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21. 发明申请

WO2014091374A2 MOTION DETECTION AND CORRECTION METHOD FOR MAGNETIC RESONANCE DIFFUSION WEIGHTED IMAGING (DWI) 审中-公开
标题翻译：磁共振扩散加权成像（DWI）的运动检测和校正方法
公开(公告)号：WO2014091374A2
公开(公告)日：2014-06-19
申请号：PCT/IB2013/060691
申请日：2013-12-06
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： STEHNING, Christian , PERKINS, Thomas , SENEGAS, Julien , KEUPP, Jochen
IPC分类号： G01R33/563
CPC分类号： G01R33/56341 , G01R33/4831 , G01R33/56509
摘要： A magnetic resonance imaging system (1) includes at least one processor (28) configured to receive (48) diffusion weighted imaging data based on a diffusion weighted imaging sequence with magnetic gradient fields applied in different directions and with different b-values. The at least one processor (28) is further configured to detect (50) motion corrupted data present in the received imaging data based on a comparison of data redundant in the received data, and substitute (52) alternative data for detected motion corrupted data.
摘要翻译：磁共振成像系统（1）包括至少一个处理器（28），其被配置为基于具有在不同方向上施加的磁梯度场的扩散加权成像序列来接收（48）扩散加权成像数据，以及具有不同的b值。所述至少一个处理器（28）还被配置为基于所接收的数据中的冗余数据的比较来检测（50）存在于所接收的成像数据中的运动损坏的数据，并且用替代（52）用于检测到的运动损坏的数据的替代数据。

22. 发明申请

WO2019179796A1 (3-N)-DIMENSIONAL DETERMINATION OF ELECTRIC CONDUCTIVITY 审中-公开
公开(公告)号：WO2019179796A1
公开(公告)日：2019-09-26
申请号：PCT/EP2019/055939
申请日：2019-03-11
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KATSCHER, Ulrich , FINDEKLEE, Christian , KEUPP, Jochen
IPC分类号： G01R33/54 , G01R33/56 , G01R33/48 , G01R33/565
摘要： The invention relates to a magnetic resonance imaging system (100) for determining an approximation (150) of an electric conductivity distribution within a three- dimensional anatomical structure of interest. The determining comprises acquiring a first set of (3-n)-dimensional magnetic resonance data (144), reconstructing a (3-n)-dimensional phase distribution (146) using the (3-n)-dimensional magnetic resonance data (144), calculating a (3-n)-dimensional electric conductivity distribution (148) using spatial derivatives within the (3-n) dimensions and applying to the (3-n)-dimensional electric conductivity distribution (148) a scaling factor compensating for the relative reduction of dimensions by n.

23. 发明申请

WO2019158695A1 RF TRANSMIT SYSTEM WITH SWITCHABLE POWER SUPPLY DEVICE 审中-公开
公开(公告)号：WO2019158695A1
公开(公告)日：2019-08-22
申请号：PCT/EP2019/053817
申请日：2019-02-15
申请人： KONINKLIJKE PHILIPS N.V.
发明人： VERNICKEL, Peter , LEUSSLER, Christoph , SCHMALE, Ingo , KEUPP, Jochen
IPC分类号： G01R33/36 , H03F3/24 , H03F3/189 , G01R33/56 , H03F1/02
摘要： The present invention is directed to a RF transmit system (1) for a magnetic resonance examination system where it is intended to provide a solution for the problem of rapidly switching between operation modes of different peak power requirements at good power efficiencies. For this purpose the RF transmit system (1) comprises at least one RF channel (14) wherein the RF channel (14) has an RF amplifier (3), at least two power supply devices (4, 5) wherein each of the power supply devices (4, 5) is configured to supply a voltage to the amplifier (3). The RF transmit system (1) further comprises a DC switch (8) configured to switch the voltage supplied to the amplifier (3) between the power supply devices (4, 5) and a controller (2) configured to switch the voltage based on sensor data.

24. 发明申请

WO2019137837A1 MAGNETIZATION TRANSFER BASED METRIC FOR CHEMICAL EXCHANGE SATURATION TRANSFER MRI 审中-公开
公开(公告)号：WO2019137837A1
公开(公告)日：2019-07-18
申请号：PCT/EP2019/050029
申请日：2019-01-02
申请人： KONINKLIJKE PHILIPS N.V.
发明人： KEUPP, Jochen
IPC分类号： G01R33/56 , A61B5/055
CPC分类号： G01R33/5605
摘要： The present disclosure relates to a medical analysis system (111) for processing magnetic resonance imaging, MRI, data (170) from a target volume (208) in a subject (218). The system (111) comprises a memory (107) for storing machine executable instructions; and a processor (103) for controlling the system (111), wherein execution of the machine executable instructions causes the processor (103) to: determine from the MRI data (103) chemical exchange saturation transfer, CEST, voxel values corresponding to a transfer of saturation between a predefined pool of protons and water protons, the pool of protons having a predefined chemical shift; and weight the CEST values in order to distinguish CEST values of fluid-rich tissues (507) from CEST values of solid tissues (505) in the target volume (208), wherein the fluid-rich tissue comprises an amount of fluid higher than a predefined minimum amount of fluid.

