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21. 发明申请

US20050064562A1 Nucleotide sequences coding for the mikE17 gene 有权
标题翻译：编码mikE17基因的核苷酸序列
公开(公告)号：US20050064562A1
公开(公告)日：2005-03-24
申请号：US10923726
申请日：2004-08-24
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle
IPC分类号： C07K14/34 , C12N1/21 , C12P13/08 , C07H21/04 , C12N9/10 , C12N9/88 , C12N15/74 , C12P13/04
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the mikE17 gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）与编码多肽的多核苷酸的程度相同的多核苷酸，所述多核苷酸包含SEQ ID NO： 2，b）编码多肽的多核苷酸，其包含与至少70％与SEQ ID No.2的氨基酸序列相同程度的氨基酸序列，c）多核苷酸，其与）或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少mikE17 基因以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

22. 发明申请

US20050130277A1 Nucleotide sequences coding for the pknB gene 有权
标题翻译：编码pknB基因的核苷酸序列
公开(公告)号：US20050130277A1
公开(公告)日：2005-06-16
申请号：US10940606
申请日：2004-09-15
申请人： Brigitte Bathe , Stephan Hans , Mike Farwick , Thomas Hermann
发明人： Brigitte Bathe , Stephan Hans , Mike Farwick , Thomas Hermann
IPC分类号： C12N9/12 , C12P13/04 , C07H21/04 , C12N1/21 , C12N9/10 , C12N9/42 , C12N15/74
CPC分类号： C12N9/1205 , C12P13/04 , C12Y207/01037
摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b) or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknB gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.
摘要翻译：一种分离的多核苷酸，其含有选自以下的多核苷酸序列：（a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％的多核苷酸，（b）编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，（c）与（a）或（b）的多核苷酸互补的多核苷酸和（ d）包含（a），（b）或（c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用其中至少pknB基因被扩增的棒状杆菌制备L-氨基酸的发酵方法以及使用含有本发明序列的多核苷酸作为杂交探针。

23. 发明授权

US06939692B2 Nucleotide sequences coding for the pknB gene 失效
公开(公告)号：US06939692B2
公开(公告)日：2005-09-06
申请号：US09949970
申请日：2001-09-12
申请人： Brigitte Bathe , Stephan Hans , Mike Farwick , Thomas Hermann
发明人： Brigitte Bathe , Stephan Hans , Mike Farwick , Thomas Hermann
IPC分类号： C12N9/12 , C12P13/04
CPC分类号： C12N9/1205 , C12P13/04 , C12Y207/01037
摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b) or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknB gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

24. 发明授权

US07226763B2 Process for preparing L-amino acids with corynebacteria with enhanced nucleotide sequences coding for pknD 有权
标题翻译：用增强的编码pknD的核苷酸序列制备具有棒状杆菌的L-氨基酸的方法
公开(公告)号：US07226763B2
公开(公告)日：2007-06-05
申请号：US11110837
申请日：2005-04-21
申请人： Brigitte Bathe , Indra Schroeder , Mike Farwick , Thomas Hermann
发明人： Brigitte Bathe , Indra Schroeder , Mike Farwick , Thomas Hermann
IPC分类号： C12P13/04 , C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/1205 , C12R1/15
摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknD gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.
摘要翻译：一种分离的多核苷酸，其含有选自以下的多核苷酸序列：（a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％的多核苷酸，（b）编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，（c）与（a）或（b）的多核苷酸互补的多核苷酸和（ d）包含（a），（b）或（c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状杆菌制备L-氨基酸的发酵方法，其中至少pknD基因是扩增和使用含有本发明序列的多核苷酸作为杂交探针。

25. 发明授权

US06916636B2 Nucleotide sequences which code for the oxyR gene 失效
标题翻译：编码oxyR基因的核苷酸序列
公开(公告)号：US06916636B2
公开(公告)日：2005-07-12
申请号：US09938641
申请日：2001-08-27
申请人： Achim Marx , Mike Farwick , Thomas Hermann , Natalie Schischka , Brigitte Bathe
发明人： Achim Marx , Mike Farwick , Thomas Hermann , Natalie Schischka , Brigitte Bathe
IPC分类号： C07K14/34 , C12P13/04
CPC分类号： C07K14/34
摘要： The invention relates to polynucleotides corresponding to the oxyR gene from Corynebacterium glutamicum and which encode a OxyR transcriptional regulator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having OxyR transcriptional regulator activity.
摘要翻译：本发明涉及对应于谷氨酸棒杆菌的oxyR基因的多核苷酸，其编码OxyR转录调节子，产生L-氨基酸的方法，以及筛选编码具有OxyR转录调节活性的蛋白质的多核苷酸的方法。

