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21. 发明授权

US5175268A DNA encoding recombinant human lymphotoxin 失效
标题翻译：编码重组人淋巴毒素的DNA
公开(公告)号：US5175268A
公开(公告)日：1992-12-29
申请号：US416657
申请日：1989-10-03
申请人： Susumu Iwasa , Tomoko Fujii , Ryuji Marumoto , Koichi Igarashi
发明人： Susumu Iwasa , Tomoko Fujii , Ryuji Marumoto , Koichi Igarashi
IPC分类号： C07K14/525 , C12N15/19
CPC分类号： C07K14/525
摘要： Lymphotoxin (LT) mutein (genetically-altered LT) is disclosed that has the following amino acid sequence, or a portion of an active portion of said protein, where 10 to 21 amino acids of LT being deleted from N-terminus and which has Pro or Phe at the N-terminus: ##STR1## Wherein R.sub.1 is Pro or Phe, R.sub.2 is a peptide chain represented by the following sequence:Ala-Gln-Thr-Ala-Arg-Gln-His-Pro-Lys-Met-His-Leu,or a portion thereof and n is 0 or 1.The LT mutein can be recovered in a higher yield and purified more efficiently under mild conditions which does not harm the LT's biological activity, than the whole LT.
摘要翻译：公开了具有以下氨基酸序列或所述蛋白质的活性部分的一部分的淋巴毒素（LT）突变蛋白（遗传改变的LT），其中LT的10至21个氨基酸从N末端缺失并且具有Pro 或N末端的Phe：Ala-His-Leu-Ile-Gly-Asp-Pro-Ser-Lys-Gln-Asn-Ser-Leu-Leu-Trp-Arg-Ala-Asn-Thr-Asp -Arg-Ala-Phe-Leu-Gln-Asp-Gly-Phe-Ser-Leu-Ser-Asn-Asn-Ser-Leu-Leu- Val-Pro-Thr-Ser-Gly-Ile-Tyr-Phe-Val - Tyr-Ser-Gln-Val-Val-Phe-Ser-Gly-Lys-Ala-Tyr-Ser-Pro-Lys-Ala-Thr-Ser-Ser-Pro-Leu-Tyr-Leu-Ala-His-Glu -Val-Gln-Leu-Phe-Ser-Ser-Gln-Tyr-Pro-Phe-His-Val-Pro-Leu-Leu-Ser-Ser-Gln-Lys-Met-Val-Tyr-Pro-Gly-Leu -Gln-Glu-Pro-Trp-Leu-His-Ser-Met-Tyr-His-Gly-Ala-Al-Phe-Gln-Leu-Thr-Gln-Gly-Asp-Gln-Leu-Ser-Thr-His -Thr-Asp-Gly-Ile-Pro-His-Leu-Val-Leu-Ser-Pro-Ser-Thr-Val-Phe-Phe-Gly-Ala-Phe-Ala-Leu-OH其中R1是Pro或Phe R2是由以下序列表示的肽链：Ala-Gln-Thr-Ala-Arg-Gln-His-Pro-Lys-Met-His-Leu或端口并且n为0或1.可以比在整个LT中更高的产率回收LT突变蛋白，并且在不影响LT的生物活性的温和条件下更有效地纯化。

