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21. 发明申请

US20070172818A1 Multiparameter FACS assays to detect alterations in cellular parameters and to screen small molecule libraries 审中-公开
标题翻译：多参数FACS测定法检测细胞参数的变化并筛选小分子文库
公开(公告)号：US20070172818A1
公开(公告)日：2007-07-26
申请号：US11636405
申请日：2006-12-07
申请人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
发明人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
IPC分类号： C40B30/06 , C40B40/02 , C40B40/10
CPC分类号： G01N33/5008 , G01N15/147 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N2015/1477 , G01N2015/149
摘要： The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.
摘要翻译：本发明涉及检测细胞或细胞群体中细胞周期调节变化的新方法，并且通过使用多参数测定法和荧光激活细胞分选仪（FACS）机器筛选能够调节细胞周期调节的试剂。

22. 发明申请

US20060184508A1 Methods and system for providing context sensitive information 有权
公开(公告)号：US20060184508A1
公开(公告)日：2006-08-17
申请号：US09681574
申请日：2001-05-01
申请人： Christopher Fuselier , John Dougherty , Joseph Fisher , Thomas Digate , Richard Carpenter , Bernardo Anger
发明人： Christopher Fuselier , John Dougherty , Joseph Fisher , Thomas Digate , Richard Carpenter , Bernardo Anger
IPC分类号： G06F17/30
CPC分类号： G06Q10/06 , Y10S707/99933
摘要： A method and system are described for providing context sensitive data to a system user. The method includes the steps of identifying the user and querying databases to create a user context. Information is aggregated from the network databases and filtered using the user context. Providing the correct data needed by the user for that particular time, location and job function.

23. 发明授权

US06897031B1 Multiparameter FACS assays to detect alterations in exocytosis 失效
标题翻译：多参数FACS测定以检测胞吐的变化
公开(公告)号：US06897031B1
公开(公告)日：2005-05-24
申请号：US09062330
申请日：1998-04-17
申请人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
发明人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
IPC分类号： G01N33/50 , G01N33/569 , G01N33/567
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/5014 , G01N33/502 , G01N33/5047 , G01N33/56966 , G01N2333/43595 , G01N2333/4718
摘要： Described is a method for screening for alterations in exocytosis of a population of cells. The cells are sorted by a FACS machine by assaying for alterations in at least three of the properties selected from the group consisting of light scattering, fluorescent dye uptake, fluorescent dye release, annexin granule binding, surface granule enzyme activity, and the quantity of granule specific proteins. Methods for screening for bioactive agents capable of modulating exocytosis in a cell are also described. The methods provide for reduced background and increased specificity without increasing the time or steps involved in assaying for exocytosis.
摘要翻译：描述了筛选细胞群的胞吐作用的方法。细胞由FACS机通过测定至少三种选自光散射，荧光染料摄取，荧光染料释放，膜联蛋白颗粒结合，表面颗粒酶活性和颗粒数量的性质的变化进行分选特异性蛋白质。还描述了筛选能够调节细胞中胞吐作用的生物活性剂的方法。所述方法提供降低的背景和增加的特异性，而不增加测定胞吐的时间或步骤。

24. 发明授权

US06623980B1 Exo1 and Exo2, exocytotic proteins 有权
标题翻译： Exo1和Exo2，胞吐蛋白
公开(公告)号：US06623980B1
公开(公告)日：2003-09-23
申请号：US09255920
申请日：1999-02-23
申请人： Joseph Fisher , James Lorens , David Anderson , Ying Luo , Chao Bai (Betty) Huang , Mary Shen
发明人： Joseph Fisher , James Lorens , David Anderson , Ying Luo , Chao Bai (Betty) Huang , Mary Shen
IPC分类号： G01N33566
CPC分类号： C07K14/4703
摘要： The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.
摘要翻译：本发明涉及新颖的胞吐多肽，例如Exo1和Exo2多肽及相关分子，其对胞吐作用具有抑制作用，以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。本发明还提供了鉴定介导胞吐多肽生物活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

