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21. 发明授权

US07078186B2 Apoptosis related polynucleotides, polypeptides, and antibodies 失效
公开(公告)号：US07078186B2
公开(公告)日：2006-07-18
申请号：US10013477
申请日：2001-12-13
申请人： Jian Ni , Paul E. Young , Steven M. Ruben
发明人： Jian Ni , Paul E. Young , Steven M. Ruben
IPC分类号： C12P21/06
CPC分类号： A61K48/00 , A61K38/00 , C07K14/4747
摘要： The present invention relates to novel human apoptosis related polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human apoptosis related polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human apoptosis related polypeptides.

22. 发明授权

US07335738B2 Heregulin-like factor 失效
标题翻译：类胰岛素样因子
公开(公告)号：US07335738B2
公开(公告)日：2008-02-26
申请号：US11354079
申请日：2006-02-15
申请人： Paul E. Young , Richter C. King , Mia Hijazi , Steven M. Ruben
发明人： Paul E. Young , Richter C. King , Mia Hijazi , Steven M. Ruben
IPC分类号： C07K1/00
CPC分类号： C07H21/04 , C07K14/4702 , C07K14/4756 , G01N33/574 , G01N33/57488 , G01N2333/475
摘要： The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
摘要翻译：本发明涉及一种作为调节蛋白家族成员的新型HLF蛋白。特别地，提供编码人HLF蛋白的分离的核酸分子。还提供了HLF多肽，载体，宿主细胞和用于制备其的重组方法。本发明还涉及用于鉴定HLF活性的激动剂和拮抗剂的筛选方法。还提供了用于检测细胞生长调节紊乱的诊断方法和用于治疗细胞生长调节紊乱的治疗方法。

23. 发明授权

US06906178B2 Vanilloid receptor-2 失效
标题翻译：香草素受体-2
公开(公告)号：US06906178B2
公开(公告)日：2005-06-14
申请号：US10137316
申请日：2002-05-03
申请人： Paul E. Young , Steven M. Ruben
发明人： Paul E. Young , Steven M. Ruben
IPC分类号： C07K14/705 , C07K14/00 , C12P21/06
CPC分类号： C07K14/705
摘要： The present invention relates to vanilloid receptor-2, a novel member of the vanilloid receptor family. The invention provides isolated nucleic acid molecules encoding human VR2 receptors. VR2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of VR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of VR2 receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, chronic pain syndromes, congenital pain insensitivity, inflammation, ischemia, host defense dysfunction, immune surveillance dysfunction, arthritis, multiple sclerosis, autoimmunity, immune dysfunction, and allergy.
摘要翻译：本发明涉及香草素受体-2，其是香草素受体家族的新成员。本发明提供编码人VR2受体的分离的核酸分子。还提供VR2多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及鉴定VR2受体活性的激动剂和拮抗剂的筛选方法。还提供了用于检测与VR2受体的异常表达相关的疾病状态的诊断方法。还提供了治疗疾病状态的治疗方法，包括但不限于慢性疼痛综合征，先天性疼痛不敏感性，炎症，缺血，宿主防御功能障碍，免疫监视功能障碍，关节炎，多发性硬化，自身免疫，免疫功能障碍和过敏。

24. 发明授权

US06849413B2 PGRP-L polynucleotides, polypeptides, and antibodies 失效
标题翻译： PGRP-L多核苷酸，多肽和抗体
公开(公告)号：US06849413B2
公开(公告)日：2005-02-01
申请号：US10068956
申请日：2002-02-11
申请人： Paul E. Young , Steven M. Ruben
发明人： Paul E. Young , Steven M. Ruben
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K48/00 , A61P37/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/566 , G01N33/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to novel human and murine proteins called PGRP-L, and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及称为PGRP-L的新型人和鼠蛋白质，以及编码这些蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

25. 发明授权

US07012134B2 Dendritic enriched secreted lymphocyte activation molecule 失效
公开(公告)号：US07012134B2
公开(公告)日：2006-03-14
申请号：US10062523
申请日：2002-02-05
申请人： Steven M. Ruben , Paul E. Young
发明人： Steven M. Ruben , Paul E. Young
IPC分类号： C07K16/18 , C07K16/24 , A61K39/395
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/5154 , C07K14/70596 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

