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21. 发明授权

US5691169A Process for preparing a desired protein 失效
标题翻译：制备所需蛋白质的方法
公开(公告)号：US5691169A
公开(公告)日：1997-11-25
申请号：US402455
申请日：1995-03-10
申请人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli Winnie Ringsted , Torben Ehlern Jessen
发明人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli Winnie Ringsted , Torben Ehlern Jessen
IPC分类号： C07K14/545 , C07K14/61 , C12N9/22 , C12N9/36 , C12N15/62 , C12P21/06 , C12N1/20 , C12P19/56
CPC分类号： C12N9/2462 , C07K14/545 , C07K14/61 , C12N15/62 , C12N9/22 , C12P21/06 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
摘要： A desired protein having the formula: A-B-C-P wherein a) A is Lys or Arg, and B and C are arbitrary amino acids, or b) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro, is produced from a biosynthetically formed amino acid extended protein having the formula: X-A-B-C-P wherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.
摘要翻译：具有下式的所需蛋白质：ABCP其中a）A是Lys或Arg，B和C是任意氨基酸，或b）A是不同于Pro，Lys和Arg的任意氨基酸，B和/或C是 Pro是由具有下式的生物合成形式的氨基酸延伸蛋白产生的：XABCP其中A，B，C和P如上定义，X是具有偶数氨基酸的氨基酸序列，其中第一个从N末端看，与Lys和Arg不同，所有其他不均匀的氨基酸与Pro，Lys和Arg不同，所有偶联的氨基酸与Pro不同，通过与酶二肽基氨基肽酶（DAP I ）。在纯状态下获得所需的蛋白质。因此，例如可以通过该过程产生没有Met-hGH含量的hGH。

22. 发明授权

US4548035A Hydraulic control apparatus for a servomotor 失效
标题翻译：伺服电机液压控制装置
公开(公告)号：US4548035A
公开(公告)日：1985-10-22
申请号：US441105
申请日：1982-11-12
申请人： Svend E. Thomsen , Thorkild Christensen
发明人： Svend E. Thomsen , Thorkild Christensen
IPC分类号： F15B9/08 , B62D5/09 , F15B9/10
CPC分类号： B62D5/09
摘要： The invention relates to a steering control unit for a bidirectional servomotor which is connectable to steerable wheels. A steering wheel controlled quantity setting unit of a known type has ports connectable to a pump and a return tank and two control ports through which metered quantities of fluid flow to opposite sides of the servomotor and to other parts of the apparatus for actuating the servomotor. A directional control valve for selectivity directing pressurized fluid from a power circuit to opposite sides of the servomotor is controlled by a control circuit containing the setting unit. A utility valve having pressure regulating and control and power valve capabilities is provided. In cases wherein the quantity setting apparatus is remotely located from the regulating valve the length of the signal channels add to the reaction time. Such reaction time is reduced herein by connecting the metering throttle as a fixed throttle between the regulating valve and quantity setting apparatus so that the regulating valve feeds a substantially constant quantity to the control cicuit, and that the quantity setting apparatus comprises a short circuit path to the tank which closes with an increase in the quantity.
摘要翻译：本发明涉及一种用于双向伺服电机的转向控制单元，其可连接到可转向的车轮。已知类型的方向盘控制量设定单元具有可连接到泵和回流罐的端口和两个控制端口，计量量的流体流过伺服电机的相对侧以及用于致动伺服电动机的装置的其它部分。用于将加压流体从功率电路选择性地引导到伺服电动机的相对侧的方向控制阀由包含设定单元的控制电路控制。本发明提供一种具有压力调节和功率阀功能的电力阀。在数量设定装置远离调节阀的情况下，信号通道的长度增加到反应时间。这样的反应时间通过将调节阀和量设定装置之间的固定节流阀连接在一起，使得调节阀向控制电路供给基本上恒定的量，并且量设定装置包括短路路径随着数量的增加关闭的油箱。

