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21. 发明申请

WO2012135834A2 DIALYSIS LIKE THERAPEUTIC (DLT) DEVICE 审中-公开
标题翻译： DIALYSIS LIKE THERAPEUTIC（DLT）DEVICE
公开(公告)号：WO2012135834A2
公开(公告)日：2012-10-04
申请号：PCT/US2012031864
申请日：2012-04-02
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , YUNG CHONG WING , DOMANSKY KAREL , TERRY RICHARD , KALISH DAVID , SCHULTE ALEXA , KANG JOO HUN , INGBER DONALD E , SUPER MIKE , COOPER RYAN M
发明人： YUNG CHONG WING , DOMANSKY KAREL , TERRY RICHARD , KALISH DAVID , SCHULTE ALEXA , KANG JOO HUN , INGBER DONALD E , SUPER MIKE , COOPER RYAN M
IPC分类号： G01N33/569 , B81B1/00 , G01N35/08 , G01N35/10
CPC分类号： C12Q1/04 , A61M1/36 , A61M1/3618 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/56 , B01L2200/0652 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887 , B01L2400/043 , B01L2400/0487 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/26
摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.
摘要翻译：提供透析治疗（DLT）装置。 DLT设备包括通过一个或多个传输信道连接至少一个收集信道的至少一个源信道。通道的流体接触表面可以是防污表面，例如滑动的液体注入的多孔表面（SLIPS）。流体可以通过通道以高流速流动。源流体的目标组分可以是磁性的或使用亲和分子结合到磁性颗粒。含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。收集通道可以包括收集流体以将目标组分冲洗出收集通道。随后分析目标成分进行检测和诊断。微流体装置的源通道和收集通道分别类似于脾小动脉和小静脉; 转移通道模拟脾脏的血管窦状，其中保留调理颗粒。因此，该装置通过组合流体学和磁性作为透析像治疗装置。

22. 发明申请

WO2012030805A3 A HIGH STRENGTH CHITIN COMPOSITE MATERIAL AND METHOD OF MAKING 审中-公开
标题翻译：高强度木质素复合材料及其制备方法
公开(公告)号：WO2012030805A3
公开(公告)日：2012-07-05
申请号：PCT/US2011049702
申请日：2011-08-30
申请人： HARVARD COLLEGE , INGBER DONALD E , FERNANDEZ JAVIER GOMEZ
发明人： INGBER DONALD E , FERNANDEZ JAVIER GOMEZ
IPC分类号： A61L27/20 , A61F2/02 , A61F13/00 , A61L27/22 , A61L27/34 , A61L27/54 , A61L27/56
CPC分类号： A61L27/24 , A61L15/225 , A61L15/28 , A61L15/325 , A61L15/38 , A61L15/425 , A61L15/44 , A61L15/52 , A61L27/20 , A61L27/227 , A61L27/34 , A61L27/48 , A61L27/54 , A61L27/56 , B05D3/104 , C08L1/02 , C08L3/02 , C08L5/00 , C08L5/08 , C08L5/10 , C08L89/00
摘要： The present invention is directed to a composite laminar material with high mechanical strength and methods of fabricating the material. The invention also provides a method of attaching a medical implant device to tissue.
摘要翻译：本发明涉及具有高机械强度的复合层状材料和制造该材料的方法。本发明还提供了一种将医疗植入物装置附接到组织的方法。

23. 发明申请

WO2011163312A3 IMPROVING EFFICACY OF CANCER THERAPY 审中-公开
标题翻译：改善癌症治疗效果
公开(公告)号：WO2011163312A3
公开(公告)日：2012-04-19
申请号：PCT/US2011041368
申请日：2011-06-22
申请人： CHILDRENS MEDICAL CENTER , NORTHEAST OHIO MEDICAL UNIVERSITY , THODETI CHARLES K , INGBER DONALD E
发明人： THODETI CHARLES K , INGBER DONALD E
IPC分类号： A61K38/17 , A61K38/16 , A61P35/00 , C12N15/12 , C12N15/63 , C12N15/83
CPC分类号： A61K38/1709 , A61K31/00 , A61K31/22 , A61K31/221 , A61K31/336 , A61K31/365 , A61K38/177 , A61K45/06 , A61N5/10
摘要： Embodiments of the invention provide a method of improving the efficacy of an anti-cancer therapy and a method of treatment of cancer by normalizing angiogenesis in cancer. By enhancing the cell signaling pathway via a TRPV4 receptor in tumor endothelial cells, either by a TRPV4 agonist or by increasing the expression of TRPV4 in the tumor endothelial cells, the tumor endothelial cells behave normally and form normal angiogenic network for better anti-cancer therapy to the tumors.
摘要翻译：本发明的实施方案提供了通过使癌症中的血管生成正常化来提高抗癌治疗的功效的方法和治疗癌症的方法。通过TRPV4激动剂或通过增加TRPV4在肿瘤内皮细胞中的表达，通过肿瘤内皮细胞中的TRPV4受体增强细胞信号传导途径，肿瘤内皮细胞表现正常并形成正常的血管生成网络以获得更好的抗癌治疗到肿瘤。

