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21. 发明授权

US06755850B2 Selective organ hypothermia method and apparatus 有权
标题翻译：选择性器官降温方法和装置
公开(公告)号：US06755850B2
公开(公告)日：2004-06-29
申请号：US10158406
申请日：2002-05-29
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F700
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues. A flexible catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in an artery feeding the selected organ. A compressed refrigerant is pumped through the catheter to an expansion element near the distal tip of the catheter, where the refrigerant vaporizes and expands to cool a flexible heat transfer element in the distal tip of the catheter. The heat transfer element cools the blood flowing through the artery, to cool the selected organ, distal to the tip of the catheter.
摘要翻译：用于对选定器官进行低温的方法和装置，对周围器官或其他组织没有显着影响。将柔性导管穿过患者的血管系统插入导管的远端以进入所选器官的动脉。压缩的制冷剂被泵送通过导管到靠近导管的远端的膨胀元件，其中制冷剂蒸发并膨胀以冷却导管的远端中的柔性传热元件。传热元件冷却流过动脉的血液，以冷却所选择的器官，远离导管的尖端。

22. 发明授权

US06576002B2 Isolated selective organ cooling method and apparatus 有权
标题翻译：分离选择器官冷却方法和装置
公开(公告)号：US06576002B2
公开(公告)日：2003-06-10
申请号：US09754452
申请日：2001-01-04
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A selective organ cooling device with a separate warming device for preventing secondary cooling which can result from cooling the selected organ. The cooling device applies cooling to the blood flowing in a selected blood vessel, while the body temperature control device warms the whole body either directly, or by warming blood returning to the heart from the selected organ, via a vein.
摘要翻译：选择性器官冷却装置，其具有单独的加温装置，用于防止冷却选定器官所产生的二次冷却。冷却装置对在所选择的血管中流动的血液进行冷却，而体温控制装置直接对整个身体进行暖气，或者通过静脉将选择的器官返回到心脏的血液变暖。

23. 发明授权

US06482226B1 Selective organ hypothermia method and apparatus 有权
标题翻译：选择性器官降温方法和装置
公开(公告)号：US06482226B1
公开(公告)日：2002-11-19
申请号：US09650940
申请日：2000-08-30
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F700
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues. A flexible catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in an artery feeding the selected organ. A compressed refrigerant is pumped through the catheter to an expansion element near the distal tip of the catheter, where the refrigerant vaporizes and expands to cool a flexible heat transfer element in the distal tip of the catheter. The heat transfer element cools the blood flowing through the artery, to cool the selected organ, distal to the tip of the catheter.
摘要翻译：用于对选定器官进行低温的方法和装置，对周围器官或其他组织没有显着影响。将柔性导管穿过患者的血管系统插入导管的远端以进入所选器官的动脉。压缩的制冷剂被泵送通过导管到靠近导管的远端的膨胀元件，其中制冷剂蒸发并膨胀以冷却导管的远端中的柔性传热元件。传热元件冷却流过动脉的血液，以冷却所选择的器官，远离导管的尖端。

