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22. 发明专利

AT340794T 未知
公开(公告)号：AT340794T
公开(公告)日：2006-10-15
申请号：AT02752178
申请日：2002-08-06
申请人： LILLY CO ELI
发明人： BASTIAN JOLIE ANNE , EVERS BRITTA LILLY , FINLEY DON RICHARD , HE JOHN XIAOQIANG , JESUDASON CYNTHIA DARSHINI , KARANJAWALA RUSHAD E , RATZ ANDREW MICHAEL , ROCCO VINCENT PATRICK , RUEHTER GERD LILLY , SALL DANIEL JON , SCHOTTEN THEO LILLY , SPINAZZE PATRICK GIANPIETRO , STEVENS FREDDIE CRAIG , TRANKLE WILLIAM GEORGE , WERNER JOHN ARNOLD
IPC分类号： A61K31/381 , A61K31/4045 , A61K31/41 , A61K31/4178 , A61K31/4196 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61P3/04 , A61P3/10 , A61P43/00 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to a beta3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity

23. 发明专利

PE20020842A1 ANTAGONISTAS DE RECEPTORES DE AMINOACIDOS EXCITADORES 未知
公开(公告)号：PE20020842A1
公开(公告)日：2002-09-21
申请号：PE2002000004
申请日：2002-01-04
申请人： LILLY CO ELI
发明人： ARNOLD MACKLIN BRIAN , BLEICH THOMAS JOHN , MANSANET ANA M CASTANO , DOMINGUEZ-MANZANARES ESTEBAN , ESCRIBANO ANA MARIA , MARTINEZ PEREZ JOSE ANTONIO , HERRANZ ANA ISABEL MATEO , ORNSTEIN PAUL LESLIE , WINTER MARK ALAN , WAY SCOTT ALLAN , RATZ ANDREW MICHAEL , THOMAS MICHAEL WILSON
IPC分类号： A61K31/472 , A61K31/4725 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/02 , A61P43/00 , C07D217/26 , C07D401/12 , C07D401/14 , C07D409/14 , C07D417/14
摘要： SE REFIERE A COMPUESTOS DE FORMULA I DONDE Z ES S, O; R1 ES H, CN, (C1-C4)ALQUIL-CO2H, TETRAZOL; R2 ES H, HALO, ARILO, ARILO SUSTITUIDO, CO2H, TETRAZOL, NHR3, ENTRE OTROS; R3 ES H, ALQUILO C1-C4, ALQUILARILO C1-C4, ENTRE OTROS; W, X, Y SON H, HALO, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS. UN COMPUESTO PREFERIDO ES 2-ETIL-BUTIL(3S,4aR, 6S,8aR) 6-[3-CLORO-2-(1(2)H-TETRAZOL-5-IL)-FENOXI]-1,2,3,4,4a,5,6,7,8,8a-DECAHIDROISOQUINOLINA-3-CARBOXILATO. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS DE FORMULA I SON ANTAGONISTAS DE RECEPTORES DE AMINOACIDOS EXCITADORES Y SON UTILES PARA EL TRATAMIENTO DE MULTIPLES TRASTORNOS NEUROLOGICOS, ENFERMEDADES NEURODEGENARATIVAS