25. 发明申请

WO2019057459A1 AUTOMATED TUMOR PARTITIONING 审中-公开
公开(公告)号：WO2019057459A1
公开(公告)日：2019-03-28
申请号：PCT/EP2018/073296
申请日：2018-08-30
申请人： KONINKLIJKE PHILIPS N.V.
发明人： GLEICH, Bernhard , BORGERT, Jörn , KEUPP, Jochen
IPC分类号： G06T7/11
CPC分类号： G06T7/11 , G06T2207/10072 , G06T2207/30096
摘要： The invention provides for a medical instrument (100, 300, 400) comprising: a memory (110) for storing machine executable instructions (112) and a processor (106) for controlling the medical instrument. Execution of the machine executable instructions cause the processor to: receive (200) three dimensional medical image data (114) descriptive of a subject (318), wherein the three dimensional medical image data comprises voxels; receive (202) a segmentation of the three dimensional medical image data, wherein the segmentation divides the three dimensional image data into non-tumor voxels (700) and tumor voxels (500); choose (204) a center point (118) of the tumor voxels; divide (206) the tumor voxels into multiple groups (120) using a set of orthogonal planes (502, 504, 600), wherein the center point is within each of the orthogonal planes; calculate (208) at least one group radiomic feature (122) selected from a set of radiomic features for each of the multiple voxel groups; compute (210) a statistical measure (124) for each of the at least one group radiomic feature; calculate (212) a scalar value (128) by calculating the sum of each statistical measure multiplied by a predetermined group weighting value (126), wherein the predetermined group weighting value is unique for each statistical measure; and provide (214) a signal using a signaling interface device (108, 402) if the scalar value is above a predetermined threshold (130).

26. 发明申请

WO2017174393A1 MRI GUIDED THERAPY SYSTEM 审中-公开
标题翻译： MRI指导治疗系统
公开(公告)号：WO2017174393A1
公开(公告)日：2017-10-12
申请号：PCT/EP2017/057232
申请日：2017-03-28
申请人： KONINKLIJKE PHILIPS N.V.
发明人： HEIJMAN, Edwin , KEUPP, Jochen , WEISS, Steffen
IPC分类号： G01R33/48 , G01R33/54 , G01R33/565 , G01R33/50 , A61N7/02
CPC分类号： G01R33/4814 , A61B90/37 , A61B2090/374 , A61N7/02 , A61N2007/0078 , A61N2007/0095 , G01R33/4804 , G01R33/50 , G01R33/546 , G01R33/56509
摘要： It is an object of the invention to provide for a MRI guided therapy system with a higher flexibility. This object is achieved by an MRI guided therapy system comprising an MRI system configured for performing multiple MRI sequences in an interleaved manner on a subject treated with the MRI guided therapy system and a therapy system configured for treating the subject guidance of the MRI system and an MRI sequence storage comprising the multiple MRI sequences, wherein the multiple MRI sequences and their acquisition order and timing are stored in a package and a package alteration module configured for changing the order and / or timing of one or more of the multiple MRI sequences in the package during a treatment procedure.
摘要翻译：本发明的目的是提供具有较高灵活性的MRI引导治疗系统。该目的通过一种MRI引导治疗系统来实现，所述MRI引导治疗系统包括MRI系统和MRI系统，所述MRI系统被配置用于以交错方式在用MRI引导治疗系统治疗的受试者上执行多个MRI序列，所述治疗系统被配置用于治疗MRI系统的受试引导，包括所述多个MRI序列的MRI序列存储器，其中所述多个MRI序列及其采集顺序和时序被存储在包中，并且包改变模块被配置用于改变所述多个MRI序列中的一个或多个的多个MRI序列的顺序和/ 在治疗过程中包装。

