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21. 发明申请

WO1995001430A1 INSECT DIURETIC HORMONE RECEPTOR, PREFERABLY ISOLATED FROM MANDUCA SEXTA 审中-公开
标题翻译：隐形胆固醇受体，优选分离自曼德拉SEXTA
公开(公告)号：WO1995001430A1
公开(公告)日：1995-01-12
申请号：PCT/EP1994002159
申请日：1994-07-01
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , REAGAN, Jeff, Dale
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/12
CPC分类号： C07K14/72 , C07K2319/00
摘要： Insect diuretic hormone receptors useful in controlling insects, identifying insect control agents and controlling gene expression.
摘要翻译：用于控制昆虫的昆虫利尿激素受体，鉴定昆虫控制剂和控制基因表达。

22. 发明申请

WO1994012659A1 PREVENTING ENDOGENOUS AMINOPEPTIDASE MEDIATED N-TERMINAL AMINO ACID CLEAVAGE DURING EXPRESSION OF FOREIGN GENES IN BACTERIA 审中-公开
标题翻译：在细菌中表达外源基因时，预防内源性氨基酸酶介导的N-末端氨基酸清除
公开(公告)号：WO1994012659A1
公开(公告)日：1994-06-09
申请号：PCT/EP1993003349
申请日：1993-11-29
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , HEITZMANN, Markus , MOVVA, Rao , RAMAGE, Paul
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12P21/06
CPC分类号： C12N15/10 , C07K14/54 , C07K14/5412 , C12P21/06
摘要： A process for the recombinant preparation in a bacterial host of the mature form of a mammalian protein or peptide of formula X-Pro-Z, which is subject to processing by endogenous bacterial aminopeptidases is provided. In the formula X-Pro-Z, X is a single N-terminal amino acid other than proline, and Z is the remaining sequence of amino acid residues of the protein or peptide. The process comprises inserting into a cell of the bacterial host an appropriate vector containing DNA coding for Met-Y-X-Pro-Z, in which Y is a natural amino acid that is specifically cleavable in vitro from X-Pro-Z by an aminopeptidase and that imparts resistance to in vivo processing by endogenous bacterial aminopeptidases. The cell is then induced to express the expression product Met-Y-X-Pro-Z which is then treated with an appropriate aminopeptidase to cleave off Met and Y.
摘要翻译：提供了在细菌宿主中重组制备哺乳动物蛋白质或通过内源性细菌氨基肽酶处理的式X-Pro-Z肽的方法。在式X-Pro-Z中，X是脯氨酸以外的单个N-末端氨基酸，Z是蛋白质或肽的氨基酸残基的剩余序列。该方法包括将含有编码Met-YX-Pro-Z的DNA的适当载体插入到细菌宿主的细胞中，其中Y是天然氨基酸，其可通过氨基肽酶从X-Pro-Z体外特异性切割，其赋予内源性细菌氨基肽酶对体内加工的抵抗力。然后诱导细胞表达表达产物Met-Y-X-Pro-Z，然后用合适的氨基肽酶处理以切割Met和Y.

23. 发明申请

WO1993016010A1 PRODUCTION OF CEMENT-MORTAR DRY MIX 审中-公开
标题翻译：生产水泥 - 麦芽糖混合物
公开(公告)号：WO1993016010A1
公开(公告)日：1993-08-19
申请号：PCT/EP1992000318
申请日：1992-02-14
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , ELLENBERGER, Peter , SCHMITT, Heinz, W. , VALENTI, Salvatore , YANG, Qiwei
IPC分类号： C04B28/04
CPC分类号： C04B28/04 , C04B24/281 , C04B28/02 , C04B40/06 , C08G59/44 , C08G59/5093 , Y02W30/92 , Y02W30/94 , C04B18/08 , C04B24/121 , C04B40/0028 , C04B2103/0067 , C04B26/14 , C04B18/146 , C04B24/12 , C04B24/28
摘要： A storable cement-mortar dry mix, which comprises the components cement, aggregate, reaction resin and hardener in a single mixture, wherein the hardener is present as the reaction product of the hardener with an organic acid or a functional derivative thereof.
摘要翻译：一种可储存的水泥砂浆干混合物，其包含单一混合物中的水泥，骨料，反应树脂和固化剂组分，其中固化剂作为硬化剂与有机酸或其官能衍生物的反应产物存在。

