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21. 发明授权

US6127431A Protein removed .beta.-1,3 glucan and coupling medium for probe of ultrasonograph containing same 失效
标题翻译：蛋白质除去β-1,3葡聚糖和用于包含其的超声波探针的偶联介质
公开(公告)号：US6127431A
公开(公告)日：2000-10-03
申请号：US115744
申请日：1998-07-15
申请人： Kazuyuki Miyazawa , Toshio Yanaki
发明人： Kazuyuki Miyazawa , Toshio Yanaki
IPC分类号： G01N29/28 , A61B8/00 , C08B37/00 , G10K11/02 , B01J13/00 , C12P19/04
CPC分类号： G10K11/02 , C08B37/0024
摘要： There is provided a .beta.-1,3 glucan obtained by applying ultrasonic treatment in a mixed solution of an organic solvent containing at least dimethyl sulfoxide to remove the contaminant proteins and there is provided a coupling medium for a probe of an ultrasonograph comprised of a gel composed of a .beta.-1,3 glucan, as a main component, from which contaminant proteins have been removed as a coupling medium for a probe of an ultrasonograph superior in physical properties and safety.
摘要翻译：提供了通过在含有至少二甲基亚砜的有机溶剂的混合溶液中进行超声波处理以除去污染物蛋白而获得的β-1,3葡聚糖，并且提供了由凝胶组成的超声波检查仪的探针的偶联介质由作为主要组分的β-1,3葡聚糖组成，从物质特性和安全性优异的超声波检查仪的探针中除去杂质蛋白质。

22. 发明授权

US4505757A Method for a specific depolymerization of a polysaccharide having a rod-like helical conformation 失效
标题翻译：具有棒状螺旋构象的多糖的特异性解聚方法
公开(公告)号：US4505757A
公开(公告)日：1985-03-19
申请号：US460300
申请日：1983-01-24
申请人： Takemasa Kojima , Kengo Tabata , Toshio Yanaki , Mitsuaki Mitani
发明人： Takemasa Kojima , Kengo Tabata , Toshio Yanaki , Mitsuaki Mitani
IPC分类号： C08B37/00 , C13K13/00
CPC分类号： C08B37/0033 , C08B37/0024
摘要： The description describes a process for depolymerization of a polysaccharide having a rod-like helical structure, comprising a step for forcing a solution of the polysaccharide in a solvent (solvent A) through a capillary at a high shear rate, to produce a lower molecular weight degraded polysaccharide, which has the same repeating unit and the same helical structure, as those of the original polysaccharide.
摘要翻译：该描述描述了具有棒状螺旋结构的多糖的解聚方法，其包括将多糖在溶剂（溶剂A）中的溶液以高剪切速率通过毛细管的步骤，以产生较低的分子量降解多糖，其具有与原始多糖相同的重复单元和相同的螺旋结构。

23. 发明授权

US07799319B2 Method for measuring skin absorbability 有权
标题翻译：皮肤吸收性测定方法
公开(公告)号：US07799319B2
公开(公告)日：2010-09-21
申请号：US11260714
申请日：2005-10-27
申请人： Eriko Takeoka , Ryuichi Takamoto , Toshio Yanaki
发明人： Eriko Takeoka , Ryuichi Takamoto , Toshio Yanaki
IPC分类号： A61K8/00 , A61K8/18 , A61Q9/00 , A61Q5/00
CPC分类号： A61K8/342 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q9/00 , G01N33/5088
摘要： A method for measuring skin absorbability of a substance, which includes measuring the amount of the substance which is penetrated into hair follicles; and using the resultant data as an index representing the amount of the substance which is absorbed through skin pores, to thereby determine the amount of the substance absorbed through skin pores and a method for measuring skin absorbability of a substance, which includes bringing the substance into contact with a first surface of a thin film that mimics the skin surface layer, a second surface of the film being brought into contact with artificial sebum; and evaluating the sebum transferability of the substance by using the degree of transfer of the substance to the artificial sebum as an index, are disclosed. A kit for performing the measurement method of the present invention is also disclosed.
摘要翻译：用于测量物质的皮肤吸收性的方法，其包括测量渗入毛囊中的物质的量; 并使用所得数据作为表示通过皮肤孔吸收的物质的量的指标，从而确定通过皮肤孔吸收的物质的量和测量物质的皮肤吸收性的方法，其包括使物质进入与模拟皮肤表面层的薄膜的第一表面接触，膜的第二表面与人造皮脂接触; 并且通过使用物质转移到人造皮脂的程度作为指标来评估物质的皮脂转移性。还公开了用于执行本发明的测量方法的套件。

