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21. 发明专利

CA2199978A1 INDOLE DERIVATIVES 未知
公开(公告)号：CA2199978A1
公开(公告)日：1997-02-06
申请号：CA2199978
申请日：1996-07-16
申请人： KYOWA HAKKO KOGYO KK
发明人： MACHII DAISUKE , TAKAI HARUKI , SUZUKI KOJI , KOSAKA NOBUO , SATO SOICHIRO
IPC分类号： C07D209/42 , A61K31/395 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/00
摘要： Indole derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R1 represents hydrogen, lower alkyl, hydroxy, lower alkoxy, halogeno, (a): -O-(CH2)n-OR5 or (b), R2 represents hydrogen, lower alkyl or halogeno; R3 represents hydrogen, lower alkyl or (c) and R4 represents hydroxy, lower alkoxy, optionally substituted aryloxy or NR10R11, provided that R4 represents -NR10R11 when R3 is hydrogen or lower alkyl.

22. 发明专利

CA2199976A1 INDOLE DERIVATIVES 未知
公开(公告)号：CA2199976A1
公开(公告)日：1997-02-06
申请号：CA2199976
申请日：1996-07-16
申请人： KYOWA HAKKO KOGYO KK
发明人： MACHII DAISUKE , TAKAI HARUKI , SUZUKI KOJI , KOSAKA NOBUO , SATO SOICHIRO
IPC分类号： C07D209/30 , C07D403/12 , A61K31/395 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/00
摘要： Indole derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, lower alkyl, hydroxy, lower alkoxy, halogeno, (a): -O- (CH2)n-OR5 or (b), R3 represents hydrogen, lower alkyl or (c) and R4 represents hydroxy, lower alkoxy, optionally substituted aryloxy or -NR10R11.

23. 发明专利

AU2003284399A1 PLK INHIBITORS 未知
公开(公告)号：AU2003284399A1
公开(公告)日：2004-06-03
申请号：AU2003284399
申请日：2003-11-14
申请人： KYOWA HAKKO KOGYO KK
发明人： UMEHARA HIROSHI , YAMASHITA YOSHINORI , TSUJITA TETSUYA , ARAI HITOSHI , HAGIHARA KOJI , MACHII DAISUKE
IPC分类号： A61P35/00 , A61P43/00 , C07D239/42 , C07D401/04 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D239/47 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/48 , C07D413/14

24. 发明专利

AU2003220968A1 ANTI-INFLAMMATORY AGENT 未知
公开(公告)号：AU2003220968A1
公开(公告)日：2003-10-13
申请号：AU2003220968
申请日：2003-03-28
申请人： KYOWA HAKKO KOGYO KK
发明人： MIKI ICHIRO , MACHII DAISUKE , YAMAURA YOSUKE , ARAI HITOSHI , YANAGAWA KOJI , OHSHIMA ETSUO , KAWANABE ARI , IWASE MIHO , KOBAYASHI KATSUYA , SATO TAKASHI
IPC分类号： A61K31/506 , A61P29/00 , A61P37/08 , A61P43/00 , C07D401/12 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/04

25. 发明专利

AU2641199A Remedies for erectile dysfunction 未知
公开(公告)号：AU2641199A
公开(公告)日：1999-09-15
申请号：AU2641199
申请日：1999-02-26
申请人： KYOWA HAKKO KOGYO KK
发明人： ONODA YASUO , TAKAMI HITOSHI , SEISHI TAKASHI , MACHII DAISUKE , NOMOTO YUJI , TAKAI HARUKI , OKUMURA HIROSHI , OHNO TETSUJI , YAMADA KOJI , ICHIMURA MICHIO
IPC分类号： C07D471/04