23. 发明授权

US4266464A Hydraulic control apparatus for servo-motor particularly for vehicle steering 失效
标题翻译：用于伺服电机的液压控制装置，特别适用于车辆转向
公开(公告)号：US4266464A
公开(公告)日：1981-05-12
申请号：US912209
申请日：1978-06-05
申请人： Johannes V. Baatrup , Thorkild Christensen , Tage Christiansen , Svend E. Thomsen
发明人： Johannes V. Baatrup , Thorkild Christensen , Tage Christiansen , Svend E. Thomsen
IPC分类号： B62D5/09 , F15B13/042
CPC分类号： B62D5/09 , Y10T137/86984
摘要： The invention relates to hydraulic control apparatus for a servomotor of the type utilized for vehicle steering systems. Such apparatus has a control circuit controlled by a manually operated device such as a steering wheel and a power circuit connected between the servomotor and a power source such as a hydraulic pump. The power circuit includes resetting apparatus for throttling the return flow branch in a manner so that forces applied to the servomotor in the same direction as actuation are absorbed with a minimum of reactionary movement by the valves on the return flow side of the apparatus.
摘要翻译：本发明涉及一种用于车辆转向系统的伺服电机的液压控制装置。这种装置具有由诸如方向盘的手动操作装置和连接在伺服电动机和诸如液压泵的电源之间的电力电路控制的控制电路。电源电路包括用于以回流流量分支节流的复位装置，使得以与致动相同的方向施加到伺服电动机的力被装置的回流侧上的阀的最小反应运动吸收。

24. 发明授权

US06566329B1 Freeze-dried preparation of human growth hormone 有权
标题翻译：冷冻干燥人体生长激素的制备
公开(公告)号：US06566329B1
公开(公告)日：2003-05-20
申请号：US09594103
申请日：2000-06-14
申请人： Giorgio Meyn , Hans Holmegaard Sørensen , Thorkild Christensen
发明人： Giorgio Meyn , Hans Holmegaard Sørensen , Thorkild Christensen
IPC分类号： A61K3800
CPC分类号： A61K38/27
摘要： A readily-soluble freeze-dried solid preparation of hGH with a minimal content of degradation products in terms of deamidation, dimers, polymers, and sulphoxide forms, obtainable by a method comprising a single lyophilization of an aqueous slurry of an amorphous hGH isoprecipitate, the slurry having a pH of from about 4.7 to 5.0 and being essentially free of buffer components other than acetate.
摘要翻译：通过包括单一冻干无定形hGH异沉淀物的水性浆液的方法可获得的脱甲基化，二聚体，聚合物和亚砜形式的降解产物含量最低的hGH的易溶性冷冻干燥固体制剂，浆液的pH值为约4.7至5.0，基本上不含乙酸盐以外的缓冲组分。

25. 发明授权

US5705482A Pharmaceutical formulation 失效
标题翻译：药物制剂
公开(公告)号：US5705482A
公开(公告)日：1998-01-06
申请号：US372635
申请日：1995-01-13
申请人： Thorkild Christensen , Per Balschmidt , Hans Holmegaard S.o slashed.rensen , Ole Hvilsted Olsen , Lars Thim
发明人： Thorkild Christensen , Per Balschmidt , Hans Holmegaard S.o slashed.rensen , Ole Hvilsted Olsen , Lars Thim
IPC分类号： A61K9/08 , A61K9/14 , A61K38/00 , A61K38/27 , A61K38/18
CPC分类号： A61K38/27
摘要： A pharmaceutical formulation comprising a growth hormone and Leu-His-Leu as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
摘要翻译：包含生长激素和Leu-His-Leu作为添加剂或缓冲物质的药物制剂显示出非常高的抗肽脱离，氧化和切割的稳定性。产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。