26. 发明授权

US07105302B2 Nucleotide sequences coding for the pknB gene 有权
公开(公告)号：US07105302B2
公开(公告)日：2006-09-12
申请号：US10940606
申请日：2004-09-15
申请人： Brigitte Bathe , Stephan Hans , Mike Farwick , Thomas Hermann
发明人： Brigitte Bathe , Stephan Hans , Mike Farwick , Thomas Hermann
IPC分类号： C12Q1/68 , C12N9/12 , C12N1/20 , C12N15/09 , C07H21/04
CPC分类号： C12N9/1205 , C12P13/04 , C12Y207/01037
摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b) or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknB gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

27. 发明申请

US20050255566A1 Nucleotide sequences coding for the pknD gene 有权
标题翻译：编码pknD基因的核苷酸序列
公开(公告)号：US20050255566A1
公开(公告)日：2005-11-17
申请号：US11110837
申请日：2005-04-21
申请人： Brigitte Bathe , Indra Schroeder , Mike Farwick , Thomas Hermann
发明人： Brigitte Bathe , Indra Schroeder , Mike Farwick , Thomas Hermann
IPC分类号： C12N9/12 , C12Q1/68 , C07H21/04 , C12N1/21 , C12N15/74 , C12P13/04
CPC分类号： C12N9/1205 , C12R1/15
摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknD gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.
摘要翻译：一种分离的多核苷酸，其含有选自以下的多核苷酸序列：（a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％的多核苷酸，（b）编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，（c）与（a）或（b）的多核苷酸互补的多核苷酸和（ d）包含（a），（b）或（c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状杆菌制备L-氨基酸的发酵方法，其中至少pknD基因是扩增和使用含有本发明序列的多核苷酸作为杂交探针。

28. 发明授权

US06927052B2 Nucleotide sequences coding for the pknD gene 失效
公开(公告)号：US06927052B2
公开(公告)日：2005-08-09
申请号：US09949971
申请日：2001-09-12
申请人： Brigitte Bathe , Indra Schroeder , Mike Farwick , Thomas Hermann
发明人： Brigitte Bathe , Indra Schroeder , Mike Farwick , Thomas Hermann
IPC分类号： C12N9/12 , C12N9/00 , C07H21/04 , C12N1/20 , C12N9/10 , C12N15/00
CPC分类号： C12N9/1205 , C12R1/15
摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknD gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

29. 发明授权

US07416863B2 Nucleotide sequences for encoding of the lysR2-gene 失效
标题翻译：编码lysR2基因的核苷酸序列
公开(公告)号：US07416863B2
公开(公告)日：2008-08-26
申请号：US11178485
申请日：2005-07-12
申请人： Bettina Moeckel , Mike Farwick , Thomas Hermann , Caroline Kreutzer , Walter Pfefferle
发明人： Bettina Moeckel , Mike Farwick , Thomas Hermann , Caroline Kreutzer , Walter Pfefferle
IPC分类号： C12P19/34
CPC分类号： C12P13/08 , C07K14/34
摘要： Isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c),and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the lysR2 gene is present in attenuated form, and the use of the polynucleotide sequences as hybridization probes.
摘要翻译：分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸，b）多核苷酸，其编码多肽，其包含与SEQ ID No.2的氨基酸序列至少70％的程度相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少lysR2基因存在于减毒形式，以及使用多核苷酸序列作为杂交探针。

30. 发明授权

US07105321B2 Nucleotide sequences which code for the ccpA2 gene 有权
标题翻译：编码ccpA2基因的核苷酸序列
公开(公告)号：US07105321B2
公开(公告)日：2006-09-12
申请号：US10724827
申请日：2003-12-02
申请人： Bettina Moeckel , Caroline Kreutzer , Thomas Hermann , Mike Farwick , Achim Marx , Walter Pfefferle
发明人： Bettina Moeckel , Caroline Kreutzer , Thomas Hermann , Mike Farwick , Achim Marx , Walter Pfefferle
IPC分类号： C12P13/04 , C12P21/06 , C12P13/06 , C12N1/20 , C12N15/00
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to polynucleotides corresponding to the ccpA2 gene and which encode a CcpA2 catabolite control protein, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having CcpA2 catabolite control activity.
摘要翻译：本发明涉及对应于ccpA2基因并且编码CcpA2分解代谢物控制蛋白质的多核苷酸，产生L-氨基酸的方法，以及筛选编码具有CcpA2分解代谢物控制活性的蛋白质的多核苷酸的方法。

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