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21. 发明申请

US20080294232A1 MAGNETIC CELL DELIVERY 审中-公开
标题翻译：磁性细胞传递
公开(公告)号：US20080294232A1
公开(公告)日：2008-11-27
申请号：US12121774
申请日：2008-05-15
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61F2/06 , A61N2/00
CPC分类号： A61F2/90 , A61B5/06 , A61B5/4839 , A61B6/12 , A61F2210/009 , A61K9/0019 , A61K9/5094
摘要： Systems and methods of delivering magnetically loaded cells to target areas within a patient are described. Cells rendered magnetically attractable by being loaded with magnetic microparticles are delivered from a hollow interventional device distal tip and attracted towards a previously placed implant. Implants, such as stents, are magnetized by application of a magnetic field sequence; magnetized cells are attracted by the local magnetic domains and associated field gradients within the implant, and adhere to and are retained by the local tissues, such as tissue protrusions through a stent struts. Application of a magnetic field or field gradient sequence concurrently with the magnetic cell delivery facilitates pulling the cells away from the lumen axis and towards the implant surface and vessel or organ walls.
摘要翻译：描述了将磁负载细胞递送到患者内的目标区域的系统和方法。通过装载磁性微粒而呈磁力吸引的细胞从中空的介入装置远端引出并被吸引到先前放置的植入物上。植入物，如支架，通过施加磁场序列被磁化; 磁化的细胞被植入物内的局部磁畴和相关的场梯度吸引，并且粘附并被局部组织保留，例如通过支架支柱的组织突起。与磁性细胞递送同时施加磁场或场梯度序列有助于将细胞从管腔轴向并且朝向植入物表面和血管或器官壁延伸。

22. 发明申请

US20080200913A1 Single Catheter Navigation for Diagnosis and Treatment of Arrhythmias 审中-公开
标题翻译：单导管导航用于诊断和治疗心律失常
公开(公告)号：US20080200913A1
公开(公告)日：2008-08-21
申请号：US12023020
申请日：2008-01-30
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B34/10 , A61B34/73 , A61B2018/00351 , A61B2018/00839
摘要： A method of conducting a therapeutic ablation of cardiac tissue based upon local electrical signals in the tissue. The method includes navigating at least one electrophysiology catheter to a plurality of locations on the surface of the heart using a remote navigation system; sensing the electrical activity in the heart tissue at a plurality of the locations in the heart; and storing a value representative of the control variables of the remote navigation system at the location and a value representative of the electrical signal at the location; displaying a representation of at least some of the locations where the electrical activity was sensed on a display using graphic indicators of the timing of the sensed activity relative to the reference; determining the location at which the sensed electrical activity is earliest relative to a reference electrocardiogram signal; and automatically navigating an electrophysiology catheter to a position relative to selected location, and ablating tissue at the location with the electrophysiology catheter.
摘要翻译：基于组织中的局部电信号进行心脏组织治疗性消融的方法。该方法包括使用远程导航系统将至少一个电生理学导管导航到心脏表面上的多个位置; 感测心脏中多个位置处的心脏组织中的电活动; 以及将表示所述远程导航系统的控制变量的值存储在所述位置处，并且在所述位置处存储代表所述电信号的值; 使用感测到的活动的相对于参考的定时的图形指示来显示在显示器上感测到电活动的至少一些位置的表示; 确定所感测的电活动相对于参考心电图信号最早的位置; 并且将电生理导管自动导航到相对于所选位置的位置，以及用所述电生理学导管在所述位置处消融组织。

