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21. 发明授权

US11603605B2 Fusible bicomponent spandex 有权
公开(公告)号：US11603605B2
公开(公告)日：2023-03-14
申请号：US13124437
申请日：2009-10-12
申请人： Steven W. Smith , Hong Liu , Willem Bakker
发明人： Steven W. Smith , Hong Liu , Dong Wang , Willem Bakker
IPC分类号： D04B1/18 , D01D5/32 , C08L75/04 , D01F6/70 , D02G3/32 , D01F1/10 , D01F8/16 , D03D15/56
摘要： Included are multiple component elastic fibers prepared by a solution-spinning process such as dry spinning or wet spinner of spandex fibers including polyurethaneurea and polyurethane compositions. These fibers have a cross-section including at least two separate regions with definable boundaries wherein at least one region defined by the boundaries of the cross-section includes a polyurethaneurea or polyurethane composition. One region of the fiber includes a fusibility improvement additive to enhance adhesion to itself or to a substrate.

22. 发明授权

US10458218B2 Method of modelling hydrocarbon production from fractured unconventional formations 有权
$Method of modelling hydrocarbon production from fractured unconventional formations$
公开(公告)号：US10458218B2
公开(公告)日：2019-10-29
申请号：US14978037
申请日：2015-12-22
申请人： Xiangzeng Wang , Ruimin Gao , Fanhua Zeng , Shanshan Yao , Hong Liu , Quansheng Liang
发明人： Xiangzeng Wang , Ruimin Gao , Fanhua Zeng , Shanshan Yao , Hong Liu , Quansheng Liang
IPC分类号： G06F17/50 , E21B43/26 , G06F17/11
摘要： A method of modeling hydrocarbon flow from a fractured unconventional reservoir, where the formation has variability in stimulated reservoir properties caused by multi-stage fracturing treatment. A map is created which divides the formation into a plurality of closed production regions, each of which in turn is divided into a plurality of flow sub-systems extending between fractures in the formation. Production behavior is then calculated for each flow sub-system based on the geography and characteristics of the individual flow sub-system. Region hydrocarbon flow for each closed production region is determined by coupling the calculated production behavior of the flow sub-systems and the reservoir hydrocarbon flow can be modeled by aggregating the region hydrocarbon flows. Type curves showing the modeled hydrocarbon flow at selected points in time can then be plotted.

23. 发明申请

US20190218223A1 COMPOUNDS USEFUL FOR ALTERING THE LEVELS OF BILE ACIDS FOR THE TREATMENT OF DIABETES AND CARDIOMETABOLC DISEASE 审中-公开
公开(公告)号：US20190218223A1
公开(公告)日：2019-07-18
申请号：US16324596
申请日：2017-08-10
申请人： Jared N. CUMMING , Kevin D. DYKSTRA , Alan HRUZA , Derun LI , Hong LIU , Haiqun TANG , Brandon M. TAOKA , Andreas VERRAS , Shawn P. WALSH , Wen-Lian WU , Merck Sharp & Dohme Corp.
发明人： Jared N. Cumming , Kevin D. Dykstra , Alan Hruza , Derun Li , Hong Liu , Haiqun Tang , Brandon M. Taoka , Andreas Verras , Shawn P. Walsh , Wen-Lian Wu
IPC分类号： C07D487/04 , C07D519/00 , C07D471/04 , C07D498/04 , C07D513/04 , A61P3/10
CPC分类号： C07D487/04 , A61P3/10 , C07D471/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as Cyp8b1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for diabetes and cardiovascular disease.

24. 发明授权

US09549917B2 Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases 有权
标题翻译：杂环取代的苯并呋喃衍生物及其用于治疗病毒性疾病的方法
公开(公告)号：US09549917B2
公开(公告)日：2017-01-24
申请号：US14343448
申请日：2012-08-16
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Zhong Lai , Qun Dang , Nicolas Zorn
IPC分类号： A61K45/06 , A61K31/506 , A61K31/444 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/695 , A61K31/424 , A61K31/4245 , A61K31/4439 , C07D405/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04 , A61K31/433 , A61K31/5365 , A61K31/5377 , A61K31/5383 , C07F7/10
CPC分类号： A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/695 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D498/04 , C07D513/04 , C07F7/10 , Y02A50/385 , Y02A50/387 , Y02A50/389 , A61K31/424 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。

