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21. 发明专利

AU2010295638A1 Generation of high polyhydroxybutrate producing oilseeds 未知
公开(公告)号：AU2010295638A1
公开(公告)日：2012-04-26
申请号：AU2010295638
申请日：2010-09-15
申请人： METABOLIX INC
发明人： PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
摘要： Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ("PHA") are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ("PHB"). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.

22. 发明专利

CA2754261A1 STABLE, FERTILE, HIGH POLYHYDROXYALKANOATE PRODUCING PLANTS AND METHODS OF PRODUCING THEM 未知
公开(公告)号：CA2754261A1
公开(公告)日：2010-09-10
申请号：CA2754261
申请日：2010-03-05
申请人： METABOLIX INC
发明人： BOHMERT-TATAREV KAREN , MCAVOY SUSAN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82
摘要： Transgenic plants that produce high levels of polyhydroxybutyrate and methods of producing them are provided. In a preferred embodiment the transgenic plants are produced using plastid transformation technologies and utilize genes which are codon optimized. Stably transformed plants able to produce greater than 10% dwt PHB in tissues are also provided.

23. 发明专利

DE60140996D1 未知
公开(公告)号：DE60140996D1
公开(公告)日：2010-02-25
申请号：DE60140996
申请日：2001-02-09
申请人： METABOLIX INC
发明人： SNELL KRISTI D
IPC分类号： C12N15/82 , C12N15/63 , C12P7/62

24. 发明专利

AU2002236464B2 Production of medium chain length polyhydroxyalkanoates from fatty acid biosynthetic pathways 未知
公开(公告)号：AU2002236464B2
公开(公告)日：2005-09-15
申请号：AU2002236464
申请日：2001-11-16
申请人： METABOLIX INC
发明人： SNELL KRISTI D , PEOPLES OLIVER P , AQUIN STEPHANIE
IPC分类号： A01H5/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48 , C12N015/82
摘要： Methods for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthase, and an acyl CoA synthetase, have been developed. Methodology for enabling PHA production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants using an enzyme having the catalytic activity of 3-hydroxy acyl ACP thioesterase, an acyl CoA synthetase with substrate specificity for medium chain length 3-hydroxy fatty acids, and a medium chain length PHA synthase, has been developed. Acyl CoA synthetase activity can be supplied either by the endogenous acyl CoA synthetase of the host organism, when sufficiently expressed, or the host organism's activity can be supplemented by the expression of a recombinant acyl CoA synthetase gene. New strategies are described for plant based PHA production in the chloroplasts, cytosol, and peroxisomes of biomass crops as well as the plastids, cytosol, and peroxisomes of oil seed crops.

25. 发明专利

CA2428713A1 PRODUCTION OF MEDIUM CHAIN LENGTH POLYHYDROXYALKANOATES FROMFATTY ACID BIOSYNTHETIC PATHWAYS 未知
公开(公告)号：CA2428713A1
公开(公告)日：2002-05-23
申请号：CA2428713
申请日：2001-11-16
申请人： METABOLIX INC
发明人： SNELL KRISTI D , PEOPLES OLIVER P , AQUIN STEPHANIE
IPC分类号： A01H5/00 , C12N1/21 , C12N9/00 , C12N9/10 , C12N9/16 , C12N15/09 , C12N15/54 , C12N15/55 , C12N15/82 , C12P7/42 , C12Q1/02 , C12Q1/25 , C12Q1/44 , C12Q1/48 , C12N15/52 , C12N15/70
摘要： Methods for producing polyhydroxyalkanoates (PHAs) from fatty acid biosynthetic pathways using a 3-hydroxy acyl ACP thioesterase, a PHA synthas e, and an acyl CoA synthetase, have been developed. Methodology for enabling PH A production from fatty acid biosynthetic pathways in non-native bacterial PHA producers and plants using an enzyme having the catalytic activity of 3- hydroxy acyl ACP thioesterase, an acyl CoA synthetase with substrate specificity for medium chain length 3-hydroxy fatty acids, and a medium chai n length PHA synthase, has been developed. Acyl CoA synthetase activity can be supplied either by the endogenous acyl CoA synthetase of the host organism, when sufficiently expressed, or the host organism's activity can be supplemented by the expression of a recombinant acyl CoA synthetase gene. Ne w strategies are described for plant based PHA production in the chloroplasts, cytosol, and peroxisomes of biomass crops as well as the plastids, cytosol, and peroxisomes of oil seed crops.

26. 发明专利

AU2010221132B2 Stable, fertile, high polyhydroxyalkanoate producing plants and methods of producing them 未知
公开(公告)号：AU2010221132B2
公开(公告)日：2013-11-21
申请号：AU2010221132
申请日：2010-03-05
申请人： METABOLIX INC
发明人： BOHMERT-TATAREV KAREN , MCAVOY SUSAN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82
摘要： Transgenic plants that produce high levels of polyhydroxybutyrate and methods of producing them are provided. In a preferred embodiment the transgenic plants are produced using plastid transformation technologies and utilize genes which are codon optimized. Stably transformed plants able to produce greater than 10% dwt PHB in tissues are also provided.