24. 发明申请

US20090047312A1 Microgel and external compositions containing the same 有权
标题翻译：微凝胶和含有它们的外用组合物
公开(公告)号：US20090047312A1
公开(公告)日：2009-02-19
申请号：US12082130
申请日：2008-04-09
申请人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki , Tadashi Nakamura , Masatoshi Ochiai , Tomoyuki Kawasoe
发明人： Kazuyuki Miyazawa , Isamu Kaneda , Toshio Yanaki , Tadashi Nakamura , Masatoshi Ochiai , Tomoyuki Kawasoe
IPC分类号： A61K8/02 , A61Q5/00
CPC分类号： A61K8/042 , A61K8/0212 , A61K8/44 , A61K8/65 , A61K8/676 , A61K8/73 , A61K8/733 , A61K8/8147 , A61K8/8152 , A61K8/8158 , A61K8/86 , A61K8/97 , A61K8/982 , A61K9/0014 , A61K47/36 , A61K47/42 , A61K2800/412 , A61Q5/06 , A61Q5/065 , A61Q19/00 , A61Q19/02 , C08L5/00 , C08L5/04 , C08L5/12 , C08L89/06 , C08L2666/02
摘要： The present invention provides a microgel having a mean particle size of 0.1-1,000 μm, the microgel being produced from a gel which is formed by use of a hydrophilic compound capable of forming a gel. An external composition containing the microgel provides an excellent sensation during use; i.e., the composition provides neither sticky sensation during use nor frictional sensation. Furthermore, even when a large amount of a pharmaceutical ingredient, such as a whitening ingredient, or a salt is incorporated into the composition, the viscosity of the composition is not lowered, and the composition exhibits excellent viscosity increasing property. In addition, the composition exhibits long-term stability, without inviting separation of water.
摘要翻译：本发明提供了一种平均粒径为0.1-1000μm的微凝胶，该微凝胶由凝胶制成，其通过使用能形成凝胶的亲水性化合物形成。含有微凝胶的外用组合物在使用过程中提供极好的感觉; 即，该组合物在使用期间既不提供粘性感，也不提供摩擦感。此外，即使在组合物中加入大量的增白成分或者盐等药物成分，也不会降低组合物的粘度，而且显示出优异的增粘性。此外，该组合物长期稳定，不会引起水分离。