23. 发明申请

US20080064933A1 Workflow driven display for medical procedures 有权
标题翻译：用于医疗程序的工作流驱动显示
公开(公告)号：US20080064933A1
公开(公告)日：2008-03-13
申请号：US11801123
申请日：2007-05-09
申请人： Jeffrey M. Garibaldi , Walter M. Blume , Nathan Kastelein , Raju R. Viswanathan
发明人： Jeffrey M. Garibaldi , Walter M. Blume , Nathan Kastelein , Raju R. Viswanathan
IPC分类号： A61B5/00
CPC分类号： A61B5/7475 , A61B5/021 , A61B5/0402 , A61B6/00 , A61B6/02 , A61B6/463 , A61B6/467 , A61B6/468 , A61B6/547 , A61B6/566 , A61B8/00 , A61B8/463 , A61B8/465 , A61B8/467 , A61B8/5238 , A61B8/56 , A61B8/565 , A61B34/20 , A61B34/25 , A61B90/36 , A61B2017/00017 , A61B2017/00199 , A61B2034/2051 , A61B2034/252 , A61B2034/254 , A61B2090/376 , G16H40/63
摘要： A display for operating a plurality of separate computer systems, each having a visual display. The display includes comprising a composite display, a video system for receiving display input from each of the plurality of separate computer systems and displaying it on the composite display, a processor which controls the content of the composite display based upon a planned procedure workflow.
摘要翻译：一种用于操作多个单独的计算机系统的显示器，每个都具有视觉显示器。显示器包括复合显示器，用于从多个单独的计算机系统中的每一个接收显示输入并将其显示在复合显示器上的视频系统，基于计划过程工作流程来控制复合显示器的内容的处理器。

24. 发明授权

US07190819B2 Image-based medical device localization 失效
标题翻译：基于图像的医疗器械定位
公开(公告)号：US07190819B2
公开(公告)日：2007-03-13
申请号：US10977488
申请日：2004-10-29
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/00 , G06K2209/05 , G06T7/12 , G06T7/136 , G06T7/44 , G06T2207/10121 , G06T2207/30021
摘要： A method of identifying an elongate medical device in a two-dimensional image of an operating region includes filtering pixels meeting a predetermined intensity requirement for linear scaling, dividing the filtered pixels into groups of contiguous pixels, and selecting from the groups a group corresponding to the medical device.
摘要翻译：识别操作区域的二维图像中的细长医疗装置的方法包括满足线性缩放的预定强度要求的滤波像素，将经滤波的像素划分成连续像素组，并且从组中选择对应于医疗装置。

25. 发明授权

US08806359B2 Workflow driven display for medical procedures 有权
标题翻译：用于医疗程序的工作流驱动显示
公开(公告)号：US08806359B2
公开(公告)日：2014-08-12
申请号：US11801123
申请日：2007-05-08
申请人： Jeffrey M. Garibaldi , Walter M. Blume , Nathan Kastelein , Raju R. Viswanathan
发明人： Jeffrey M. Garibaldi , Walter M. Blume , Nathan Kastelein , Raju R. Viswanathan
IPC分类号： G06F3/048
CPC分类号： A61B5/7475 , A61B5/021 , A61B5/0402 , A61B6/00 , A61B6/02 , A61B6/463 , A61B6/467 , A61B6/468 , A61B6/547 , A61B6/566 , A61B8/00 , A61B8/463 , A61B8/465 , A61B8/467 , A61B8/5238 , A61B8/56 , A61B8/565 , A61B34/20 , A61B34/25 , A61B90/36 , A61B2017/00017 , A61B2017/00199 , A61B2034/2051 , A61B2034/252 , A61B2034/254 , A61B2090/376 , G06F19/00 , G16H40/63
摘要： A display for operating a plurality of separate computer systems, each having a visual display. The display includes comprising a composite display, a video system for receiving display input from each of the plurality of separate computer systems and displaying it on the composite display, a processor which controls the content of the composite display based upon a planned procedure workflow.
摘要翻译：一种用于操作多个单独的计算机系统的显示器，每个都具有视觉显示器。显示器包括复合显示器，用于从多个单独的计算机系统中的每一个接收显示输入并将其显示在复合显示器上的视频系统，基于计划过程工作流程来控制复合显示器的内容的处理器。

