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21. 发明专利

GB190201710A Improvements in Wheel Grinding Machines. 未知
公开(公告)号：GB190201710A
公开(公告)日：1902-11-27
申请号：GB190201710D
申请日：1902-01-22
申请人： MILLER THOMAS
发明人： MILLER THOMAS
摘要： 1710. Miller, T. Jan. 22. Surfacing.-Relates to machines for grinding or trueing the wheels of railway and tramway vehicles. One end of the axle x of the pair of wheels is held in a chuck f, g carried by a headstock. The chuck has a driving-stud h for acting on the arms of the wheel in case of any slipping of the conical sleeve f. At the tailstock end the axle runs in a V- shaped bearing J with renewable bearing-strips S. A cover K is connected to the slide R by bolts and nuts, and is arranged to swivel on one side for convenience in removing the axle. The axle is removed from the chuck by operating the slide R through the screw N. In the case of plain axles the cover K is screwed down hard ; but in the case of axles with a groove L, a plate M is fitted into this groove to obtain the necessary hold. The grinding-wheel is mounted on a slide opposite to the wheel being acted upon.

22. 发明专利

CA26817A METHOD OF CONVERTING USED STEEL RAILS INTO NAIL PLATE AT ONE HEAT 未知
公开(公告)号：CA26817A
公开(公告)日：1887-06-01
申请号：CA26817D
申请人： ROBERTSON JAMES C , MILLER THOMAS
发明人： ROBERTSON JAMES C , MILLER THOMAS

23. 发明专利

CA11888A IMPROVEMENTS IN IRON BOX PILES FOR THE MANUFACTURE OF NAILPLATE IRON 未知
公开(公告)号：CA11888A
公开(公告)日：1880-10-20
申请号：CA11888D
申请人： MILLER THOMAS
发明人： MILLER THOMAS

24. 发明申请

WO2007055942A2 SUBSTITUTED NICOTINAMIDE COMPOUNDS 审中-公开
标题翻译：取代的NICOTINAMIDE化合物
公开(公告)号：WO2007055942A2
公开(公告)日：2007-05-18
申请号：PCT/US2006042199
申请日：2006-10-30
申请人： MERCK & CO INC , HAMBLETT CHRISTOPHER , MAMPREIAN DAWN M , METHOT JOEY L , MILLER THOMAS , SLOMAN DAVID L , STANTON MATTHEW G , WILSON KEVIN
发明人： HAMBLETT CHRISTOPHER , MAMPREIAN DAWN M , METHOT JOEY L , MILLER THOMAS , SLOMAN DAVID L , STANTON MATTHEW G , WILSON KEVIN
IPC分类号： A61K31/506
CPC分类号： C07D213/56 , C07D239/28 , C07D401/12 , C07D487/08
摘要： The present invention relates to a novel class of substituted nicotinamides.. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo.
摘要翻译：本发明涉及一类新的取代烟酰胺。这些化合物可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的细胞生长和/或细胞凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫性，过敏性和炎性疾病，以及预防和/或治疗中枢神经系统（CNS）的疾病，例如神经退行性疾病本发明进一步提供包含本发明化合物和易于遵循的这些药物组合物的安全给药方案的药物组合物，并且其在体内导致治疗有效量的这些化合物。

