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    • 21. 发明授权
    • Tricyclic compound having anti-allergic activities
    • 三环化合物具有抗过敏活性
    • US5643920A
    • 1997-07-01
    • US325339
    • 1994-10-27
    • Hidenori MochizukiKazuo KatoIchiro YamamotoKiyoshi Mizuguchi
    • Hidenori MochizukiKazuo KatoIchiro YamamotoKiyoshi Mizuguchi
    • C07D471/06A61K31/44C07D221/06C07D455/03
    • C07D471/06
    • A nitrogen-containing tricyclic compound represented by formula (I): ##STR1## a salt thereof, or a solvate of said compound or said salt, wherein R represents phenyl or naphthyl group which is unsubstituted or substituted at one to five sites with a group such as a halogen atom; a straight chain or branched alkyl group containing 1 to 10 carbon atoms which is unsubstituted or substituted with one or more halogen atoms; or the like; Y represents hydrogen atom; and Z represents a group such as hydrogen atom, hydroxyl group, or the like; or Y and Z together represent a group such as hydrazono group, hydroxyimino group, or the like which is unsubstituted or substituted with a particular group; and X.sup.1 -X.sup.2 .about.C.about.X.sup.3 represents CH--N--C.dbd.C or N--C.dbd.C--N; provided that when X.sup.1 -X.sup.2 .about.C.about.X.sup.3 represents N--C.dbd.C--N, Y and Z does not together represent hydroxyimino group or oxygen atom; is capable of inhibiting the production of IgE antibody, and therefore, is useful as a prophylactic and/or therapeutic agent for allergic diseases.
    • PCT No.PCT / JP93 / 00549 Sec。 371日期:1994年10月27日 102(e)日期1994年10月27日PCT提交1993年4月27日PCT公布。 公开号WO93 / 22313 日本公开号为1993年11月11日,由式(I)表示的含氮三环化合物:其中R 1表示未取代或取代的苯基或萘基的化合物或其盐的溶剂化物 在一至五个具有卤素原子的位置; 含有1至10个碳原子的直链或支链烷基,其未被取代或被一个或多个卤素原子取代; 或类似物; Y表示氢原子; Z表示氢原子,羟基等基团, 或Y和Z一起表示未被取代或被特定基团取代的亚氨基,羟基亚氨基等基团; X1-X2差异C差异X3表示CH-N-C = C或N-C = C-N; 条件是当X 1 -X 2差异C差异X3表示N-C = C-N时,Y和Z不一起表示羟基亚氨基或氧原子; 能够抑制IgE抗体的产生,因此可用作过敏性疾病的预防和/或治疗剂。
    • 28. 发明授权
    • 4-hydroxypiperidine derivatives having antiarrhythmic activity
    • 具有抗心律不齐活性的4-羟基哌啶衍生物
    • US06710060B2
    • 2004-03-23
    • US09969639
    • 2001-10-04
    • Ichiro YamamotoManabu ItohFumiaki YamasakiYutaka MiyazakiShinichi Ogawa
    • Ichiro YamamotoManabu ItohFumiaki YamasakiYutaka MiyazakiShinichi Ogawa
    • A61K31445
    • C07D405/06C07D211/48C07D407/06C07D409/06
    • The present invention relates to a compound represented by the following formula (I) or a salt thereof, or a pharmaceutical composition containing the compound as an effective ingredient: (wherein A represents, for example, phenyl group substituted with R1 and R2 or unsubstituted thienyl group; R1 and R2 each independently represent, for example, hydrogen atom, halogen atom or lower alkoxycarbonyl group; R3 represents, for example, hydrogen atom; R4 represents, for example, lower alkyl group; R5 represents, for example, lower alkoxy group; R6 represents, for example, hydrogen atom; R7 and R8 each represent, for example, hydrogen atom, respectively; X represents, for example, a single bond; Y represents, for example, methylene group or benzylidene group substituted with R1; and Z represents, for example, methylene group.) The compounds according to the present invention that do not suppress the transient sodium current of the cardiac muscle and do not manifest proarrhythimic activity is useful as a therapeutic agent for preventing and/or treating arrhythimia and for preventing sudden death.
    • 本发明涉及由下式(I)表示的化合物或其盐或含有该化合物作为有效成分的药物组合物:(其中A表示例如被R 1和R 2取代的苯基) 2或未取代的噻吩基; R 1和R 2各自独立地表示例如氢原子,卤素原子或低级烷氧基羰基; R 3表示例如氢原子; R 4, 表示例如低级烷基; R 5表示例如低级烷氧基; R 6表示例如氢原子; R 7和R 8各自表示例如氢 原子; X表示例如单键; Y表示例如被R 1取代的亚甲基或亚苄基; Z表示例如亚甲基。)根据本发明的化合物 不抑制心肌的瞬时钠电流,并不表现出血浆 节奏活动可用作预防和/或治疗心律失常并用于预防猝死的治疗剂。
    • 29. 发明授权
    • Method for forming a bottom electrode of a storage capacitor
    • 用于形成存储电容器的底部电极的方法
    • US06271085B1
    • 2001-08-07
    • US09761692
    • 2001-01-18
    • Ichiro Yamamoto
    • Ichiro Yamamoto
    • H01L218242
    • H01L28/87H01L27/10852
    • The present invention provides a method of forming an electrode, comprising the steps of: forming a dummy electrode having an uneven side face; forming a template insulating film which completely buries the dummy electrode; removing the dummy electrode with leaving the template insulating film so as to form a hole in the template insulating film, wherein a shape of the uneven side face of the dummy electrode as removed is transferred to an inside wall of the hole; filling a metal film into the hole of the template insulating film, wherein the shape of the uneven inside wall of the hole is transferred to a side face of the metal film; and removing the template insulating film to form a metal electrode with an uneven side face.
    • 本发明提供一种形成电极的方法,包括以下步骤:形成具有不平坦侧面的虚拟电极; 形成完全埋入虚拟电极的模板绝缘膜; 通过离开模板绝缘膜去除虚拟电极以在模板绝缘膜中形成孔,其中去除的虚拟电极的不平坦侧面的形状被转移到孔的内壁; 将金属膜填充到模板绝缘膜的孔中,其中孔的不均匀内壁的形状被转移到金属膜的侧面; 并且去除模板绝缘膜以形成具有不均匀侧面的金属电极。