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21. 发明授权

US08921363B2 Derivatives of 1 H-isoindol-3-amine, 1 H-iso-aza-indol-3amine, 3,4-dihydroisoquinolin-1-amine, and 1,4-dihydroisoquinolin-3-amine as beta-secretase inhibitors 有权
标题翻译： 1H-异吲哚-3-胺，1H-异氮杂 - 吲哚-3-胺，3,4-二氢异喹啉-1-胺和1,4-二氢异喹啉-3-胺的衍生物作为β-分泌酶抑制剂
公开(公告)号：US08921363B2
公开(公告)日：2014-12-30
申请号：US13814232
申请日：2011-08-04
申请人： Ana Elena Minatti , Yuan Cheng , Wenge Zhong
发明人： Ana Elena Minatti , Yuan Cheng , Wenge Zhong
IPC分类号： C07D491/20 , A61K31/436 , A61K31/437 , A61K31/537 , C07D491/22 , C07D498/20 , C07D498/22
CPC分类号： C07D491/20 , A61K31/436 , A61K31/437 , A61K31/537 , C07D491/22 , C07D498/20 , C07D498/22
摘要： The present invention relates to a compound represented by general formula I: or a stereoisomer, tautomer, hydrate, solvate or pharmaceutically acceptable salt thereof, wherein A1, A2, A3, A4, A5, A6, R2, R7, W, X, Y and Z are defined within. These compounds are useful for the modulation of β-secretase enzyme activity and for the treatment of β-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions.
摘要翻译：本发明涉及由通式I表示的化合物或其立体异构体，互变异构体，水合物，溶剂化物或药学上可接受的盐，其中A1，A2，A3，A4，A5，A6，R2，R7，W，X，Y 和Z在其中定义。这些化合物可用于调节分泌酶活性和用于治疗分泌型介导的疾病，包括阿尔茨海默病（AD）和相关病症。

22. 发明申请

US20130172343A1 Derivatives of 1H-isoindol-3-amine, 1H-iso-aza-indol-3amine, 3,4-dihydroisoquinolin-1-amine, and 1,4-dihydroisoquinolin-3-amine as Beta-secretase Inhibitors 有权
标题翻译： 1H-异吲哚-3-胺的衍生物，1H-异氮杂 - 吲哚-3-胺，3,4-二氢异喹啉-1-胺和1,4-二氢异喹啉-3-胺作为β-分泌酶抑制剂
公开(公告)号：US20130172343A1
公开(公告)日：2013-07-04
申请号：US13814232
申请日：2011-08-04
申请人： Ana Elena Minatti , Yuan Cheng , Wenge Zhong
发明人： Ana Elena Minatti , Yuan Cheng , Wenge Zhong
IPC分类号： C07D491/20 , C07D498/20 , C07D498/22 , C07D491/22
CPC分类号： C07D491/20 , A61K31/436 , A61K31/437 , A61K31/537 , C07D491/22 , C07D498/20 , C07D498/22
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I: (I). In another embodiment, the compounds have a general Formula II: (II). In another embodiment, the compounds have a general Formula III: (III). Variables A1, A2, A3, A4, A5, A6, R2, R7, V, W, X, Y and Z of Formulas I, II and III are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formulas I, II and III, intermediates and processes useful for the preparation of compounds of Formulas I, II and III.
摘要翻译：本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。在一个实施方案中，化合物具有通式I：（I）。在另一个实施方案中，化合物具有通式II：（II）。在另一个实施方案中，化合物具有通式III：（III）。式I，II和III的变量A1，A2，A3，A4，A5，A6，R2，R7，V，W，X，Y和Z在本文中定义。本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。这种病症包括例如阿尔茨海默氏病，认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。本发明还包括式I，II和III的其它实施方案，可用于制备式I，II和III化合物的中间体和方法。

23. 发明授权

US08497264B2 Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use 有权
公开(公告)号：US08497264B2
公开(公告)日：2013-07-30
申请号：US13047693
申请日：2011-03-14
申请人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
发明人： Jian J. Chen , Wenge Zhong , Bryant Yang , Ryan White , Matthew Weiss , Timothy Powers , Yuan Cheng
IPC分类号： C07D513/10 , C07D498/20 , A61K31/547 , A61K31/5386
CPC分类号： C07D513/10 , C07D498/10 , C07D498/20 , C07D513/20
摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