22. 发明授权

US5142026A Recombinant human lymphotoxins that possess N-terminal extended linker peptides for antibody-binding sites 失效
标题翻译：具有抗体结合位点的N-末端延伸的接头肽的重组人淋巴毒素
公开(公告)号：US5142026A
公开(公告)日：1992-08-25
申请号：US346745
申请日：1989-05-03
申请人： Susumu Iwasa , Hiroko Tada
发明人： Susumu Iwasa , Hiroko Tada
IPC分类号： A61K47/48 , C07K14/525 , C07K16/24 , C07K16/28
CPC分类号： C07K14/525 , A61K47/48238 , A61K47/48423 , A61K47/48438 , C07K16/241 , C07K16/2881 , Y10S530/82
摘要： Disclosed is a novel recombinant human lyphotoxin (LT) mutein which combines with an antibody at an inactive site of an LT molecule and liberates the LT molecule easily from the antibody after incorporation of the mutein into tumor cells.The recombinant human LT mutein is prepared by introducing a polydeoxyribonucleic acid containing a nucleotide sequence coding for the particular amino acid sequence into a replicable vector, transforming a microorganism or a cell with the recombinant DNA thus obtained, and cultivating the resulting transformant to express genetic information of the polydeoxyribonucleic acid.The recombinant human LT mutein is useful for tumor-selective carcinostatics, and effective for increasing the actively of LT and reducing the side effects thereof.
摘要翻译：公开了一种新型的重组人类赖克辛（LT）突变蛋白，其与LT分子的非活性位点处的抗体结合，并且在将突变蛋白掺入肿瘤细胞后，容易从抗体中释放LT分子。通过将含有编码特定氨基酸序列的核苷酸序列的多脱氧核糖核酸引入到可复制载体中，用由此获得的重组DNA转化微生物或细胞，并培养所得转化体以表达遗传信息来制备重组人LT突变蛋白的多脱氧核糖核酸。重组人LT突变蛋白可用于肿瘤选择性制剂，对于增加LT的积极性和降低其副作用是有效的。

23. 发明授权

US4496658A Method for enzyme immunoassay and production of antibody 失效
标题翻译：酶免疫测定法和抗体制备方法
公开(公告)号：US4496658A
公开(公告)日：1985-01-29
申请号：US311327
申请日：1981-10-14
申请人： Koichi Kondo , Susumu Iwasa , Isamu Yoshida
发明人： Koichi Kondo , Susumu Iwasa , Isamu Yoshida
IPC分类号： C07K14/59 , C07K16/26 , C12N9/96 , G01N33/531 , G01N33/535 , G01N33/543 , G01N33/76 , G01N33/54 , G01N33/56 , G01N33/58
CPC分类号： C07K14/59 , C07K16/26 , C12N9/96 , G01N33/531 , G01N33/535 , G01N33/54306 , G01N33/76 , Y10S435/975 , Y10S436/80 , Y10S436/804 , Y10S436/808 , Y10S436/813 , Y10S436/814 , Y10S436/819 , Y10S930/11 , Y10S930/28
摘要： In a method for immunochemical assay of human chorionic gonadotropin involving use of an antibody immobilized on a carrier, an antigen and an antibody to which a labeling agent has been attached, when the antibody supported on the carrier and the antibody coupled to a labeling agent are different antibodies which are not overlapping in antigen-determining site and one of said different antibodies is specifically reactive to human chorionic gonadotropin, a high reproducibility of the result of the immunochemical assay is obtained.
摘要翻译：在涉及使用固定在载体上的抗体，附着有标记试剂的抗原和抗体的人绒毛膜促性腺激素的免疫化学测定方法中，当载体上载有抗体和与标记试剂偶联的抗体时，在抗原决定部位和所述不同抗体之一中不重叠的不同抗体与人绒毛膜促性腺激素特异性反应，获得了免疫化学测定结果的高再现性。

24. 发明授权

US4140754A Hemagglutination-inhibition test for togaviruses 失效
标题翻译：披膜病毒的血细胞凝集抑制试验
公开(公告)号：US4140754A
公开(公告)日：1979-02-20
申请号：US739514
申请日：1976-11-08
申请人： Susumu Iwasa
发明人： Susumu Iwasa
IPC分类号： C12Q1/44 , G01N33/569 , G01N31/00 , G01N33/16
CPC分类号： C12Q1/44 , G01N33/56983 , G01N2333/18 , G01N2333/916 , Y10S436/826 , Y10T436/101666 , Y10T436/107497 , Y10T436/108331
摘要： The non-specific inhibitors of hemagglutination in a subject serum for hemagglutination-inhibition test for a togavirus such as rubella virus can be inactivated by subjecting the subject serum to the action of phospholipase C. By subjecting thus-treated serum to the hemagglutination-inhibition test employing fixed erythrocytes the togavirus hemagglutination-inhibition antibody titer of the serum can be determined accurately and with high sensitivity.
摘要翻译：通过使受试者的血清受到磷脂酶C的作用，用于血浆凝集抑制试验例如风疹病毒的披膜病毒的受试血清中的血凝作用的非特异性抑制剂可以失活。通过将如此处理的血清进行血细胞凝集抑制试验使用固定的红细胞可以准确和高灵敏度地测定血清的披膜病毒血凝抑制抗体滴度。