26. 发明授权

US5618697A Process for preparing a desired protein 失效
标题翻译：制备所需蛋白质的方法
公开(公告)号：US5618697A
公开(公告)日：1997-04-08
申请号：US372692
申请日：1995-01-13
申请人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli W. Ringsted , Torben E. Jessen
发明人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli W. Ringsted , Torben E. Jessen
IPC分类号： C07K14/545 , C07K14/61 , C12N9/22 , C12N9/36 , C12N15/62 , C12P21/06 , C12N5/10 , C12N15/18
CPC分类号： C12N9/2462 , C07K14/545 , C07K14/61 , C12N15/62 , C12N9/22 , C12P21/06 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
摘要： A process for producing ripe human growth hormone is described which comprises introducing into bacteria a recombinant DNA vector comprising a DNA sequence encoding an amino-terminal extended human growth hormone which amino-terminal extension has a negatively charged amino acid sequence and has an even number of amino acids, growing the bacteria such that the amino-terminal extended human growth is expressed, separating the amino-terminal extended human grown hormone from contaminants, cleaving the amino-terminal extension with dipeptidyl aminopeptidase I to obtain ripe human growth hormone and isolating the ripe human growth hormone produced.
摘要翻译：描述了一种生产成熟人生长激素的方法，其包括向细菌中引入包含编码氨基末端延伸的人生长激素的DNA序列的重组DNA载体，所述氨基末端延伸具有带负电荷的氨基酸序列，并具有偶数个氨基酸生长，使得氨基末端延长的人生长被表达，将氨基末端延长的人生长激素与污染物分离，用二肽基氨基肽酶I切割氨基末端延伸以获得成熟的人生长激素并分离成熟人类生长激素产生。

27. 发明授权

US5552385A Pharmaceutical formulation 失效
标题翻译：药物制剂
公开(公告)号：US5552385A
公开(公告)日：1996-09-03
申请号：US463159
申请日：1995-06-05
申请人： Thorkild Christensen , Per Balschmidt , Hans S.o slashed.rensen , Ole Olsen , Lars Thim
发明人： Thorkild Christensen , Per Balschmidt , Hans S.o slashed.rensen , Ole Olsen , Lars Thim
IPC分类号： A61K38/27 , C07K5/11 , A61K38/07 , C07K5/10
CPC分类号： A61K38/27 , C07K5/1019
摘要： A pharmaceutical formulation comprising a growth hormone and Lys-Gly-Asp-Ser (SEQ ID No: 1) as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
摘要翻译：包含生长激素和作为添加剂或缓冲物质的Lys-Gly-Asp-Ser（SEQ ID No：1）的药物制剂显示出非常高的抗磷酸化，氧化和肽键切割的稳定性。产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。

28. 发明授权

US07456276B2 Peptide purification by means of metal ion affinity chromatography 失效
标题翻译：通过金属离子亲和层析纯化肽
公开(公告)号：US07456276B2
公开(公告)日：2008-11-25
申请号：US10495302
申请日：2002-11-12
申请人： Thorkild Christensen , William Milton Thomas Hearn , Leone Spiccia , Wei Jiang , Therese Jane Mooney , Bimbil Graham
发明人： Thorkild Christensen , William Milton Thomas Hearn , Leone Spiccia , Wei Jiang , Therese Jane Mooney , Bimbil Graham
IPC分类号： C07H1/00 , C07D251/00
CPC分类号： C08J7/12 , B01D15/3828 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/285 , B01J20/286 , B01J20/3265 , B01J45/00 , B01J2220/54 , C07K1/16 , C07K7/08 , C08B11/04 , C08B15/00 , C08B37/0021 , C08B37/0039 , C08F8/00 , C08F20/56
摘要： A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S.
摘要翻译：具有官能度官能度的聚合物底物，其官能团包含至少一个环状金属离子配位配体基团，所述环状配体基团包含至少3个独立地选自N，O和S的金属离子配位供体原子。

