专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明公开

EP2712316A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS 审中-公开
标题翻译： LYSINDEMETHYLASEINHIBITOREN骨髓增生或淋巴增生性疾病或干扰
公开(公告)号：EP2712316A1
公开(公告)日：2014-04-02
申请号：EP12708260.0
申请日：2012-02-08
申请人： Oryzon Genomics, S.A.
发明人： FYFE, Matthew Colin Thor , MAES, Tamara , MARTINELL PEDEMONTE, Marc , TIRAPU FERNÁNDEZ DE LA CUESTA, Iñigo
IPC分类号： A61K31/135 , A61P35/02
CPC分类号： A61K31/495 , A61K31/00 , A61K31/135 , A61K31/145 , A61K31/164 , A61K31/165 , A61K31/40 , A61K31/44 , A61K31/4965 , A61K45/06 , C07C215/64 , C07C237/20 , C07C311/13 , C07D207/14 , C07D213/38 , C07D241/04
摘要： The present invention relates to methods and compositions for the treatment or prevention of diseases and disorder associated with myeloproliferative and lymphoproliferative disorders. In particular, the invention relates to an LSD1 inhibitor for use in treating or preventing diseases and disorder associated with myeloproliferative and lymphoproliferative disorders.

22. 发明授权

EP1034261B1 METHOD OF PARALLEL SCREENING FOR INSERTION MUTANTS AND A KIT TO PERFORM THIS METHOD 有权
标题翻译：方法用于搜索并行和试剂插入突变体来处理这个
公开(公告)号：EP1034261B1
公开(公告)日：2008-05-21
申请号：EP98965172.4
申请日：1998-11-23
申请人： Oryzon Genomics, S.A.
发明人： MAES, Tamara , GERATS, Tom
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1082 , B01J2219/00664 , C12Q1/6809 , C12Q1/6858
摘要： The current invention is a novel approach termed "parallel screening" which allows to simultaneously screen a population for insertions in all genes cloned from that or a closely related organism. In order to test this approach the flowering plant Petunia hybrida was used as a model system. Petunia hybrida line W137 contains a high copy number of the endogenous transposable element dTph1 and has been presented as a genetic tool before (Gerats et al., 1989). A 3D library of the plant genomic DNA of 1000 Petunia hybrida W137 plants was generated as described by Koes et al. (1995). The 3D library consists of 30 pools of DNA from a 100 plants each. These were used to generate 30 pools of insertion flanking sequences by nested iPCR using a set of transposon specific primers or by Transposon Display PCR. Insertions into a gene were detected by hybridizing the amplified insertion flanking sequences fixed to a filter with a gene specific probe, an approach termed simple screening for insertion elements. Alternatively, the amplified insertion element flanking sequences were labeled and used as a probe to hybridize a filter displaying multiple gene targets, an approach termed parallel screening for insertion elements, which allows the simultaneous screening for insertions in all genes of an organism, appearing in a population of insertion mutants.

23. 发明公开

EP3429571A1 COMBINATIONS OF LSD1 INHIBITORS FOR USE IN THE TREATMENT OF SOLID TUMORS 审中-实审
公开(公告)号：EP3429571A1
公开(公告)日：2019-01-23
申请号：EP17710261.3
申请日：2017-03-13
申请人： Oryzon Genomics, S.A.
发明人： DEMARIO, Mark , PIERCEALL, William , MACK, Fiona , MAES, Tamara , LUNARDI, Serena
IPC分类号： A61K31/12 , A61K31/135 , A61K31/19 , A61K31/282 , A61K31/337 , A61K31/4045 , A61K31/4745 , A61K31/475 , A61K31/495 , A61K31/519 , A61K31/555 , A61K31/704 , A61K31/7068 , A61P35/00

24. 发明公开

EP3307267A1 METHOD OF TREATING MULTIPLE SCLEROSIS EMPLOYING A LSD1-INHIBITOR 有权
标题翻译：采用LSD1抑制剂治疗多发性硬化的方法
公开(公告)号：EP3307267A1
公开(公告)日：2018-04-18
申请号：EP17735004.8
申请日：2017-06-09
申请人： Oryzon Genomics, S.A.
发明人： MAES, Tamara , MASCARÓ CRUSAT, Cristina , ROTLLANT POZO, David
IPC分类号： A61K31/42
CPC分类号： A61K31/42
摘要： Provided herein are methods for treating multiple sclerosis using (-) 5-((((trans)-2-(4-(benzyloxy)phenyl)cyclopropyl)amino)methyl)-1,3,4-oxadiazol-2-amine, or a pharmaceutically acceptable salt or solvate thereof.