25. 发明授权

US4947860A Non-invasive method and apparatus for measuring mixed venous carbon dioxide pressure (PvCO.sub.2) and other physiological variables 失效
标题翻译：用于测量混合静脉二氧化碳压力（PvCO2）和其他生理变量的非侵入性方法和装置
公开(公告)号：US4947860A
公开(公告)日：1990-08-14
申请号：US912969
申请日：1986-09-29
申请人： Joseph Fisher
发明人： Joseph Fisher
IPC分类号： A61B5/083 , G01N33/49
CPC分类号： G01N33/4925 , A61B5/0836
摘要： A method of determining the mixed venous PCO.sub.2 (PvCO.sub.2) is disclosed, the method comprising the steps of:(a) measuring the PCO.sub.2 of the gases inhaled and exhaled by the patient under controlled conditions without rebreathing;(b) causing the patient to inhale a test gas containing at least a small concentration of CO.sub.2 and continuing to measure the PCO.sub.2 of the inspired and expired gases, the patient taking at least two breaths without rebreathing;(c) determining the PCO.sub.2 of the inspried gases (P.sub.I CO.sub.2) and the end tidal PCO.sub.2 of expired gases (PECO.sub.2);(d) determing the differences between the end tidal PCO.sub.2 and inspired PCO.sub.2 under control and test conditions, and relating it to the inspired PCO.sub.2 used in the determination of the difference. This relationship can be used to calculate the mixed venous PCO.sub.2.
摘要翻译：公开了一种测定混合静脉PCO2（PvCO2）的方法，所述方法包括以下步骤：（a）测量患者在受控条件下吸入和呼出的气体的PCO2，而无需再呼吸; （b）使患者吸入含有至少少量二氧化碳的测试气体，并继续测量启发和呼气的PCO2，患者至少进行两次呼吸，无需再呼吸; （c）确定呼出气体（PECO2）的气体（PICO2）和末端潮气PCO2的PCO2; （d）在控制和测试条件下确定末端潮汐PCO2和启发PCO2之间的差异，并将其与用于确定差异的灵敏PCO2相关。这种关系可用于计算混合静脉PCO2。

26. 发明申请

US20150082541A1 CONNECTOR AND MEDICAL DEVICE SYSTEM INCORPORATING SAME 审中-公开
标题翻译：连接器和医疗设备系统
公开(公告)号：US20150082541A1
公开(公告)日：2015-03-26
申请号：US14508594
申请日：2014-10-07
申请人： Veso Tijanic , Joseph Fisher , Bryan Kowalchuk , Bryan Drew Miller , Kevin Ramkhelawan , Kevin Kowalchuk , Cliff Ansel , David Dunn , Ludwik Fedorko
发明人： Veso Tijanic , Joseph Fisher , Bryan Kowalchuk , Bryan Drew Miller , Kevin Ramkhelawan , Kevin Kowalchuk , Cliff Ansel , David Dunn , Ludwik Fedorko
IPC分类号： A61G1/04
CPC分类号： A61G1/04 , A61G13/101 , A61G2220/10
摘要： In one aspect, the invention is directed to a connector for connecting a medical device to a support member on a patient support device, such as a stretcher. The connector includes a support member connector that is fixedly connectable to the support member and a device connector for fixedly connecting to the medical device. The device connector is movable relative to the support member connector between a first position wherein the device connector is positioned to hold the medical device adjacent the patient support device and a second position that is inboard of the first position relative to the patient support device.
摘要翻译：一方面，本发明涉及一种用于将医疗装置连接到患者支撑装置（例如担架）上的支撑构件的连接器。连接器包括可固定地连接到支撑构件的支撑构件连接器和用于固定地连接到医疗装置的装置连接器。所述设备连接器可在第一位置和第二位置之间相对于所述支撑构件连接器移动，所述第一位置处于所述设备连接器被定位成将所述医疗设备保持在所述患者支撑设备附近，以及相对于所述患者支撑设备处于所述第一位置的第二位置

