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21. 发明授权

US08845631B2 Systems and methods of performing medical procedures 有权
标题翻译：执行医疗程序的系统和方法
公开(公告)号：US08845631B2
公开(公告)日：2014-09-30
申请号：US12769350
申请日：2010-04-28
申请人： Randell L. Werneth , Marshall Sherman , Mark T. Stewart , J. Christopher Flaherty
发明人： Randell L. Werneth , Marshall Sherman , Mark T. Stewart , J. Christopher Flaherty
IPC分类号： A61B18/12 , A61B5/06 , A61B5/053 , A61B18/00 , A61B5/00 , A61B19/00 , A61B5/01 , A61B5/08 , A61B18/24 , A61B18/02 , A61B18/14 , A61B5/103 , A61B5/0402
CPC分类号： A61B18/1492 , A61B5/01 , A61B5/0402 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/063 , A61B5/08 , A61B5/103 , A61B5/6885 , A61B5/7207 , A61B5/743 , A61B18/02 , A61B18/0206 , A61B18/24 , A61B2018/00791 , A61B2018/00875 , A61B2018/0262 , A61B2034/2046 , A61B2090/065 , G06F19/00
摘要： A medical method is provided, including a medical device having a distal assembly including at least one electrode and at least one treatment element, the medical device generating information regarding at least one of a physiological measurement and an operational parameter of the medical device; a plurality of surface electrodes affixable to a skin of the patient, wherein the surface electrodes are in electrical communication with the distal assembly to obtain position information of the medical device; and a processor pairing the position information and the at least one of a physiological measurement and an operational parameter of the medical device.
摘要翻译：提供了一种医疗方法，包括具有远端组件的医疗装置，所述远端组件包括至少一个电极和至少一个治疗元件，所述医疗装置产生关于所述医疗装置的生理测量和操作参数中的至少一个的信息; 多个表面电极可固定在患者皮肤上，其中表面电极与远端组件电连通以获得医疗装置的位置信息; 以及将所述位置信息和所述医疗装置的生理测量和操作参数中的至少一个配对的处理器。

22. 发明申请

US20090149848A1 RF Energy Delivery System and Method 有权
标题翻译：射频能量传输系统和方法
公开(公告)号：US20090149848A1
公开(公告)日：2009-06-11
申请号：US12332236
申请日：2008-12-10
申请人： Randell L. Werneth , Ricardo D. Roman , Christopher G. Kunis , Alexander J. Asconeguy , Sadaf Soleymani , Jeffrey Trinidad , Nenita Trinidad , Martin Chambers , Hakan Oral , Fred Morady , Jerald L. Cox , Guillermo W. Moratorio , Samuel Fu , J. Christopher Flaherty
发明人： Randell L. Werneth , Ricardo D. Roman , Christopher G. Kunis , Alexander J. Asconeguy , Sadaf Soleymani , Jeffrey Trinidad , Nenita Trinidad , Martin Chambers , Hakan Oral , Fred Morady , Jerald L. Cox , Guillermo W. Moratorio , Samuel Fu , J. Christopher Flaherty
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/1492 , A61B17/00234 , A61B18/18 , A61B2017/00044 , A61B2017/003 , A61B2018/00184 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00839
摘要： Devices, systems and methods are disclosed for the ablation of tissue. A steerable ablation catheter can include one or more ablation elements at its distal end and one or more ablation elements fixedly attached to its shaft. The distal end of the ablation catheter can be deflected to assume a number of different deflection geometries in at least one direction along the shaft. One feature of the ablation catheter is that its shaft can comprise materials of differing durometers or stiffnesses attached together at a joint. Methods associated with use of the ablation catheter are also covered.
摘要翻译：公开了用于组织消融的装置，系统和方法。可引导的消融导管可包括其远端处的一个或多个消融元件和固定地附接到其轴的一个或多个消融元件。消融导管的远端可以沿着轴在至少一个方向上被偏转以呈现多个不同的偏转几何形状。消融导管的一个特征是其轴可以包括在接头处附接在一起的不同硬度的刚度的材料。还涉及与使用消融导管相关的方法。

