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1. 发明授权

US06946271B2 Nucleotide sequences which code for the menE gene 失效
标题翻译：编码menE基因的核苷酸序列
公开(公告)号：US06946271B2
公开(公告)日：2005-09-20
申请号：US09834722
申请日：2001-04-16
申请人： Mike Farwick , Klaus Huthmacher , Achim Marx , Walter Pfefferle
发明人： Mike Farwick , Klaus Huthmacher , Achim Marx , Walter Pfefferle
IPC分类号： C12N9/00 , C12P13/08
CPC分类号： C12N9/93 , C12P13/08 , C12Y602/01026
摘要： The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the menE gene is present in attenuated form, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及一种分离的多核苷酸，其包含多核苷酸序列，所述多核苷酸序列选自a）与编码多肽的多核苷酸的程度相同的多核苷酸，所述多核苷酸包含SEQ ID NO： 2，b）编码多肽的多核苷酸，其包含与至少70％与SEQ ID No.2的氨基酸序列相同程度的氨基酸序列，c）多核苷酸，其与）或b），和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少所述menE 基因以减毒形式存在，并且使用包含根据本发明的序列的多核苷酸作为杂交探针。

2. 发明授权

US06822085B2 Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 有权
标题翻译：编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列
公开(公告)号：US06822085B2
公开(公告)日：2004-11-23
申请号：US09962357
申请日：2001-09-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： C07H2104
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译：来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。

3. 发明授权

US06759224B2 Nucleotide sequences which code for the sahH gene 有权
标题翻译：编码sahH基因的核苷酸序列
公开(公告)号：US06759224B2
公开(公告)日：2004-07-06
申请号：US09919854
申请日：2001-08-02
申请人： Mike Farwick , Klaus Huthmacher , Jennifer Brehme , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Jennifer Brehme , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： C12N914
CPC分类号： C12N9/88 , A23K10/12 , A23K20/142 , A23K40/35 , A23K50/10 , C12P13/08 , C12P13/12
摘要： An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide that comprises an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and a process for the fermentative preparation of L-amino acids using coryneform bacteria, in which at least the sahH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes.
摘要翻译：一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码多肽，其包含与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列，c）与a）或b）的多核苷酸互补的多核苷酸，和d）包含至少15个连续的多核苷酸的多核苷酸 a），b）或c）的多核苷酸序列的核苷酸，以及使用棒状细菌发酵制备L-氨基酸的方法，其中至少sahH基因以增强形式存在，以及使用多核苷酸含有根据本发明的序列作为杂交探针。

4. 发明授权

US06924134B2 Nucleotide sequences which code for the gorA gene 失效
标题翻译：编码gorA基因的核苷酸序列
公开(公告)号：US06924134B2
公开(公告)日：2005-08-02
申请号：US09946764
申请日：2001-09-06
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Achim Marx
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Achim Marx
IPC分类号： C12N9/02 , C12P13/08 , C07H21/04 , C07K1/00 , C12N1/20 , C12N15/00
CPC分类号： C12N9/0036 , C12P13/08
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the gorA gene, and a host-vector system having a coryneform host bacterium in which the gorA gene is present in attenuated form and a vector which carries at least the gorA gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码gorA基因的多核苷酸序列的分离的多核苷酸，以及具有其中gorA基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带gorA基因的载体至SEQ ID No 1，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

5. 发明授权

US06777206B2 Nucleotide sequences which code for the RodA protein 失效
标题翻译：编码RodA蛋白的核苷酸序列
公开(公告)号：US06777206B2
公开(公告)日：2004-08-17
申请号：US09950071
申请日：2001-09-12
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Brigitte Bathe
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Brigitte Bathe
IPC分类号： C12P2106
CPC分类号： C12P13/08 , C07K14/34
摘要： The invention provides nucleotide sequences from Coryneform bacteria which code for the RodA protein and a process for the fermentative preparation of amino acids using bacteria in which the rodA gene is enhanced.
摘要翻译：本发明提供了编码RodA蛋白质的棒状细菌的核苷酸序列和使用其中rodA基因增强的细菌发酵制备氨基酸的方法。