24. 发明申请

WO2010123545A2 ANGIOGENESIS INHIBITORS 审中-公开
标题翻译：血管生成抑制剂
公开(公告)号：WO2010123545A2
公开(公告)日：2010-10-28
申请号：PCT/US2010001121
申请日：2010-04-16
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , COREY ELIAS JAMES , CZAKO BARBARA , KUERTI LASZLO , MAMMOTO AKIKO , INGBER DONALD E
发明人： COREY ELIAS JAMES , CZAKO BARBARA , KUERTI LASZLO , MAMMOTO AKIKO , INGBER DONALD E
IPC分类号： C07J41/00 , A61K31/56 , A61P35/00 , C07J43/00
CPC分类号： C07J43/003 , C07J41/0005
摘要： Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:
摘要翻译：结构式I的化合物或其药学上可接受的盐是血管生成的有效抑制剂：

25. 发明申请

WO0193785A2 ORTHOPEDIC IMPLANT AND METHOD OF MAKING METAL ARTICLES 审中-公开
标题翻译： ORTHOPEDIC植入物和制造金属制品的方法
公开(公告)号：WO0193785A2
公开(公告)日：2001-12-13
申请号：PCT/US0118160
申请日：2001-06-05
申请人： TENSEGRA INC , MANASAS MARK , OSLAKOVIC KEITH E , SULTAN CORNEL , HAMILTON JOHN V , INGBER DONALD E , SAMMARCO CARMINE , KUMMAILIL JOHN , SKINNER DAVID J
发明人： MANASAS MARK , OSLAKOVIC KEITH E , SULTAN CORNEL , HAMILTON JOHN V , INGBER DONALD E , SAMMARCO CARMINE , KUMMAILIL JOHN , SKINNER DAVID J
IPC分类号： A61B17/86 , A61F2/00 , A61F2/30 , A61F2/44 , B22F3/105 , B29C67/00
CPC分类号： B22F3/1055 , A61B17/86 , A61F2/3094 , A61F2/30942 , A61F2/30965 , A61F2/442 , A61F2/4425 , A61F2002/30014 , A61F2002/30018 , A61F2002/30085 , A61F2002/30125 , A61F2002/30135 , A61F2002/30225 , A61F2002/30329 , A61F2002/30563 , A61F2002/30565 , A61F2002/30571 , A61F2002/30662 , A61F2002/30777 , A61F2002/30785 , A61F2002/30841 , A61F2002/30892 , A61F2002/30904 , A61F2002/3092 , A61F2002/30968 , A61F2002/3097 , A61F2002/30971 , A61F2002/443 , A61F2220/0025 , A61F2230/0004 , A61F2230/0008 , A61F2230/0069 , A61F2250/0018 , A61F2250/0029 , A61F2310/00023 , A61F2310/00179 , B29C64/153 , Y02P10/295
摘要： The present application is directed to an orthopedic implant. More specifically, the orthopedic implant is suitable for arthroplasty procedures where optimized multifunctional behavior of the implant is desired. In some embodiments the implant is suitable for the replacement of a spinal disc. In one embodiment, the present application is directed to an orthopedic implant including a first plate a second plate and a flexible support. The flexible support may have a single connection to the first plate and a single connection to the second plate and may vary in cross section. The first plate, the second plate and the flexible support may be unitarily formed. This application is also directed to methods of producing metal articles having microstructure for improved mechanical properties. Such methods may be suitable for the production of medical devices. In one embodiment, the method includes directing a stream including a particulate material in a pattern corresponding to at least a portion of a structure of an orthopedic implant and fusing at least a portion of the particulate material with a laser.
摘要翻译：本申请涉及整形外科植入物。更具体地说，整形外科植入物适用于需要优化植入物的多功能行为的关节成形手术。在一些实施例中，植入物适合于替换脊椎盘。在一个实施例中，本申请涉及包括第一板，第二板和柔性支撑件的整形外科植入物。柔性支撑件可以具有到第一板的单一连接和到第二板的单一连接，并且可以在横截面上变化。第一板，第二板和柔性支撑件可以整体形成。本申请还涉及生产具有改善机械性能的微结构的金属制品的方法。这种方法可能适用于生产医疗器械。在一个实施例中，该方法包括以对应于整形外科植入物的结构的至少一部分的图案引导包括微粒材料的流，并且利用激光熔合至少一部分微粒材料。