25. 发明授权

US06429296B2 Complex of human growth hormone and zinc and use 失效
标题翻译：人体生长激素和锌的复合物和使用
公开(公告)号：US06429296B2
公开(公告)日：2002-08-06
申请号：US09767144
申请日：2001-01-23
申请人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
发明人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
IPC分类号： A61K3827
CPC分类号： A61K9/1647 , A61K38/27 , C07K14/61 , Y10S530/839
摘要： The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.
摘要翻译：本发明提供人体生长激素和含锌人体生长激素和锌的复合物，其摩尔比为约1:1.6至约1:2.4，以及包含人生长激素和锌的复合物的缓释制剂和可生物降解的聚合物，并且其具有高的人生长激素的截留比并表现出稳定的持续释放，抑制了初始爆发。

26. 发明授权

US5814324A Injectable composition and a method of producing the same 失效
标题翻译：可注射组合物及其制备方法
公开(公告)号：US5814324A
公开(公告)日：1998-09-29
申请号：US454151
申请日：1995-06-13
申请人： Jun Sato , Akiko Watanabe , Susumu Iwasa
发明人： Jun Sato , Akiko Watanabe , Susumu Iwasa
IPC分类号： A61K9/107 , A61K31/41 , A61K31/415 , A61K31/4196 , A01N25/04 , B01J13/00
CPC分类号： A61K9/1075 , A61K31/41 , A61K31/415 , A61K31/4196 , Y10S514/938
摘要： An injectable oil-in-water emulsion composition comprises an antifungal triazole compound of the following formula (I) ##STR1## wherein Ar represents a substituted phenyl group; R.sup.1 and R.sup.2 represent, independently, a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 may together form a lower alkylene group; R.sup.4 represents a hydrogen atom or an acyl group; and A represents an optionally substituted cyclic amide group bonded through a nitrogen atom, or a salt thereof. The solubility of the triazole compound having poor water-solubility and fat-solubility can remarkably be increased by dispersing in water with use of an oil component (e.g. a triglyceride of fatty acids) and an emulsifier (e.g. a phospholipid).
摘要翻译： PCT No.PCT / JP95 / 00260 Sec。 371日期：1995年6月13日 102（e）1995年6月13日PCT 1995年2月23日提交PCT公布。出版物WO95 / 22973 日期：1995年3月8日可注射的水包油乳液组合物包含下列式（I）的抗真菌三唑化合物：其中Ar表示取代的苯基; R1和R2独立地表示氢原子或低级烷基，或者R1和R2可以一起形成低级亚烷基; R4表示氢原子或酰基; A表示通过氮原子键合的任选取代的环状酰胺基或其盐。通过使用油成分（例如脂肪酸的甘油三酯）和乳化剂（例如磷脂）分散在水中，可以显着提高具有差的水溶性和脂肪溶解性的三唑化合物的溶解度。

