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21. 发明申请

WO1997007671A1 CHIMERIC ANIMAL AND METHOD FOR CONSTRUCTING THE SAME 审中-公开
标题翻译：重要动物及其构建方法
公开(公告)号：WO1997007671A1
公开(公告)日：1997-03-06
申请号：PCT/JP1996002427
申请日：1996-08-29
申请人： KIRIN BEER KABUSHIKI KAISHA , TOMIZUKA, Kazuma , YOSHIDA, Hitoshi , HANAOKA, Kazunori , OSHIMURA, Mitsuo , ISHIDA, Isao
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/18 , C12N15/8509 , C12N15/90 , C12N2517/02
摘要： A method for constructing a chimeric nonhuman animal which comprises preparing microcells containing one or more foreign chromosomes or fragments of the same, and transferring the foreign chromosome(s) or fragments of the same into cells having differentiative pluripotency via the fusion with the microcells; a chimeric nonhuman animal which can be constructed by the above method and offsprings of the same; tissues and cells originating in the same; a method for utilizing the tissues and cells; cells which contain one or more foreign chromosomes or fragments of the same and sustain differentiative pluripotency; a method for constructing the cells; and a method for utilizing the cells.
摘要翻译：一种构建嵌合非人动物的方法，其包括制备含有一种或多种外来染色体或其片段的微细胞，并通过与所述微细胞融合将所述外源染色体或其片段转移到具有微分多能性的细胞中; 可以通过上述方法和其后代构建的嵌合非人动物; 起源于其的组织和细胞; 一种利用组织和细胞的方法; 含有一个或多个外来染色体或相同片段并维持差异多能性的细胞; 构建细胞的方法; 以及利用这些电池的方法。

22. 发明申请

WO1997000959A1 ANTIGEN NON-SPECIFIC GLYCOSYLATION INHIBITING FACTOR DERIVATIVES 审中-公开
标题翻译：抗原非特异性糖蛋白抑制因子衍生物
公开(公告)号：WO1997000959A1
公开(公告)日：1997-01-09
申请号：PCT/JP1996001721
申请日：1996-06-21
申请人： KIRIN BEER KABUSHIKI KAISHA , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , MIKAYAMA, Toshifumi , TOMURA, Takafumi , WATARAI, Hiroshi , KUROKI, Ryota , KATO, Yoicho , ISHIZAKA, Kimishige , NAKANO, Tatsumi
发明人： KIRIN BEER KABUSHIKI KAISHA , LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
IPC分类号： C12N15/19
CPC分类号： C07K14/52 , A61K38/00
摘要： A derivative of an antigen non-specific human glycosylation inhibiting factor of SEQ ID NO: 1, wherein the derivative has enhanced biological activity as compared to the antigen non-specific human glycosylation inhibiting factor having the amino acid sequence of SEQ ID NO: 1; a polynucleotide encoding a derivative of an antigen non-specific human glycosylation inhibiting factor of SEQ ID NO: 1, wherein the derivative contains a mutation of the nucleotide sequence of SEQ ID NO: 1, and has enhanced biological activity as compared to the antigen non-specific human glycosylation inhibiting factor having the amino acid sequence of SEQ ID NO: 1; recombinant vectors containing the polynucleotide; prokaryotic or eucaryotic cells transformed with the polynucleotide; methods of producing the antigen non-specific human glycosylation inhibiting factor derivatives; pharmaceutical compositions comprising the antigen non-specific human glycosylation inhibiting factor derivative and a pharmaceutically acceptable carrier; and methods of suppressing a human immune response to an antigen are provided.
摘要翻译： SEQ ID NO：1的抗原非特异性人糖基化抑制因子的衍生物，其中与具有SEQ ID NO：1的氨基酸序列的抗原非特异性人糖基化抑制因子相比，所述衍生物具有增强的生物学活性; 编码SEQ ID NO：1的抗原非特异性人糖基化抑制因子的衍生物的多核苷酸，其中所述衍生物含有SEQ ID NO：1的核苷酸序列的突变，并且与抗原非抗原相比具有增强的生物活性具有SEQ ID NO：1的氨基酸序列的特异性人糖基化抑制因子; 含有多核苷酸的重组载体; 用多核苷酸转化的原核或真核细胞; 产生抗原非特异性人糖基化抑制因子衍生物的方法; 包含抗原非特异性人糖基化抑制因子衍生物和药学上可接受的载体的药物组合物; 并提供抑制对抗原的人免疫应答的方法。