24. 发明申请

WO1993007150A1 TETRAPHENYLPORPHYN DERIVATIVES 审中-公开
标题翻译：四苯并噻吩衍生物
公开(公告)号：WO1993007150A1
公开(公告)日：1993-04-15
申请号：PCT/EP1992002283
申请日：1992-10-02
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , EHRHARDT, Claus , GIGER, Karl, Andreas, Rudolf
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , Y02P20/55
摘要： A hapten formed of a metalloporphyrin cofactor bound to a residue of a substrate. The hapten is designed to mimic a transition state of a metalloporphyrin catalyst and the substrate in a reaction and is characterised in that the metalloporphyrin cofactor is of formula (II), in which: R1, R2, R2', R3, R3', R8 and R8' are as defined in the specification; R4 is a bridging group connecting the metalloporphyrin catalyst to the residue of the substrate; and M is a metal ion having a co-ordination number of at least 4. Also claimed are metalloporphyrin cofactors in which R4 is H, a linker group or a removable protecting group.
摘要翻译：由与底物残基结合的金属卟啉辅因子形成的半抗原。半抗原被设计为在反应中模拟金属卟啉催化剂和底物的过渡态，其特征在于金属卟啉辅因子具有式（II），其中：R 1，R 2，R 2'，R 3，R 3'，R 8 和R8'如说明书中所定义; R4是连接金属卟啉催化剂与底物残留物的桥连基团; 并且M是具有至少4的配位数的金属离子。还要求的是金属卟啉辅因子，其中R 4是H，连接基团或可除去的保护基团。

25. 发明申请

WO1992007837A1 HETEROCYCLIC DIONE DERIVATIVES AS PESTICIDES AND PLANT GROWTH REGULATORS 审中-公开
标题翻译：作为杀虫剂和植物生长调节剂的杂环二氢衍生物
公开(公告)号：WO1992007837A1
公开(公告)日：1992-05-14
申请号：PCT/EP1991002014
申请日：1991-10-23
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , LEE, Shy-Fuh
IPC分类号： C07D265/02
CPC分类号： A01N43/72 , C07C205/59 , C07D265/02
摘要： The present invention concerns substituted 3,5-dioxo-3,4,5,6-tetrahydrooxazines as herbicides, processes and intermediates for their preparation, compositions containing them and their use as herbicides and acaricides.
摘要翻译：本发明涉及取代的3,5-二氧代-3,4,5,6-四氢恶嗪作为除草剂，其制备方法和中间体，含有它们的组合物及其作为除草剂和杀螨剂的用途。

26. 发明申请

WO1991004661A2 MICROENCAPSULATED AGRICULTURAL CHEMICALS 审中-公开
标题翻译：微型农业化学品
公开(公告)号：WO1991004661A2
公开(公告)日：1991-04-18
申请号：PCT/EP1990001618
申请日：1990-09-24
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , CREECH, David, C. , CURTIS, Ralston
IPC分类号： A01N25/28
CPC分类号： B01J13/18 , A01N25/28
摘要： Very sparingly soluble salt forms of rapidly leaching agrochemicals, encapsulated forms thereof, and their method of manufacture and use are disclosed.
摘要翻译：公开了非常微溶盐形式的快速浸出农药，其包封形式及其制造和使用方法。