25. 发明申请

US20160136172A1 SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权
公开(公告)号：US20160136172A1
公开(公告)日：2016-05-19
申请号：US14898768
申请日：2014-06-19
申请人： Xing DAI , Hong LIU , Anandan PALANI , Shuwin HE , Ravi NARGUND , Dong XIAO , Nicolas ZORN , Qun DANG , Casey C. MCCOMAS , Xuanjia PENG , Peng LI , Richard SOLL
发明人： Xing Dai , Hong Liu , Anandan Palani , Shuwen He , Ravi Nargund , Dong Xiao , Nicolas Zorn , Qun Dang , Casey C. McComas , Xuanjia Peng , Peng Li , Richard Soll
IPC分类号： A61K31/5365 , C07D471/04 , A61K31/519 , C07D405/04 , A61K45/06 , C07D475/02 , A61K31/437 , A61K31/4725 , A61K31/53 , C07D405/14 , C07D498/04 , A61K31/517
CPC分类号： A61K31/5365 , A61K31/437 , A61K31/4725 , A61K31/517 , A61K31/519 , A61K31/53 , A61K45/06 , C07D405/04 , C07D405/14 , C07D471/04 , C07D475/02 , C07D498/04
摘要： The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

26. 发明授权

US09328190B2 Non-textile polymer compositions and methods 有权
标题翻译：非纺织聚合物组合物和方法
公开(公告)号：US09328190B2
公开(公告)日：2016-05-03
申请号：US12559114
申请日：2009-09-14
申请人： Charles Frank Iavarone , James Michael Lambert , Hong Liu , Sonia Menot , Federica Maria Roberta Stoppa
发明人： Charles Frank Iavarone , James Michael Lambert , Hong Liu , Sonia Menot , Federica Maria Roberta Stoppa
IPC分类号： C09D175/04 , D06M15/564 , D06M101/38 , D06M23/08 , A61K8/87 , A61K8/88 , A61Q19/00 , A61Q19/10 , C08G18/12 , C08G18/08 , C08G18/48 , C08G18/66 , C08G18/76 , C11D3/37 , C11D3/50 , D06M15/59 , A61K8/02 , A61Q1/12
CPC分类号： C08G18/12 , A61K8/0241 , A61K8/87 , A61K8/88 , A61K2800/28 , A61K2800/654 , A61Q1/12 , A61Q19/00 , A61Q19/10 , C08G18/0823 , C08G18/0861 , C08G18/4854 , C08G18/6692 , C08G18/7671 , C09D175/04 , C11D3/3726 , C11D3/505 , D06M15/564 , D06M15/59 , D06M23/08 , D06M2200/20 , C08G18/302 , C08G18/3228
摘要： Included are nylon and polyurethane urea compositions such as in the form of powders, beads and flock to be included in extruded and molded articles containing a thermoplastic resin such as nylon 12. The addition of the powders, beads or flock improve flexibility and shape retention of such molded articles, for example in eyewear frames.
摘要翻译：包括尼龙和聚氨酯脲组合物，例如粉末，珠粒和绒毛的形式，包括在包含热塑性树脂如尼龙12的挤出和模塑制品中。加入粉末，珠粒或绒毛提高了柔软性和形状保持性这种模塑制品，例如在眼镜框架中。

27. 发明授权

US08953942B1 Hybrid WDM-TDM passive optical network 有权
标题翻译：混合WDM-TDM无源光网络
公开(公告)号：US08953942B1
公开(公告)日：2015-02-10
申请号：US13458360
申请日：2012-04-27
申请人： Cedric F. Lam , Ryohei Urata , Hong Liu , Yut Loy Chan
发明人： Cedric F. Lam , Ryohei Urata , Hong Liu , Yut Loy Chan
IPC分类号： H04J14/00 , H04J14/08
CPC分类号： H04J14/0282 , H04J14/0256
摘要： A technique for providing time division multiplexing (“TDM”) and wavelength division multiplexing (“WDM”) communication services to customer premises (“CP”) over a passive optical network (“PON”) includes multiplexing a downstream TDM signal with downstream WDM signals onto a fiber trunk line coupled between a central office and a remote node (“RN”), separating the downstream WDM signals from the downstream TDM signal at the RN with a wavelength selective filter, power splitting the downstream TDM signal at the RN onto a plurality of fiber access lines as split TDM signals; and recombining each of the WDM signals with a corresponding one of the split TDM signals onto a corresponding one of the fiber access lines.
摘要翻译：通过无源光网络（“PON”）向客户驻地（“CP”）提供时分多路复用（“TDM”）和波分复用（“WDM”）通信服务的技术包括将下游TDM信号与下行WDM 信号到耦合在中心局和远程节点（“RN”）之间的光纤干线上，用下行WDM信号与RN处的下行TDM信号用波长选择滤波器分离，将RN处的下行TDM信号分解功率多个光纤接入线作为分离TDM信号; 以及将每个所述WDM信号与所述分离的TDM信号中的相应一个信号重新组合到相应的所述光纤接入线路中。