25. 发明申请

WO2007002248A3 MODIFIED MALONATE DERIVATIVES 审中-公开
标题翻译：改性的马来酸酯衍生物
公开(公告)号：WO2007002248A3
公开(公告)日：2007-05-03
申请号：PCT/US2006024236
申请日：2006-06-21
申请人： MERCK & CO INC , ATON PHARMA INC , GRIMM JONATHAN , HARRINGTON PAUL , HEIDEBRECHT RICHARD JR , MILLER THOMAS , OTTE KARIN , SILIPHAIVANH PHIENG , SLOMAN DAVID , STANTON MATTHEW , WILSON KEVIN , WITTER DAVID , KATTAR SOLOMON , TEMPEST PAUL
发明人： GRIMM JONATHAN , HARRINGTON PAUL , HEIDEBRECHT RICHARD JR , MILLER THOMAS , OTTE KARIN , SILIPHAIVANH PHIENG , SLOMAN DAVID , STANTON MATTHEW , WILSON KEVIN , WITTER DAVID , KATTAR SOLOMON , TEMPEST PAUL
IPC分类号： C07C233/02
CPC分类号： C07C235/78 , C07C233/75 , C07C233/80 , C07C235/42 , C07C235/56 , C07C235/74 , C07C235/84 , C07C255/60 , C07C311/08 , C07C311/16 , C07C311/46 , C07C2602/08 , C07D207/06 , C07D207/327 , C07D209/14 , C07D209/20 , C07D211/06 , C07D213/40 , C07D213/56 , C07D213/82 , C07D215/06 , C07D215/12 , C07D215/40 , C07D231/40 , C07D249/08 , C07D261/14 , C07D265/30 , C07D277/28 , C07D277/46 , C07D277/56 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/68 , C07D319/16 , C07D319/18 , C07D333/20 , C07D333/38 , C07D333/70 , C07D413/14 , C07D495/04
摘要： The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the modified malonate derivatives in vivo.
摘要翻译：本发明涉及一类新的改性丙二酸衍生物。修饰的丙二酸酯化合物可用于治疗癌症。修饰的丙二酸酯化合物还可以抑制组蛋白脱乙酰酶并适用于选择性诱导终末分化，并阻止肿瘤细胞的细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明化合物还可用于预防和治疗TRX介导的疾病，如自身免疫性疾病，变应性疾病和炎性疾病，以及用于预防和/或治疗中枢神经系统（CNS）疾病，例如神经退行性疾病。本发明进一步提供了包含这些修饰的丙二酸衍生物和这些药物组合物的安全给药方案的药物组合物，其易于追踪并且导致治疗有效量的修饰的丙二酸衍生物在体内。

26. 发明申请

WO2006115835A2 BENZOTHIOPHENE HYDROXAMIC ACID DERIVATIVES 审中-公开
标题翻译：苯并噻吩异羟肟酸衍生物
公开(公告)号：WO2006115835A2
公开(公告)日：2006-11-02
申请号：PCT/US2006014093
申请日：2006-04-14
申请人： MERCK & CO INC , ATON PHARMA INC , HUBBS JED LEE , KATTAR SAM , METHOT JOEY , MILLER THOMAS , SILIPHAIVANH PHIENG , STANTON MATTHEW , WILSON KEVIN , WITTER DAVID J
发明人： HUBBS JED LEE , KATTAR SAM , METHOT JOEY , MILLER THOMAS , SILIPHAIVANH PHIENG , STANTON MATTHEW , WILSON KEVIN , WITTER DAVID J
IPC分类号： A61K31/381
CPC分类号： C07D333/70 , A61K31/38 , A61K31/381 , A61K31/41
摘要： The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.
摘要翻译：本发明涉及一类新的异羟肟酸衍生物。异羟肟酸化合物可用于治疗癌症。异羟肟酸化合物还可以抑制组蛋白脱乙酰酶，适用于选择性诱导终末分化，阻止肿瘤细胞的生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有以肿瘤细胞增殖为特征的肿瘤的患者。本发明化合物还可用于预防和治疗TRX介导的疾病，如自身免疫疾病，变应性疾病和炎症疾病，以及用于预防和/或治疗中枢神经系统（CNS）疾病，如神经变性疾病。本发明进一步提供了包含异羟肟酸衍生物和这些药物组合物的安全给药方案的药物组合物，其易于遵循并且导致治疗有效量的异羟肟酸衍生物在体内。

27. 发明授权

US1154265A Bolt and nut therefor. 失效
标题翻译：螺栓和螺母
公开(公告)号：US1154265A
公开(公告)日：1915-09-21
申请号：US1913797764
申请日：1913-10-28
申请人： MILLER THOMAS
发明人： MILLER THOMAS
CPC分类号： F16B21/12 , Y10S411/939 , Y10S411/945

28. 发明授权

US995275A Oil-can rack. 失效
标题翻译：油罐架。
公开(公告)号：US995275A
公开(公告)日：1911-06-13
申请号：US1911609048
申请日：1911-02-16
申请人： MILLER THOMAS
发明人： MILLER THOMAS
CPC分类号： H04M1/11 , A47B81/007

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