27. 发明申请

WO2016074946A1 MAGNETIC RESONANCE FINGERPRINTING IN SLICES ALONG A ONE-DIMENSIONAL EXTENSION 审中-公开
标题翻译：在一维延伸中指向单曲的磁共振
公开(公告)号：WO2016074946A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/075194
申请日：2015-10-30
申请人： KONINKLIJKE PHILIPS N.V.
发明人： AMTHOR, Thomas Erik , DONEVA, Mariya Ivanova , KOKEN, Peter , KEUPP, Jochen , BOERNERT, Peter
IPC分类号： G01R33/483 , G01R33/50 , A61B5/055 , G01R33/30 , G01R33/48 , G01R33/54
CPC分类号： A61B5/055 , A61B5/4872 , G01R33/307 , G01R33/4828 , G01R33/4835 , G01R33/50 , G01R33/54 , G01R33/563
摘要： The invention provides for a magnetic resonance imaging system (100) which comprise a magnet (104) and a magnetic field gradient generator (110, 112) for generating a gradient magnetic field within an imaging zone (108). The gradient magnetic field is aligned with a predetermined direction. The magnetic resonance imaging system further comprise a memory (134, 136) for storing machine executable instructions (150, 152, 154), a pre-calculated magnetic resonance fingerprinting dictionary (144), and pulse sequence instructions (140). The pulse sequence instructions cause the magnetic resonance imaging system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The magnetic resonance fingerprinting technique encodes the magnetic resonance data as slices (125). The pre-calculated magnetic resonance fingerprinting dictionary contains a listing of calculated magnetic resonance signals in response to execution of the pulse sequence instructions for a set of predetermined substances. Execution of the machine executable instructions causes a processor (130) controlling the magnetic resonance imaging system to: acquire (300) the magnetic resonance data by controlling the magnetic resonance imaging system with pulse sequence instructions; divide (302) the magnetic resonance data into a set of slices; calculate (304) the abundance of each of the set of predetermined substances within each of the set of slices by comparing the magnetic resonance data for each of the set of slices with the pre-calculated magnetic resonance fingerprinting dictionary; and calculate (306) amagnetic resonance fingerprint chart by plotting abundance of each of the set of predetermined substances within each of the set of slicesas a function of position along the predetermined direction.
摘要翻译：本发明提供一种磁共振成像系统（100），其包括用于在成像区域（108）内产生梯度磁场的磁体（104）和磁场梯度发生器（110,112）。梯度磁场与预定方向对齐。磁共振成像系统还包括用于存储机器可执行指令（150,152,154），预先计算的磁共振指纹词典（144）和脉冲序列指令（140）的存储器（134,136）。脉冲序列指令使得磁共振成像系统根据磁共振指纹技术获取磁共振数据。磁共振指纹技术将磁共振数据编码为片（125）。预先计算的磁共振指纹词典包含响应于一组预定物质的脉冲序列指令的执行而计算的磁共振信号的列表。执行机器可执行指令使得控制磁共振成像系统的处理器（130）通过用脉冲序列指令控制磁共振成像系统来获取（300）磁共振数据; 将（302）磁共振数据划分成一组切片; 通过将所述一组切片中的每一个的磁共振数据与所述预先计算的磁共振指纹词典进行比较，来计算（304）所述一组切片中的每组中的所述一组预定物质的丰度; 并且通过绘制在所述一组切片中的每组中的所述一组预定物质中的每一个的丰度作为沿着所述预定方向的位置的函数来计算（306）磁共振指纹图。

28. 发明申请

WO2014154728A1 AMIDE PROTON TRANSFER (APT) AND ELECTRIC PROPERTIES TOMOGRAPHY (EPT) IMAGING IN A SINGLE MR ACQUISITION 审中-公开
标题翻译：单次MR获取中的AMAT PROTON TRANSFER（APT）和电子性质TOMOGRAPHY（EPT）成像
公开(公告)号：WO2014154728A1
公开(公告)日：2014-10-02
申请号：PCT/EP2014/056018
申请日：2014-03-26
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： KATSCHER, Ulrich , DONEVA, Mariya Ivanova , STEHNING, Christian , VAN DEN BRINK, Johan Samuel , KEUPP, Jochen
IPC分类号： G01R33/48 , G01R33/56
CPC分类号： G01R33/5605 , G01R33/48 , G01R33/4828
摘要： The present invention relates to a magnetic resonance imaging, MRI, system (200) for acquiring magnetic resonance data from a target volume in a subject (218), the MRI system (200) comprising a memory (236) for storing machine executable instructions; and a processor (230) for controlling the MRI system (200), wherein execution of the machine executable instructions causes the processor (230) to use a first MRI sequence (401) containing a first selective RF pulse (413) followed by a first excitation RF pulse (415) to control the MRI system (200) to selectively excite and saturate exchangeable amide protons within a first frequency range in the target volume; irradiate said target volume with the first excitation RF pulse (415) that is adapted to excite bulk water protons in the target volume; and acquire first magnetic resonance imaging data from the target volume in response to the first excitation RF pulse (415); use a second MRI sequence (403) containing a second selective RF pulse (423) followed by a second excitation RF pulse (425) to control the MRI system (200) to selectively excite and saturate the exchangeable amide protons within a second frequency range in the target volume; irradiate said target volume with the second excitation RF pulse (425) that is adapted to excite said bulk water protons; and acquire second magnetic resonance imaging data from said target volume in response to the second excitation RF pulse (425); wherein the first MRI sequence (401) comprises gradients (417) having first gradient polarities reverse of second gradient polarities (427) of the second MRI sequence (403).
摘要翻译：本发明涉及一种用于从对象（218）中的目标体积获取磁共振数据的磁共振成像（MRI）系统（200），所述MRI系统（200）包括用于存储机器可执行指令的存储器（236）以及用于控制所述MRI系统（200）的处理器（230），其中所述机器可执行指令的执行使所述处理器（230）使用包含第一选择性RF脉冲（413）的第一MRI序列（401）激励RF脉冲（415）以控制MRI系统（200）以在目标体积的第一频率范围内选择性地激发和饱和可交换的酰胺质子; 用适于激发目标体积中的体积水质子的第一激发RF脉冲（415）照射所述目标体积; 并且响应于所述第一激发RF脉冲（415）从所述目标体积获取第一磁共振成像数据; 使用包含第二选择性RF脉冲（423）的第二MRI序列（403），随后是第二激发RF脉冲（425）以控制MRI系统（200）在第二频率范围内选择性地激发和饱和可交换的酰胺质子目标体积; 用适于激发所述主体水质子的第二激发RF脉冲（425）照射所述目标体积; 并响应于所述第二激励RF脉冲从所述目标体积获取第二磁共振成像数据（425）; 其中所述第一MRI序列（401）包括具有与所述第二MRI序列（403）的第二梯度极性（427）相反的第一梯度极性的梯度（417）。