26. 发明申请

WO2012118799A3 CELL CULTURE SYSTEM 审中-公开
标题翻译：细胞培养系统
公开(公告)号：WO2012118799A3
公开(公告)日：2012-11-22
申请号：PCT/US2012026934
申请日：2012-02-28
申请人： HARVARD COLLEGE , INGBER DONALD E , KIM HYUN JUNG
发明人： INGBER DONALD E , KIM HYUN JUNG
IPC分类号： C12M3/02 , C12N1/14 , C12N1/20 , C12N5/071
CPC分类号： C12N5/0697 , C12M21/08 , C12M23/20 , C12M23/26 , C12M23/34 , C12M23/38 , C12M25/02 , C12M27/02 , C12M29/04 , C12M29/06 , C12M35/04 , C12M35/08 , C12M41/12 , C12M41/26 , C12M41/40 , C12M41/44 , C12N1/14 , C12N1/20 , C12N5/0679 , C12N5/068 , C12N5/0696
摘要： The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.
摘要翻译：本文描述的本发明的实施方案涉及用于在体外培养和/或维持肠细胞，组织和/或类器官的系统和方法。根据本文所述的方法和系统培养的细胞，组织和/或器官可以模拟或再现天然肠上皮结构和行为以及支持肠微生物群落的共培养。

27. 发明申请

WO2011090954A3 ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT 审中-公开
标题翻译：用于病原体检测和治疗的工程OPSONIN
公开(公告)号：WO2011090954A3
公开(公告)日：2012-01-12
申请号：PCT/US2011021603
申请日：2011-01-19
申请人： HARVARD COLLEGE , SUPER MICHAEL , WAY JEFFREY CHARLES , INGBER DONALD E
发明人： SUPER MICHAEL , WAY JEFFREY CHARLES , INGBER DONALD E
IPC分类号： C07K19/00
CPC分类号： C07K14/4726 , C07K16/44 , C07K17/00 , C07K2317/53 , C07K2317/66 , C07K2319/30 , G01N33/56961 , G01N2333/40
摘要： The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.
摘要翻译：本发明提供了可用于结合生物病原体或鉴定用于治疗和诊断感染性疾病，血源性感染或败血症患者的装置和系统的亚类或特定病原体物种的工程化分子调理素。本发明的一个方面提供了甘露糖结合凝集素（MBL），其是作为先天免疫系统的一部分的丰富的天然血清蛋白。这种蛋白凝集素在几乎所有类型的生物病原体（病毒，细菌，真菌，原生动物）上结合表面分子的能力使MBL的工程化形式在诊断和治疗感染性疾病和败血症方面非常有用。