6. 发明授权

US07129066B2 Nucleotide sequences coding for the citE gene 失效
标题翻译：编码citE基因的核苷酸序列
公开(公告)号：US07129066B2
公开(公告)日：2006-10-31
申请号：US10375355
申请日：2003-02-28
申请人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
发明人： Mike Farwick , Klaus Huthmacher , Achim Marx , Brigitte Bathe , Walter Pfefferle
IPC分类号： C12P13/08 , C12P13/04 , C12N9/88 , C07H21/04
CPC分类号： C12Y401/03006 , C12N9/88
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence selected from the group a) polynucleotide that is at least 70% identical with a polynucleotide that codes for a polypeptide containing the amino acid sequence of SEQ ID No. 2, b) polynucleotide that codes for a polypeptide containing an amino acid sequence that is at least 70% identical with the amino acid sequence of SEQ ID No. 2, c) polynucleotide that is complementary to the polynucleotides of a) or b), and d) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b) or c), and to a process for the production of L-amino acids by fermentation using coryneform bacteria in which at least the citE gene is present in attenuated form, and to the use of polynucleotides containing the sequences of the invention as hybridization probes.
摘要翻译：本发明涉及含有多核苷酸序列的多核苷酸序列，该多核苷酸序列选自a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％相同的多核苷酸，b）编码对于含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，c）与a）或b）的多核苷酸互补的多核苷酸，以及d）至少含有 a），b）或c）的多核苷酸序列的15个连续核苷酸，以及通过发酵使用其中至少有citE基因以减毒形式存在的棒状细菌产生L-氨基酸的方法，使用含有本发明序列的多核苷酸作为杂交探针。

7. 发明申请

US20060177912A1 Nucleotide sequences which code for the dep34 gene 审中-公开
公开(公告)号：US20060177912A1
公开(公告)日：2006-08-10
申请号：US11274317
申请日：2005-11-16
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
IPC分类号： C12P13/04 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the dep34 gene, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

8. 发明授权

US07029904B2 Nucleotide sequences which code for the dep34 gene 失效
标题翻译：编码dep34基因的核苷酸序列
公开(公告)号：US07029904B2
公开(公告)日：2006-04-18
申请号：US09946763
申请日：2001-09-06
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
IPC分类号： C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C07K14/34 , C12P13/08
摘要： The invention relates to an isolated polynucleotide from Corynebacterium glutamicum having a polynucleotide sequence which codes for the dep34 efflux protein, and a host-vector system having a coryneform host bacterium in which the dep34 gene is present in attenuated form and a vector which carries at least the dep34 gene according to SEQ ID NO: 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
摘要翻译：本发明涉及具有编码dep34流出蛋白的多核苷酸序列的谷氨酸棒杆菌分离的多核苷酸，以及具有其中dep34基因以减毒形式存在的棒状细胞宿主细菌的宿主 - 载体系统和至少携带至少根据SEQ ID NO：1的dep34基因，以及使用包含根据本发明的序列的多核苷酸作为杂交探针。

9. 发明申请

US20050233424A1 Nucleotide sequences which code for the cysD, cysN, cysK, cysE and cysH genes 审中-公开
标题翻译：编码cysD，cysN，cysK，cysE和cysH基因的核苷酸序列
公开(公告)号：US20050233424A1
公开(公告)日：2005-10-20
申请号：US10898345
申请日：2004-07-26
申请人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
发明人： Mike Farwick , Klaus Huthmacher , Natalie Schischka , Brigitte Bathe , Walter Pfefferle , Michael Binder , Dieter Greissinger , Georg Thierbach
IPC分类号： A23K1/00 , A23K1/16 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/88 , C12P13/08 , C12P13/12 , C07H21/04 , C12N15/74
CPC分类号： C12N9/0051 , A23K10/12 , A23K20/142 , A23K40/10 , C12N9/1029 , C12N9/1241 , C12N9/88 , C12P13/08 , C12P13/12
摘要： Nucleotide sequences from coryneform bacteria which code for the cysD, cysN, cysK, cysE and cysH genes and a process for the fermentative preparation of amino acids using bacteria in which the genes mentioned are enhanced, a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the cysD gene, the cysN gene, the cysK gene, the cysE gene and/or the cysH gene is present in enhanced form, and the use of polynucleotides which contain the sequences according to the invention as hybridization probes and a process for the preparation of an L-methionine-containing animal feedstuffs additive from fermentation broths.
摘要翻译：来自编码cysD，cysN，cysK，cysE和cysH基因的棒状细菌的核苷酸序列和使用其中所述基因的细菌发酵制备氨基酸的方法，L-氨基酸的发酵制备方法使用其中至少cysD基因，cysN基因，cysK基因，cysE基因和/或cysH基因至少以增强形式存在的棒状细菌，以及含有根据本发明的序列的多核苷酸作为杂交探针以及从发酵液中制备含有L-甲硫氨酸的动物饲料添加剂的方法。

10. 发明授权

US07038034B2 Nucleotide sequences coding for the Dep33 efflux protein 失效
公开(公告)号：US07038034B2
公开(公告)日：2006-05-02
申请号：US09948777
申请日：2001-09-10
申请人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
发明人： Mike Farwick , Klaus Huthmacher , Walter Pfefferle , Thomas Hermann , Brigitte Bathe
IPC分类号： C07H21/02 , C12Q1/68
CPC分类号： C12P13/08 , C07K14/34 , C12N15/77
摘要： The invention provides nucleotide sequences from Coryneform bacteria coding for the dep33 efflux protein and a process for the fermentative preparation of amino acids using bacteria in which the dep33 efflux protein is attenuated.

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