29. 发明申请

WO2014033185A1 SYSTEM AND METHOD FOR CLASSIFYING TISSUE OXYGENATION PROPERTIES BASED ON CLUSTER ANALYSIS OF THE MULTI-PARAMETRIC MR RESPONSE TO AN OXYGEN BREATHING CHALLENGE 审中-公开
标题翻译：基于多参数MR反应对氧气呼吸挑战的聚类分析的组织氧化特性分类的系统和方法
公开(公告)号：WO2014033185A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/067848
申请日：2013-08-28
申请人： KONINKLIJKE PHILIPS N.V. , PHILIPS DEUTSCHLAND GMBH
发明人： REMMELE, Stefanie , SENEGAS, Julien , KEUPP, Jochen
IPC分类号： G01R33/50 , G01R33/56
CPC分类号： G01R33/50 , G01R33/385 , G01R33/546 , G01R33/56 , G01R33/5601 , G01R33/5608 , G06T15/08
摘要： A magnetic resonance (MR) imaging system (600) for generating information indicative of an MR response to an oxygen breathing challenge, the MRI (600) system comprising at least one controller (610) which is configured to define a reference region (302) within a region of interest (ROI) (300 A) of reconstructed MR image information (300) including a plurality of voxels, the reference region (302) comprising a plurality of reference voxels selected from the plurality of voxels, each of the plurality of voxels having associated ΔR 2 * and ΔR 1 values; select a cluster of voxels comprising voxels from at least the reference voxels from a multiparametric ΔR 2 * and ΔR 1 mapping of the plurality of voxels; determine AR2* and AR\ limit points based upon at least minimum ΔR 2 * and ΔR 1 values of voxels of the cluster of voxels; and determine outlier voxels (115) based upon a comparison of ΔR 2 * and ΔR 1 of at least one of the plurality of voxels with respective values of the ΔR 2 * and ΔR 1 limit points.
摘要翻译：一种用于产生指示对氧气呼吸挑战的MR响应的信息的磁共振（MR）成像系统（600），所述MRI（600）系统包括被配置为限定参考区域（302）的至少一个控制器（610）在包括多个体素的重构MR图像信息（300）的感兴趣区域（ROI）（300A）内，所述参考区域（302）包括从所述多个体素中选择的多个参考体素，具有相关DeltaR2 *和DeltaR1值的体素; 从至少来自所述多个体素的多参数DeltaR2 *和DeltaR1映射的参考体素中选择包含体素的体素簇; 基于体素簇的体素的至少最小DeltaR2 *和DeltaR1值来确定AR2 *和AR \限制点; 并且基于多个体素中的至少一个的DeltaR2 *和DeltaR1与DeltaR2 *和DeltaR1限制点的相应值的比较来确定异常体素（115）。

30. 发明公开

EP4062414A1 APPARATUS FOR DIAGNOSTIC IMAGE ACQUISITION DETERMINATION 审中-公开
公开(公告)号：EP4062414A1
公开(公告)日：2022-09-28
申请号：EP20804296.0
申请日：2020-11-17
申请人： Koninklijke Philips N.V.
发明人： VAN DER ZAAG, Pieter, Jan , VERHAEGH, Wilhelmus, Franciscus, Johannes , KEUPP, Jochen
IPC分类号： G16H20/10 , G16H20/17 , G16H20/40 , G16H30/00 , G16H40/63 , G16H50/20

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