24. 发明授权

US06475231B2 Method and device for applications of selective organ cooling 有权
标题翻译：选择性器官冷却应用的方法和装置
公开(公告)号：US06475231B2
公开(公告)日：2002-11-05
申请号：US09755919
申请日：2001-01-05
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： The invention provides a method and device for selectively controlling the temperature of a selected organ of a patient for performance of a specified application. The method includes introducing a guide catheter into a blood vessel. The guide catheter may have a soft tip and a retaining flange, and may be used to provide treatments such as administration of thrombolytic drug therapies, stenting procedures, angiographic procedures, etc. A supply tube is provided having a heat transfer element attached to a distal end thereof. The heat transfer element having a plurality of exterior surface irregularities, these surface irregularities having a depth greater than the boundary layer thickness of flow in the feeding artery of the selected organ. The supply tube and heat transfer element may be inserted through the guide catheter to place the heat transfer element in the feeding artery of the selected organ. Turbulence is created around the surface irregularities at a distance from the heat transfer element greater than the boundary layer thickness of flow in the feeding artery, thereby creating turbulence throughout the blood flow in the feeding artery. A working fluid is circulated into the heat transfer element via the supply tube and via an internal lumen of the heat transfer element. The fluid may be circulated out of the heat transfer element via an external lumen of the heat transfer element and through the guide catheter. Heat is thereby transferred between the heat transfer element and the blood in the feeding artery to selectively control the temperature of the selected organ during or soon before or after the specified application.
摘要翻译：本发明提供一种用于选择性地控制患者的选定器官的温度以执行特定应用的方法和装置。该方法包括将引导导管引入血管。引导导管可以具有柔软的尖端和保持凸缘，并且可以用于提供诸如溶栓药物治疗的施用，支架植入程序，血管造影术等的治疗。提供了一种供应管，其具有附接到远端的传热元件结束。所述传热元件具有多个外表面凹凸，这些表面凹凸具有大于所选器官的供给动脉中的流动的边界层厚度的深度。供应管和传热元件可以通过引导导管插入，以将传热元件放置在所选器官的进食动脉中。在距离传热元件一定距离的表面不规则处产生湍流大于供给动脉中的流动的边界层厚度，从而在进食动脉中的整个血流中产生湍流。工作流体经由供给管和传热元件的内腔循环到传热元件中。流体可以经由传热元件的外腔并通过引导导管从传热元件循环出来。因此，热量在传送元件和供给动脉中的血液之间转移，以在特定应用之前或之后选择性地控制所选器官的温度。

25. 发明授权

US6151901A Miniature mixed gas refrigeration system 失效
标题翻译：微型混合气体制冷系统
公开(公告)号：US6151901A
公开(公告)日：2000-11-28
申请号：US542123
申请日：1995-10-12
申请人： John D. Dobak, III , Ray Radebaugh , Marcia L. Huber , Eric D. Marquardt
发明人： John D. Dobak, III , Ray Radebaugh , Marcia L. Huber , Eric D. Marquardt
IPC分类号： A61B18/02 , C09K5/04 , F25B9/00 , F25B9/02 , F28D7/12 , F28F13/06 , F28F21/08 , F25B19/02
CPC分类号： F28F13/06 , A61B18/02 , C09K5/045 , F25B9/006 , F25B9/02 , F28D7/12 , F28F21/08 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F28F2260/00
摘要： A miniature mixed gas refrigeration system is disclosed, having a coaxial catheter with an inner high pressure supply lumen and an outer low pressure return lumen. The gas mixture is pressurized by a compressor to a pressure less than 420 psia, for safety reasons. The distal portion of the outer lumen contains a micro-miniature heat exchanger constructed of laminated plates or sheets. The plates or sheets establish high pressure and low pressure passageways, with high surface area, having a tortuous path for the gas flow to maximize heat exchange. The high pressure outlet of the heat exchanger is connected to a Joule-Thomson expansion element where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 180K. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter, to cool an external object. Return gas flows back through the heat exchanger to pre-cool the incoming high pressure gas mixture.
摘要翻译：公开了一种微型混合气体制冷系统，其具有具有内部高压供应内腔和外部低压返回内腔的同轴导管。为了安全起见，气体混合物被压缩机压力低于420psia。外腔的远侧部分包含由层叠板或片构成的微型热交换器。板或板建立了高压和低压通道，具有高的表面积，具有用于气流最大化热交换的曲折路径。热交换器的高压出口连接到焦耳 - 汤姆森膨胀元件，高压气体在等离子体中扩散至低至少低至180K的较低温度。该低温气体冷却安装在导管的外壁中的传热元件，以冷却外部物体。回流气体通过热交换器流回，以对进入的高压气体混合物进行预冷却。

