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21. 发明授权

US07684841B2 Living body ingredient concentration measuring instrument 有权
标题翻译：活体成分浓度测定仪
公开(公告)号：US07684841B2
公开(公告)日：2010-03-23
申请号：US11915889
申请日：2007-03-08
申请人： Masahiko Shioi
发明人： Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/6817 , G01J1/04 , G01J1/0448 , G01J1/0451 , G01J2003/1213 , G01N21/35
摘要： A device for measuring the concentration of a biological constituent based on infrared radiation emitted by a subject's eardrum with the influence of the eardrum's thickness taken into account is provided.The biological constituent concentration measuring device includes: a detecting section for detecting infrared radiation emitted by an eardrum; an acquisition section for acquiring thickness information about the thickness of the eardrum; and a computing section for figuring out the concentration of the biological constituent based on the infrared radiation detected and the thickness information acquired. The infrared radiation emitted by the eardrum is subject to the influence of the subject's eardrum thickness. Therefore, by calculating the biological constituent concentration based on not only the infrared radiation detected but also the eardrum thickness information, the biological constituent concentration can be measured highly accurately.
摘要翻译：提供了一种用于根据所考虑的鼓膜厚度的影响来测量基于被检体耳膜发射的红外辐射的生物成分浓度的装置。所述生物体成分浓度测定装置包括：检测部，其检测由鼓膜发射的红外线辐射; 用于获取关于所述鼓膜厚度的厚度信息的获取部分; 以及计算部，用于基于所检测的红外辐射和获取的厚度信息来计算生物成分的浓度。由鼓膜发射的红外辐射受到受试者耳膜厚度的影响。因此，通过不仅检测出红外辐射而且基于鼓膜厚度信息计算生物成分浓度，所以可以高精度地测定生物成分浓度。

22. 发明申请

US20060183982A1 Optical element for measuring information of living body and device for measuring information of living body using the optical element 失效
标题翻译：用于测量生物体信息的光学元件和使用该光学元件测量生物体信息的装置
公开(公告)号：US20060183982A1
公开(公告)日：2006-08-17
申请号：US10547670
申请日：2005-03-28
申请人： Masahiko Shioi
发明人： Masahiko Shioi
IPC分类号： A61B5/00
CPC分类号： G01N21/31 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/146 , G01N21/01 , G01N21/8507 , G01N2021/8535 , G01N2201/064
摘要： The present invention provides an optical element for measuring information of living body for noninvasively measuring a body fluid component in a test sample of living body with high accuracy, stability, and ease. The optical element includes a light incident surface, a contact surface contacting living body and having a groove to protrude living body and a light emission surface, in which a light incident from the light incident surface is applied to living body, and the light absorbed and scattered by living body is received and emitted from the light emission surface, a light transmittance controlling means is formed from the bottom part of the valley part of the groove, on at least a part of a wall surface of the light incident surface side and/or on a wall surface of the light emission surface side of the groove.
摘要翻译：本发明提供了一种用于测量生物体的信息的光学元件，用于以高精度，稳定性和容易度非机械地测量生物体的测试样品中的体液成分。光学元件包括光入射表面，接触表面接触生物体并具有突出的生物体的凹槽和发光表面，其中从入射表面入射的光被施加到生物体，并且光吸收和由发光体散射的发光表面的光入射面侧的壁面的至少一部分上形成有从该凹部的谷部的底部形成的透光率控制装置和/ 或在凹槽的发光表面侧的壁表面上。

