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    • 21. 发明授权
    • Process for preparing high-melting chenodeoxycholic acid
    • 制备高熔点鹅脱氧胆酸的方法
    • US4213911A
    • 1980-07-22
    • US958508
    • 1978-11-07
    • Michael C. AttwellThomas F. MassiahRoberto A. VergottiniPeter Ziegler
    • Michael C. AttwellThomas F. MassiahRoberto A. VergottiniPeter Ziegler
    • C07J9/00
    • C07J9/005
    • A process for preparing a high-melting form of CDCA having a melting point of at least about 160.degree. C. is disclosed which comprises the steps of:(a) suspending at least one form of CDCA having a melting point of below 160.degree. C. in a non-aromatic liquid hydrocarbon, preferably cyclohexane, to form a suspension having a boiling point of at least 65.degree. C.;(b) heating the suspension to a sufficiently high temperature of between about 65.degree. and about 140.degree. C., preferably between about 75.degree. and about 100.degree. C., during a sufficiently long period of time for converting substantially all of the CDCA into the high-melting form;(c) recovering the high-melting form of CDCA from the suspension.Low-melting amorphous and/or crystalline forms of CDCA, as well as CDCA-solvent inclusion complexes can be treated in the above-described process. The high-melting CDCA is obtained in form of a substantially granular powder, which is suitable to be formulated into therapeutical compositions.
    • 公开了一种制备熔点至少为约160℃的高熔点形式的CDCA的方法,其包括以下步骤:(a)将至少一种形式的熔点低于160℃的CDCA悬浮 在非芳族液体烃,优选环己烷中,形成沸点至少为65℃的悬浮液。 (b)在足够长的时间内将悬浮液加热至约65℃至约140℃,优选约75℃至约100℃的足够高的温度,以将基本上所有的CDCA转化为 高熔点形式; (c)从悬浮液中回收高熔点形式的CDCA。 可以在上述方法中处理低熔点无定形和/或结晶形式的CDCA,以及CDCA-溶剂包合物。 获得高熔点CDCA,其形式为基本上粒状粉末,其适于配制成治疗组合物。
    • 25. 发明申请
    • Modular Testing Plant
    • 模块化测试厂
    • US20090077904A1
    • 2009-03-26
    • US12087648
    • 2006-12-21
    • Peter ZieglerChristoph Schmidt
    • Peter ZieglerChristoph Schmidt
    • E04H5/02E04B1/00
    • E04B1/3483E04B2001/34892
    • A modular testing plant comprising at least two building modules which are designed as transportable containers and which each have two side walls and two transverse walls connecting the side walls, wherein at least one building module having a length L2 and a width B2 and designed as a first testing module for receiving a test item is provided, and at least one building module having a length L4 and a width B4 and designed as a first supply module for receiving supply technology is provided, wherein the first supply module is arranged above the first testing module and the length L4 is less than the length L2. To complete the testing plant, at least a third building module designed as a first testing technology module for receiving testing technology is provided, wherein the first testing technology module has two side walls, two transverse walls connecting the side walls, a length L3 and a width B3, wherein the first testing technology module can be placed, in respect of the side wall, laterally next to the first testing module against the side wall, and the width B4 is at least 20% less than the width B2 or B3, which means that the ratio of B4/B2 or the ratio of B4/B3 is at most 2/2.5.