24. 发明专利

CO5121066A1 SECRETAGOGOS DE LA HORMONA DEL CRECIMIENTO Y DERIVADOS DE CARBODIAMIDAS 未知
公开(公告)号：CO5121066A1
公开(公告)日：2002-01-30
申请号：CO98047011
申请日：1998-08-18
申请人： LILLY CO ELI
发明人： DODGE JEFFREY ALAN , JONES SCOTT ALAN , UHLMAN BRYANT HENRY , ALT CHARLES ARTHUR , BARNETT CHARLES JACKSON , COHEN JEFFREY DANIEL , DENSMORE COPP JAMES , KENNAN JOSEPH FAHEY , GRITTON WILLIAM HARLAN , RUI LIN GU , JUNGHEIM LOUIS NICKOLAUS , KENNEDY JOSEPH HENRY , LUGAR III CHARLES WILLS , MUEHL BRIAN STEPHEN , PALKOWITZ ALAN DAVID , RATZ ANDREW MICHAEL , RHODES GARY ANTHONY , TOBEY ROGER LEWIS , SEYLER DAVID EDWARD , SHEPHERD TIMOTHY ALAN , THRASHER KENNETH JEFF , TRANIDE WILLIAM GEORGE
IPC分类号： A61K38/00 , A61K31/445 , C07D233/54 , C07D233/88 , C07K1/10 , C07K5/06 , C07K5/062
摘要： Un compuesto de fórmula I en la que: A es un alquilo C1-C6, arilo, (alquil C1-C6)arilo, (alquil C1-C6) (O) (alquil C1-C6) arilo, -SH, -OH, indolilo, indolinilo, tienilo, benzotienilo, benzofuranilo, naftanilo, ciclohexilo, (alquil C1-C6)indol-3-ilo, (alquil C1-C6)benzotien-3-ilo), (alquil C1-C6)naftan-2-ilo, (alquil C1-C6)benzofuran-3-ilo y (alquil C1-C6) ciclohexilo;B es NH2 NHR1 (alquil C1-C6)NH2, (alquil C1-C6)NHR1, (alquil C1-C6)aril-NH2, (alquil C1-C6)aril-NHR1, (alquil C1-C6)ciclohexil-NH2, (alquil C1-C6)ciclohexil-NHR1, R1-piperidin-3-il(alquilo C1-C6), R1-piperidin-2-il (alquilo C1-C6), R1-piperidin-4-il(alquilo C1-C6), R1-quinolin-2-il(alquilo C1-C6), R1-(2,4-dihidroquinolin-2-il)alquilo C1-C6), R1-isoquinolin-2-il(alquilo C1-C6) y R1-(2,4-dihidroisoquinolin-2-il) (alquilo C1-C6);R1 es hidrógeno, alquilo C1-C6, (alquil C1-C6) OH o (alquilidenil C1-C6) (OH)R2;R2 es alquilo C1-C6, alquenilo C1-C6, (alquil C1-C6) (O) (alquilo C1-C6), C(0)-O-alquilo C1-C6, arilo o (alquil C1-C6)arilo;X es un enlace, alquilidenilo C1-C6, O, S, HN o N(alquiloC1-C6);V se selecciona entre el grupo formado por - 2 -W es S, O, NH ó CH2;Y es N ó CH;Z es N ó CH;Y´ es N, S, CH2, O;Z' es N, CH2;R4 y R5 son, de forma independiente, hidrógeno, alquilo C1-C6, arilo, (alquil C1-C6)arilo, C(O)O(alquilo C1-C6), C(O)ON(alquilo C1-C6)2 o (alquil C1-C6)COR7;R7 es hidrógeno, alquilo C1-C6, pirrolidinilo, piperidinilo, homoprolina o prolina;D es C(O)R6, (alquil C1-C6)OH, (alquil C1-C6)C(0)R6, (alquil C1-C6)R6, arilo, CH2NHSO2(alquilo C1-C6),R6 es H, alquilo C1-C6, arilo, (alquil C1-C6) arilo, acetilo, NH2, NH(alquilo C1-C6), NH(alquilidenil C1-C6)OCH3,NH(alquil C1-C6)arilo, N(alquilo C1-C6)2, N(alquil C1-C6)arilo,N(alquil C1-C6) (alquil C1-C6) )arilo, O(alquilo C1-C6), piperidinilo o piperidinilo opcionalmente sustituido, pirrolidinilo o pirrolidinilo opcionalmente sustituido, pirrolinilo o pirrolinilo opcionalmente sustituido, morfolino, hexametilenimino, heptametilenimino, quinolinilo, 2,4-dihidroquinolinilo, isoquinolinilo, 2,4-dihidroisoquinolinilo, un aminoácido seleccionado entre el grupo de prolina, homoprolina, glicina, alanina, valina, leucina, isoleucina, tirosina, triptófano, fenilalanina, serina, treonina, asparragina, ácido glutámico, ácido aspártico, lisina, arginina, glutamina, histidina, cisteína y metionina o un heterociclo que contiene un nitrógeno seleccionado entre el grupo formado por E es hidrógeno, alquilo C1-C6, C(O)alquilo C1-C6, arilo (alquil C1-C6) arilo, C(0)arilo, (alquil C1-C6)(O)arilo, naftilo, (alquil C1-C6)naftilo, C(0)naftilo, (alquil C1-C6)C(O)naftilo, heteroarilo, (alquil C1-C6)heteroarilo, C(O)heteroarilo y (alquil C1-C6)C(0)heteroarilo;G es hidrógeno, alquilo C1-C6, arilo, (alquil C1-C6)arilo y alquenilo C1-C6;J es hidrógeno, alquilo, arilo y (alquil C1-C6) arilo;L es hidrógeno, alquilo C1-C6, arilo, (alquil C1-C6) arilo, alquenilo C1-C6, -F y -CN;o una sal farmacéuticamente aceptable o un solvato delmismo.