25. 发明申请

US20060034762A1 Method for measuring skin absorbability 审中-公开
标题翻译：皮肤吸收性测定方法
公开(公告)号：US20060034762A1
公开(公告)日：2006-02-16
申请号：US11259882
申请日：2005-10-27
申请人： Eriko Takeoka , Ryuichi Takamoto , Toshio Yanaki
发明人： Eriko Takeoka , Ryuichi Takamoto , Toshio Yanaki
IPC分类号： A61K49/00 , C12Q1/00
CPC分类号： A61K8/342 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q9/00 , G01N33/5088
摘要： A method for measuring skin absorbability of a substance, which includes measuring the amount of the substance which is penetrated into hair follicles; and using the resultant data as an index representing the amount of the substance which is absorbed through skin pores, to thereby determine the amount of the substance absorbed through skin pores and a method for measuring skin absorbability of a substance, which includes bringing the substance into contact with a first surface of a thin film that mimics the skin surface layer, a second surface of the film being brought into contact with artificial sebum; and evaluating the sebum transferability of the substance by using the degree of transfer of the substance to the artificial sebum as an index, are disclosed. A kit for performing the measurement method of the present invention is also disclosed.
摘要翻译：用于测量物质的皮肤吸收性的方法，其包括测量渗入毛囊中的物质的量; 并使用所得数据作为表示通过皮肤孔吸收的物质的量的指标，从而确定通过皮肤孔吸收的物质的量和测量物质的皮肤吸收性的方法，其包括使物质进入与模拟皮肤表面层的薄膜的第一表面接触，膜的第二表面与人造皮脂接触; 并且通过使用物质转移到人造皮脂的程度作为指标来评估物质的皮脂转移性。还公开了用于执行本发明的测量方法的套件。

26. 发明授权

US06326011B1 Copolymer containing reactive silyl groups, composition containing the same and method of treatment with the same 有权
标题翻译：含有反应性甲硅烷基的共聚物，含有相同的组成和与之相同的处理方法
公开(公告)号：US06326011B1
公开(公告)日：2001-12-04
申请号：US09230582
申请日：1999-01-28
申请人： Kazuyuki Miyazawa , Toshio Yanaki , Fumiaki Matsuzaki
发明人： Kazuyuki Miyazawa , Toshio Yanaki , Fumiaki Matsuzaki
IPC分类号： A61K600
摘要： A copolymer having silyl groups with at least one reactive functional group bonded thereto. The copolymer comprises a monomer (A) shown by the following Formula (I): wherein R1 is hydrogen atom or methyl; R2 is alkylene group having 1-6 carbon atoms; and R3, R4 and R5 each is a reactive functional group which can cross-link molecules of the copolymer by hydrolyzing. Further, the copolymer preferably comprises, as a constituent monomer, an alkyl (meth)acrylate and a siloxane-containing (meth)acrylate. A coating-forming method comprises hydrolyzing the composition on a material to be treated to cross-link molecules of the copolymer when on the material. A coating of the cross-linked copolymer has resistance to washing. This coating can modify the nature of hair, improve make-up retention, and provide skin-protecting. It can impart water-repellency, resistance to fouling, suitability as a sizing and crease resistance to fibers. Further, it can improve a skin-cleaning effect, applicability, strippability and coating-strength of a peeling-off type cosmetic pack.
摘要翻译：具有与其键合有至少一个反应性官能团的甲硅烷基的共聚物。共聚物包含由下式（I）表示的单体（A）：其中R 1 是氢原子或甲基; R 2 是具有1-6个碳原子的亚烷基; 和R 3 ，R 4 和R 5 各自是可通过水解将共聚物分子交联的反应性官能团。此外，共聚物优选包含（甲基）丙烯酸烷基酯和含硅氧烷的（甲基）丙烯酸酯作为构成单体。涂覆形成方法包括在待处理的材料上水解组合物以在材料上交联共聚物的分子。交联共聚物的涂层具有耐洗涤性。这种涂层可以改变头发的性质，改善补妆保持性，并提供皮肤保护。它可以赋予防水性，耐污垢性，适合性作为纤维的上胶和抗折皱性。此外，它可以改善剥离型化妆品包装的皮肤清洁效果，适用性，剥离性和涂布强度。

