专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明专利

AU2004224061B2 17beta-hydroxysteroid dehydrogenase inhibitors 未知
公开(公告)号：AU2004224061B2
公开(公告)日：2011-06-16
申请号：AU2004224061
申请日：2004-03-22
申请人： STERIX LTD
发明人： BUBERT CHRISTIAN , LAWRENCE HARSHANI RITHMA RUCHIRANANI , PUROHIT ATUL , POTTER BARRY VICTOR LLOYD , FISCHER DELPHINE SOPHIE MARION , ALLAN GILLIAN MARGARET , VICKER NIGEL , REED MICHAEL JOHN
IPC分类号： C07J71/00 , A61K31/56 , A61K31/566 , C07J20060101 , C07J41/00
摘要： There is provided a compound of Formula I wherein (I) R 1 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R 2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkylheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is - CH 2 - or -CH 2 CH 2 -, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of alkylheterocycle group, alkenylheterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) -CHO so that R 1 together with R 3 provide the enol tautomer OR R 1 together with R 3 form (xii) a pyrazole wherein (a) R 4 is =N-O-alkyl or =N-O-H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from -OH and -O-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula (II) R 2 is selected from groups capable of forming a hydrogen bond , a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III)R 3 is selected from -OH, =O, or a -C(=O)- mimetic

23. 发明专利

CA2715113A1 COMPOUND 未知
公开(公告)号：CA2715113A1
公开(公告)日：2009-09-03
申请号：CA2715113
申请日：2009-02-25
申请人： STERIX LTD
发明人： VICKER NIGEL , SU XIANGDONG , PRADAUX-CAGGIANO FABIENNE , POTTER BARRY VICTOR LLOYD
IPC分类号： C07D213/30 , A61K31/4164 , A61K31/4196 , A61K31/433 , A61K31/4402 , A61K31/4406 , A61P35/00 , C07D213/32 , C07D213/34 , C07D213/50 , C07D213/61 , C07D213/65 , C07D213/68 , C07D213/70 , C07D213/71 , C07D213/80 , C07D213/82 , C07D213/89 , C07D233/84 , C07D235/28 , C07D249/12 , C07D257/04 , C07D285/125 , C07D285/135 , C07D405/04 , C07D409/04
摘要： There is provided a compound of formula R1-CO-X-Y-Z-R2 wherein X and Z are each optional groups independently selected from saturated or unsaturated carbon chains having a length of 1 to 3 carbons; Y is SO, S, SO2, CH=CH, CH2CH2 or O; R1 is selected from the following groups (A) wherein - - - denotes the point of attachment; R2 is a heteroaryl group comprising an optionally substituted 5 or 6 membered ring, which ring contains only carbon and at least one nitrogen, or contains only carbon, and at least two nitrogens and at least one sulphur; and wherein (i) when R1 is group (B) and -CO-X-Y-Z- is CO-CH2-SO, CO-CH2-S, or CO-CH2-SO2, R2 is other than group (C) and; (ii) when R1 is group (D) and -CO-X-Y-Z- is -CO-CH2-O-, R2 is other than group (E).

24. 发明专利

AU2008327709A1 Inhibitors of 17beta-hydroxysteroid dehydrogenase 未知
公开(公告)号：AU2008327709A1
公开(公告)日：2009-05-28
申请号：AU2008327709
申请日：2008-11-19
申请人： STERIX LTD
发明人： DAY JOANNA MARY , BAILEY HELEN VICTORIA , HEATON WESLEY , POTTER BARRY VICTOR LLOYD , PUROHIT ATUL , VICKER NIGEL
IPC分类号： A61K31/167 , A61K31/36 , A61K31/4409 , A61P5/24 , A61P35/00 , C07C209/14 , C07C211/50 , C07C233/43 , C07C237/42 , C07D207/26 , C07D211/58 , C07D211/62 , C07D317/66
摘要： There is provided a compound having Formula I wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3, -OCH(R13)2, -OCH2R13, C(R13)3, -CH(R13)2, or -CH2R13 wherein R13 is a halogen; (c) -CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) -SO2-alkyl; and (n) -N(R14)C(O)R15, wherein R14 and R15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=0, S(=O)2, C=O, S(=O)2NR16, C=ONR17, NR18, in which R16, R17, and R18 are independently selected from H and hydrocarbyl, R10 is selected from H and hydrocarbyl, R11 is selected from CR19R20 and C=O, in which R19 and R20 are independently selected from H and hydrocarbyl, R12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups.

25. 发明专利

CA2643670A1 DIARYL COMPOUNDS AS NON-STEROIDAL INHIBITORS OF 17-BETA HYDROXYSTEROID DEHYDROGENASE AND/OR STEROID SULPHATASE FOR THE TREATMENT OF OESTROGEN-RELATED DISEASES SUCH AS HORMONE DEPENDENT BREAST CANCER 未知
公开(公告)号：CA2643670A1
公开(公告)日：2007-08-30
申请号：CA2643670
申请日：2007-02-26
申请人： STERIX LTD
发明人： LAWRENCE HARSHANI RITHMA RUCHI , POTTER BARRY VICTOR LLOYD , REED MICHAEL JOHN , PUROHIT ATUL , ALLAN GILLIAN MARGARET , VICKER NIGEL , DAY JOANNA MARY
IPC分类号： C07D213/75 , C07C43/205 , C07C43/275 , C07C49/757 , C07C255/40 , C07D213/40 , C07D231/12 , C07D231/14 , C07D231/38 , C07D231/40 , C07D231/54 , C07D261/08 , C07D277/40 , C07D307/52 , C07D307/60 , C07D317/54
摘要： There is provided a compound of Formula I wherein the various symbols are as defined in the description, and a method of manufacturing a medicament for use in the therapy of a condition or disease associated with 17beta-hydroxysteroid dehydrogenase (17beta-HSD), comprising a compound of Formula I.

