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21. 发明申请

US20050124565A1 Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics 审中-公开
公开(公告)号：US20050124565A1
公开(公告)日：2005-06-09
申请号：US10873853
申请日：2004-06-21
申请人： John Diener , David Epstein , Alicia Ferguson , Dilara Grate , Anthony Keefe , Thomas McCauley , Jeffrey Preiss , Martin Stanton , Charles Wilson
发明人： John Diener , David Epstein , Alicia Ferguson , Dilara Grate , Anthony Keefe , Thomas McCauley , Jeffrey Preiss , Martin Stanton , Charles Wilson
IPC分类号： A61K48/00 , C07H21/04 , C12N15/85
CPC分类号： A61K48/00 , C07H21/04 , C12N15/85
摘要： Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.

22. 发明申请

US20050105679A1 Tomosynthesis imaging system and method 有权
标题翻译：系统合成成像系统及方法
公开(公告)号：US20050105679A1
公开(公告)日：2005-05-19
申请号：US10776690
申请日：2004-02-11
申请人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel Kopans , Richard Moore
发明人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel Kopans , Richard Moore
IPC分类号： A61B6/00 , A61B6/03 , G01N23/04 , G06T11/00 , G21K1/12 , G01N23/00 , H05G1/60
CPC分类号： G06T11/006 , A61B6/025 , A61B6/502 , A61B6/583 , G01N23/04 , G06T2211/424 , G06T2211/436
摘要： A system for three-dimensional tomosynthesis imaging of a target element is provided having an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element. The system can gain further accuracy where the iterative reconstruction algorithm is applied using cone-beam forward projection and back projection.
摘要翻译：提供了具有图像采集元件和处理器的目标元件的三维断层合成成像系统。图像采集元件从多个角度获得目标元件的多个图像，并且包括可相对于目标元件以多个角度定位的辐射源和放射线检测器。放射线检测器被定位成检测通过目标元件的辐射源发射的辐射，并确定用于通过目标元件的辐射的多个衰减值，以建立用于特定辐射源的目标元件的辐射吸收投影图像角度。处理器被配置为对从多个辐射源角度获得的目标元件的辐射吸收投影图像应用迭代重建算法，以产生目标元素的三维重建。在使用锥束前向投影和反投影应用迭代重建算法的情况下，系统可以获得进一步的准确性。

23. 发明申请

US20090053138A1 Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics 审中-公开
标题翻译：稳定的血小板衍生生长因子及其作为肿瘤学治疗的用途
公开(公告)号：US20090053138A1
公开(公告)日：2009-02-26
申请号：US11666954
申请日：2005-11-02
申请人： Jeffrey Preiss , Charles Wilson , Martin Stanton , John Diener , David Epstein , Dilara McCauley , Thomas McCauley
发明人： Jeffrey Preiss , Charles Wilson , Martin Stanton , John Diener , David Epstein , Dilara McCauley , Thomas McCauley
IPC分类号： A61K49/00 , C07H21/04 , A61P35/00 , A61K31/711
CPC分类号： C12N15/115 , A61K31/711 , A61K47/549 , A61K47/60 , C07H21/04 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/3521
摘要： Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
摘要翻译：提供材料和方法用于生产和使用适配体作为能够以亲和力和特异性结合PDGF，PDGF同种型，PDGF受体，VEGF和/或VEGF受体或其任何组合的肿瘤学治疗剂。本发明的组合物特别可用于实体瘤治疗，并且可以单独使用或与已知的细胞毒剂组合用于治疗实体瘤。还公开了具有一个或多个CpG基序嵌入其中或附着于其上的适体。