23. 发明申请

US20080281312A1 Ablation Therapy System and Method for Treating Continuous Atrial Fibrillation 有权
标题翻译：消融治疗系统及治疗连续性房颤的方法
公开(公告)号：US20080281312A1
公开(公告)日：2008-11-13
申请号：US12116753
申请日：2008-05-07
申请人： Randell L. Werneth , Christopher G. Kunis , Hakan Oral , Fred Morady , J. Christopher Flaherty
发明人： Randell L. Werneth , Christopher G. Kunis , Hakan Oral , Fred Morady , J. Christopher Flaherty
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1206 , A61B2018/00214 , A61B2018/00375 , A61B2018/1407 , A61B2018/1467 , A61B2018/1475
摘要： An ablation therapy system and systematic method is provided for treating continuous atrial fibrillation. The therapy system includes a Multi-Channel RF Ablation Generator, an ECG interface, an assembly of at least three ablation catheters, and an ECG interface operably coupling and interfacing the catheters to both an ECG unit and the RF Ablation Generator. The systematic method includes transseptally accessing the Left Atrium (LA) through the septum of the patient's heart, and performing an endocardial pulmonary vein ablation procedure on the pulmonary vein ostial tissue surrounding one or more pulmonary veins in a manner treating aberrant conductive pathways therethrough. After performing the pulmonary vein ablation, the method further includes performing an endocardial atrial septum ablation procedure on the septal tissue in a manner treating aberrant conductive pathways therethrough.
摘要翻译：提供消融治疗系统和系统方法治疗连续性房颤。治疗系统包括多通道RF消融发生器，ECG接口，至少三个消融导管的组件，以及将导管可操作地耦合和接口到ECG单元和RF消融发生器的ECG接口。系统方法包括通过患者心脏的隔膜经皮穿透左心房（LA），并以围绕一个或多个肺静脉的肺静脉口腔组织以以治疗异常导电通路的方式进行心内膜肺静脉消融手术。在进行肺静脉消融后，该方法还包括以处理通过其中的异常导电通路的方式对隔膜组织进行心内膜心房隔膜消融手术。

24. 发明授权

US08647336B2 Cryogenic medical device with thermal guard and method 有权
标题翻译：具有保温和低温保护的低温医疗器械
公开(公告)号：US08647336B2
公开(公告)日：2014-02-11
申请号：US12816479
申请日：2010-06-16
申请人： Randell L. Werneth
发明人： Randell L. Werneth
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B18/18 , A61B2017/00243 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device, system and method are provided for thermal medical treatment. A medical device for cryogenic treatment may include a tip and a thermal guard or shield. The tip may be at a distal end of a catheter shaft, having a distal surface and lateral surfaces. The thermal guard may be coupled to the catheter proximal of the distal tip, surrounding the longitudinal axis and exposing the distal surface, to resist heat transfer from body fluids to the lateral surfaces of the tip. An efficiency of heat transfer from selected tissue to be treated to the distal surface of the cryogenic tip is thereby increased.
摘要翻译：提供用于热疗治疗的医疗装置，系统和方法。用于低温处理的医疗装置可以包括尖端和保护罩或护罩。尖端可以在导管轴的远端处，具有远侧表面和侧表面。热保护器可以耦合到远侧末端的近端的导管，围绕纵向轴线并暴露远侧表面，以抵抗从体液到尖端的侧表面的热传递。因此，从被处理的选定组织到低温尖端的远端表面的热传递效率提高。

25. 发明授权

US07211106B2 Selective organ cooling apparatus and method 有权
公开(公告)号：US07211106B2
公开(公告)日：2007-05-01
申请号：US10763542
申请日：2004-01-23
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.

26. 发明授权

US06679907B2 Method and device for applications of selective organ cooling 有权
标题翻译：选择性器官冷却应用的方法和装置
公开(公告)号：US06679907B2
公开(公告)日：2004-01-20
申请号：US10210819
申请日：2002-07-31
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： The invention provides a method and device for heating or cooling a surrounding fluid in a feeding vessel. The device includes a catheter assembly capable of insertion to a selected feeding vessel in the vascular system of a patient. The assembly includes a heat transfer element at a distal end of the catheter assembly, the heat transfer element having a plurality of exterior surface irregularities shaped and arranged to create turbulence in a surrounding fluid, the surface irregularities having a depth at least equal to the boundary layer thickness of flow of the surrounding fluid in the feeding vessel. The assembly also includes a supply catheter to deliver a working fluid to an interior of the heat transfer element, a return catheter to return a working fluid from the interior of the heat transfer element, and a drug delivery catheter running substantially parallel to the axis of the catheter assembly. The method includes selectively controlling the temperature of a selected volume of blood in a patient by introducing a catheter assembly into a blood vessel feeding a selected volume of blood in a patient and delivering a working fluid through a supply catheter in the catheter assembly and returning the working fluid through a return catheter in the catheter assembly. Heat is transferred between a heat transfer element forming a distal end of the catheter assembly and the volume of blood in the feeding vessel. A liquid, such as a drug, is delivered through a drug delivery catheter to the volume of blood in the feeding vessel.
摘要翻译：本发明提供一种用于加热或冷却进料容器中的周围流体的方法和装置。该装置包括能够插入患者血管系统中的选定进料容器的导管组件。所述组件包括在所述导管组件的远端处的传热元件，所述传热元件具有多个外表面凹凸，其形状和布置成在周围流体中产生湍流，所述表面凹凸具有至少等于边界的深度进料容器中周围流体的流动层厚度。该组件还包括供应导管，用于将工作流体输送到传热元件的内部;返回导管，用于从工作流体从传热元件的内部返回;以及药物输送导管，其基本上平行于导管组件。该方法包括通过将导管组件引入供给患者中选定体积的血液的血管中并通过导管组件中的供应导管输送工作流体来选择性地控制患者中所选体积的血液的温度，工作流体通过导管组件中的返回导管。在形成导管组件的远端的传热元件和进料容器中的血液体积之间传递热量。诸如药物的液体通过药物输送导管递送到进料容器中的血液体积。