23. 发明申请

WO1995034642A1 NOVEL TRANSFERASE AND AMYLASE, PROCESS FOR PRODUCING THE ENZYMES,USE THEREOF, AND GENE CODING FOR THE SAME 审中-公开
标题翻译：新型转移酶和淀粉酶，生产酶的方法，用途及其基因编码
公开(公告)号：WO1995034642A1
公开(公告)日：1995-12-21
申请号：PCT/JP1995001189
申请日：1995-06-14
申请人： KIRIN BEER KABUSHIKI KAISHA , KATO, Masaru , MIURA, Yutaka , KETTOKU, Masako , IWAMATSU, Akihiro , KOBAYASHI, Kazuo , KOMEDA, Toshihiro
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： C12N09/10
CPC分类号： C12N9/2411 , C12N9/1048 , C12N9/2408 , C12N9/2414 , C12N9/2417 , C12P19/14
摘要： The invention provides a novel transferase that acts on a saccharide, as a substrate, composed of at least three sugar units wherein at least three glucose residues on the reducing end side are linked alpha -1,4 so as to transfer the alpha -1,4 lingages to a alpha -1, alpha -1 linkages; a process for producing the transferase; a gene coding for the same; and a process for producing an oligosaccharide by using the same. Also provided are a novel amylase that has a principal activity of acting on a saccharide, as a substrate, composed of at least three sugar units wherein at least three sugar units on the reducing end side are glucose units and the linkage between the first and the second glucose units is alpha -1, alpha -1 while the linkage between the second and the third glucose units is alpha -1,4 so as to liberate alpha , alpha -trehalose by hydrolyzing the alpha -1,4 linkage and another activity of hydrolyzing the alpha -1,4 linkage within the molecular chain of the substrate and that liberates dissaccharides and/or monosaccharides as the principal final products; a process for producing the amylase; a gene coding for the same; and a process for producing alpha , alpha -trehalose by using a combination of the transferase and the amylase.
摘要翻译：本发明提供了一种新的转移酶，其作用为由至少三个糖单元组成的作为底物的糖，其中还原末端侧的至少三个葡萄糖残基连接成α-1,4，以转移α-1， 4个碱基对α-1，α-1键; 生产转移酶的方法; 编码相同的基因; 以及使用该寡糖的方法。还提供了一种新的淀粉酶，其具有作用于由至少三个糖单元组成的糖类作为底物的主要活性，其中还原端侧的至少三个糖单元是葡萄糖单元，第一和第第二葡萄糖单位是α-1，α-1，而第二和第三葡萄糖单元之间的连接是α-1,4，以便通过水解α-1,4键和另一种活性来释放α，α-海藻糖水解基质分子链内的α-1,4键，释放出脱糖和/或单糖作为主要的最终产物; 淀粉酶的制造方法; 编码相同的基因; 以及通过使用转移酶和淀粉酶的组合产生α，α-海藻糖的方法。

24. 发明申请

WO1995016462A1 METHOD FOR ANTIGEN-SPECIFIC IMMUNOREGULATION BY T-CELL ALPHA CHAIN 审中-公开
标题翻译： T细胞ALPHA链抗原特异性免疫调节方法
公开(公告)号：WO1995016462A1
公开(公告)日：1995-06-22
申请号：PCT/US1994014542
申请日：1994-12-13
申请人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , KIRIN BEER KABUSHIKI KAISHA
发明人： LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY , KIRIN BEER KABUSHIKI KAISHA , GREEN, Douglas , FOTEDAR, Arun , BISSONNETTE, Reid , MIKAYAMA, Toshifumi , ISHII, Yasuyuki
IPC分类号： A61K39/395
CPC分类号： C07K14/7051 , A61K38/00 , C12N2799/027
摘要： Methods for modulating immune responses in an antigen-specific fashion are disclosed. The methods utilize soluble TCR alpha chains which are capable of binding to the antigen, and which, in the presence of an accessory component, suppress the immune response in an antigen-specific manner. The use of TCR alpha chains which demonstrate such activity in therapeutic protocols for treating hyperimmune and immunodeficient conditions is described.
摘要翻译：公开了以抗原特异性方式调节免疫应答的方法。该方法利用能够结合抗原的可溶性TCRα链，并且在辅助成分的存在下，以抗原特异性方式抑制免疫应答。描述了在用于治疗超免疫和免疫缺陷状况的治疗方案中证明这种活性的TCRα链的使用。

25. 发明申请

WO1991014359A1 PROCESS FOR PRODUCING TUBER 审中-公开
标题翻译：生产管子的方法
公开(公告)号：WO1991014359A1
公开(公告)日：1991-10-03
申请号：PCT/JP1991000382
申请日：1991-03-25
申请人： KIRIN BEER KABUSHIKI KAISHA , ONISHI, Noboru , HAYASHIDA, Kunihiro , MAMIYA, Kanji
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A01H04/00
CPC分类号： A01H4/005
摘要： A process for producing tubers of a solanum readily in a large amount, wherein the stolon and foliage which have grown in a liquid phase under application of carbon dioxide in the light period of the foliage growth stage are exposed to a gas phase in the tuber formation stage to form tubers in a high yield, and the culture in the tuber formation stage is conducted while aerating the gas phase of a culture tank to form a large amount of tubers not only near the boundary of the culture medium but also in the gas phase apart from the medium. As a result, the efficiency of tuber formation and the quality of the tuber are improved.