26. 发明授权

US08799792B2 Workflow driven method of performing multi-step medical procedures 有权
标题翻译：执行多步骤医疗程序的工作流驱动方法
公开(公告)号：US08799792B2
公开(公告)日：2014-08-05
申请号：US11801121
申请日：2007-05-08
申请人： Jeffrey M. Garibaldi , Walter M. Blume , Nathan Kastelein , Raju R. Viswanathan
发明人： Jeffrey M. Garibaldi , Walter M. Blume , Nathan Kastelein , Raju R. Viswanathan
IPC分类号： G06F3/00
CPC分类号： A61B5/7475 , A61B5/021 , A61B5/0402 , A61B6/00 , A61B6/02 , A61B6/463 , A61B6/467 , A61B6/468 , A61B6/547 , A61B6/566 , A61B8/00 , A61B8/463 , A61B8/465 , A61B8/467 , A61B8/5238 , A61B8/56 , A61B8/565 , A61B34/20 , A61B34/25 , A61B90/36 , A61B2017/00017 , A61B2017/00199 , A61B2034/2051 , A61B2034/252 , A61B2034/254 , A61B2090/376 , G06F19/00 , G16H40/63
摘要： A work flow driven method of performing multi-step medical procedures includes displaying the visual displays from separate computer controlled systems on a composite display, and displaying prompts for a plurality of steps of the multi-step medical procedure, and in response to user selection from the prompts, automatically reconfiguring the composite display based in part on the selection. Alternatively the display can be changed in response to user actions other than selection. In other embodiments, the composite display can change automatically to match a planned work flow.
摘要翻译：执行多步骤医疗程序的工作流驱动方法包括在复合显示器上显示来自分开的计算机控制系统的视觉显示，并显示多步骤医疗程序的多个步骤的提示，以及响应于来自提示，部分基于选择自动重新配置复合显示。或者，可以响应于除选择之外的用户动作来改变显示。在其他实施例中，复合显示器可以自动地改变以匹配计划的工作流程。

27. 发明授权

US08721655B2 Efficient closed loop feedback navigation 有权
标题翻译：高效闭环反馈导航
公开(公告)号：US08721655B2
公开(公告)日：2014-05-13
申请号：US10879694
申请日：2004-06-29
申请人： Raju R. Viswanathan , Walter M. Blume
发明人： Raju R. Viswanathan , Walter M. Blume
IPC分类号： A61F11/00
CPC分类号： A61B6/12 , A61B1/00147 , A61B6/4441 , A61B6/463 , A61B6/466 , A61B6/5235 , A61B17/22 , A61B34/20 , A61B34/25 , A61B34/70 , A61B34/73 , A61B90/00 , A61B90/10 , A61B90/36 , A61B2017/003 , A61B2018/00839 , A61B2034/107 , A61B2034/2051 , A61B2034/733 , A61B2090/376 , A61B2090/3954 , A61M25/0108
摘要： The present invention provides a means for guiding a medical device within the body to approach a target destination. The system and method provide a means for determining a predicted length and orientation, navigating the device to an intermediate point less than the predicted length, determining an error between the projected destination and actual target destination, and successively updating a predicted value of a control variable to yield an orientation within a predetermined distance error before advancing the device the remaining distance to the destination. This provides a physician with the capability of verifying the device will be accurately guided to the target destination without trial and error. A method is also provided for intuitive navigation to targets with limited trial and error based on user-applied device orientation adjustments, where the user chooses the magnitude of the adjustments and the system determines the adjustment direction.
摘要翻译：本发明提供一种用于引导身体内的医疗装置接近目标目的地的装置。该系统和方法提供了一种用于确定预测长度和方向的装置，将设备导航到小于预测长度的中间点，确定投影目的地与实际目标目的地之间的误差，并且连续更新控制变量的预测值以在将设备的剩余距离提前到目的地之前产生在预定距离误差内的取向。这为医师提供了验证设备将能够被准确地引导到目标目的地的尝试和错误的能力。还提供了一种方法，用于基于用户应用的设备方向调整，用于直观地导航到具有有限尝试和错误的目标，其中用户选择调整的大小并且系统确定调整方向。