26. 发明专利

NO20052469D0 未知
公开(公告)号：NO20052469D0
公开(公告)日：2005-05-23
申请号：NO20052469
申请日：2005-05-23
申请人： STERIX LTD
发明人： POTTER BARRY VICTOR LLOYD , REED MICHAEL JOHN , VICKER NIGEL , SU XIANGDONG , GANESHAPILLAI DHARSHINI , PUROHIT ATUL
IPC分类号： A61K20060101 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61P3/04 , A61P9/12 , A61P19/02 , A61P27/06 , C07C209/42 , C07D209/08 , C07D209/42 , C07D235/08 , C07D235/30 , C07D263/56 , C07D277/62 , C07D277/64 , C07D277/68 , C07D277/74 , C07D277/82 , C07D417/12 , C12Q1/32 , A61K
摘要： There is provided a compound having Formula (I): wherein one of R1 and R2 is a group of the Formula (a), wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group (Formula (a)) wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.

27. 发明专利

CA2519956C COMPOUND 未知
公开(公告)号：CA2519956C
公开(公告)日：2012-12-18
申请号：CA2519956
申请日：2004-03-22
申请人： STERIX LTD
发明人： VICKER NIGEL , LAWRENCE HARSHANI , ALLAN GILLIAN , BUBERT CHRISTIAN , FISCHER DELPHINE , PUROHIT ATUL , REED MICHAEL , POTTER BARRY
IPC分类号： C07J71/00 , A61K31/56 , A61K31/566 , C07J20060101 , C07J41/00
摘要： There is provided a compound of Formula (I) wherein (I) R1 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkyiheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is - CH2- or -CH2CH2-, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of a I kyl heterocycle group, al ke nyl heterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) -CHO so that R, together with R3 provide the enol tautomer (a); OR R1 together with R3 form (xii) a pyrazole wherein (a) R4 is =N-0-alkyl or =N-0-H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl. group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from -OH and -0-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula (b); (II) R2is selected from groups capable of forming a hydrogen bond, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III) R3 is selected from -OH, =O, or a -C(=O)-mimetic.

28. 发明专利

AT485258T 未知
公开(公告)号：AT485258T
公开(公告)日：2010-11-15
申请号：AT02704938
申请日：2002-03-07
申请人： STERIX LTD
发明人： POTTER BARRY , PUROHIT ATUL , REED MICHAEL , VICKER NIGEL
IPC分类号： C07C62/32 , A61K31/19 , A61K31/57 , A61P5/38 , A61P5/44 , A61P5/46 , C07C62/34 , C07C62/38 , C07C69/753 , C07C235/40 , C07D213/40 , C07D295/13 , C07D295/182 , C07J7/00 , C07J9/00 , C07J51/00

29. 发明专利

CA2703893A1 COMPOUND 未知
公开(公告)号：CA2703893A1
公开(公告)日：2009-05-28
申请号：CA2703893
申请日：2008-11-19
申请人： STERIX LTD
发明人： VICKER NIGEL , BAILEY HELEN VICTORIA , HEATON WESLEY , DAY JOANNA MARY , PUROHIT ATUL , POTTER BARRY VICTOR LLOYD
IPC分类号： C07C209/14 , A61K31/167 , A61K31/36 , A61K31/4409 , A61P5/24 , A61P35/00 , C07C211/50 , C07C233/43 , C07C237/42 , C07D207/26 , C07D211/58 , C07D211/62 , C07D317/66
摘要： There is provided a compound having Formula (I), wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3, -OCH(R13)2, -OCH2R13, -C(R13)3, -CH(R13)2, or -CH2R13 wherein R13 is a halogen; (c) -CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (I) aryloxy; (m) -SO2-alkyl; and (n) -N(R14)C(O)R15, wherein R14 and R15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (T) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=O, S(=O)2, C=O, S(=O)2NR16, C=ONR17, NR18, in which R16, R17, and R18 are independently selected from H and hydrocarbyl, R10 is selected from H and hydrocarbyl, R11 is selected from CR19R20 and C=O, in which R19 and R20 are independently selected from H and hydrocarbyl, R12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups.

30. 发明专利

PL376301A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 AND TYPE 2 未知
公开(公告)号：PL376301A1
公开(公告)日：2005-12-27
申请号：PL37630103
申请日：2003-10-23
申请人： STERIX LTD
发明人： VICKER NIGEL , SU XIANGDONG , GANESHAPILLAI DHARSHINI , PUROHIT ATUL , REED MICHAEL JOHN , POTTER BARRY VICTOR LLOYD
IPC分类号： A61K20060101 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61P3/04 , A61P9/12 , A61P19/02 , A61P27/06 , C07C209/42 , C07D209/08 , C07D209/42 , C07D235/08 , C07D235/30 , C07D263/56 , C07D277/62 , C07D277/64 , C07D277/68 , C07D277/74 , C07D277/82 , C07D417/12 , C12Q1/32
摘要： There is provided a compound having Formula (I): wherein one of R1 and R2 is a group of the Formula (a), wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group (Formula (a)) wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式