24. 发明授权

US07356113B2 Tomosynthesis imaging system and method 有权
标题翻译：系统合成成像系统及方法
公开(公告)号：US07356113B2
公开(公告)日：2008-04-08
申请号：US10776690
申请日：2004-02-11
申请人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
发明人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
IPC分类号： A61B6/02
CPC分类号： G06T11/006 , A61B6/025 , A61B6/502 , A61B6/583 , G01N23/04 , G06T2211/424 , G06T2211/436
摘要： A system for three-dimensional tomosynthesis imaging of a target element includes an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element.
摘要翻译：用于目标元件的三维断层合成成像的系统包括图像采集元件和处理器。图像采集元件从多个角度获得目标元件的多个图像，并且包括可相对于目标元件以多个角度定位的辐射源和放射线检测器。放射线检测器被定位成检测通过目标元件的辐射源发射的辐射，并确定用于通过目标元件的辐射的多个衰减值，以建立用于特定辐射源的目标元件的辐射吸收投影图像角度。处理器被配置为对从多个辐射源角度获得的目标元件的辐射吸收投影图像应用迭代重建算法，以产生目标元素的三维重建。

25. 发明申请

US20080232545A1 TOMOSYNTHESIS IMAGING SYSTEM AND METHOD 审中-公开
标题翻译： TOMOSYNTHESIS成像系统和方法
公开(公告)号：US20080232545A1
公开(公告)日：2008-09-25
申请号：US12099416
申请日：2008-04-08
申请人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
发明人： Tao Wu , Alex Stewart , Martin Stanton , Walter Phillips , Daniel B. Kopans , Richard Moore
IPC分类号： A61B6/00
CPC分类号： G06T11/006 , A61B6/025 , A61B6/502 , A61B6/583 , G01N23/04 , G06T2211/424 , G06T2211/436
摘要： A system for three-dimensional tomosynthesis imaging of a target element is provided having an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation source that is positionable at a plurality of angles with respect to the target element and a radiation detector. The radiation detector is positioned so as to detect radiation emitted by the radiation source passing through the target element and determine a plurality of attenuation values for radiation passing through the target element to establish a radiation absorbance projection image of the target element for a particular radiation source angle. The processor is configured to apply an iterative reconstruction algorithm to the radiation absorbance projection images of the target element obtained from a plurality of radiation source angles to generate a three-dimensional reconstruction of the target element. The system can gain further accuracy where the iterative reconstruction algorithm is applied using cone-beam forward projection and back projection.
摘要翻译：提供了具有图像采集元件和处理器的目标元件的三维断层合成成像系统。图像采集元件从多个角度获得目标元件的多个图像，并且包括可相对于目标元件以多个角度定位的辐射源和放射线检测器。放射线检测器被定位成检测通过目标元件的辐射源发射的辐射，并确定通过目标元件的辐射的多个衰减值，以建立用于特定辐射源的目标元件的辐射吸收投影图像角度。处理器被配置为对从多个辐射源角度获得的目标元件的辐射吸收投影图像应用迭代重建算法，以产生目标元素的三维重建。在使用锥束前向投影和反投影应用迭代重建算法的情况下，系统可以获得进一步的准确性。

26. 发明授权

US07125660B2 Nucleic acid sensor molecules and methods of using same 失效
标题翻译：核酸传感器分子及其使用方法
公开(公告)号：US07125660B2
公开(公告)日：2006-10-24
申请号：US10215982
申请日：2002-08-09
申请人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
发明人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
IPC分类号： C12Q1/00 , C12Q1/68 , C07H19/00
CPC分类号： B82Y30/00 , B01J2219/00385 , B01J2219/00479 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00691 , B01J2219/00722 , C07H21/02 , C07H21/04 , C12Q1/485 , C12Q1/6816 , C12Q1/6825 , C40B40/06 , C40B60/14 , C12Q2565/101 , C12Q2525/179 , C12Q2521/337 , C12Q2521/501
摘要： Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.
摘要翻译：提供了设计核酸传感器分子的方法。生物传感器包含用第一信号传导部分和第二信号传导部分标记的多个核酸传感器分子。核酸传感器分子识别不天然结合DNA的靶分子。靶分子与传感器分子的结合触发信号部分的接近度的变化，导致生物传感器上的核酸传感器分子的光学性质的变化。还提供了用于执行该方法的试剂和系统。该方法可用于诊断应用和药物优化。

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