24. 发明授权

US08178557B2 Compounds and methods of use 有权
标题翻译：化合物和使用方法
公开(公告)号：US08178557B2
公开(公告)日：2012-05-15
申请号：US12157303
申请日：2008-06-09
申请人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
发明人： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph L. Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian L. Hodous , Russell Graceffa , William H. Buckner , Craig E. Masse , Deborah Choquette , Matthew W. Martin , Julie Germain , Lucian V. DiPietro , Stuart C. Chaffee , Joseph J. Nunes , John L. Buchanan , David C. McGowan , Douglas A. Whittington , Gregory J. Habgood , Vinod F. Patel , Daniel La
IPC分类号： A61K31/04
CPC分类号： C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

25. 发明授权

US08078857B2 Method and system for monitoring and adaptively pre-loading crucial dynamic link libraries 有权
标题翻译：用于监控和自适应预加载关键动态链接库的方法和系统
公开(公告)号：US08078857B2
公开(公告)日：2011-12-13
申请号：US12165886
申请日：2008-07-01
申请人： Yuan Cheng , Hua Feng Hong , Min Qu , Xing Wei , Xiao Bing Yan
发明人： Yuan Cheng , Hua Feng Hong , Min Qu , Xing Wei , Xiao Bing Yan
IPC分类号： G06F9/00 , G06F9/24 , G06F15/177
CPC分类号： G06F9/44521
摘要： The invention provides a system and method for adaptively loading frequently loaded dynamic link libraries. The system comprises: a monitor for monitoring loading events of dynamic link libraries while an operating system is running, and logging a name and related loading information of the corresponding dynamic link library into a log file in response to the loading events; and an invoker for automatically loading at least one of the most frequently loaded dynamic link libraries logged in the log file upon a subsequent startup of the operating system. By using the system and method, startup performance of the most frequently used applications can be greatly improved.
摘要翻译：本发明提供一种用于自适应地加载经常加载的动态链接库的系统和方法。该系统包括：用于在操作系统运行时监视动态链接库的加载事件的监视器，并且响应于加载事件将对应的动态链接库的名称和相关加载信息记录到日志文件中; 以及在随后启动操作系统时自动加载日志文件中记录的最频繁加载的动态链接库中的至少一个的调用者。通过使用系统和方法，可以大大提高最常用的应用程序的启动性能。

26. 发明授权

US07880000B2 Protein kinase modulators and method of use 有权
标题翻译：蛋白激酶调节剂及其使用方法
公开(公告)号：US07880000B2
公开(公告)日：2011-02-01
申请号：US11126000
申请日：2005-05-09
申请人： Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
发明人： Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul A. Tempest , Philip R. Olivieri , Rebecca E. Johnson , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Ning Xi , Karina Romero , Hanh Nho Nguyen , Holly L. Deak
IPC分类号： C07D401/14 , C07D403/14 , A61K31/53 , A61K31/4427 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D213/73 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
摘要翻译：本发明涉及具有通式I的化合物，其中A，B，D，E，G，H1-5和R1-4在本文中定义，以及能够调节各种蛋白激酶受体酶的合成中间体，从而影响与这些激酶的活性相关的各种疾病状态和状况。例如，这些化合物能够调节激酶，从而影响血管生成过程并治疗血管生成相关疾病和其它包括癌症和炎症的复发性疾病。本发明还包括药物组合物，包括该化合物，以及治疗与蛋白激酶活性有关的疾病状态的方法。

27. 发明申请

US20060205331A1 Sanding apparatus with molded elastomeric pad 有权
公开(公告)号：US20060205331A1
公开(公告)日：2006-09-14
申请号：US11079770
申请日：2005-03-14
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： B24D11/00
CPC分类号： B24D15/04
摘要： A sander comprises a body member molded of polypropylene to which a soft pad member is integrally molded or directly bonded thereto. Preferably, the material comprising the pad member is of a thermoplastic elastomer material, such as Santoprene®. Significantly, when the pad member is molded directly to the body member, the pad has internal dimensions only slightly larger than the external dimensions of the body member so that, when the body member is located within the confines of the pad member, a secure fit is formed between these two members, without any space between them. Further, the respective dimensions of the body member and pad member give the sander a thick, one-piece appearance in side and end views. The pad member may also include a plurality of openings which help provide a “spongy” effect to the user, smoothing the peaks and reaching the valleys of an uneven surface upon which the sander is utilized.