27. 发明申请

US20150059744A1 ANESTHETIC DELIVERY SYSTEM 审中-公开
标题翻译： ANESTHETIC交付系统
公开(公告)号：US20150059744A1
公开(公告)日：2015-03-05
申请号：US14389329
申请日：2013-03-28
申请人： Joseph Fisher , James Duffin , Joel Ironstone
发明人： Joseph Fisher , James Duffin , Joel Ironstone
IPC分类号： A61M16/18 , A61M16/08 , A61M16/22 , A61M16/00
CPC分类号： A61M16/183 , A61B5/087 , A61B5/4821 , A61M16/0066 , A61M16/0075 , A61M16/0081 , A61M16/0093 , A61M16/01 , A61M16/024 , A61M16/0833 , A61M16/0891 , A61M16/18 , A61M16/22 , A61M2016/0027 , A61M2016/0039 , A61M2016/102 , A61M2016/1035 , A61M2202/048 , A61M2205/3334 , A61M2205/502 , A61M2230/437 , A61M2202/0007
摘要： An anesthetic delivery system for use in conjunction with an anesthetic return system for reutilizing anesthetic exhaled by a subject, the system including a measurement system operatively connected to a breathing circuit for continuously measuring at least one flow parameter and anesthetic content of a gas stream reaching the subject and a control system for receiving input from the measurement system and controlling the amount of anesthetic entering the system, the control system including an input device for inputting a setting that corresponds to a desired amount of anesthetic in the gas stream reaching the subject, and utilizing a control algorithm for controlling the amount of anesthetic entering the system based on said desired amount of anesthetic, and flow and anesthetic content parameters as determined by the measurement system, such that the control algorithm is adapted to supplement anesthetic already in gas stream flowing to the subject to attain a level of anesthetic reaching the subject that correspond to the desired amount set via the input device.
摘要翻译：一种与麻醉返回系统结合使用以麻醉受试者呼出的麻醉剂的麻醉剂递送系统，该系统包括可操作地连接到呼吸回路的测量系统，用于连续地测量至少一个流动参数和到达主体和用于接收来自测量系统的输入并控制进入系统的麻醉剂的量的控制系统，所述控制系统包括用于输入对应于到达对象的气流中的期望量的麻醉剂的设定的输入装置，以及利用控制算法来控制基于所述所需量的麻醉剂进入系统的麻醉剂的量，以及由测量系统确定的流量和麻醉剂含量参数，使得控制算法适于补充已经在气流中流动的麻醉剂达到一定程度的麻醉剂铰接对应于通过输入装置设定的期望量的对象。

28. 发明授权

US08460202B2 Method of measuring cardiac related parameters non-invasively via the lung during spontaneous and controlled ventilation 失效
标题翻译：在自发和受控通气期间通过肺非侵入性测量心脏相关参数的方法
公开(公告)号：US08460202B2
公开(公告)日：2013-06-11
申请号：US10545562
申请日：2004-02-18
申请人： Joseph Fisher , David Preiss , Takafumi Asami , Alex Vesely , Eltan Prisman , Ron Somogyi , Steve Iscoe
发明人： Joseph Fisher , David Preiss , Takafumi Asami , Alex Vesely , Eltan Prisman , Ron Somogyi , Steve Iscoe
IPC分类号： A61B5/08
CPC分类号： A61B5/0205 , A61B5/083 , A61B5/14551 , A61B5/7225 , A61B5/7278 , A61M16/08 , A61M16/0833 , A61M16/085 , A61M16/0858 , A61M16/202 , A61M16/205 , A61M16/206 , A61M16/208 , A61M16/22
摘要： An apparatus to measure cardiac output (Q) and other parameters such as alveolar ventilation (VA), minute CO2 elimination from the lung (VCO2), minute oxygen consumption (VO2), oxygenated mixed venous partial pressure of CO2, (PvCO2-oxy), true mixed venous partial pressure of CO2(PvCO2), PaCO2, mixed venous oxygen saturation (SvO2), pulmonary shunt, and anatomical dead space, consisting of: a) a breathing circuit with characteristics that: i. on exhalation, exhaled gas is kept substantially separate from inhaled gas; ii. on inhalation, when VE is greater than FGS flow, the subject inhales FGS first and then inhales a gas that is substantially SGS, for the balance of inhalation; b) gas sensor means for monitoring gas concentrations at the patient-circuit interface c) a first gas set (FGS), and a second gas set (SGS), said second gas set which may comprise previously exhaled gases or exogenous gases or both d) a gas flow control means for controlling the rate of FGS flow into the breathing circuit e) means to identify phase of breathing, said means may consist of pressure sensors or analysis of signal generated by gas sensors or other means known to those skilled in the art; f) machine intelligence consisting of a computer or logic circuit capable of controlling the gas flow control means, receiving the output of the gas sensor means and means to identify phase of breathing, and performing the calculations for measuring cardiac output and other parameters as outlined in the disclosure.
摘要翻译：测量心输出量（Q）和其他参数如肺泡通气（VA），从肺中消除二氧化碳（VCO2），微量氧消耗（VO2），氧合混合静脉分压CO2（PvCO2-氧），真正的混合静脉分压二氧化碳（PvCO2），PaCO2，混合静脉血氧饱和度（SvO2），肺动脉分流和解剖死空间组成：a）具有以下特征的呼吸回路：在呼气时，呼出气体与吸入气体基本分离; ii。吸入时，当VE大于FGS流量时，受试者首先吸入FGS，然后吸入基本上为SGS的气体，用于吸入余量; b）用于监测患者 - 电路接口处的气体浓度的气体传感器装置c）第一气体组（FGS）和第二气体组（SGS），所述第二气体组可以包括先前呼出的气体或外来气体或二者）用于控制FGS流入呼吸回路的速率的气体流量控制装置e）识别呼吸相位的装置，所述装置可包括压力传感器或由气体传感器产生的信号分析或本领域技术人员已知的其它装置艺术; f）机器智能，包括能够控制气体流量控制装置的计算机或逻辑电路，接收气体传感器装置的输出和识别呼吸相位的装置，以及执行用于测量心输出量和其他参数的计算，如披露。