27. 发明授权

US5217713A Cytotoxic bispecific monoclonal antibody, its production and use 失效
标题翻译：细胞毒性双特异性单克隆抗体，其生产和使用
公开(公告)号：US5217713A
公开(公告)日：1993-06-08
申请号：US842426
申请日：1992-02-27
申请人： Susumu Iwasa , Kaori Harada , Yukio Toyoda
发明人： Susumu Iwasa , Kaori Harada , Yukio Toyoda
IPC分类号： A61K31/535 , A61K38/00 , A61K47/48 , C07K16/14 , C07K16/30 , C07K16/44 , C07K16/46
CPC分类号： A61K47/48384 , A61K31/535 , A61K47/48607 , A61K47/48676 , C07K16/14 , C07K16/3038 , C07K16/44 , C07K16/468 , A61K38/00
摘要： The present invention discloses, a bispecific monoclonal antibody to an ansamitocin derivative and a target antigen, particularly tumor-associated antigen, which can carry an ansamitocin derivative in a stable and inactive form at other sites than the target and release the active-form ansamitocin derivative at the target site, so that an anticancer agent having excellent durability and selectivity with little adverse action can be prepared using the bispecific monoclonal antibody and ansamitocin derivatives.
摘要翻译：本发明公开了一种针对安沙霉素衍生物的双特异性单克隆抗体和靶抗原，特别是肿瘤相关抗原，其可以在比目标的其他位置携带稳定和无活性形式的安曲霉素衍生物，并释放活性形式的安曲霉素衍生物在目标部位，可以使用双特异性单克隆抗体和安曲霉素衍生物制备具有优异的耐久性和选择性，几乎没有不利作用的抗癌剂。

28. 发明授权

US4312943A Method for enzyme immunoassay of pancreatic glucagon 失效
标题翻译：胰高血糖素酶免疫测定方法
公开(公告)号：US4312943A
公开(公告)日：1982-01-26
申请号：US69180
申请日：1979-08-24
申请人： Susumu Iwasa , Hayao Ueno , Mitsuhiro Wakimasu
发明人： Susumu Iwasa , Hayao Ueno , Mitsuhiro Wakimasu
IPC分类号： C12N9/00 , C07K5/083 , C07K5/103 , C07K14/605 , C12N9/96 , C12Q1/00 , G01N33/53 , G01N33/535 , G01N33/54
CPC分类号： C07K14/605 , C07K5/0808 , C07K5/101 , C12N9/96 , G01N33/535 , Y10S435/964
摘要： A novel peptide-enzyme conjugate obtained by coupling a labeling enzyme with a peptide of the general formula:H-R.sub.1 -Phe-Val-Gln-Trp-Leu-R.sub.2 -Asn-Thr-OH(wherein R.sub.1 is a peptide fragment consisting of 1 to 10 amino acid residues in the sequence of and including the Asp in 10-position of ##STR1## and R.sub.2 is Met or Nle) is useful for a method for enzyme immunoassay of pancreatic glucagon.
摘要翻译：通过将标记酶与通式如下的肽H-R1-Phe-Val-Gln-Trp-Leu-R2-Asn-Thr-OH偶联得到的新型肽 - 酶偶联物（其中R1是由序列中含有1〜10个氨基酸的残基，包括 10位的Asp，R2是Met或Nle）可用于胰腺胰高血糖素的酶免疫测定方法。

29. 发明授权

US4059491A Diluents for rubella virus hemagglutination-inhibition test 失效
标题翻译：稀释剂用于风疹病毒血细胞凝集抑制试验
公开(公告)号：US4059491A
公开(公告)日：1977-11-22
申请号：US764058
申请日：1977-01-31
申请人： Susumu Iwasa , Isamu Yoshida
发明人： Susumu Iwasa , Isamu Yoshida
IPC分类号： A61K39/00 , C12Q1/70 , G01N33/569 , H04R1/02 , G01N33/16 , C12K1/04
CPC分类号： H04R1/02 , G01N33/56983 , Y10T436/108331
摘要： In the rubella virus hemagglutination-inhibition test, the hemagglutination-inhibition antibody titers of the test sera can be determined with accuracy and high sensitivity by employing a novel diluent, which contains N-2-hydroxyethylpiperazine-N'-2'-ethanesulfonic acid in a low concentration and which is free from calcium ion, for the dilution of the rubella virus hemagglutinating antigen and of the test sera.
摘要翻译：在风疹病毒血细胞凝集抑制试验中，可以通过使用含有N-2-羟乙基哌嗪-N'-2'-乙磺酸的新型稀释剂，以准确性和高灵敏度测定血清凝血抑制抗体滴度低浓度且不含钙离子，用于稀释风疹病毒血凝抗原和测试血清。

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