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21. 发明专利

NO328753B1 未知
公开(公告)号：NO328753B1
公开(公告)日：2010-05-03
申请号：NO20031238
申请日：2003-03-18
申请人： SCHERING CORP
发明人： CHACKALAMANNIL SAMUEL , WANG YUGUANG , STAMFORD ANDREW W , BOYLE CRAIG D
IPC分类号： C07D473/04 , A61K31/522 , A61K45/00 , A61P1/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/12 , A61P15/00 , A61P15/10 , A61P27/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D473/02 , C07D473/06 , C07D473/08 , C07F7/18
摘要： A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: For example, a representative compound of the invention is:

23. 发明专利

CA2730593A1 BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS 未知
公开(公告)号：CA2730593A1
公开(公告)日：2010-01-21
申请号：CA2730593
申请日：2009-07-15
申请人： SCHERING CORP
发明人： NEELAMKAVIL SANTHOSH FRANCIS , BOYLE CRAIG D , CHACKALAMANNIL SAMUEL , GREENLEE WILLIAM J , NEUSTADT BERNARD R , STAMFORD ANDREW W
IPC分类号： C07D451/06 , A61K31/439 , A61K31/46 , A61P3/04 , A61P3/10 , A61P9/00 , C07D451/10 , C07D471/08 , C07D491/18
摘要： The present invention relates to Bicyclic Heterocycle Derivatives of Formula (I), compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of a G-protein coupled receptor (GPCR) such as GPR119 in a patient.

24. 发明专利

CA2721738A1 THIOPHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE 未知
公开(公告)号：CA2721738A1
公开(公告)日：2009-10-29
申请号：CA2721738
申请日：2009-04-21
申请人： SCHERING CORP
发明人： STAMFORD ANDREW W , ZHU ZHAONING , MANDAL MIHIRBARAN , LIU XIAOXIANG
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28
摘要： In its many embodiments, the present invention provides provides certain thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds (or tautomers or a pharmaceutically acceptable salts thereof) having the structural Formula (III): wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aß) protein, including Alzheimer's Disease, are also disclosed.

25. 发明专利

DK1319003T3 未知
公开(公告)号：DK1319003T3
公开(公告)日：2009-09-28
申请号：DK01971092
申请日：2001-09-17
申请人： SCHERING CORP
发明人： BOYLE CRAIG D , STAMFORD ANDREW W , CHACKALAMANNIL SAMUEL , WANG YUGUANG
IPC分类号： C07D473/04 , A61K31/522 , A61K45/00 , A61P1/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/00 , A61P13/12 , A61P15/00 , A61P27/06 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D473/02 , C07D473/06 , C07D473/08 , C07F7/18
摘要： A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: For example, a representative compound of the invention is:

26. 发明专利

AU2009222047A1 1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists 未知
公开(公告)号：AU2009222047A1
公开(公告)日：2009-09-11
申请号：AU2009222047
申请日：2009-03-03
申请人： SCHERING CORP
发明人： HARRIS JOEL M , STAMFORD ANDREW W , NEUSTADT BERNARD R , HAO JINSONG
IPC分类号： C07D487/14 , A61K31/519 , A61P25/16 , C07D487/04
摘要： Compounds of the Formula I wherein R1 and R2 together with the carbon atoms to which they are bonded optionally form a further heteroaromatic ring of the formula (II) as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.

27. 发明专利

PE20090157A1 DERIVADOS DE PIRIMIDINONA COMO MODULADORES DEL RECEPTOR ACOPLADO A PROTEINA G 119 (GPR119) 未知
公开(公告)号：PE20090157A1
公开(公告)日：2009-03-27
申请号：PE2008000679
申请日：2008-04-18
申请人： SCHERING CORP
发明人： BOYLE CRAIG D , CHACKALAMANNIL SAMUEL , LANKIN CLAIRE M , SHAH UNMESH G , LIU HONG , STAMFORD ANDREW W , NEUSTADT BERNARD R
IPC分类号： A61K31/519 , A61P3/10 , C07D401/04
摘要： SE REFIERE A COMPUESTOS DERIVADOS DE PIRIMIDINONA DE FORMULA (I) DONDE R ESTA AUSENTE O ES O; R1 ES H, ALQUILO(C1-C12), HALOALQUILO(C1-C12), C(O)-ARILO(C6-C14), ENTRE OTROS; R2 ES ALQUILO(C1-C12), HALOALQUILO(C1-C12), C(O)-ALQUILO(C1-C12), ALQUILEN(C1-C12)-O-ARILO(C6-C14), ENTRE OTROS; R3 ES ALQUILO(C1-C12), C(O)-ARILO(C6-C14), C(O)-ALQUILO(C1-C12), ENTRE OTROS; R4 ES H, ALQUILO(C1-C12), ALQUILEN(C1-C12)-O-ALQUILO(C1-C12), ALQUILEN(C1-C12)-O-ARILO(C6-C14), ENTRE OTROS; R10 ES H, ALQUILO(C1-C12), HETEROARILO DE 5 A 14 MIEMBROS, CICLOALQUILO(C3-C10), ENTRE OTROS; R11 ES H, ALQUILO(C1-C12), CICLOALQUILO(C3-C10), ENTRE OTROS; R12 ES H, ALQUILO(C1-C12), HETEROCICLOALQUILO DE 3 A 10 MIEMBROS, ALCOXI(C1-C12), ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), (iii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR ACOPLADO A PROTEINA G 119 (GPR119) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES TIPO 1 Y 2, OBESIDAD, SINDROME METABOLICO

