所述粉末的体积密度d b b为0.1至0.3g / cc; - 所述粉末的敲击密度d t t为0.15-0.7g / cc; - 比率d / b / d 在0.2和0.65之间。

29. 发明授权

US06447752B2 Amorphous porous particles for deep lung delivery 有权
标题翻译：用于深肺输送的无定形多孔颗粒
公开(公告)号：US06447752B2
公开(公告)日：2002-09-10
申请号：US09888781
申请日：2001-06-25
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Robert S. Langer , Abdellaziz Ben-Jebria
IPC分类号： A61K912
CPC分类号： A61K9/0075 , A61K9/1647 , A61K31/137 , Y10S514/826 , Y10S514/851
摘要： Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The porous particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.
摘要翻译：提供用于向肺系统递送药物的改进的多孔颗粒，以及用于其合成和给药的方法。在优选的实施方案中，多孔颗粒由可生物降解的材料制成，其质量密度小于0.4g / cm 3 /。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化聚酯接枝共聚物形成，该聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的聚（氨基酸）侧链组成集团在聚酯骨干。在一个实施方案中，具有相对大的平均直径，例如大于5um的多孔颗粒可用于增强治疗剂递送至肺的肺泡区域。掺入治疗剂的多孔颗粒可以有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。

30. 发明授权

US6136295A Aerodynamically light particles for pulmonary drug delivery 有权
标题翻译：用于肺部药物递送的空气动力学轻微颗粒
公开(公告)号：US6136295A
公开(公告)日：2000-10-24
申请号：US211940
申请日：1998-12-15
申请人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
发明人： David A. Edwards , Giovanni Caponetti , Jeffrey S. Hrkach , Noah Lotan , Justin Hanes , Abdell Aziz Ben-Jebria , Robert S. Langer
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K47/32 , A61L9/04 , A61F2/00
CPC分类号： A61K9/0075 , A61K31/137 , A61K9/1647
摘要： Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear .alpha.-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 .mu.m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.
摘要翻译：提供用于向肺系统输送药物的空气动力学轻微颗粒，以及用于其合成和给药的方法。在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且具有小于0.4g / cm 3的振实密度和5μm-30μm之间的质量平均直径。颗粒可以由可生物降解的材料如可生物降解的聚合物形成。例如，颗粒可以由官能化的聚酯接枝共聚物形成，该聚酯接枝共聚物由具有至少一个氨基酸基团的直链α-羟基酸聚酯主链和至少一个从氨基酸延伸的聚（氨基酸）侧链组成集团在聚酯骨干。在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻的颗粒可用于增强治疗剂递送至肺的肺泡区域。掺入治疗剂的空气动力学轻微颗粒可以被有效地雾化，用于给予呼吸道以允许全身或局部递送多种治疗剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式