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21. 发明专利

CA2951902C ENTERIC ELASTOMERS 未知
公开(公告)号：CA2951902C
公开(公告)日：2022-08-23
申请号：CA2951902
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , THE BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A , ZHANG SHIYI
IPC分类号： C08L33/26 , A61K9/00 , A61K47/32 , A61L27/26 , C08L33/02 , C08L33/08
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

22. 发明专利

AU2019269636A1 Systems for electrical stimulation 未知
公开(公告)号：AU2019269636A1
公开(公告)日：2020-11-19
申请号：AU2019269636
申请日：2019-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , DELLAL DAVID
IPC分类号： A61N1/05 , A61B5/00 , A61M31/00 , A61N1/372 , A61N1/375
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In certain embodiments, the self-righting article a tissue- interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.

23. 发明专利

AU2018375145A1 Gastric resident electronics 未知
公开(公告)号：AU2018375145A1
公开(公告)日：2020-06-18
申请号：AU2018375145
申请日：2018-11-28
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , KONG YONG LIN
IPC分类号： A61B5/07 , A61B5/00
摘要： Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

24. 发明专利

AU2018269556A1 Tissue anchoring articles 未知
公开(公告)号：AU2018269556A1
公开(公告)日：2019-11-28
申请号：AU2018269556
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , DELLAL DAVID , LANGER ROBERT S
IPC分类号： A61M31/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

25. 发明专利

AU2018269544A1 Self-righting articles 未知
公开(公告)号：AU2018269544A1
公开(公告)日：2019-11-28
申请号：AU2018269544
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61K9/20 , A61K9/22 , A61K9/48
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

26. 发明专利

CA3079421A1 COMPOSITIONS AND METHODS TO ENHANCE ULTRASOUND-MEDIATED DELIVERY OF PHARMACEUTICAL AGENTS 未知
公开(公告)号：CA3079421A1
公开(公告)日：2019-04-25
申请号：CA3079421
申请日：2018-10-16
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , MINAHAN DAN , BENSEL TAYLOR A , VON ERLACH THOMAS , TRAVERSO CARLO GIOVANNI , SCHOELLHAMMER CARL MAGNUS
IPC分类号： A61K49/22 , A61B10/02
摘要： Disclosed herein are compositions comprising a pharmaceutical agent and an ultrasound enhancing agent. The compositions are useful in combination with ultrasound to enhance delivery of a pharmaceutical agent to, for example, tissue of a subject in need thereof. Accordingly, also provided herein are methods involving ultrasound for delivering a pharmaceutical agent to a subject, e.g., a subject that has inflammatory bowel disease or proctitis.

27. 发明专利

CA3063712A1 SELF-RIGHTING ARTICLES 未知
公开(公告)号：CA3063712A1
公开(公告)日：2018-11-22
申请号：CA3063712
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61K9/48 , A61M5/20 , A61M5/32 , A61M31/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

28. 发明专利

AU2015274453A2 Enteric elastomers 未知
公开(公告)号：AU2015274453A2
公开(公告)日：2017-01-19
申请号：AU2015274453
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： ZHANG SHIYI , BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： C07C57/04 , A61K31/197 , A61K31/78
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

29. 发明专利

AU2015274456A1 Self-assembled residence devices and related methods 未知
公开(公告)号：AU2015274456A1
公开(公告)日：2017-01-12
申请号：AU2015274456
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , LIN JIAQI , DICICCIO ANGELA , GLETTIG DEAN LIANG , WOOD JR LOWELL L , ECKHOFF PHILIP A
IPC分类号： A61M29/04 , A61M31/00
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.

30. 发明专利

CA2951909C SELF-ASSEMBLED RESIDENCE DEVICES AND RELATED METHODS 未知
公开(公告)号：CA2951909C
公开(公告)日：2022-08-16
申请号：CA2951909
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： BELLINGER ANDREW , ZHANG SHIYI , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , MO STACY , LIN JIAQI , DICICCIO ANGELA , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A
IPC分类号： A61K9/00 , A61K47/10 , A61K47/34 , A61M31/00
摘要： Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.

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