26. 发明授权

US6149677A Circulating fluid hypothermia method 有权
标题翻译：循环液低温法
公开(公告)号：US6149677A
公开(公告)日：2000-11-21
申请号：US306865
申请日：1999-05-07
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61F7/00 , A61F7/12 , A61M25/14 , A61M25/16
CPC分类号： A61F7/12 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： A method for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues. A flexible coaxial catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in an artery feeding the selected organ. A chilled perfluorocarbon fluid is pumped through an insulated inner supply conduit of the catheter to cool a flexible bellows shaped heat transfer element in the distal tip of the catheter. The heat transfer bellows cools the blood flowing through the artery, to cool the selected organ, distal to the tip of the catheter.
摘要翻译：对周围器官或其他组织没有显着影响的选择器官进行低体温的方法。柔性同轴导管通过患者的血管系统插入以将导管的远侧末端放置在供给所选择的器官的动脉中。冷冻的全氟化碳流体被泵送通过导管的绝缘内部供应管道，以冷却导管的远侧末端中的柔性波纹管状传热元件。传热波纹管冷却流过动脉的血液，冷却选定的器官，远离导管的尖端。

27. 发明授权

US6070415A Precooling system for Joule-Thomson probe 失效
公开(公告)号：US6070415A
公开(公告)日：2000-06-06
申请号：US75374
申请日：1998-05-07
申请人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Terry L. Brown , Kambiz Ghaerzadeh , Xiaoyu Yu
摘要： A miniature refrigeration system and method of operation. A primary refrigerant is pressurized by a compressor to a relatively low pressure, for safety reasons. The compressed primary refrigerant is passed through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary-to-secondary heat exchanger is cooled by a secondary refrigeration system. The primary refrigerant exiting the primary outlet of the primary-to-secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded to a lower temperature. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter or cryoprobe, to cool surrounding tissue. Return gas can flow back through a distal primary-to-primary heat exchanger to further cool the incoming high pressure gas mixture. A proximal primary-to-primary heat exchanger can be added between the primary-to-secondary heat exchanger and the primary compressor.

28. 发明授权

US6042559A Insulated catheter for selective organ perfusion 失效
标题翻译：绝缘导管用于选择性器官灌注
公开(公告)号：US6042559A
公开(公告)日：2000-03-28
申请号：US28567
申请日：1998-02-24
申请人： John D. Dobak, III
发明人： John D. Dobak, III
IPC分类号： A61M1/36 , A61M5/00 , A61F7/12
CPC分类号： A61M1/369 , A61B2018/00166 , A61M2205/3633 , A61M2205/366
摘要： A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues, by perfusion of the organ with blood cooled externally from the body of the patient. A flexible supply catheter is inserted percutaneously into an artery. Blood from the supply catheter is cooled in a finned tube heat exchanger or a fluid bath. A flexible delivery catheter is inserted percutaneously through the vascular system of the patient to place the distal end of the catheter in an artery feeding the selected organ. An occlusion device is expanded to occlude the feeder artery at a point proximal to the distal end of the delivery catheter. Cooled blood from the chiller is pumped through the delivery catheter to an outlet near the distal end of the catheter, to cool the selected organ, distal to the tip of the delivery catheter.
摘要翻译：通过用从患者身体外部冷却的血液灌注器官，对所选择的器官进行体温低温的方法和装置，而不对周围器官或其他组织产生显着影响。灵活的供应导管经皮插入动脉。来自供应导管的血液在翅片管式热交换器或流体浴中冷却。通过患者的血管系统经皮插入柔性递送导管，以将导管的远端放置在供给所选择的器官的动脉中。闭塞装置被膨胀以在靠近输送导管的远端的点处封闭供给动脉。将来自冷冻机的冷却的血液通过输送导管泵送到导管远端附近的出口，以冷却选定的器官，远离输送导管的尖端。