25. 发明公开

EP2750671A2 LYSINE DEMETHYLASE INHIBITORS FOR THROMBOSIS AND CARDIOVASCULAR DISEASES 审中-公开
标题翻译：赖氨酸DEMETHYLASEINHIBITOREN血栓和心血管疾病
公开(公告)号：EP2750671A2
公开(公告)日：2014-07-09
申请号：EP12728418.0
申请日：2012-05-21
申请人： Oryzon Genomics, S.A.
发明人： MAES, Tamara , MARTINELL PEDEMONTE, Marc
IPC分类号： A61K31/135 , A61K31/165 , A61K31/18 , A61K31/40 , A61K31/44 , A61K31/495 , A61P7/02
CPC分类号： A61K31/495 , A61K31/135 , A61K31/165 , A61K31/18 , A61K31/40 , A61K31/4418 , A61K45/06
摘要： The invention relates to methods and compositions for the treatment or prevention of thrombosis, thrombus formation, a thrombotic event or complication, or a cardiovascular disease or event. In particular, the invention relates to an LSD inhibitor such as a 2-cyclylcyclopropan-1-amine derivative, a phenelzine derivative and a propargylamine derivative, for use in treating or preventing thrombosis, thrombus formation, a thrombotic event or complication, or a cardiovascular disease or event.

26. 发明公开

EP2741741A2 LYSINE DEMETHYLASE INHIBITORS FOR INFLAMMATORY DISEASES OR CONDITIONS 审中-公开
标题翻译： LYSINDEMETHYLASEINHIBITOREN炎症疾病或状态
公开(公告)号：EP2741741A2
公开(公告)日：2014-06-18
申请号：EP12728416.4
申请日：2012-05-21
申请人： Oryzon Genomics, S.A.
发明人： MAES, Tamara , MARTINELL PEDEMONTE, Marc , CASTRO-PALOMINO LARIA, Julio César
IPC分类号： A61K31/135 , A61K31/165 , A61K31/18 , A61K31/40 , A61K31/44 , A61K31/495 , A61P7/02
CPC分类号： C07D295/192 , A61K31/135 , A61K31/165 , A61K31/18 , A61K31/40 , A61K31/44 , A61K31/4418 , A61K31/495 , A61K45/06 , C07C215/64 , C07C237/06 , C07C311/08 , C07D207/14 , C07D213/38
摘要： The invention relates to methods and compositions for the treatment or prevention of inflammation and inflammatory diseases or conditions. In particular, the invention relates to an LSD1 inhibitor, such as a 2-cyclylcylopropan-1-amine derivative, a phenelzine derivative and a propargylamine derivative, for use in treating or preventing inflammation and inflammatory diseases or conditions.

27. 发明公开

EP3981395A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS 审中-公开
公开(公告)号：EP3981395A1
公开(公告)日：2022-04-13
申请号：EP21210016.8
申请日：2012-02-08
申请人： Oryzon Genomics, S.A.
发明人： BAKER, Jonathan Alleman , CASTRO PALOMINO, Julio , FYFE, Matthew Colin Thor , MAES, Tamara , MARTINELL PEDEMONTE, Marc
IPC分类号： A61K31/135 , A61P35/02
摘要： The invention relates to the methods and compositions for the treatment or prevention of diseases and disorders associated with myeloproliferative disorders. In particular, the invention relates to an LSD 1 inhibitor for use in treating or preventing Philadelphia chromosome negative myeloproliferative disorders.

28. 发明授权

EP3307267B1 MULTIPLE SCLEROSIS TREATMENT 有权
公开(公告)号：EP3307267B1
公开(公告)日：2019-04-10
申请号：EP17735004.8
申请日：2017-06-09
申请人： Oryzon Genomics, S.A.
发明人： MAES, Tamara , MASCARÓ CRUSAT, Cristina , ROTLLANT POZO, David
IPC分类号： A61K31/42

30. 发明公开

EP3307909A1 BIOMARKERS ASSOCIATED WITH LSD1 INHIBITORS AND USES THEREOF 审中-公开
标题翻译：与LSD1抑制剂相关的生物标志物及其用途
公开(公告)号：EP3307909A1
公开(公告)日：2018-04-18
申请号：EP16734564.4
申请日：2016-06-10
申请人： Oryzon Genomics, S.A.
发明人： MAES, Tamara , MASCARÓ CRUSAT, Cristina , ROTLLANT POZO, David
IPC分类号： C12Q1/68 , G01N33/50 , A61K31/42
CPC分类号： G01N33/15 , A61K31/165 , A61K31/40 , A61K31/4245 , A61K31/495 , A61P25/28 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2500/00 , G01N2800/52
摘要： The invention relates to biomarkers associated with LSD1 inhibitors and uses thereof to assess target engagement and to follow patient response to treatment. The invention further relates to novel therapeutic uses for LSD1 inhibitors based on said biomarkers.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式