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21. 发明授权

US07510531B2 System and method for discrimination of central and obstructive disordered breathing events 有权
标题翻译：用于区分中枢性和阻塞性无序呼吸事件的系统和方法
公开(公告)号：US07510531B2
公开(公告)日：2009-03-31
申请号：US10824776
申请日：2004-04-15
申请人： Kent Lee , John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/08
CPC分类号： A61B5/7264 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0478 , A61B5/0488 , A61B5/0496 , A61B5/08 , A61B5/0809 , A61B5/11 , A61B5/113 , A61B5/1135 , A61B5/4818
摘要： Disordered breathing events may be classified as central, obstructive or a combination of central an obstructive in origin based on patient motion associated with respiratory effort. Central disordered breathing is associated with disrupted respiration with reduced respiratory effort. Obstructive disordered breathing is associated with disrupted respiration accompanied by respiratory effort. A disordered breathing classification system includes a disordered breathing detector and a respiratory effort motion sensor. Components of the disordered breathing classification system may be fully or partially implantable.
摘要翻译：基于与呼吸努力相关的患者运动，无序呼吸事件可被分类为中枢性，阻塞性或中枢性阻塞性组合。呼吸中枢紊乱与呼吸力下降相关联。阻塞性无序呼吸与伴随呼吸功能的呼吸中断有关。无序呼吸分类系统包括无序呼吸检测器和呼吸力运动传感器。无序呼吸分类系统的组成部分可以完全或部分植入。

22. 发明申请

US20080319500A1 Systems, Devices and Methods Relating to Endocardial Pacing for Resynchronization 有权
标题翻译：用于再同步的与心内膜起搏相关的系统，设备和方法
公开(公告)号：US20080319500A1
公开(公告)日：2008-12-25
申请号：US12147293
申请日：2008-06-26
申请人： Qingsheng Zhu , Daniel Felipe Ortega
发明人： Qingsheng Zhu , Daniel Felipe Ortega
IPC分类号： A61N1/37 , A61N1/05
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0565 , A61N1/36114 , A61N1/3625 , A61N1/368 , A61N1/3684
摘要： Tools and methods are particularly suited for certain cardiac conditions advantaged by pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by delivering pulses to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. Other specific aspects include: determining a pacing threshold, beyond the capture threshold, to improve heart function; delivering pulses of opposite polarity to achieve such heart-function improvement; bi-ventricular pacing from a lead in the right ventricle for such improved heart function; delivering pulses of opposite polarity at a site near the His bundle; electrode-based His-pacing, without penetrating the myocardium; generating and/or delivering multiple pacing profiles including a pacing profile that delivers pulses of opposite polarity and another pacing profile; delivering a pacing profile to generate a synchronous contraction of the septal wall and free wall of the LV from a RV pacing location; and treating one or more of distal LBBB and/or diffuse LBBB by pacing at a site near the His bundle.
摘要翻译：工具和方法特别适用于通过在右心室中的引线引导右心室和左心室有利的某些心脏状况，以促进用于再同步的机械和/或电同步收缩。某些方面涉及通过将脉搏递送到心脏位置，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/压力，或其组合。其他具体方面包括：确定超出捕获阈值的起搏阈值，以改善心脏功能; 递送相反极性的脉冲以实现这种心脏功能的改善; 双心室起搏从右心室的引导改善心脏功能; 在His束附近的位置递送相反极性的脉冲; 基于电极的His起搏，不渗透心肌; 生成和/或递送多个起搏分布，包括递送相反极性的脉冲和另一起搏分布的起搏分布; 提供起搏剖面以产生来自RV起搏位置的LV的隔膜壁和自由壁的同步收缩; 并通过在靠近His束的位置进行起搏来治疗远端LBBB和/或扩散LBBB中的一种或多种。

23. 发明申请

US20080319499A1 Devices and Methods for Steering Electrical Stimulation in Cardiac Rhythm Management 有权
标题翻译：心律管理转向电刺激的装置和方法
公开(公告)号：US20080319499A1
公开(公告)日：2008-12-25
申请号：US12147317
申请日：2008-06-26
申请人： Qingsheng Zhu , Daniel Felipe Ortega
发明人： Qingsheng Zhu , Daniel Felipe Ortega
IPC分类号： A61N1/37 , A61N1/05
CPC分类号： A61N1/37 , A61N1/3627
摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by delivering pulses to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, a catheter arrangement includes a fixation mechanism to attach the catheter arrangement to heart tissue, individually-addressable electrodes for providing pacing signals to the heart tissue, and an elongated structure that supports the fixation mechanism and the electrodes. The elongated structure is used to direct an end thereof to the target region in the right ventricle, and deliver an electrical pacing signal to different portions within the target region of the heart when the fixation mechanism is operative to attach to heart tissue and also when the fixation mechanism is not attaching the catheter arrangement to heart tissue.
摘要翻译：工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。某些方面涉及通过将脉搏递送到心脏位置，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/压力，或其组合。在一个实施例中，导管装置包括用于将导管装置附接到心脏组织的固定机构，用于向心脏组织提供起搏信号的单独寻址电极，以及支撑固定机构和电极的细长结构。细长结构用于将其末端引导到右心室中的目标区域，并且当固定机构可操作地附接到心脏组织时，以及当心脏组织的运动时，将电起搏信号递送到心脏的目标区域内的不同部分固定机构不将导管装置附接到心脏组织。