28. 发明授权

US08898474B2 Support of multiple pre-shared keys in access point 有权
标题翻译：在接入点支持多个预共享密钥
公开(公告)号：US08898474B2
公开(公告)日：2014-11-25
申请号：US12359987
申请日：2009-01-26
申请人： Hui Shen , Xiong Jiang , Anirban Banerjee , Hong Liu , Taroon Mandhana
发明人： Hui Shen , Xiong Jiang , Anirban Banerjee , Hong Liu , Taroon Mandhana
IPC分类号： H04L9/30 , H04L29/06 , H04L9/08 , H04W12/04 , H04W88/08
CPC分类号： H04L9/0844 , H04L63/061 , H04L2209/80 , H04W12/04 , H04W88/08
摘要： A method of operating an access point (AP) configured to support multiple pre-shared keys at a given time to authenticate its associated client devices. Each client device associated with the AP is provisioned with a key. To authenticate the client device that attempts to connect to the AP, the AP determines which pre-shared key (PSK) of the multiple supported pre-shared keys (PSKs), if any, matches information including the key received from the client device. When the information matches, the client device is allowed to connect to the AP. Provisioning the AP with multiple PSKs allows selectively disconnecting associated client devices from the AP. The AP may be configured to support PSKs of different lifetime and complexity. Removing a PSK of the multiple PSKs supported by the AP and disconnecting a client device that uses this PSK does not disconnect other client devices using different keys to access the AP.
摘要翻译：一种操作接入点（AP）的方法，所述接入点（AP）被配置为在给定时间支持多个预共享密钥以验证其相关联的客户端设备。与AP相关联的每个客户端设备都配置了一个密钥。为了验证尝试连接到AP的客户端设备，AP确定多个支持的预共享密钥（PSK）的哪个预共享密钥（PSK）（如果有的话）匹配包括从客户端设备接收的密钥的信息。当信息匹配时，允许客户端设备连接到AP。为AP配置多个PSK可以有选择地断开与AP的关联的客户端设备。 AP可以被配置为支持不同寿命和复杂性的PSK。删除AP支持的多个PSK的PSK并断开使用此PSK的客户端设备不会使用不同的密钥断开其他客户端设备访问AP。

29. 发明授权

US08722692B2 Compounds and compositions as Syk kinase inhibitors 失效
标题翻译：化合物和组合物作为Syk激酶抑制剂
公开(公告)号：US08722692B2
公开(公告)日：2014-05-13
申请号：US13386645
申请日：2010-07-30
申请人： Jianwei Che , Qiang Ding , Xiaohui He , Hong Liu , Yahua Liu , Pierre-Yves Michellys , Barun Okram , Xu Wu , Kunyong Yang , Xuefeng Zhu
发明人： Jianwei Che , Qiang Ding , Xiaohui He , Hong Liu , Yahua Liu , Pierre-Yves Michellys , Barun Okram , Xu Wu , Kunyong Yang , Xuefeng Zhu
IPC分类号： A01N43/90 , A61K31/519 , C07D471/00 , C07D487/00
CPC分类号： C07D471/04
摘要： Provided herein are a novel class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
摘要翻译：本文提供了一类新的式（I）化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。

30. 发明授权

US08693866B1 Fiber diagnosis system for WDM optical access networks 有权
标题翻译： WDM光接入网络的光纤诊断系统
公开(公告)号：US08693866B1
公开(公告)日：2014-04-08
申请号：US13355233
申请日：2012-01-20
申请人： Cedric F. Lam , Ben W. Segura , Ryohei Urata , Hong Liu
发明人： Cedric F. Lam , Ben W. Segura , Ryohei Urata , Hong Liu
IPC分类号： H04B10/00
CPC分类号： H04B10/071 , H04Q11/0067 , H04Q2011/0083
摘要： A technique for detecting a fiber fault in a WDM optical access network includes launching a test signal into a fiber trunk line linking a central office (“CO”) to a remote node (“RN”) of the WDM optical access network. The test signal is generated by an optical time domain reflectometry unit to simultaneously fault test fiber access lines linking the RN to customer premises. The test signal is separated from downstream WDM signals at the RN. The test signal is power split at the RN into a plurality of access line test signals. The access line test signals are each recombined with a corresponding one of the downstream WDM signals onto a corresponding one of the fiber access lines. Test signal reflections are received at the CO from the fiber access lines as a reflection signature and analyzed to identify a location of the fiber fault.
摘要翻译：一种用于检测WDM光接入网络中的光纤故障的技术包括将测试信号发射到连接WDM光接入网络的中心局（“CO”）到远程节点（“RN”）的光纤干线。测试信号由光时域反射测量单元产生，以同时故障测试将RN连接到客户驻地的光纤接入线路。测试信号与RN处的下行WDM信号分离。测试信号在RN处被分配成多个接入线测试信号。接入线路测试信号各自与下行WDM信号中的相应一个信号复合到相应的一条光纤接入线路上。在来自光纤接入线路的CO处接收到测试信号反射作为反射特征，并进行分析以识别光纤故障的位置。

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