26. 发明申请

WO1991009110A1 CONTINUOUS FERMENTATION PROCESS AND REACTOR THEREFOR 审中-公开
标题翻译：连续发酵过程及其反应器
公开(公告)号：WO1991009110A1
公开(公告)日：1991-06-27
申请号：PCT/JP1990001623
申请日：1990-12-12
申请人： KIRIN BEER KABUSHIKI KAISHA , SUZUKI, Akira , SUEKI, Masaaki , ARIKAWA, Keiichi , KOBAYASHI, Noritaka , EHARA, Takashi
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： C12C11/04
CPC分类号： C12P7/06 , C12G3/02 , C12M21/12 , C12M25/18 , C12M41/32 , Y02E50/17
摘要： A continuous fermentation process which comprises supplying additional starting material stepwise into an upstream zone of a starting material solution, which flows from an inlet (3) of starting material toward an outlet (4) of product in a reaction tank (1) packed with a carrier (2) containing a microorganism immobilized thereon, in such a manner that the substrate concentration in the tank (1) is kept on a high level suitable for effecting microbial reaction so that the starting material component will have completed its reaction near the outlet (4) of the tank (1) and a desired alcohol concentration is reached. A reactor for continuous fermentation which is equipped with at least one inlet (5, 6) for supplying additional starting material into an upstream zone of a starting material solution, which flows from an inlet (3) of starting material toward an outlet (4) of product in a reaction tank (1) packed with a carrier (2) containing a microorganism immobilized thereon, and which has, in the tank (1), a reaction promoting zone (7) for keeping the substrate concentration on a high level suitable for effecting microbial reaction and a reaction completing zone (8) for completing the reaction of remaining starting material so that a desired alcohol concentration is reached near the outlet of the tank.

27. 发明申请

WO1990001539A1 DOUBLE-CYLINDER TYPE BIO-REACTOR 审中-公开
标题翻译：双缸型生物反应器
公开(公告)号：WO1990001539A1
公开(公告)日：1990-02-22
申请号：PCT/JP1989000787
申请日：1989-08-01
申请人： KIRIN BEER KABUSHIKI KAISHA , SUZUKI, Akira , NAGARA, Akira , MITSUI, Shunsuke
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： C12M01/40
CPC分类号： C12M25/16 , C12M27/22 , C12M27/24 , C12M41/12
摘要： This invention relates to a double-cylinder type bio-reactor of a vertical cylinder type wherein an inner cylinder is put into an outer tank so as to separate an outer passage from an inner passage and to form an inner-outer two-layered structure. A liquid inlet (13) is formed at a lower part of the outer passage (3), and a liquid outlet (14) at a lower part of the inner passage (4). A cooling jacket (8) is fitted to the outer periphery of the outer tank (1) and a gas vent chamber (15) to which the upper surfaces of the inner and outer passages (3), (4) are open is formed at an inner upper part of the outer tank (1). Attachment carriers (7) for a bio-catalyst is packed into the outer and inner passages (3), (4).
摘要翻译：本发明涉及一种垂直圆柱型双缸型生物反应器，其中将内筒放入外罐中，以将外通道与内通道分开并形成内外两层结构。在外部通道（3）的下部形成有液体入口（13），在内部通道（4）的下部形成有液体出口（14）。一个冷却套（8）安装在外箱（1）的外周和一个排气室（15）上，内，外通道（3），（4）的上表面打开，外罐（1）的内上部。用于生物催化剂的附着载体（7）被包装到外部和内部通道（3），（4）中。