24. 发明申请

US20080221635A1 IMPLANTABLE CARDIAC RHYTHM MANAGEMENT SYSTEM HAVING MULTIPLE THERAPY MODALITIES 有权
标题翻译：具有多种治疗方式的可持续心脏健康管理系统
公开(公告)号：US20080221635A1
公开(公告)日：2008-09-11
申请号：US12048144
申请日：2008-03-13
申请人： Julio C. Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
发明人： Julio C. Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
IPC分类号： A61N1/365
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
摘要翻译：一种用于提供多种治疗方式的心律管理系统。例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。可以使用各种手动和自动方法来选择操作模式。此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

25. 发明申请

US20080215104A1 Apparatus and method for temporary treatment of acute heart failure decompensation 有权
标题翻译：临床治疗急性心力衰竭失代偿的装置及方法
公开(公告)号：US20080215104A1
公开(公告)日：2008-09-04
申请号：US12151569
申请日：2008-05-07
申请人： Joseph M. Pastore , Qingsheng Zhu
发明人： Joseph M. Pastore , Qingsheng Zhu
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/368
摘要： A system for providing temporary therapy, such as cardiac resynchronization therapy, to a patient suffering a decompensation event. The system can include a device having an external module for generating electrical stimuli, a first lead coupled to the module and implanted into an atrial region of a patient's heart, and a second lead coupled to the module and implanted into a ventricular region of the patient's heart. The device can also include a storage module coupled to the external module to store data associated with physiological data measured by the device. The external module is configured to temporarily generate electrical stimuli that are delivered by at least one of the first and second leads to provide therapy cardiac resynchronization therapy to the heart. A network can be coupled to the device to allow data stored in the device to be downloaded through the network to a central repository.
摘要翻译：用于向患有失代偿事件的患者提供诸如心脏再同步治疗的临时治疗的系统。该系统可以包括具有用于产生电刺激的外部模块的装置，耦合到模块并且植入患者心脏的心房区域中的第一引线，以及耦合到模块的第二引线，并且植入患者的心室区域心。该设备还可以包括耦合到外部模块的存储模块，以存储与由该设备测量的生理数据相关联的数据。外部模块被配置为临时产生由第一和第二引线中的至少一个引出的电刺激，以向心脏提供治疗心脏再同步治疗。网络可以耦合到设备，以允许存储在设备中的数据通过网络被下载到中央存储库。

26. 发明申请

US20080208274A1 Method for treating myocardial infarction 有权
标题翻译：心肌梗死的治疗方法
公开(公告)号：US20080208274A1
公开(公告)日：2008-08-28
申请号：US12150296
申请日：2008-04-25
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.
摘要翻译：公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

27. 发明授权

US07346393B2 Implantable cardiac rhythm management system having multiple therapy modalities 有权
标题翻译：具有多种治疗方式的植入式心律管理系统
公开(公告)号：US07346393B2
公开(公告)日：2008-03-18
申请号：US10460975
申请日：2003-06-12
申请人： Julio Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
发明人： Julio Spinelli , Qingsheng Zhu , Bruce H. Kenknight , Yinghong Yu , Jiang Ding
IPC分类号： A61N1/36
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management system for providing a plurality of therapy modalities. For example, the system may include a cardiac resynchronization therapy module for providing cardiac resynchronization therapy and a pacemaker module for providing bradycardia therapy, as well as a selector module coupled to the cardiac resynchronization therapy module and the bradycardia module. The selector module may select an operating mode from among a plurality of operating modes including the cardiac resynchronization therapy module and the pacemaker module. Various manual and automatic methods may be used to select the operating mode. In addition, a reversion management system may be included to assist the cardiac rhythm management system to recover in case of a disruption to the system.
摘要翻译：一种用于提供多种治疗方式的心律管理系统。例如，该系统可以包括用于提供心脏再同步治疗的心脏再同步治疗模块和用于提供心动过缓治疗的起搏器模块，以及耦合到心脏再同步治疗模块和心动过缓模块的选择器模块。选择器模块可以从包括心脏再同步治疗模块和起搏器模块的多个操作模式中选择操作模式。可以使用各种手动和自动方法来选择操作模式。此外，还可以包括回归管理系统以帮助心律管理系统在系统中断的情况下恢复。

28. 发明授权

US07340303B2 Evoked response sensing for ischemia detection 有权
标题翻译：诱发反应感觉缺血检测
公开(公告)号：US07340303B2
公开(公告)日：2008-03-04
申请号：US09962852
申请日：2001-09-25
申请人： Qingsheng Zhu
发明人： Qingsheng Zhu
IPC分类号： A61N1/37
CPC分类号： A61N1/36507 , A61N1/3712
摘要： A cardiac pacemaker in which an electrogram is recorded from an evoked response sensing channel in order to detect changes indicative of cardiac ischemia. If such changes are detected, the maximum allowable pacing rate can be decreased for those pacing modes that allow the pacing rate to change with metabolic demand.
摘要翻译：一种心脏起搏器，其中从诱发的响应感测通道记录电描记图，以便检测指示心脏缺血的变化。如果检测到这种变化，那些起搏模式允许起搏速率随代谢需求而改变的最大允许起搏速率可以降低。

29. 发明授权

US07328067B2 Cardiac rhythm management system and method 有权
公开(公告)号：US07328067B2
公开(公告)日：2008-02-05
申请号：US10858580
申请日：2004-06-02
申请人： Qingsheng Zhu , Avram Scheiner
发明人： Qingsheng Zhu , Avram Scheiner
IPC分类号： A61N1/00
CPC分类号： A61N1/3712
摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

30. 发明授权

US07257443B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US07257443B2
公开(公告)日：2007-08-14
申请号：US11184325
申请日：2005-07-19
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

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