27. 发明申请

WO1997007218A1 ALLERGEN-XCD32 FUSION PROTEINS 审中-公开
标题翻译： ALLERGEN-XCD32融合蛋白
公开(公告)号：WO1997007218A1
公开(公告)日：1997-02-27
申请号：PCT/EP1996003616
申请日：1996-08-16
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , MUDDE, Geert, C.
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C12N15/62
CPC分类号： C07K14/43531 , A61K38/00 , C07K16/283 , C07K2317/24 , C07K2319/00
摘要： Fusion proteins comprising one or more antigens and one or more moieties interacting with human Fc gamma receptor II (Fc gamma RII) (CD32).
摘要翻译：包含一个或多个抗原和一个或多个与人Fcγ受体II（FcγRII）（CD32）相互作用的部分的融合蛋白。

28. 发明申请

WO1996040876A1 METHOD OF EXPANDING HEMATOPOIETIC STEM CELLS, REAGENTS AND BIOREACTORS FOR USE THEREIN 审中-公开
标题翻译：扩增HEMATOPOIETIC干细胞的方法，用于其的试剂和生物反应器
公开(公告)号：WO1996040876A1
公开(公告)日：1996-12-19
申请号：PCT/EP1996002464
申请日：1996-06-06
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , TUCKER, Sean, Newton , CHARY, Srikanth, Ranga , KUO, Suzanne, Chang , SCHWARTZ, Richard, Merrill
IPC分类号： C12N05/08
CPC分类号： C12M25/06 , C12M23/02 , C12M23/04 , C12M23/24 , C12M25/02 , C12M41/32 , C12N5/0647 , C12N2500/02 , C12N2500/90 , C12N2501/125 , C12N2501/22 , C12N2501/23
摘要： The present invention provides methods and bioreactors for expanding stem cells in a population of cells substantially enriched in hematopoietic stem cells and substantially free of stromal cells. The method preferably comprises the steps of inoculating the population of cells in an expansion container in a volume of suitable medium such that the cell density is at least about 5,000 cells/1 mL and at an initial oxygen concentration of less than 8 %; adding an effective amount of at least one cytokine to cause stem cell expansion; culturing the cells under suitable conditions such that the cells condition the medium; increasing the oxygen concentration to about 20 %; exchanging the medium at a rate which allows expansion of the stem cells; and culturing the cells under conditions such that the stem cells are expanded. The present invention also provides a bioreactor constructed to accommodate the operational requirements for stroma-free stem cell expansion.
摘要翻译：本发明提供用于在基本上富含造血干细胞并基本上不含基质细胞的细胞群中扩增干细胞的方法和生物反应器。该方法优选包括以下步骤：将细胞群接种在一定体积的合适培养基中的膨胀容器中，使得细胞密度为至少约5,000个细胞/ 1mL，初始氧浓度小于8％; 加入有效量的至少一种细胞因子以引起干细胞扩张; 在合适的条件下培养细胞，使细胞调节培养基; 将氧浓度提高到约20％; 以允许干细胞扩增的速率交换培养基; 并在使干细胞扩大的条件下培养细胞。本发明还提供了一种生物反应器，其被构造为适应无基质干细胞扩增的操作要求。

29. 发明申请

WO1996020927A1 DIBENZ[cd,f]INDOLE DERIVATIVES 审中-公开
标题翻译： DIBENZ [cd，f] INDOLE DERIVATIVES
公开(公告)号：WO1996020927A1
公开(公告)日：1996-07-11
申请号：PCT/EP1995005167
申请日：1995-12-29
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , GIGER, Rudolf, Karl, Andreas
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D209/56
CPC分类号： C07D209/80
摘要： 1-Alkyl-9,10-dihydroxy-4,5,5a,6-tetrahydro-dibenz[cd,f]indoles of formula (I) may be used in the treatment of Morbus Parkinson, alcohol abuse and drug dependency. In said formula, R1, R2 and R3 are independently (C1-4)alkyl, in free or acid addition salt form.
摘要翻译：式（I）的1-烷基-9,10-二羟基-4,5,5a，6-四氢 - 二苯并[cd，f]吲哚可用于治疗Morbus帕金森氏症，酒精滥用和药物依赖性。在所述式中，R 1，R 2和R 3独立地为（C 1-4）烷基，为游离或酸加成盐形式。