26. 发明专利

AT93838T 未知
公开(公告)号：AT93838T
公开(公告)日：1993-09-15
申请号：AT90108091
申请日：1990-04-27
申请人： KYOWA HAKKO KOGYO KK
发明人： KINOSHITA IWAO , MACHII DAISUKE , ONODA YASUO , TAKAI HARUKI , KOSAKA NOBUO , SHUTO KATSUICHI , GOMI KATSUSHIGE , MORIMOTO MAKOTO , ISHII AKIO
IPC分类号： A61K31/09 , A61K31/135 , A61K31/165 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/472 , A61P3/00 , A61P9/00 , A61P19/10 , C07C217/58 , C07C217/60 , C07C233/11 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/65 , C07C233/75 , C07C235/42 , C07C235/44 , C07C235/46 , C07C235/54 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/32 , C07C237/40 , C07C323/42 , C07D207/09 , C07D211/14 , C07D211/58 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/06 , C07D217/04 , C07D221/20 , C07D223/20 , C07D225/08 , C07D277/20 , C07D277/44 , C07D277/46 , C07D277/82 , C07D295/08 , C07D295/096 , C07D295/10 , C07D295/112 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/182 , C07D295/192 , C07D295/205 , C07D307/00 , C07D311/00 , C07D333/20 , C07D333/38 , C07D401/04 , C07D413/04
摘要： A triphenylmethane derivative represented by the following general formula: exhibits born absorption inhibiting effects and is useful as a medicament for treating osteoporosis.

27. 发明专利

CA2015473A1 TRIPHENYLMETHANE DERIVATIVES 未知
公开(公告)号：CA2015473A1
公开(公告)日：1990-10-28
申请号：CA2015473
申请日：1990-04-26
申请人： KYOWA HAKKO KOGYO KK
发明人： KINOSHITA IWAO , MACHII DAISUKE , ONODA YASUO , TAKAI HARUKI , KOSAKA NOBUO , SHUTO KATSUICHI , GOMI KATSUSHIGE , MORIMOTO MAKOTO , ISHII AKIO
IPC分类号： A61K31/09 , A61K31/135 , A61K31/165 , A61K31/365 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4406 , A61K31/4427 , A61K31/47 , A61K31/472 , A61P3/00 , A61P9/00 , A61P19/10 , C07C217/58 , C07C217/60 , C07C233/11 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/60 , C07C233/65 , C07C233/75 , C07C235/42 , C07C235/44 , C07C235/46 , C07C235/54 , C07C235/56 , C07C235/64 , C07C235/84 , C07C237/32 , C07C237/40 , C07C323/42 , C07D207/09 , C07D211/14 , C07D211/58 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/06 , C07D217/04 , C07D221/20 , C07D223/20 , C07D225/08 , C07D277/20 , C07D277/44 , C07D277/46 , C07D277/82 , C07D295/08 , C07D295/096 , C07D295/10 , C07D295/112 , C07D295/125 , C07D295/13 , C07D295/135 , C07D295/182 , C07D295/192 , C07D295/205 , C07D307/00 , C07D311/00 , C07D333/20 , C07D333/38 , C07D401/04 , C07D413/04
摘要： A triphenylmethane derivative represented by the following general formula: exhibits born absorption inhibiting effects and is useful as a medicament for treating osteoporosis.

