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    • 22. 发明申请
    • IMPLANTABLE FLOW REGULATOR WITH FAILSAFE MODE AND RESERVE DRUG SUPPLY
    • 具有故障安全模式和储备药物供应的植入式流量调节器
    • WO2004012794A8
    • 2004-06-10
    • PCT/US0228575
    • 2002-09-06
    • DURECT CORPPOUTIATINE ANDREW IGILLIS EDWARD MMAEUSLI PIERRE-ALAINGASS VOLKER
    • POUTIATINE ANDREW IGILLIS EDWARD MMAEUSLI PIERRE-ALAINGASS VOLKER
    • A61M5/168A61M39/28A61M5/00
    • A61M5/16877A61M5/16881A61M39/28
    • An implantable flow regulator (22) for regulating flow of a drug along a drug delivery pathway (14) form a drug source to a treatment site within a subject includes a movable diversion member (24) and an actuator. The movable diversion member (24) is operably coupled to a delivery pathway (14). The actuator is actuatable to move the diversion member (24) between at least a first mode position where the diversion member (24) restricts flow through the delivery pathway (14) (i.e., delivery pathway is "closed"), and a second mode position where the diversion member (24) is positioned to allow flow through the delivery pathway (14) (i.e., delivery pathway is "open"). Supplying power to actuate the actuator moves the diversion member (24) from its normally biased first mode or "closed" position, which is also a failsafe position, toward its second mode or "open" position. In the "open" position, drug is supplied to target sites, typically from a drug supply reserve within the regulator.
    • 用于调节药物沿着药物输送通道(14)的药物流动的可植入流量调节器(22)形成到对象内治疗部位的药物源,包括可移动转向构件(24)和致动器。 可移动转向构件(24)可操作地联接到输送通道(14)。 致动器可致动以在至少第一模式位置和第二模式之间移动分流构件24,在第一模式位置中分流构件24限制通过输送通路14的流动(即输送通路“关闭”), (24)定位成允许流过输送通道(14)(即输送通道“打开”)的位置。 提供致动致动器的动力将分流构件24从其正常偏置的第一模式或“关闭”位置(其也是故障安全位置)朝向其第二模式或“打开”位置移动。 在“开放”的位置,药物通常来自监管机构内的药物供应储备,供应给目标地点。