23. 发明授权

US08515508B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08515508B2
公开(公告)日：2013-08-20
申请号：US13267625
申请日：2011-10-06
申请人： Tatsurou Kawamura , Masahiko Shioi , Masaru Minamiguchi
发明人： Tatsurou Kawamura , Masahiko Shioi , Masaru Minamiguchi
IPC分类号： A61B5/1455
CPC分类号： G01N21/658 , A61B5/14532 , A61B5/14558 , A61B5/6861
摘要： The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation: R(t)=Am ·sin(ωt)+D, where R(t): received signal, Am: amplitude, t: time, D: a constant number, and ω: angular speed.
摘要翻译：本发明的目的是提供一种用于测量生物体中包含的生物物质的浓度的方法，其中抑制了由于反射光和中断成分引起的精度的劣化。线性偏振光通过调制其调制方向连续地发射到植入皮肤的粒子芯片上。颗粒上产生生物物质的表面增强拉曼散射光。基于接收到的信号计算生物物质的浓度。接收信号满足下列公式：R（t）= Am·sin（omegat）+ D，其中R（t）：接收信号，Am：幅度，t：时间，D：常数，ω：角速度。

24. 发明申请

US20130003058A1 Methods and Systems for Surface Enhanced Optical Detection 有权
标题翻译：表面增强光学检测方法与系统
公开(公告)号：US20130003058A1
公开(公告)日：2013-01-03
申请号：US13634620
申请日：2011-03-22
申请人： Pol Van Dorpe , Kristof Lodewijks , Masahiko Shioi , Jian Ye
发明人： Pol Van Dorpe , Kristof Lodewijks , Masahiko Shioi , Jian Ye
IPC分类号： G01J3/44 , B32B5/16 , B05D5/12 , B05D3/10 , B82Y30/00
CPC分类号： G01N21/658 , B22F2001/0029 , B82Y15/00 , B82Y30/00 , G01N21/553 , G01N21/554 , G01N21/648 , Y10S977/773 , Y10T428/25
摘要： A substrate is described that is suitable for surface enhanced optical detection. The substrate comprises an electrically conductive layer (110), such as for example a gold layer. It furthermore comprises at least one nanoparticle (1404) comprising an electrically conductive portion. The electrically conductive portion in some embodiments provides an opening to an underlying material. Such at least one nanoparticles (1404) thus may for example be a nanoring, a nanodisc, or a non-spherical nanoshell. The substrate furthermore comprises a dielectric spacer (1406) for spacing the electrically conductive layer from the at least one nanoparticles. The dielectric spacer (1406) is a dielectric material substantially only present under the at least one nanoparticle (1404), leaving the electrically conductive layer (110) uncovered from dielectric material at positions away from the nanoparticles (1404). The at least one nanoparticle (1404) and the dielectric spacer (1406) are interfaced along a first major surface (1402) and the at least one nanoparticle (1404) comprises an upstanding surface not in line with an upstanding surface of the dielectric spacer (1406).
摘要翻译：描述了适用于表面增强光学检测的衬底。衬底包括导电层（110），例如金层。它还包括至少一个包含导电部分的纳米颗粒（1404）。在一些实施例中，导电部分为下层材料提供开口。因此，这样的至少一种纳米颗粒（1404）可以例如是纳米级，纳米棒状或非球形纳米壳。衬底还包括用于将导电层与至少一种纳米颗粒间隔开的电介质间隔物（1406）。电介质间隔物（1406）是基本上仅存在于至少一个纳米颗粒（1404）下面的电介质材料，留下导电层（110）在远离纳米颗粒（1404）的位置处不与电介质材料覆盖。至少一个纳米颗粒（1404）和电介质间隔物（1406）沿着第一主表面（1402）接合，并且所述至少一个纳米颗粒（1404）包括不与介电间隔物的直立表面 1406）。

25. 发明申请

US20120215078A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120215078A1
公开(公告)日：2012-08-23
申请号：US13458544
申请日：2012-04-27
申请人： Tatsurou KAWAMURA , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou KAWAMURA , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1459
CPC分类号： A61B5/14532 , A61B5/1455
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的基本上平行的光照射到植入皮肤的颗粒上，产生反射光; 基于倾斜前后的信号差，倾斜光源并计算生物来源物质的浓度。

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