27. 发明专利

AT521710T 未知
公开(公告)号：AT521710T
公开(公告)日：2011-09-15
申请号：AT06738572
申请日：2006-03-16
申请人： METABOLIX INC
发明人： KOURTZ LAURALYNN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
摘要： Methods and constructs for the introduction of multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway are provided. In one embodiment, the constructs contain two or more enzyme-encoding genes, each under the control of an inducible promoter and each with a polyadenylation signal. The constructs are used to produce transgenic plants, in which the expression of the enzymes are increased when a chemical inducing agent is applied, and a biosynthetic product of the series of enzymes encoded by the transgenes is produced. Constructs may be used which contain two or more enzyme-encoding genes under the control of one or more promoters activated by activator molecules or complexes expressed from a transgene or transgenes, which are themselves under the control of one or more inducible promoters and switched on following the external application of a chemical. The transgene or transgenes expressing the activator molecules or complexes may be included in the same construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. Alternatively, the transgene or transgenes expressing the activator molecules or complexes may be on a different construct from the construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. The activator molecule can be expressed using a constitutive promoter in an inactive form which is converted to the active form following application of the chemical inducing agent.

28. 发明专利

CA2773707A1 GENERATION OF HIGH POLYHYDROXYBUTRATE PRODUCING OILSEEDS WITH IMPROVED GERMINATION AND SEEDLING ESTABLISHMENT 未知
公开(公告)号：CA2773707A1
公开(公告)日：2011-03-24
申请号：CA2773707
申请日：2010-09-15
申请人： METABOLIX INC
发明人： PATTERSON NII , TANG JIHONG , HAN JIXIANG , TAVVA VENKATA , HERTIG ANDREW , ZHANG ZHIGANG , RAMSEIER THOMAS MARTIN , BOHMERT-TATAREV KAREN , PEOPLES OLIVER P , SNELL KRISTI D
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
摘要： Transgenic plants, plant material, plant cells, and genetic constructs for synthesis of biopolymers, for example polyhydroxyalkanoates ("PHA") are provided. In one embodiment, the transgenic plants synthesize polyhydroxybutyrate ("PHB"). In one embodiment the transgenic plant encodes siRNA for one or more of the genes encoding enzymes for producing PHA. In a more preferred embodiment, the siRNA expression is under the control of an inducible regulatory element. In another embodiment, the transgenic plant contains transgenes that encode expression enzymes that will degrade the polymer. In a preferred embodiment, the expression of these enzymes is under the control of a germination specific, inducible, or minimal promoter. In another embodiment, the transgenic plant contains transgenes encoding enzymes that increase carbon flow for polymer synthesis. In a preferred embodiment, these transgenes encode enzymes that increase carbon flow in the Calvin Cycle.

29. 发明专利

CA2600882A1 CHEMICALLY INDUCIBLE EXPRESSION OF BIOSYNTHETIC PATHWAYS 未知
公开(公告)号：CA2600882A1
公开(公告)日：2006-09-28
申请号：CA2600882
申请日：2006-03-16
申请人： METABOLIX INC
发明人： KOURTZ LAURALYNN , SNELL KRISTI D , PEOPLES OLIVER P
IPC分类号： C12N15/82 , A01H5/00 , C12P7/62
摘要： Methods and constructs for the introduction of multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway are provided. In one embodiment, the constructs contain two or more enzyme-encoding genes, each under the control of an inducible promoter and each with a polyadenylation signal. The constructs are used to produce transgenic plants, in which the expression of the enzymes are increased when a chemical inducing agent is applied, and a biosynthetic product of the series of enzymes encoded by the transgenes is produced. Constructs may be used which contain two or more enzyme-encoding genes under the control of one or more promoters activated by activator molecules or complexes expressed from a transgene or transgenes, which are themselves under the control of one or more inducible promoters and switched on following the external application of a chemical. The transgene or transgenes expressing the activator molecules or complexes may be included in the same construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. Alternatively, the transgene or transgenes expressing the activator molecules or complexes may be on a different construct from the construct containing multiple genes encoding enzymes in a multi-enzyme biosynthetic pathway. The activator molecule can be expressed using a constitutive promoter in an inactive form which is converted to the active form following application of the chemical inducing agent.

30. 发明专利

AU3683901A Multi-gene expression constructs containing modified inteins 未知
公开(公告)号：AU3683901A
公开(公告)日：2001-08-20
申请号：AU3683901
申请日：2001-02-09
申请人： METABOLIX INC
发明人： SNELL KRISTI D
IPC分类号： C12N15/82 , C12P7/62 , C12N15/00

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