    • 模块化测试设备包括至少两个建筑模块,其被设计为可运输的容器,并且每个具有两个侧壁和连接侧壁的两个横向壁,其中至少一个具有长度L2和宽度B2的建筑模块被设计为 提供了用于接收测试项目的第一测试模块,并且提供了具有长度L4和宽度B4并被设计为用于接收供应技术的第一供应模块的至少一个构建模块,其中,第一供应模块被布置在第一测试 模块,长度L4小于长度L2。 为了完成测试工厂,提供了至少第三建筑模块,被设计成用于接收测试技术的第一测试技术模块,其中第一测试技术模块具有两个侧壁,连接侧壁的两个横向壁,长度L3和 宽度B3,其中所述第一测试技术模块可相对于所述侧壁相对于所述侧壁横向放置在所述第一测试模块的旁边,并且所述宽度B4比所述宽度B2或B3小至少20% 意味着B4 / B2的比例或B4 / B3的比率至多为2 / 2.5。
    • 26. 发明授权
    • Chenodeoxycholic acid recovery process
    • 去氧胆酸恢复过程
    • US4186143A
    • 1980-01-29
    • US932176
    • 1978-08-09
    • Peter ZieglerMichael C. AttwellThomas F. MassiahRoberto A. Vergottini
    • Peter ZieglerMichael C. AttwellThomas F. MassiahRoberto A. Vergottini
    • C07J9/00
    • C07J9/005
    • A method of isolating chenodeoxycholic acid from hog bile is provided, which comprises the steps of treating the hog bile under saponifying conditions separating the bile acids from the water-soluble constituents of the saponified bile; esterifying the bile acids to obtain a mixture of bile acid esters; isolating from the mixture of bile acid esters the hyodeoxycholic acid ester as its adduct with a compound selected from the group consisting of benzene and toluene; treating the remaining bile acid esters under acetylating conditions; isolating the hyocholic acid ester triacetate; isolating the chenodeoxycholic acid ester diacetate; treating the chenodeoxycholic acid ester diacetate under saponifying conditions; isolating the chenodeoxycholic acid thus obtained; and, optionally purifying the chenodeoxycholic acid.The method described yields chenodeoxycholic acid of exceedingly high purity, which may be used in the treatment of gallstones by their dissolution in vivo.
    • 提供了从猪胆中分离鹅脱氧胆酸的方法,其包括在皂化条件下将胆汁酸与皂化胆汁的水溶性成分分离的步骤: 酯化胆汁酸以获得胆汁酸酯的混合物; 从胆汁酸酯的混合物中分离猪脱氧胆酸酯作为其加合物与选自苯和甲苯的化合物; 在乙酰化条件下处理剩余的胆汁酸酯; 隔离天holic酸酯三醋酸酯; 分离鹅脱氧胆酸酯二乙酸酯; 在皂化条件下处理鹅脱氧胆酸酯二乙酸酯; 分离由此获得的鹅脱氧胆酸; 和任选地纯化鹅脱氧胆酸。 所述方法得到具有非常高纯度的鹅脱氧胆酸,其可用于通过其在体内溶解来治疗胆结石。
    • 28. 发明授权
    • Drill hammer
    • 钻锤
    • US6112830A
    • 2000-09-05
    • US435349
    • 1999-11-08
    • Peter ZieglerStephan Kuchinke
    • Peter ZieglerStephan Kuchinke
    • B23B45/16B25D16/00B25D17/24B25D11/04
    • B25D16/00B25D17/24B25D2211/061B25D2217/0088
    • The invention concerns a drill hammer having an air cushion percussion mechanism with which an energizing bushing (24) is disposed concentric to the drill tool axis (10) and forms a cavity (26) containing the air cushion in which a percussion piston (28) can move back and forth, and with a wobble drive device (34) for moving the energizing bushing (24) back and forth in the direction of the drill tool axis (10), the rotation element (36) of which driving the nutating disk (42) being disposed for rotational drive parallel to the drill tool axis (10) at a separation therefrom. In order to increase the smoothness of running of the drill hammer, a weight (50) is disposed under restrictive guidance for linear back and forth motion parallel to the drill tool axis (10) in response to the action of the nutating disk (42), at that side of the nutating disk (42) lying diametrically across from the energizing bushing (24).
    • 本发明涉及一种具有气垫冲击机构的钻锤,其中通电衬套(24)与钻杆工具轴线(10)同心地设置并形成容纳气垫的空腔(26),冲击活塞(28) 可以前后移动,并且通过摆动驱动装置(34),用于沿着钻具工具轴线(10)的方向前后移动激励衬套(24),其旋转元件(36)驱动章动盘 (42)设置成与其分离时平行于钻具轴线(10)旋转驱动。 为了增加钻锤的运行平稳度,在限制性引导下,响应于章动盘(42)的作用,平衡于钻具轴线(10)的直线前后运动设置重物(50) 在止动盘(42)的与激励衬套(24)直径相对的侧面上。