29. 发明授权

US5901783A Cryogenic heat exchanger 失效
标题翻译：低温热交换器
公开(公告)号：US5901783A
公开(公告)日：1999-05-11
申请号：US895681
申请日：1997-07-17
申请人： John D. Dobak, III , Ray Radebaugh , Eric D. Marquardt
发明人： John D. Dobak, III , Ray Radebaugh , Eric D. Marquardt
IPC分类号： F28F7/00 , A61B18/02 , C09K5/04 , F25B9/00 , F25B9/02 , F28D7/02 , F28D7/12 , F28F13/06 , F28F21/08 , F28F3/00
CPC分类号： C09K5/045 , A61B18/02 , F25B9/006 , F25B9/02 , F28D7/12 , F28F13/06 , F28F21/082 , F28F21/085 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F28F2260/02
摘要： A microminiature laminated heat exchanger for use in a cryogenic probe, and a method of manufacture. The heat exchanger has high and low pressure flow patterns etched into oxygen free copper sheets, with the flow patterns being tortuous paths promoting turbulent flow. The sheets containing the flow patterns are bonded into a laminated assembly in the shape of a cylinder, with a high pressure inlet and a low pressure outlet in a first end, and a high pressure outlet and a low pressure inlet in a second end. The high pressure flow path lies alongside the low pressure flow path, with flow in the two paths being in opposite directions, to accomplish counterflow heat exchange. Substantial portions of the flow paths are either parallel to, or transverse to, the longitudinal axis of the heat exchanger, with the resulting heat flow being essentially radial or axial, respectively.
摘要翻译：用于低温探针的微型层压热交换器及其制造方法。热交换器具有蚀刻成无氧铜片的高压和低压流动图案，其中流动模式是促进湍流的曲折路径。含有流动图案的片材以气缸的形式结合到层叠组件中，在第一端具有高压入口和低压出口，在第二端中具有高压出口和低压入口。高压流动路径位于低压流动路径旁边，两条路径中的流动处于相反的方向，以实现逆流热交换。流动路径的实质部分或者平行于或横向于热交换器的纵向轴线，所得到的热流分别基本上是径向的或轴向的。

30. 发明授权

US5787715A Mixed gas refrigeration method 失效
标题翻译：混合气体制冷方法
公开(公告)号：US5787715A
公开(公告)日：1998-08-04
申请号：US698044
申请日：1996-08-15
申请人： John D. Dobak, III , Ray Radebaugh , Marcia L. Huber , Eric D. Marquardt
发明人： John D. Dobak, III , Ray Radebaugh , Marcia L. Huber , Eric D. Marquardt
IPC分类号： F25D3/10 , A61B18/02 , C09K5/04 , F25B7/00 , F25B9/00 , F25B9/02 , F28D7/12 , F28F13/06 , F28F21/08 , F25B19/02
CPC分类号： F28D7/12 , A61B18/02 , C09K5/045 , F25B9/006 , F25B9/02 , F28F13/06 , F28F21/08 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F25B7/00 , F28F2260/00
摘要： A miniature mixed gas refrigeration system and method of operation are disclosed, having a coaxial catheter with an inner high pressure supply lumen and an outer low pressure return lumen. An optimum gas mixture is formulated from a group of component fluids, according to calculated thermodynamic properties of a group of candidate fluid mixtures. The gas mixture is pressurized by a compressor to a pressure less than 420 psia, for safety reasons. The distal portion of the outer lumen contains a micro-miniature heat exchanger constructed of laminated plates or sheets. The plates or sheets establish high pressure and low pressure passageways, with high surface area, having a tortuous path for the gas flow to maximize heat exchange. The high pressure outlet of the heat exchanger is connected to a Joule-Thomson expansion element where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 183K. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter, to cool an external object. Return gas flows back through the heat exchanger to pre-cool the incoming high pressure gas mixture.
摘要翻译：公开了一种微型混合气体制冷系统和操作方法，其具有具有内部高压供应内腔和外部低压返回内腔的同轴导管。根据一组候选流体混合物的计算的热力学性质，从一组组分流体配制最佳气体混合物。为了安全起见，气体混合物被压缩机压力低于420psia。外腔的远侧部分包含由层叠板或片构成的微型热交换器。板或板建立了高压和低压通道，具有高的表面积，具有用于气流最大化热交换的曲折路径。热交换器的高压出口连接到焦耳 - 汤姆森膨胀元件，高压气体在等离子体中扩散至至少低至183K的较低温度。该低温气体冷却安装在导管的外壁中的传热元件，以冷却外部物体。回流气体通过热交换器流回，以对进入的高压气体混合物进行预冷却。

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