28. 发明授权

US07085351B2 Method and apparatus for controlling electron beam current 有权
公开(公告)号：US07085351B2
公开(公告)日：2006-08-01
申请号：US10358160
申请日：2003-02-05
申请人： Jianping Lu , Otto Zhou , Yuan Cheng
发明人： Jianping Lu , Otto Zhou , Yuan Cheng
IPC分类号： H01J35/32
CPC分类号： H01J35/06 , A61B6/032 , A61B6/4021 , A61B6/4028 , A61B6/405 , A61B6/4488 , A61B6/482 , B82Y10/00 , H01J3/021 , H01J35/065 , H01J35/08 , H01J35/105 , H01J35/14 , H01J35/22 , H01J35/28 , H01J35/30 , H01J2201/30469 , H01J2235/06 , H01J2235/062 , H01J2235/064 , H01J2235/068 , H05G1/34
摘要： An x-ray generating device includes a field emission cathode formed at least partially from a nanostructure-containing material having an emitted electron current density of at least 4 A/cm2. High energy conversion efficiency and compact design are achieved due to easy focusing of cold cathode emitted electrons and dramatic reduction of heating at the anode. In addition, by pulsing the field between the cathode and the gate or anode and focusing the electron beams at different anode materials, pulsed x-ray radiation with varying energy can be generated from a single device. Methods and apparatus for independent control of electron emission current and x-ray energy in x-ray tubes are also provided. The independent control can be accomplished by adjusting the distance between the cathode and anode. The independent control can also be accomplished by adjusting the temperature of the cathode. The independent control can also be accomplished by optical excitation of the cathode. The cathode can include field emissive materials such as carbon nanotubes.

29. 发明申请

US20050236443A1 Multifunction pouring spout and removable lid 有权
标题翻译：多功能倾倒口和可拆卸盖
公开(公告)号：US20050236443A1
公开(公告)日：2005-10-27
申请号：US10830275
申请日：2004-04-22
申请人： Donald Gringer , Yuan Cheng
发明人： Donald Gringer , Yuan Cheng
IPC分类号： B44D3/12 , B65D5/72
CPC分类号： B44D3/128 , B44D3/127
摘要： An inventive pouring spout for containers of liquid, having a removable lid and a strip with magnets located thereon. The spout is selectively attachable and is fitted to the diameter of an opening of a particular container. In a preferred embodiment, the spout is fitted to the diameter of a paint can opening, where it may replace the typical lid of a paint can for the duration of its use. Essentially, the spout effectively prevents the entry of paint in the sealing groove of the paint can or on the sides of the can.
摘要翻译：一种用于液体容器的创新性倾倒嘴，其具有可移除的盖和位于其上的磁体的带。喷嘴可选择性地附接并且被安装到特定容器的开口的直径上。在一个优选实施例中，喷嘴适合于油漆罐开口的直径，其中可以在其使用期间替换油漆罐的典型盖。基本上，喷口有效地防止油漆在油漆罐的密封槽或罐的侧面上的进入。

30. 发明申请

US20050156290A1 Concealable chip leadframe unit structure 失效
标题翻译：可控芯片引线框单元结构
公开(公告)号：US20050156290A1
公开(公告)日：2005-07-21
申请号：US10959207
申请日：2004-10-07
申请人： Jeffrey Lien , Yuan Cheng
发明人： Jeffrey Lien , Yuan Cheng
IPC分类号： H01L21/58 , H01L23/31 , H01L23/495
CPC分类号： H01L23/49551 , H01L23/3114 , H01L23/4951 , H01L24/48 , H01L24/49 , H01L2224/32245 , H01L2224/451 , H01L2224/48091 , H01L2224/4826 , H01L2224/49171 , H01L2224/73215 , H01L2924/00014 , H01L2924/00 , H01L2924/00015 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A concealable chip leadframe unit structure is disclosed which is made up of multiple lead units arranged in order, each lead in the lead unit is formed by pressing and comprising of a piece body with upper placement plane, the lower surface of the piece body is pressed to form at least an inner conducting plane which can be connected to the chip, and at least one protruding bump is formed adjacent to the inner conducting plane, the end surface of the protruding bump is used as an out-conducting plane to be connected to outside; in this structure, chip can be attached to the upper placement plane of the lead structure, and the inner conducting plane can be connected to the chip through metallic wire.
摘要翻译：公开了一种可隐藏的芯片引线框单元结构，其由依次布置的多个引线单元构成，引线单元中的每个引线通过压制形成，并且包括具有上放置平面的片体，片体的下表面被按压至少形成能够连接到芯片的内部导电平面，并且与内部导电平面相邻地形成至少一个突出凸块，突出凸起的端面用作与外部导电平面连接的导电平面外; 在该结构中，芯片可以安装在引线结构的上部放置平面上，并且内部导电平面可以通过金属线连接到芯片。

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