28. 发明申请

WO2011091037A3 RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD 审中-公开
标题翻译：快速病理诊断装置及方法
公开(公告)号：WO2011091037A3
公开(公告)日：2011-12-08
申请号：PCT/US2011021718
申请日：2011-01-19
申请人： HARVARD COLLEGE , YUNG CHONG WING , INGBER DONALD E , COOPER RYAN MCOMBER , VOLLMER FRANK , DOMANSKY KAREL , LESLIE DANIEL CHRISTOPHER , SUPER MICHAEL
发明人： YUNG CHONG WING , INGBER DONALD E , COOPER RYAN MCOMBER , VOLLMER FRANK , DOMANSKY KAREL , LESLIE DANIEL CHRISTOPHER , SUPER MICHAEL
IPC分类号： G01N35/08 , G01N1/38 , G01N33/48 , G01N33/52 , G01N33/58
CPC分类号： C12Q1/04 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2400/043 , G01N33/54306 , G01N33/54333 , G01N33/54366 , G01N35/0098
摘要： A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or elecrto-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples.
摘要翻译：诊断和检测系统的微流体装置包括通过一个或多个微通道连接到出口的入口端口，并且包括连接到至少一个微通道的捕获和可视化室（CVC）。要分析的流体可以与具有亲和性的磁性微珠混合，以结合到目标组分，例如流体中的病原体。包括磁结合的靶组分的流体可以通过微流体装置注入。磁场梯度，例如由永久磁铁或电磁铁提供的磁场梯度可以被施加到流过微流体装置的流体和磁力结合的目标组分，以使磁结合的目标组分迁移到（CVC）中并与流体。可以使用各种技术来分析和测试磁结合的靶组分，以检测特定有机和无机材料（例如生物流体中的病原体和液体食物来源（例如水））中的污染物的存在。该装置和方法提供用于在相对小的流体样品中快速检测病原体和污染物的系统。

29. 发明申请

WO2010123594A3 DEVICE FOR FILTRATION OF FLUIDS THERE THROUGH AND ACCOMPANYING METHOD 审中-公开
公开(公告)号：WO2010123594A3
公开(公告)日：2010-11-18
申请号：PCT/US2010021195
申请日：2010-01-15
申请人： CHILDRENS MEDICAL CENTER , YUNG CHONG WING , INGBER DONALD E
发明人： YUNG CHONG WING , INGBER DONALD E
IPC分类号： B03C5/02 , B01D17/032 , B03C1/02 , G01N1/34 , G01N33/48
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , G01N1/40 , G01N33/54326 , G01N33/54366
摘要： A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

30. 发明申请

WO2009155504A9 METHODS FOR THE MODULATION OF ANGIOGENESIS 审中-公开
标题翻译：调节血管生成的方法
公开(公告)号：WO2009155504A9
公开(公告)日：2010-04-08
申请号：PCT/US2009047935
申请日：2009-06-19
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E , MAMMOTO AKIKO
发明人： INGBER DONALD E , MAMMOTO AKIKO
IPC分类号： A61K38/00 , A61K31/7088 , A61K39/395 , C07K14/47 , C07K16/18 , C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , A61K45/06 , C12N2310/14
摘要： The present invention relates to methods and compositions of promoting or inhibiting capillary endothelial (CE) cell migration, promoting or inhibiting the formation of CE networks and promoting or inhibiting angiogenesis, and uses thereof. In particular, the present invention relates to methods and compositions for promoting capillary endothelial (CE) cell migration, promoting the formation of CE networks and promoting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by loss or decreased angiogenesis, such as ischemic injury and the like. One aspect of the invention related to use of at least one pro-angiogenic agent selected from at least one of an p190RhoGAP inhibitor, a TFII-I inhibitor or a GATA-2 activator for promoting the formation of CE networks and promoting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. Another aspect of the invention related to use of at least one anti-angiogenic agent selected from at least one of an p190RhoGAP activator, a TFII-I activator or a GATA-2 inhibitor for inhibiting the formation of CE networks and inhibiting angiogenesis, and uses thereof for the purposes of treating angiogenesis-related disorders characterized by uncontrolled or elevated angiogenesis.
摘要翻译：本发明涉及促进或抑制毛细血管内皮（CE）细胞迁移，促进或抑制CE网络形成和促进或抑制血管生成的方法和组合物，及其用途。具体而言，本发明涉及用于促进毛细血管内皮（CE）细胞迁移，促进CE网络形成和促进血管生成的方法和组合物，以及其用于治疗以血管生成丧失或减少为特征的血管生成相关病症的目的，如缺血性损伤等。本发明的一个方面涉及使用选自p190RhoGAP抑制剂，TFII-1抑制剂或GATA-2激活剂中的至少一种的至少一种促血管发生剂用于促进CE网络的形成和促进血管生成，和使用其目的在于治疗以血管生成丧失或减少为特征的血管生成相关病症。本发明的另一方面涉及使用选自p190RhoGAP激活剂，TFII-1活化剂或GATA-2抑制剂中的至少一种的至少一种抗血管生成剂用于抑制CE网络形成和抑制血管生成的用途，和使用其目的是治疗以血管生成不受控制或升高为特征的血管生成相关病症。

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