29. 发明授权

US5633352A Biosynthetic human growth hormone 失效
标题翻译：生物合成人生长激素
公开(公告)号：US5633352A
公开(公告)日：1997-05-27
申请号：US402286
申请日：1995-03-10
申请人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli W. Ringsted , Torben E. Jessen
发明人： Henrik Dalb.o slashed.ge , John Pedersen , Thorkild Christensen , J.o slashed.rli W. Ringsted , Torben E. Jessen
IPC分类号： C07K14/545 , C07K14/61 , C12N9/22 , C12N9/36 , C12N15/62 , C12P21/06
CPC分类号： C12N9/2462 , C07K14/545 , C07K14/61 , C12N15/62 , C12N9/22 , C12P21/06 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
摘要： A desired protein having the formula:A-B-C-Pwhereina) A is Lys or Arg, and B and C are arbitrary amino acids, orb) A is an arbitrary amino acid different from Pro, Lys and Arg, and B and/or C is Pro,is produced from a biosynthetically formed amino acid extended protein having the formula:X-A-B-C-Pwherein A, B, C and P are as defined above, and X is an amino acid sequence with an even number of amino acids, of which the first one, seen from the N-terminal end, is different from Lys and Arg, all other uneven amino acids are different from Pro, Lys and Arg, and all even amino acids are different from Pro, by reaction with the enzyme dipeptidyl aminopeptidase (DAP I). The desired protein is obtained in a pure state. Thus, e.g. hGH without content of Met-hGH may be produced by the process.
摘要翻译：具有下式的所需蛋白质：ABC-P，其中a）A是Lys或Arg，B和C是任意氨基酸，或b）A是不同于Pro，Lys和Arg的任意氨基酸，B和/或C Pro是由具有下式的生物合成形成的氨基酸延伸蛋白产生：XABC-P，其中A，B，C和P如上所定义，X是具有偶数氨基酸的氨基酸序列，其中第一个，从N末端看，与Lys和Arg不同，所有其他不均匀的氨基酸与Pro，Lys和Arg不同，所有偶联氨基酸与Pro不同，通过与酶二肽基氨基肽酶（ DAP I）。在纯状态下获得所需的蛋白质。因此，例如可以通过该过程产生没有Met-hGH含量的hGH。

30. 发明授权

US4535678A Hydraulic control apparatus for a servo-motor, particularly for vehicle steering 失效
标题翻译：伺服电机液压控制装置，特别适用于车辆转向
公开(公告)号：US4535678A
公开(公告)日：1985-08-20
申请号：US419154
申请日：1982-09-16
申请人： Svend E. Thomsen , Thorkild Christensen
发明人： Svend E. Thomsen , Thorkild Christensen
IPC分类号： F15B9/08 , B62D5/07 , B62D5/087 , B62D5/09 , F16K17/22 , F15B13/042
CPC分类号： B62D5/09 , Y10T137/2564
摘要： The invention relates to a steering control unit for a bidirectional servomotor which is connectable to steerable wheels. A steering wheel controlled quantity setting unit of a known type has ports connectable to a pump and a return tank and two control ports through which metered quantities of fluid flow to opposite sides of the servomotor and to other parts of the apparatus for actuating the servomotor. A directional control valve for selectively directing pressurized fluid from a power circuit to opposite sides of the servomotor is controlled by a control circuit containing the setting unit. A utility valve having the pressure regulating and control and power valve capabilities required for this type of apparatus is characterized by having only a single slide spool for performing all of these functions.
摘要翻译：本发明涉及一种用于双向伺服电机的转向控制单元，其可连接到可转向的车轮。已知类型的方向盘控制量设定单元具有可连接到泵和回流罐的端口和两个控制端口，计量量的流体流过伺服电机的相对侧以及用于致动伺服电动机的装置的其它部分。用于将加压流体从功率电路选择性地引导到伺服电动机的相对侧的方向控制阀由包含设定单元的控制电路控制。具有这种类型设备所需的压力调节和功率阀能力的公用阀的特征在于仅具有用于执行所有这些功能的单个滑阀。

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