28. 发明公开

EP0741132A4 INDOLE DERIVATIVE 失效
标题翻译：吲哚衍生物
公开(公告)号：EP0741132A4
公开(公告)日：1997-09-17
申请号：EP95905756
申请日：1995-01-11
申请人： KYOWA HAKKO KOGYO KK
发明人： MACHII DAISUKE , TAKAI HARUKI , KOSAKA NOBUO , SEO HISAKATSU , SUGIYAMA TOMOMI , NAKAMURA JOJI , ISHIDA HIROYUKI , GOMI KATSUSHIGE , SATO SOICHIRO , UCHII MASAKO
IPC分类号： C07D209/42 , A61K31/40
CPC分类号： C07D209/42
摘要： An indole derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R?1 and R2¿ may be the same or different and each represents hydrogen, lower alkyl, -(CH¿2?)n-OR?6 (R6¿ representing hydrogen or lower alkyl, and n representing an integer of 1 to 6), or -(CH¿2?)m-NR?7R8¿ (wherein R?7 and R8¿ may be the same or different and each represents hydrogen or lower alkyl, or alternatively R?7 and R8¿ are combined to represent, together with the nitrogen atom to which they are bonded, an (un)substituted heteroalicyclic group, and m represents an integer of 2 to 6); R3 represents hydrogen, lower alkyl or -(CH¿2?)p-NR?9R10¿ (wherein R?9 and R10¿ may be the same or different and each represents hydrogen or lower alkyl, or alternatively R?9 and R10¿ are combined to represent, together with the nitrogen atom to which they are bonded, an (un)substituted heteroalicyclic group, and p represents an integer of 2 to 6); and R?4 and R5¿ may be the same or different and each represents hydrogen, lower alkyl, cycloalkyl, (un)substituted aryl or (un)substituted heterocycle, or alternatively R?4 and R5¿ are combined to represent, together with the nitrogen atom to which they are bonded, an (un)substituted heteroalicyclic group.
摘要翻译：由通式（Ⅰ）表示的吲哚衍生物或其药理学上可接受的盐，其中R 1和R 2可以相同或不同，各自代表氢，低级烷基， - （CH 2）n -OR 6 （R6代表氢或低级烷基，n代表1至6的整数），或 - （CH2）m-NR7R8（其中R7和R8可以相同或不同，每个表示氢或低级烷基，或者R17和R8与它们所键合的氮原子一起表示一个（未）取代的杂脂环基团，m表示2-6的整数。 R 3代表氢，低级烷基或 - （CH 2 2）p -NR 9 R 10（其中R 9和R 10可以相同或不同，各代表氢或低级烷基，或者R 9和R 10 与它们所键合的氮原子一起表示（未）取代的杂脂环族基团，并且p表示2至6的整数。（未）取代的芳基或（未）取代的杂环，或者R 14和R 5'结合在一起表示与R 4和R 5'一起代表氢，低级烷基，环烷基，它们所键合的氮原子，（未）取代的杂脂环基团。

29. 发明公开

EP0668280A4 IMIDAZOQUINAZOLINE DERIVATIVE. 失效
标题翻译：咪唑并CHINAZOLIN衍生物。
公开(公告)号：EP0668280A4
公开(公告)日：1995-07-04
申请号：EP94925621
申请日：1994-09-02
申请人： KYOWA HAKKO KOGYO KK
发明人： MACHII DAISUKE , MATSUNO KENJI , KINOSHITA IWAO , NOMOTO YUJI , TAKAI HARUKI , OHNO TETSUJI , NAGASHIMA KEN , ISHIKAWA TOMOKO , YAMADA KOJI , ICHIMURA MICHIO , KASE HIROSHI
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04
摘要： An imidazoquinazoline derivative represented by formula (I) or a pharmacologically acceptable salt thereof, wherein R1 andR2 may be the same or different from each other and each represents hydrogen, lower alkyl, lower alkenyl, aryl, etc.; R3 represents hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aryl, etc.; and X represents O or S. This compound has a potent and selective cCMP-specific PDE inhibitor activity and is useful for treating or mitigating cardiovascular diseases such as thrombosis, angina pectoris, hypertension and arteriosclerosis, asthma, and so forth.

30. 发明公开

EP1533312A4 HETERO-BICYCLIC COMPOUNDS 审中-公开
标题翻译：混合动力学VERBINDUNGEN
公开(公告)号：EP1533312A4
公开(公告)日：2006-05-31
申请号：EP03760954
申请日：2003-06-25
申请人： KYOWA HAKKO KOGYO KK
发明人： MACHII DAISUKE , SUZUKI KOJI , MATSUMURA TSUTOMU , ARAI HITOSHI , IWASE MIHO , YANO HIROSHI , NAKANISHI S , OGINO FUMIKO , TAKASAKI KOTARO , KUSAKA HIDEAKI
IPC分类号： A61K31/437 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/10 , A61P13/12 , A61P25/00 , A61P43/00 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/55 , C07D487/04
摘要： Compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein X··Y··Z is R5N-C=O (wherein R5 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted lower alkenyl, or substituted or unsubstituted lower alkynyl) or the like; R1 and R2 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like; and R3 and R4 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like.
摘要翻译：通式（I）表示的化合物或其药理学上可接受的盐：（I）其中X·Y·Z是R5N-C = O（其中R5是氢，取代或未取代的低级烷基，取代或未取代的芳烷基，取代的或未取代的低级链烯基，或取代或未取代的低级炔基）等; R1和R2各自独立地为氢，取代或未取代的低级烷基等; 并且R3和R4各自独立地为氢，取代或未取代的低级烷基等。

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