28. 发明授权

US08369934B2 Contact over-torque with three-dimensional anatomical data 有权
标题翻译：接触过扭矩与三维解剖数据
公开(公告)号：US08369934B2
公开(公告)日：2013-02-05
申请号：US12830708
申请日：2010-07-06
申请人： Raju R. Viswanathan
发明人： Raju R. Viswanathan
IPC分类号： A61B5/055 , A61B19/00
CPC分类号： A61B1/00158 , A61B5/042 , A61B5/06 , A61B5/1076 , A61B5/6885 , A61B34/73
摘要： A method is provided for establishing contact of a medical device against a three-dimensional surface geometry within a subject body, the method comprising obtaining a three-dimensional tissue surface geometry of an anatomical region within the subject body, obtaining a target location on the surface for the device to contact, determining local surface geometry information in a neighborhood of the target location, and using this information to determine a change of at least one control variable for effecting an over-torque of the medical device to enhance contact of the device with the target surface.
摘要翻译：提供了一种用于建立医疗装置与受试者体内的三维表面几何形状的接触的方法，所述方法包括获得所述对象体内的解剖区域的三维组织表面几何形状，获得所述表面上的目标位置用于使所述设备接触，确定所述目标位置附近的局部表面几何信息，以及使用所述信息来确定至少一个控制变量的变化，以实现所述医疗设备的过扭矩以增强所述设备与目标表面。

29. 发明授权

US08348858B2 Stent delivery guide wire 有权
标题翻译：支架输送导丝
公开(公告)号：US08348858B2
公开(公告)日：2013-01-08
申请号：US11325680
申请日：2006-01-04
申请人： Raju R. Viswanathan , Jonathan C. Sell
发明人： Raju R. Viswanathan , Jonathan C. Sell
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61F2/958 , A61F2002/9583 , A61F2210/009 , A61M25/0127
摘要： A guide wire for magnetically navigating a medical device through in a subject's body comprising an elongate wire having a proximal and distal end, a portion adjacent the distal end that is more flexible than the more proximal portions of the elongate wire, and a first magnetically responsive element on the distal end of the elongate wire. The guide wire further comprises one or more magnetically responsive elements spaced apart from the first magnetically responsive element and disposed on the more flexible portion of the elongate wire. The guide wire provides for bending or deflecting the distal end of the stent, to provide easier navigation of the distal end of the guide wire and the stent through the vasculature of a subject body.
摘要翻译：一种用于磁性导航医疗装置通过被检体的引导线，包括具有近端和远端的细长线，与远端相邻的部分比细长线的较近端部更柔性，以及第一磁性响应细长丝线的远端上的元件。引导线还包括一个或多个与第一磁响应元件间隔开的并且设置在细长线的更柔性部分上的磁响应元件。引导线用于弯曲或偏转支架的远端，以便通过主体的脉管系统提供引导线和支架远端的更容易的导航。

30. 发明授权

US08135185B2 Location and display of occluded portions of vessels on 3-D angiographic images 有权
标题翻译： 3-D血管造影图像上血管闭塞部位的位置和显示
公开(公告)号：US08135185B2
公开(公告)日：2012-03-13
申请号：US11874895
申请日：2007-10-18
申请人： Walter M. Blume , Jeffrey M. Garibaldi , Heather Drury , Raju R. Viswanathan
发明人： Walter M. Blume , Jeffrey M. Garibaldi , Heather Drury , Raju R. Viswanathan
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B6/481 , G06T7/73 , G06T2207/10116 , G06T2207/20101 , G06T2207/30101 , G06T2207/30172 , Y10S128/92 , Y10S128/921 , Y10S128/922 , Y10S128/923 , Y10S128/924
摘要： A method of finding the location of an occluded portion of a blood vessel relative to a three-dimensional angiographic image of a subject's vasculature includes identifying the location of the occluded portion of the blood vessel on each of a series of displayed two dimensional images derived from the three dimensional image data in planes substantially transverse to direction of the occluded portion of the vessel. The identified locations in the occluded portion of the vessel can then be used to determine the path of the occluded portion of the vessel.
摘要翻译：找到相对于受试者脉管系统的三维血管造影图像的血管的封闭部分的位置的方法包括在从一个或多个第二个图像中导出的一系列显示的二维图像中的每一个上识别血管的封闭部分的位置基本上横向于容器的封闭部分的方向的平面中的三维图像数据。然后可以使用容器闭塞部分中的识别位置来确定容器的封闭部分的路径。

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