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21. 发明申请

US20130217147A1 DETECTION OF COMPLEXES OF TAU AND AMYLOID 审中-公开
标题翻译：检测TAU和AMYLOID的复合物
公开(公告)号：US20130217147A1
公开(公告)日：2013-08-22
申请号：US13718682
申请日：2012-12-18
申请人： Winton G. Gibbons , Thomas L. Holzman , Lei Chang , Claude G. Lerner
发明人： Winton G. Gibbons , Thomas L. Holzman , Lei Chang , Claude G. Lerner
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N33/6893 , G01N2800/2821 , G01N2800/50
摘要： The invention relates to methods for detecting complexes of Tau, Tau variants, including phosphorylated variants, and amyloid containing molecules, as well as autoantibodies to those complexes or components of those complexes, in physiological fluid samples.
摘要翻译：本发明涉及用于检测Tau，Tau变体，包括磷酸化变体和含淀粉样蛋白的分子的复合物的方法，以及生理液体样品中那些复合物或这些复合物的组分的自身抗体的方法。

22. 发明申请

US20120246643A1 FILE SYSTEM FOR STORAGE AREA NETWORK 有权
标题翻译：用于存储区域网络的文件系统
公开(公告)号：US20120246643A1
公开(公告)日：2012-09-27
申请号：US13073461
申请日：2011-03-28
申请人： Lei Chang , Ziye Yang , Wenbo Mao , Ying He , Junping Du
发明人： Lei Chang , Ziye Yang , Wenbo Mao , Ying He , Junping Du
IPC分类号： G06F9/455 , G06F17/30
CPC分类号： G06F17/30233 , G06F17/30197 , H04L67/1097
摘要： Methods and apparatus are disclosed for managing access to data in a data storage system. For example, an apparatus comprises at least one processing platform associated with a distributed virtual infrastructure. The processing platform comprises at least one processing device having a processor coupled to a memory. The processing platform is operative to instantiate a meta data management process that is configured to provide at least one client process with information to allow the client process to perform one or more operations in accordance with one or more data storage devices through a storage area network. The information provided to the client process may comprise one or more data block descriptors. Each of the one or more data block descriptors may comprise path information for at least one of the data storage devices and an offset address in the at least one data storage device. The one or more data block descriptors may correspond to one or more data blocks of a given data file that is stored or storable across the one or more data storage devices.
摘要翻译：公开了用于管理对数据存储系统中的数据的访问的方法和装置。例如，设备包括与分布式虚拟基础设施相关联的至少一个处理平台。处理平台包括至少一个具有耦合到存储器的处理器的处理设备。处理平台用于实例化元数据管理过程，其被配置为向至少一个客户端进程提供信息以允许客户端进程根据一个或多个数据存储设备通过存储区域网络执行一个或多个操作。提供给客户端进程的信息可以包括一个或多个数据块描述符。所述一个或多个数据块描述符中的每一个可以包括至少一个数据存储设备的路径信息和至少一个数据存储设备中的偏移地址。一个或多个数据块描述符可以对应于一个或多个数据文件的一个或多个数据块，该数据块可被存储或存储在一个或多个数据存储设备上。

23. 发明申请

US20110212462A1 ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS 有权
标题翻译：使用双重检测方法进行超声检测分子
公开(公告)号：US20110212462A1
公开(公告)日：2011-09-01
申请号：US12731135
申请日：2010-03-24
申请人： David C. Duffy , David M. Rissin , David R. Walt , Linan Song , Lei Chang
发明人： David C. Duffy , David M. Rissin , David R. Walt , Linan Song , Lei Chang
IPC分类号： G01N33/53
CPC分类号： G01N33/54393 , G01N33/5306
摘要： Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.
摘要翻译：本文描述了用于检测和/或确定流体样品中分析物分子或颗粒的浓度的测量的系统和方法。在某些情况下，系统和方法采用技术来减少或限制与非特异性结合事件相关的负面影响。本发明的某些方法包括将分析物分子与至少第一类型的结合配体和至少第二类型的结合配体相关联，并将分析物分子空间分离成表面上的多个位置。可以通过确定第一类型的结合配体和第二类型的结合配体的存在来确定在位置处或位置处的分析物分子的存在。

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