28. 发明专利

ES2306200T3 INHIBIDORES MACROCICLICOS DE BETA-SECRETASA. 未知
公开(公告)号：ES2306200T3
公开(公告)日：2008-11-01
申请号：ES05776414
申请日：2005-07-26
申请人： SCHERING CORP
发明人： STAMFORD ANDREW W , HUANG YING , LI GUOQING , STRICKLAND COREY O , VOIGT JOHANNES H
IPC分类号： A61K31/00 , C07D413/06 , A61P25/28 , C07D498/04
摘要： Un compuesto que tienen la Fórmula estructural: (Ver fórmula) o una de sus sales o solvatos farmacéuticamente aceptable, en donde: (Ver fórmula) R 1 es: R 2 es -N(R 5 )C(O)R 4 - o un anillo de heterociclileno; R 3 es arileno, heteroarileno, heterociclileno o cicloalquileno; R 4 es arileno, heteroarileno, heterociclileno o cicloalquileno; R 5 es hidrógeno, alquilo, arilo, heteroarilo o cicloalquilo; R 6 y R 7 se seleccionan independientemente de hidrógeno, -OH, alquilo, cicloalquilo, cicloalquilalquilo, heterociclilo, arilo, heteroarilo, aralquilo, heteroaralquilo, aralcoxi, heteroaralcoxi y alcoxi, con la condición de que cuando R 6 y R 7 son -OH, aralcoxi, heteroaralcoxi y alcoxi, R 6 y R 7 no están unidos a un carbono del anillo adyacente a un nitrógeno de anillo; R 8 es hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, arilo, heteroarilo, aralquilo, heteroaralquilo, heterociclilo, heterociclilalquilo, -C(O)R 9 , -C(O)OR 12 , -S(O)R 9 , -S(O2)R 9 o -CN; con la condición de que cuando Y es =O, R 8 no puede ser -C(O)R 9 , -C(O)OR 12 , -S(O)R 9 , -S(O2)R 9 ni -CN; R 9 es hidrógeno, alquilo, cicloalquilo, arilo, heteroarilo, cicloalquilalquilo, aralquilo, heteroaralquilo, heterociclilo, heterociclilalquilo, alquenilo, alquinilo o -N(R 10 )(R 11 ); R 10 y R 11 se seleccionan independientemente del grupo que consiste en hidrógeno, alquilo, cicloalquilo, cicloalquilalquilo, arilo, heteroarilo, heterociclilo, aralquilo, heteroaralquilo, heterociclilalquilo, alquenilo y alquinilo; o R 10 y R 11 , junto con el nitrógeno al que están unidos, forman un anillo heterociclilo de 3-7 miembros; R 12 es...

29. 发明专利

AU2005202987B2 Heteroaryl urea neuropeptide Y Y5 receptor antagonists 未知
公开(公告)号：AU2005202987B2
公开(公告)日：2007-12-13
申请号：AU2005202987
申请日：2005-07-07
申请人： SCHERING CORP
发明人： DONG YOUHAO , MCCOMBIE STUART W , STAMFORD ANDREW W
IPC分类号： C08F2/48 , C08F2/50 , C08F220/18

30. 发明专利

CA2637057A1 DIARYL PIPERIDINES AS CB1 MODULATORS 未知
公开(公告)号：CA2637057A1
公开(公告)日：2007-07-26
申请号：CA2637057
申请日：2007-01-11
申请人： SCHERING CORP
发明人： GREENLEE WILLIAM J , XIA YAN , STAMFORD ANDREW W , MILLER MICHAEL W , SCOTT JACK D , LI WEI , WEINSTEIN JAY , GILBERT ERIC J
IPC分类号： C07D211/18 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06
摘要： A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome (e.g., obesity, waist circumference, lipid profile, and insulin sensitivity), neuroinflammatory disorders, cognitive disorders, psychosis, addictive behavior, gastrointestinal disorders, and cardiovascular conditions.

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