26. 发明申请

US20080254466A1 Heregulin-like Factor 审中-公开
标题翻译：类胰岛素样因子
公开(公告)号：US20080254466A1
公开(公告)日：2008-10-16
申请号：US12036630
申请日：2008-02-25
申请人： Paul E. Young , C. Richter King , Mai Hijazi , Steven M. Ruben
发明人： Paul E. Young , C. Richter King , Mai Hijazi , Steven M. Ruben
IPC分类号： C12Q1/68 , C12N15/11 , C12N15/00 , C12N15/87 , C12P21/04 , C07K14/00 , C07K16/18
CPC分类号： C07H21/04 , C07K14/4702 , C07K14/4756 , G01N33/574 , G01N33/57488 , G01N2333/475
摘要： The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
摘要翻译：本发明涉及一种作为调节蛋白家族成员的新型HLF蛋白。特别地，提供编码人HLF蛋白的分离的核酸分子。还提供了HLF多肽，载体，宿主细胞和用于制备其的重组方法。本发明还涉及用于鉴定HLF活性的激动剂和拮抗剂的筛选方法。还提供了用于检测细胞生长调节紊乱的诊断方法和用于治疗细胞生长调节紊乱的治疗方法。

27. 发明授权

US07312051B2 Polynucleotides encoding dendritic enriched secreted lymphocyte activation molecule 失效
标题翻译：编码树突状细胞分泌淋巴细胞活化分子的多核苷酸
公开(公告)号：US07312051B2
公开(公告)日：2007-12-25
申请号：US10892171
申请日：2004-07-16
申请人： Steven M. Ruben , Paul E. Young
发明人： Steven M. Ruben , Paul E. Young
IPC分类号： C12N15/12 , C12N5/10 , C12P21/02 , C07K14/47
CPC分类号： C07K14/47 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/5154 , C07K14/70596 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及称为树突状分泌型分泌淋巴细胞活化分子的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

28. 发明授权

US07049409B2 Heregulin-like factor antibodies 失效
标题翻译：类胰岛素样因子抗体
公开(公告)号：US07049409B2
公开(公告)日：2006-05-23
申请号：US10609370
申请日：2003-07-01
申请人： Paul E. Young , C. Richter King , Mia Hijazi , Steven M. Ruben
发明人： Paul E. Young , C. Richter King , Mia Hijazi , Steven M. Ruben
IPC分类号： C07K16/00
CPC分类号： C07H21/04 , C07K14/4702 , C07K14/4756 , G01N33/574 , G01N33/57488 , G01N2333/475
摘要： The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
摘要翻译：本发明涉及一种作为调节蛋白家族成员的新型HLF蛋白。特别地，提供编码人HLF蛋白的分离的核酸分子。还提供了HLF多肽，载体，宿主细胞和用于制备其的重组方法。本发明还涉及用于鉴定HLF活性的激动剂和拮抗剂的筛选方法。还提供了用于检测细胞生长调节紊乱的诊断方法和用于治疗细胞生长调节紊乱的治疗方法。

29. 发明授权

US06727077B1 Heregulin-like factor 失效
标题翻译：类胰岛素样因子
公开(公告)号：US06727077B1
公开(公告)日：2004-04-27
申请号：US09097681
申请日：1998-06-16
申请人： Paul E. Young , C. Richter King , Mai Hijazi , Steven M. Ruben
发明人： Paul E. Young , C. Richter King , Mai Hijazi , Steven M. Ruben
IPC分类号： C12N1500
CPC分类号： C07H21/04 , C07K14/4756
摘要： The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of HLF activity. Also provided are diagnostic methods for detecting disorders of the regulation of cell growth and therapeutic methods for treating disorders of the regulation of cell growth.
摘要翻译：本发明涉及一种作为调节蛋白家族成员的新型HLF蛋白。特别地，提供编码人HLF蛋白的分离的核酸分子。还提供了HLF多肽，载体，宿主细胞和用于制备其的重组方法。本发明还涉及用于鉴定HLF活性的激动剂和拮抗剂的筛选方法。还提供了用于检测细胞生长调节紊乱的诊断方法和用于治疗细胞生长调节紊乱的治疗方法。

30. 发明授权

US06620912B2 Dendritic enriched secreted lymphocyte activation molecule 失效
标题翻译：树突状细胞分泌淋巴细胞活化分子
公开(公告)号：US06620912B2
公开(公告)日：2003-09-16
申请号：US09369248
申请日：1999-08-05
申请人： Paul E. Young , Steven M. Ruben
发明人： Paul E. Young , Steven M. Ruben
IPC分类号： C07K1447
CPC分类号： C07K14/70596 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/5154 , C07K14/47 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译：本发明涉及一种称为树突状分泌型分泌淋巴细胞活化分子的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

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