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21. 发明申请

US20060078586A1 Barrier layer 有权
标题翻译：屏障层
公开(公告)号：US20060078586A1
公开(公告)日：2006-04-13
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
摘要翻译：阻挡层和相应的制备方法为可植入患者体内的医疗装置提供抗炎，非炎症和抗粘附功能。除了改善的愈合，非炎性和抗炎反应之外，阻挡层可以与医疗装置结构组合以提供抗粘附特性。阻挡层通常由天然存在的油或由天然存在的油的一部分形成的油组合物形成，其至少部分固化形成交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。

22. 发明申请

US20060067976A1 Formation of barrier layer 审中-公开
标题翻译：阻挡层的形成
公开(公告)号：US20060067976A1
公开(公告)日：2006-03-30
申请号：US11238532
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip Mcnamara , William Quigley , Mark Avella , Rick Chenel
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip Mcnamara , William Quigley , Mark Avella , Rick Chenel
IPC分类号： A61F2/00 , B05D3/00
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.
摘要翻译：阻挡层和相应的制备方法为可植入患者的医疗装置提供抗炎和抗粘附功能。除了改善的愈合和抗炎反应之外，阻挡层可以与医疗装置结构组合以提供抗粘附特性。阻挡层通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。

23. 发明申请

US20070202149A1 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings 有权
标题翻译：用于生物可吸收药物载体涂层的疏水交联凝胶
公开(公告)号：US20070202149A1
公开(公告)日：2007-08-30
申请号：US11582135
申请日：2006-10-16
申请人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
发明人： Keith Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve Herweck , Theodore Karwoski
IPC分类号： A61F2/00 , A61F2/02
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.
摘要翻译：描述了用于医疗装置的涂层，制备涂层的方法及其使用方法。

24. 发明申请

US20060067983A1 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US20060067983A1
公开(公告)日：2006-03-30
申请号：US11237264
申请日：2005-09-28
申请人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
发明人： Thomas Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K31/355 , A61K31/225
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

25. 发明授权

US08858978B2 Heat cured gel and method of making 有权
标题翻译：热固化凝胶及其制作方法
公开(公告)号：US08858978B2
公开(公告)日：2014-10-14
申请号：US11237263
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith M. Faucher , Thomas M. Swanick
IPC分类号： A61F2/00 , A61K9/14 , A61K35/60
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of heat in both temperature and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译：提供固化方法和相应的所得非聚合交联凝胶。交联凝胶可以与医疗装置结构组合。除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。固化方法可以在温度和持续时间内改变热量的应用以实现形成凝胶的所需量的交联。

26. 发明申请

US20060058737A1 Catheter treatment stylet 审中-公开
标题翻译：导管治疗探针
公开(公告)号：US20060058737A1
公开(公告)日：2006-03-16
申请号：US10944393
申请日：2004-09-16
申请人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Joseph Ferraro
发明人： Steve Herweck , Paul Martakos , Geoffrey Moodie , Joseph Ferraro
IPC分类号： A61M5/178
CPC分类号： A61M25/00
摘要： A therapeutic agent-eluting stylet treats a catheter by at least temporarily locating the stylet in a lumen of an indwelling catheter placed into a patient. The therapeutic agent-carrying stylet provides a localized therapeutic effect to the catheter and patient by eluting one or more therapeutic agents directly into the lumen of the catheter, into the fluid within the catheter, into the fluid and tissue in contact with the catheter, and onto the surface of the catheter. By removal and replacement of the temporary stylet from the catheter, renewable therapeutic agent doses can be provided to a component, such as the lumen, of the catheter while the catheter remains within in a patient. One or more therapeutically effective doses of medicated agents can be tailored along the length of the stylet and controlled by the length of time by which the stylet remains installed in the catheter.
摘要翻译：治疗剂洗脱的管心针通过至少临时将探针置于置于患者体内的留置导管的内腔中来治疗导管。治疗剂携带管心针通过将一种或多种治疗剂直接洗脱到导管的内腔，导管内的流体中，与导管接触的流体和组织中，向导管和患者提供局部治疗效果，以及到导管的表面。通过从导管中移除和替换临时探针，当导管保持在患者体内时，可将可再生治疗剂剂量提供给导管的部件（例如内腔）。一个或多个治疗有效剂量的药剂可以沿着探针的长度进行调整，并由探针保持安装在导管中的时间长度来控制。

27. 发明申请

US20080113001A1 Tissue separating device with reinforced support for anchoring mechanisms 有权
标题翻译：组织分离装置，具有用于锚固机构的加强支撑
公开(公告)号：US20080113001A1
公开(公告)日：2008-05-15
申请号：US11980155
申请日：2007-10-30
申请人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
发明人： Steve Herweck , Joseph Ferraro , Paul Martakos , Theodore Karwoski , Anthony Horton
IPC分类号： A61F2/02
CPC分类号： A61L31/14 , A61F2/0063 , A61L31/08
摘要： A barrier layer device is formed of an underlying biocompatible structure having a barrier layer coating that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. As implemented herein, the barrier layer is a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The underlying structure can be in the form of a surgical mesh. The barrier device is further provided with reinforced sections or portions to aid with the fastening of the barrier device for implantation purposes and prohibits or substantially reduces the occurrence of excessive stretching and tearing. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
摘要翻译：阻挡层装置由潜在的生物相容性结构形成，该结构具有可显示抗炎性质，非炎症性质和/或粘附限制性质的阻隔层涂层，并且对损伤的组织产生调节的愈合作用。如本文所实施的，阻挡层是至少部分地由脂肪酸化合物衍生的非聚合交联凝胶，并且可以包括治疗剂。底层结构可以是手术网的形式。阻挡装置还设置有加强部分或部分，以帮助阻挡装置紧固以用于植入目的，并且禁止或基本上减少过度拉伸和撕裂的发生。阻挡装置可植入患者体内以进行短期或长期应用，并且可包括治疗剂的受控释放。

28. 发明授权

US08795703B2 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US08795703B2
公开(公告)日：2014-08-05
申请号：US11237264
申请日：2005-09-28
申请人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00 , A61K9/14 , A61K35/60
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

29. 发明授权

US08501229B2 Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings 有权
公开(公告)号：US08501229B2
公开(公告)日：2013-08-06
申请号：US13404487
申请日：2012-02-24
申请人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
发明人： Keith M. Faucher , Hui Tang , Lisa Rogers , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski
IPC分类号： A61K9/00 , A61F2/00
CPC分类号： A61L31/16 , A61L29/08 , A61L29/16 , A61L31/08 , A61L2300/41 , A61L2300/416 , A61L2300/802 , B05D3/0254
摘要： Coatings for medical devices, methods of making the coatings, and methods of using them are described.

30. 发明授权

US09801913B2 Barrier layer 有权
公开(公告)号：US09801913B2
公开(公告)日：2017-10-31
申请号：US11237420
申请日：2005-09-28
申请人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61K35/60 , A61K38/13 , A61L27/36 , A61L27/52 , A61K9/00 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L31/10 , A61L27/54 , A61F13/02 , A61L2/07 , A61L2/08 , A61L2/20 , A61L31/00 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.

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