27. 发明授权

US4965354A Process for producing a condensed polysaccharide 失效
标题翻译：缩合多糖的制造方法
公开(公告)号：US4965354A
公开(公告)日：1990-10-23
申请号：US161170
申请日：1988-02-26
申请人： Toshio Yanaki , Shigeki Maehata , Tomoko Satoh , Shinji Ikeda
发明人： Toshio Yanaki , Shigeki Maehata , Tomoko Satoh , Shinji Ikeda
IPC分类号： A23L1/308 , C08B37/00
CPC分类号： C08B37/0009 , A23L33/26 , C08B37/00 , Y10S426/804
摘要： A process for producing a condensed polysaccharide, which comprises heat-melting at least one compound selected from the group consisting of glucose, mannose, galactose, xylose and arabinose, which contains from 8 to 180 ppm of hydrogen chloride, followed by dehydration condensation under reduced pressure.
摘要翻译：一种冷凝多糖的制备方法，其包括将至少一种选自葡萄糖，甘露糖，半乳糖，木糖和阿拉伯糖的化合物加热熔融，所述化合物含有8至180ppm的氯化氢，然后在还原下进行脱水缩合压力。

28. 发明申请

US20110165323A1 Production method of dry water 审中-公开
标题翻译：干水生产方法
公开(公告)号：US20110165323A1
公开(公告)日：2011-07-07
申请号：US12926497
申请日：2010-11-22
申请人： Takashi Oka , Nobuyoshi Koga , Emiko Takasu , Toshio Yanaki
发明人： Takashi Oka , Nobuyoshi Koga , Emiko Takasu , Toshio Yanaki
IPC分类号： B05D5/00 , B05D7/00 , B82Y99/00
CPC分类号： A61K8/11 , A61K2800/412 , A61Q1/12 , B01F3/1214 , B01F3/1221
摘要： A production method of dry water containing an aqueous ingredient coated with a hydrophobic powder to form a powder state capable of liquefying upon embrocation at the time of use, wherein the dry water is produced by charging a hydrophobic powder and an aqueous ingredient into a hollow container forming a hydrophobic enclosed space in the inside thereof, followed by agitating at a high speed in the enclosed hydrophobic hollow container to form the aqueous ingredient to fine aqueous droplets, and then allowing the surfaces of the fine aqueous droplets to be uniformly adsorbed with the hydrophobic powder, whereby the dry water in the form of a powder state, but is capable of being liquefied upon embrocation at the time of use to be simply produced in a large scale.
摘要翻译：一种干燥水的制造方法，其含有涂覆有疏水性粉末的水性成分，以形成在使用时能够在通气时液化的粉末状态，其中所述干燥水是通过将疏水性粉末和水性成分装入中空容器在其内部形成疏水封闭空间，随后在封闭的疏水性中空容器中高速搅拌，以形成水性成分以精细的水滴，然后使细小水滴的表面均匀地被疏水性吸附粉末，由此形成粉末形式的干燥水，但是在使用时能够在刺穿时液化，以便大量简单地生产。

29. 发明授权

US07927615B2 Thickener, cosmetic preparation containing the same, and process for producing the same 有权
标题翻译：增稠剂，含有其的化妆品及其制备方法
公开(公告)号：US07927615B2
公开(公告)日：2011-04-19
申请号：US12576438
申请日：2009-10-09
申请人： Isamu Kaneda , Toshio Yanaki
发明人： Isamu Kaneda , Toshio Yanaki
IPC分类号： A61K8/81 , A61K8/04 , A61Q1/00 , A61Q15/00 , A61Q5/00
CPC分类号： C08F2/32 , A61K8/042 , A61K8/8158 , A61Q1/02 , A61Q5/00 , A61Q5/065 , A61Q5/08 , A61Q15/00 , A61Q17/005 , A61Q19/00 , A61Q19/002 , A61Q19/04 , C09K3/00 , Y10S514/844
摘要： The present invention is a thickener consisting of a microgel obtained by radical polymerization of water soluble ethylene-type unsaturated monomers dissolved in the dispersion phase in a composition having an organic solvent or an oil component as the dispersion medium and water as the dispersion phase, as well as a cosmetic containing said thickener.Also, the present invention is a method of manufacturing a water-swelling polymer in a radical polymerization system consisting of a composition having an organic solvent or oil component as the dispersion medium and an aqueous solution of a water soluble ethylene type unsaturated monomer as the dispersion phase wherein said system contains a surfactant chosen in such a way that the aforementioned composition forms a single phase W/O microemulsion or fine W/O emulsion at a thermal radical polymerization temperature and said thermal radical polymerization is carried out at a temperature equal to or higher than the phase transition temperature of the radical polymerization system, yet not higher than the phase transition temperature by 20° C. or more.
摘要翻译：本发明是一种增稠剂，其由通过溶解在分散相中的水溶性乙烯型不饱和单体在具有有机溶剂或作为分散介质的油成分的组合物中的自由基聚合而获得的增稠剂，作为分散相的水作为以及含有所述增稠剂的化妆品。此外，本发明是一种在由具有有机溶剂或油性成分作为分散介质的组合物和作为分散体的水溶性乙烯型不饱和单体的水溶液组成的自由基聚合体系中制造水溶性聚合物的方法相，其中所述体系含有选择的表面活性剂，使得上述组合物在热自由基聚合温度下形成单相W / O微乳液或细W / O乳液，并且所述热自由基聚合在等于或等于高于自由基聚合体系的相变温度，但不高于相转变温度20℃以上。

