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21. 发明公开

EP2391380A2 POLYNUCLEOTIDE APTAMER-BASED CROSS -LINKED MATERIALS AND USES THEREOF 审中-公开
标题翻译：基于多核苷酸APTAMER的交叉连接材料及其用途
公开(公告)号：EP2391380A2
公开(公告)日：2011-12-07
申请号：EP10736343.4
申请日：2010-01-27
申请人： Smartcells, Inc.
发明人： ZION, Todd, C. , LANCASTER, Thomas, M.
IPC分类号： A61K38/28 , C12P21/08
CPC分类号： C12N15/111 , A61K47/549 , C12N2310/16 , C12N2310/51
摘要： In one aspect, the disclosure provides cross-linked materials that include multivalent polynucleotide aptamers that bind a target molecule; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with the target molecule for binding with the aptamers and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between aptamers and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of the target molecule. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label. The drug, detectable label and affinity ligands may be covalently or non-covalently bound to the conjugate framework.
摘要翻译：在一个方面，本公开提供交联材料，其包括结合靶分子的多价多核苷酸适体; 以及包含与偶联物框架结合的两个或更多个分开的亲和配体的偶联物，其中所述两个或更多个亲和配体与所述靶分子竞争与所述适体结合，并且其中偶联物由于非共价结合而在所述物质内交联适体和不同缀合物上的亲和配体之间的相互作用。这些材料被设计成响应目标分子的所需浓度而释放缀合物的量。取决于最终应用，在各种实施方案中，缀合物还可以包含药物和/或可检测标记。药物，可检测标记和亲和配体可以共价或非共价结合到缀合物框架上。

22. 发明公开

EP2391215A1 BINDING-SITE MODIFIED LECTINS AND USES THEREOF 审中-公开
标题翻译：结合位点的修饰凝集素及其用途
公开(公告)号：EP2391215A1
公开(公告)日：2011-12-07
申请号：EP10736332.7
申请日：2010-01-27
申请人： Smartcells, Inc.
发明人： ZION, Todd, C. , LANCASTER, Thomas, M.
IPC分类号： A01N45/00
CPC分类号： C07K14/42 , A61K38/28 , A61K47/61 , A61K47/641 , A61K47/6415 , C07K14/4726 , G01N33/66 , G01N2333/4724
摘要： In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one covalently linked affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label.

23. 发明公开

EP2408808A1 TERMINALLY-FUNCTIONALIZED CONJUGATES AND USES THEREOF 审中-公开
标题翻译：终端官能化的结合物及其用途
公开(公告)号：EP2408808A1
公开(公告)日：2012-01-25
申请号：EP10753832.4
申请日：2010-01-27
申请人： Smartcells, Inc.
发明人： ZION, Todd, C. , LANCASTER, Thomas, M.
IPC分类号： C07K14/62 , A61K38/28
CPC分类号： A61K38/28 , A61K47/58
摘要： The present disclosure provides inter alia conjugates of formula (I): wherein n, R1, R2, Rx, Z, X, Y and Z are as defined herein. A conjugate of formula (I) can also be converted to a conjugate of formulae (II) or (III) as described herein. Without limitation, the conjugates can be used to make controlled release materials and chemical sensors.

24. 发明公开

EP2391218A1 CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY 有权
标题翻译：基于共轭的控制药物输送系统
公开(公告)号：EP2391218A1
公开(公告)日：2011-12-07
申请号：EP10736354.1
申请日：2010-01-27
申请人： Smartcells, Inc.
发明人： ZION, Todd, C. , LANCASTER, Thomas, M.
IPC分类号： A01N45/00
摘要： Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the conjugate is sensitive to serum concentration of a second saccharide. Exemplary conjugates and sustained release formulations are provided in addition to methods of use and preparation.
摘要翻译：包含药物和包含第一种糖的配体的缀合物; 其中所述缀合物的特征在于当所述缀合物施用于哺乳动物时，所述缀合物的至少一种药代动力学或药效学性质对第二种糖的血清浓度敏感。除了使用和制备方法外，还提供了示例性的缀合物和缓释制剂。

25. 发明授权

EP2391646B1 CRYSTALLINE INSULIN-CONJUGATES 无效
标题翻译：结晶胰岛素
公开(公告)号：EP2391646B1
公开(公告)日：2016-08-10
申请号：EP10736359.0
申请日：2010-01-27
申请人： Smartcells, Inc.
发明人： ZION, Todd, C. , LANCASTER, Thomas, M.
IPC分类号： C07K14/62 , A61K38/28 , A61K47/48
CPC分类号： C07K14/62 , A61K38/28 , A61K47/549
摘要： The present disclosure provides crystalline insulin-conjugates. The present disclosure also provides formulations, methods of treatment, methods of administering, and methods of making that encompass these crystalline insulin-conjugates.

26. 发明公开

EP2627347A1 USES OF MACROPHAGE MANNOSE RECEPTOR TO SCREEN COMPOUNDS AND USES OF THESE COMPOUNDS 审中-公开
标题翻译：使用巨噬细胞甘露糖受体筛选化合物及这些化合物的用途
公开(公告)号：EP2627347A1
公开(公告)日：2013-08-21
申请号：EP11833005.9
申请日：2011-09-27
申请人： Smartcells, Inc.
发明人： MURIKIPUDI, Sylaja , LANCASTER, Thomas, M. , ZION, Todd, C.
IPC分类号： A61K38/14 , C07K17/00 , C07K1/00 , C07K14/00 , A01N25/00
CPC分类号： G01N33/5308 , A61K47/61 , C07K14/705 , G01N33/566 , G01N2333/62
摘要： Methods and associated compositions of matter (e.g., kits, cell lines, etc.) for screening compounds that bind to macrophase mannose receptor (MMR). Compounds identified by these methods and drug conjugates that includes these compounds are also encompassed as are their uses in the manufacture of medicaments.

27. 发明公开

EP2598522A2 RECOMBINANT LECTINS, BINDING-SITE MODIFIED LECTINS AND USES THEREOF 审中-公开
标题翻译：重组凝集素，凝集素结合位点的修饰及其用途
公开(公告)号：EP2598522A2
公开(公告)日：2013-06-05
申请号：EP11812983.2
申请日：2011-07-22
申请人： Smartcells, Inc.
发明人： LANCASTER, Thomas, M. , BUTTERS, Robert , CHOODNOVSKIY, Naomi, R. , ZION, Todd, C.
IPC分类号： C07K14/42
CPC分类号： C07K14/42
摘要： In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites and is covalently linked to a cysteine residue of the lectins; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label.

28. 发明公开

EP2391646A1 CRYSTALLINE INSULIN-CONJUGATES 无效
标题翻译： KRISTALLINE INSULINKONJUGATE
公开(公告)号：EP2391646A1
公开(公告)日：2011-12-07
申请号：EP10736359.0
申请日：2010-01-27
申请人： Smartcells, Inc.
发明人： ZION, Todd, C. , LANCASTER, Thomas, M.
IPC分类号： C07K14/62 , A61K38/28
CPC分类号： C07K14/62 , A61K38/28 , A61K47/549
摘要： The present disclosure provides crystalline insulin-conjugates. The present disclosure also provides formulations, methods of treatment, methods of administering, and methods of making that encompass these crystalline insulin-conjugates.
摘要翻译：本公开提供结晶胰岛素缀合物。本公开还提供了制剂，治疗方法，给药方法和制备其包括这些结晶性胰岛素缀合物的方法。

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