25. 发明专利

HU0003807A2 PROCESS TO MAKE CHIRAL PROPILAMINE DERIVATIVES 未知
公开(公告)号：HU0003807A2
公开(公告)日：2001-04-28
申请号：HU0003807
申请日：1998-09-23
申请人： LILLY CO ELI
发明人： RATZ ANDREW MICHAEL
IPC分类号： C07C59/50 , C07C213/06 , C07C213/10 , C07C215/30 , C07C217/48 , C07C319/20 , C07C323/20 , C07C209/86
摘要： A process to make the S(+)mandelic acid salt of N-methyl-3R-hydroxy-3-phenylpropylamine comprising reacting N-methyl-3(R,S)-hydroxy-3-phenylpropylamine with S(+)mandelic acid is described and claimed. Also described and claimed are processes to make N-methyl-3R-(2-methylthiophenoxy)-3-phenylpropylamine and N-methyl-3R-(2-methylphenoxy)-3-phenylpropylamine.

26. 发明专利

TR200000930T2 未知
公开(公告)号：TR200000930T2
公开(公告)日：2000-11-21
申请号：TR200000930
申请日：1998-08-19
申请人： LILLY CO ELI
发明人： DODGE JEFFREY ALAN , HAUSER KENNETH LEE , HEIMAN MARK LOUIS , JONES SCOTT ALAN , ALT CHARLES ARTHUR , BRYANT HENRY UHLMAN , COHEN JEFFREY DANIEL , COPP JAMES DENSMORE , GRITTON WILLIAM HARLAN , JUNGHEIM LOUIS NICKOLAUS , III CHARLES WILLIS LUGAR , MUEHL BRIAN STEPHEN , PALKOWITZ ALAN DAVID , RATZ ANDREW MICHAEL , RHODES GARY ANTHONY , ROBEY ROBERT LEWIS , SHEPHERD TIMOTHY ALAN , THRASHER KENNETH JEFF , TRANKLE WILLIAM GEORGE
IPC分类号： A61K38/00 , C07D233/88 , C07K1/10 , C07K5/06 , C07K5/062 , A61K38/05
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

27. 发明专利

TR200000969T2 未知
公开(公告)号：TR200000969T2
公开(公告)日：2000-09-21
申请号：TR200000969
申请日：1998-09-23
申请人： LILLY CO ELI
发明人： RATZ ANDREW MICHAEL
IPC分类号： C07C59/50 , C07C213/06 , C07C213/10 , C07C215/30 , C07C217/48 , C07C319/20 , C07C323/20 , A61K31/135 , C07C209/86 , C07C209/88 , C07C211/26 , C07C215/12
摘要： A process to make the S(+)mandelic acid salt of N-methyl-3R-hydroxy-3-phenylpropylamine comprising reacting N-methyl-3(R,S)-hydroxy-3-phenylpropylamine with S(+)mandelic acid is described and claimed. Also described and claimed are processes to make N-methyl-3R-(2-methylthiophenoxy)-3-phenylpropylamine and N-methyl-3R-(2-methylphenoxy)-3-phenylpropylamine.