30. 发明申请

US20050175564A1 Tickener, cosmetic preparation containing the same, and process for producing the same 审中-公开
标题翻译：口服剂，含有其的美容制剂及其制备方法
公开(公告)号：US20050175564A1
公开(公告)日：2005-08-11
申请号：US10513824
申请日：2003-05-12
申请人： Isamu Kaneda , Toshio Yanaki
发明人： Isamu Kaneda , Toshio Yanaki
IPC分类号： A61K8/02 , A61K8/04 , A61K8/81 , A61Q1/02 , A61Q5/00 , A61Q5/06 , A61Q5/08 , A61Q15/00 , A61Q17/00 , A61Q19/00 , A61Q19/04 , C08F2/32 , C09K3/00 , A61K7/06
CPC分类号： C08F2/32 , A61K8/042 , A61K8/8158 , A61Q1/02 , A61Q5/00 , A61Q5/065 , A61Q5/08 , A61Q15/00 , A61Q17/005 , A61Q19/00 , A61Q19/002 , A61Q19/04 , C09K3/00 , Y10S514/844
摘要： The present invention is a thickener consisting of a microgel obtained by radical polymerization of water soluble ethylene-type unsaturated monomers dissolved in the dispersion phase in a composition having an organic solvent or an oil component as the dispersion medium and water as the dispersion phase, as well as a cosmetic containing said thickener. Also, the present invention is a method of manufacturing a water-swelling polymer in a radical polymerization system consisting of a composition having an organic solvent or oil component as the dispersion medium and an aqueous solution of a water soluble ethylene type unsaturated monomer as the dispersion phase wherein said system contains a surfactant chosen in such a way that the aforementioned composition forms a single phase W/O microemulsion or fine W/O emulsion at a thermal radical polymerization temperature and said thermal radical polymerization is carried out at a temperature equal to or higher than the phase transition temperature of the radical polymerization system, yet not higher than the phase transition temperature by 20° C. or more.
摘要翻译：本发明是一种增稠剂，其由通过溶解在分散相中的水溶性乙烯型不饱和单体在具有有机溶剂或作为分散介质的油成分的组合物中的自由基聚合而获得的增稠剂，作为分散相的水作为以及含有所述增稠剂的化妆品。此外，本发明是一种在由具有有机溶剂或油性成分作为分散介质的组合物和作为分散体的水溶性乙烯型不饱和单体的水溶液组成的自由基聚合体系中制造水溶性聚合物的方法相，其中所述体系含有选择的表面活性剂，使得上述组合物在热自由基聚合温度下形成单相W / O微乳液或细W / O乳液，并且所述热自由基聚合在等于或等于高于自由基聚合体系的相变温度，但不高于相转变温度20℃以上。

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