27. 发明授权

US08682410B2 Multi-array monophasic action potential medical device 有权
标题翻译：多阵列单相动作电位医疗器械
公开(公告)号：US08682410B2
公开(公告)日：2014-03-25
申请号：US13044698
申请日：2011-03-10
申请人： Randell L. Werneth , Meleze Hocini , Mark T. Stewart , Dan Wittenberger , Timothy J. Corvi , Michael Lau , Vinod Sharma
发明人： Randell L. Werneth , Meleze Hocini , Mark T. Stewart , Dan Wittenberger , Timothy J. Corvi , Michael Lau , Vinod Sharma
IPC分类号： A61B5/042 , A61B18/14
CPC分类号： A61B5/0422 , A61B18/1492 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.
摘要翻译：一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。

28. 发明申请

US20120283585A1 Atrial Appendage Occlusion and Arrhythmia Treatment 审中-公开
标题翻译：心房闭塞和心律失常治疗
公开(公告)号：US20120283585A1
公开(公告)日：2012-11-08
申请号：US13368685
申请日：2012-02-08
申请人： Randell L. Werneth , David Zarbatany
发明人： Randell L. Werneth , David Zarbatany
IPC分类号： A61B5/02 , A61F2/01
CPC分类号： A61N1/3756 , A61B17/0057 , A61B2017/00243 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615
摘要： Atrial appendage occlusion devices and arrhythmia treatment.
摘要翻译：心房闭塞装置和心律失常治疗。

29. 发明授权

US08163000B2 Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device 有权
标题翻译：选择性器官冷却导管与导丝装置和温度监测装置
公开(公告)号：US08163000B2
公开(公告)日：2012-04-24
申请号：US11983946
申请日：2007-11-13
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F7/12
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61B2018/0262 , A61F7/12 , A61F2007/0056 , A61F2007/126 , G05D23/1919 , G05D23/22 , G05D23/24
摘要： A guidable catheter for heating or cooling fluid in a feeding vessel in a vasculature of a patient includes a heat transfer element having exterior surface irregularities to create turbulence in a surrounding fluid. A supply catheter delivers a working fluid to an interior of the heat transfer element, and a return catheter returns a working fluid from the interior of the heat transfer element. A guidewire tube is provided adjacent one of the supply catheter or the return catheter and runs substantially parallel to the axis of the guidable catheter to receive a guidewire disposed within the guidewire tube. A temperature-monitoring device is disposed at the distal tip of the guidewire. Feedback is provided to control the temperature of a source of working fluid.
摘要翻译：用于在患者脉管系统中的供给容器中加热或冷却流体的可引导导管包括具有外表面不规则性以在周围流体中产生湍流的传热元件。供应导管将工作流体输送到传热元件的内部，并且返回导管从传热元件的内部返回工作流体。在导管或返回导管之一附近提供导丝管，并且基本上平行于可导引导管的轴线延伸，以接纳设置在导丝管内的导丝。温度监视装置设置在导丝的远端。提供反馈来控制工作流体源的温度。

30. 发明申请

US20100057073A1 Irrigated Ablation Catheter System and Methods 审中-公开
标题翻译：灌肠消融导管系统与方法
公开(公告)号：US20100057073A1
公开(公告)日：2010-03-04
申请号：US12552531
申请日：2009-09-02
申请人： Ricardo D. Roman , Randell L. Werneth , Sadaf Soleymani , Alexander J. Asconeguy , Guillermo W. Moratorio
发明人： Ricardo D. Roman , Randell L. Werneth , Sadaf Soleymani , Alexander J. Asconeguy , Guillermo W. Moratorio
IPC分类号： A61B18/14 , A61B18/18
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00047
摘要： An ablation catheter for performing tissue ablation has an elongate shaft with a lumen. A tip ablation electrode is mounted on the distal end of the shaft. The tip electrode has walls that, together with the plug, define a chamber. The tip electrode has a fluid exit port. A shaft ablation electrode is mounted on the shaft proximal to the tip electrode. The catheter has a cooling fluid delivery system with a connection to a cooling fluid source. A fluid within the lumen of the elongate shaft penetrates the plug and delivers cooling fluid to the fluid exit port.
摘要翻译：用于进行组织消融的消融导管具有带腔的细长轴。顶端消融电极安装在轴的远端。尖端电极具有与插塞一起限定腔室的壁。尖端电极具有流体出口。轴消融电极安装在靠近尖端电极的轴上。导管具有与冷却流体源连接的冷却流体输送系统。细长轴腔内的流体穿过塞子并将冷却流体输送到流体出口。

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