28. 发明专利

BR9811948A 未知
公开(公告)号：BR9811948A
公开(公告)日：2000-08-22
申请号：BR9811948
申请日：1998-08-19
申请人： LILLY CO ELI
发明人： DODGE JEFFREY ALAN , HAUSER KENNETH LEE , HEIMAN MARK LOUIS , JONES SCOTT ALAN , ALT CHARLES ARTHUR , BRYANT HENRY UHLMAN , JUNGHEIM LOUIS NICKLAUS , COHEN JEFFREY DANIEL , COPP JAMES DENSMORE , GRITTON WILLIAM HARLAN , MUEHL BRIAN STEPHEN , PALKOWITZ ALAN DAVID , RATZ ANDREW MICHAEL , RHODES GARY ANTHONY , ROBEY ROBERT LEWIS , SHEPHERD TIMOTHY ALAN , THRASHER KENNETH JEFF , TRANKLE WILLIAM GEORGE
IPC分类号： A61K38/00 , C07D233/88 , C07K1/10 , C07K5/06 , C07K5/062 , A61K38/05
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

29. 发明专利

NO20001728L 未知
公开(公告)号：NO20001728L
公开(公告)日：2000-04-04
申请号：NO20001728
申请日：2000-04-04
申请人： LILLY CO ELI
发明人： RATZ ANDREW MICHAEL
IPC分类号： C07C59/50 , C07C213/06 , C07C213/10 , C07C215/30 , C07C217/48 , C07C319/20 , C07C323/20 , C07C209/86 , C07C211/26 , C07C215/12 , A61K31/135
摘要： A process to make the S(+)mandelic acid salt of N-methyl-3R-hydroxy-3-phenylpropylamine comprising reacting N-methyl-3(R,S)-hydroxy-3-phenylpropylamine with S(+)mandelic acid is described and claimed. Also described and claimed are processes to make N-methyl-3R-(2-methylthiophenoxy)-3-phenylpropylamine and N-methyl-3R-(2-methylphenoxy)-3-phenylpropylamine.

30. 发明专利

CY1108259T1 ΑΝΤΑΓΩΝΙΣΤΕΣ ΥΠΟΔΟΧΕΑ ΔΙΕΓΕΡΤΙΚΟΥ ΑΜΙΝΟΞΕΟΣ 未知
公开(公告)号：CY1108259T1
公开(公告)日：2014-02-12
申请号：CY081100860
申请日：2008-08-13
申请人： LILLY CO ELI
发明人： BLEISCH THOMAS JOHN , MARTINEZ PEREZ JOSE ANTONIO , ORNSTEIN PAUL LESLIE , MAY SCOTT ALLAN , RATZ ANDREW MICHAEL , WILSON THOMAS MICHAEL
IPC分类号： A61K31/472 , A61K31/4725 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/02 , A61P43/00 , C07D217/26 , C07D401/12 , C07D401/14 , C07D409/14 , C07D417/14
摘要： ΗπαρούσαεφεύρεσηπαρέχεινέεςενώσειςτουΤύπου (Ι) καιτουτύπου (Ι)a)) ήταφαρκαμευτικώςαποδεκτάάλατααυτών, μεθόδουςθεραπείαςνευρολογικώνδιαταραχώνκαινευροεκφυλιστικώνασθενειών, ιδιαιτέρωςπόνουκαιημικρανίαςπουπεριλαμβάνουνχορήγησημιαςένωσηςτουΤύπου (Ι) ήτουΤύπου (Ι)a)) καιμεθόδουςπαρασκευήςενώσεωντουΤύπου (Ι) ήτουΤύπου (Ι)a)).

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