30. 发明申请

WO1996017843A2 NOVEL PYRIMIDINYLOXY- AND PYRIMIDINYLAMINO-ETHYLPHENYL-DIOXOLANE DERIVATIVES 审中-公开
标题翻译：新型吡咯烷酮和吡咯烷基氨基 - 乙基苯基二氧化物衍生物
公开(公告)号：WO1996017843A2
公开(公告)日：1996-06-13
申请号：PCT/EP1995004795
申请日：1995-12-06
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , LAMBERTH, Clemens , SCHAUB, Fritz
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , A01N43/54 , C07C69/78 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/28 , C07D495/04
摘要： The invention discloses 2-[4-(2-(pyrimidin-4-yloxy- and -4-ylamino)-ethyl-phenyl]-dioxolanes of formula (I) wherein R1 is hydrogen, C1-4alkyl, C1-4haloalkyl or C3-6cycloalkyl, R2 is hydrogen, C1-10alkyl, C1-8alkoxy-C1-4alkyl, C3-8alkenyloxy-C1-4alkyl, C3-8haloalkenyloxy-C1-4alkyl, C3-8alkynyloxy-C1-4alkyl, C1-8haloalkoxy-C1-4alkyl, C1-8alkylthio-C1-4alkyl, aryl, aryloxy-C1-4alkyl, aryl-C1-4alkoxy-C1-4-alkyl, heteroaryloxy-C1-4alkyl, C1-4alkoxy-C1-4alkoxy-C1-4alkyl or aryl-C1-8alkyl, R3 and R4 independently are halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxy-C1-4alkyl, C1-4alkoxycarbonyl-C1-4alkyl, C1-4alkoxycarbonyl, cyano-C1-4alkyl, cyano, or -COOH, or R3 and R4 together form a bridge member selected from 1,4-butylene, 1,4-butadienylene, or -S-CH=CH-, each optionally substituted by one or two radicals selected from halogen or C1-4alkyl, and Z is NH or oxygen; the use of such compounds for the control of undesired acarinae, fungi, and insects, compositions for facilitating such use, and the preparation of the compounds of formula I.
摘要翻译：本发明公开了式（I）的2- [4-（2-（嘧啶-4-基氧基 - 和-4-基氨基） - 乙基 - 苯基] - 二氧杂环戊烷，其中R 1是氢，C 1-4烷基，C 1-4卤代烷基或C 3 -6-环烷基，R 2是氢，C 1-10烷基，C 1-8烷氧基-C 1-4烷基，C 3-8烯烃氧基-C 1-4烷基，C 3-8卤代烯氧基-C 1-4烷基，C 3-8炔氧基-C 1-4烷基，C 1-8卤代烷氧基-C 1-4烷基，C 1-8烷硫基-C 1-4烷基，芳基，芳氧基-C 1-4烷基，芳基-C 1-4烷氧基-C 1-4 - 烷基，杂芳氧基-C 1-4烷基，C 1-4烷氧基-C 1-4烷氧基-C 1-4烷基或芳基-C1 烷基，R 3和R 4独立地是卤素，C 1-4烷基，C 1-4烷氧基，C 1-4烷氧基-C 1-4烷基，C 1-4烷氧基羰基-C 1-4烷基，C 1-4烷氧基羰基，氰基-C 1-4烷基，氰基或-COOH，或R 3和R 4一起形成选自1,4-亚丁基，1,4-丁二烯基或-S-CH = CH-的桥连体，每个任选被一个或两个选自卤素或C 1-4烷基的基团取代，Z 是NH或氧;使用这些化合物来控制不希望的螨虫，真菌和昆虫，用于促进这种使用的组合物，以及制备式Ⅰ化合物。

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