29. 发明授权

US08334238B2 Multiparameter FACS assays to detect alterations in cellular parameters and to screen small molecule libraries 有权
标题翻译：多参数FACS测定法检测细胞参数的变化并筛选小分子文库
公开(公告)号：US08334238B2
公开(公告)日：2012-12-18
申请号：US09293670
申请日：1999-04-16
申请人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
发明人： Joseph Fisher , James Lorens , Donald Payan , Alexander Rossi
IPC分类号： C40B20/08 , G01N33/574
CPC分类号： G01N33/5008 , G01N15/147 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5044 , G01N2015/1477 , G01N2015/149
摘要： The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.
摘要翻译：本发明涉及检测细胞或细胞群体中细胞周期调节变化的新方法，并且通过使用多参数测定法和荧光激活细胞分选仪（FACS）机器筛选能够调节细胞周期调节的试剂。

30. 发明授权

US08283555B2 Photovoltaic solar power generation system with sealed evaporative cooling 失效
标题翻译：光伏太阳能发电系统采用密封蒸发冷却
公开(公告)号：US08283555B2
公开(公告)日：2012-10-09
申请号：US13056197
申请日：2009-06-23
申请人： Yuri Kokotov , Michael A. Reyz , Joseph Fisher
发明人： Yuri Kokotov , Michael A. Reyz , Joseph Fisher
IPC分类号： H01L31/024
CPC分类号： H01L31/0521 , F24S10/90 , F24S20/70 , F24S23/70 , Y02E10/44 , Y02E10/47 , Y02E10/50
摘要： A solar power generation system includes a plurality of individual modules, each formed from a photovoltaic cell, a solar concentrator, a sealed evaporative cooling system and a heat sink. The solar concentrator focuses sunlight onto a front side the cell to generate electricity. The cooling system circulates a coolant in a liquid state to an evaporative cooling chamber having a wall defined at least partially by a back side of the cell to remove heat from the cell by direct contact between the coolant and the cell, and emits coolant in a vapor state to a condenser where the vapor coolant is condensed to a liquid state. The heat sink may be any suitable body of water, such that the condenser may be at least partially submerged therein. The modules are combined to form a platform that is rotated on the body of water by a drive device to provide tracking of the sun.
摘要翻译：太阳能发电系统包括由光伏电池，太阳能集中器，密封蒸发冷却系统和散热器形成的多个单独模块。太阳能集中器将阳光聚焦在电池的正面以发电。冷却系统将液体状态的冷却剂循环到蒸发冷却室，该蒸发冷却室具有至少部分地由电池的背面限定的壁，以通过冷却剂和电池之间的直接接触从电池中除去热量，并且在蒸汽状态到冷凝器，其中蒸汽冷却剂被冷凝成液态。散热器可以是任何合适的水体，使得冷凝器可以至少部分地浸没在其中。模块组合形成一个平台，该平台通过驱动装置在水体上旋转以提供对太阳的跟踪。

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