28. 发明申请

WO1998029135A1 DRUGS FOR AMELIORATING OPHTHALMIC CIRCULATORY DISTURBANCE 审中-公开
标题翻译：用于改善眼底循环障碍的药物
公开(公告)号：WO1998029135A1
公开(公告)日：1998-07-09
申请号：PCT/JP1997004665
申请日：1997-12-17
申请人： KIRIN BEER KABUSHIKI KAISHA , OGAWA, Takahiro , WATANABE, Noriko , WAKI, Mitsunori
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A61K45/00
CPC分类号： A61K31/4406 , A61K31/275 , A61K31/44
摘要： Drugs for ameliorating ophthalmic circulatory disturbance characterized by containing as the active ingredient potassium channel openers. As the potassium channel openers, use may be preferably mado of carboxyimidamide derivatives represented by general formula (I), acid-addition salts thereof or hydrates of the same, wherein each symbol is as defined in the specification. When dropped into eyes, in particular, drugs for ameliorating ophthalmic circulatory disturbance containing the compounds of general formula (I) can increase the blood flow in the optic papillae of normal eyes and inhibit retinal vessel contraction and a decrease in the blood flow in the optic papillae of eyes suffering from circulatory disturbance caused by ET-1 while scarcely affecting the blood pressure. It is therefore suggested that these compounds are useful as remedies for glaucoma, in particular, normotensive glaucoma caused by ophthalmic circulatory disturbance, retinal pigment degeneration, macular degeneration, ischemic optic nerve disease, iridocyclitis, retinal arterial obliteration, retinal phlebemphraxis, diabetic retinopathy, ischemic optic nerve disease, choroid diseases following retinal lesions, retinal choroid diseases accompanied by systemic diseases, etc.
摘要翻译：用于改善眼部循环障碍的药物，其特征在于含有作为活性成分的钾通道开放剂。作为钾通道开放剂，可以优选使用通式（I）表示的羧酰亚胺酰胺衍生物，其酸加成盐或其水合物，其中每个符号如说明书中所定义。特别地，当掉入眼睛时，特别是用于改善含有通式（I）化合物的眼科循环障碍的药物可以增加正常眼睛的视乳头中的血流量，并抑制视网膜血管收缩，并减少视神经中的血流量患有ET-1引起的循环障碍的眼睛乳头，几乎不影响血压。因此，认为这些化合物可用作青光眼的药物治疗，特别是由眼周循环障碍引起的血压正常的青光眼，视网膜色素变性，黄斑变性，缺血性视神经疾病，虹膜睫状体炎，视网膜动脉闭塞，视网膜血le症，糖尿病性视网膜病变，缺血性视神经疾病，视网膜病变后的脉络丛疾病，伴有全身性疾病的视网膜脉络丛疾病等

29. 发明申请

WO1998001417A1 CALCIUM RECEPTOR-ACTIVE COMPOUNDS 审中-公开
标题翻译：钙受体活性化合物
公开(公告)号：WO1998001417A1
公开(公告)日：1998-01-15
申请号：PCT/JP1997002358
申请日：1997-07-08
申请人： KIRIN BEER KABUSHIKI KAISHA , NPS PHARMACEUTICALS, INC. , SAKAI, Teruyuki , TAKAMI, Atsuya , SUZUKI, Rika
发明人： KIRIN BEER KABUSHIKI KAISHA , NPS PHARMACEUTICALS, INC.
IPC分类号： C07C211/30
CPC分类号： C07D207/335 , C07B2200/07 , C07C211/30 , C07C217/20 , C07C217/58 , C07C237/06 , C07C237/08 , C07C237/10 , C07C317/18 , C07C317/28 , C07C323/25 , C07C2603/18 , C07D209/08 , C07D209/14 , C07D209/88 , C07D213/38 , C07D213/40 , C07D213/70 , C07D215/36 , C07D241/12 , C07D263/58 , C07D277/28 , C07D277/74 , C07D281/06 , C07D307/52 , C07D307/91 , C07D311/30 , C07D317/58 , C07D333/20 , C07D333/34
摘要： Novel calcium receptor-active compounds represented by the following general formula: Ar1-[CR R ]p-X-[CR R ]q-[CR R ]-NR -[CR R ]-Ar2 wherein Ar1 is selected from the group consisting of aryl, heteroaryl, bis(arylmethyl)amino, bis(heteroaryl-methyl)amino and arylmethyl(heteroarylmethyl)amino; X is selected from the group consisting of oxygen, sulfur, sulfinyl, sulfonyl, carbonyl and amino; R , R , R , R , R , R , R , R and R represent, for example, each hydrogen or alkyl; Ar2 is selected from the group consisting of aryl and heteroaryl; p is an integer of from 0 to 6; and q is an integer of from 0 to 14.
摘要翻译：由以下通式表示的新型钙受体活性化合物：Ar1- [CR 1 R 2] pX- [CR 3 R 4] q- [CR 5 R 6] - NR 7 - [CR 8 R 9] -Ar 2，其中Ar 1选自芳基，杂芳基，双（芳基甲基）氨基，双（杂芳基 - 甲基）氨基和芳基甲基（杂芳基甲基）氨基; X选自氧，硫，亚磺酰基，磺酰基，羰基和氨基; R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9表示例如各自氢或烷基; Ar 2选自芳基和杂芳基; p是0至6的整数; q为0〜14的整数。

30. 发明申请

WO1997022242A1 MOLD-RESISTANT PLANT AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：耐模霉素植物及其生产方法
公开(公告)号：WO1997022242A1
公开(公告)日：1997-06-26
申请号：PCT/JP1996003653
申请日：1996-12-13
申请人： KIRIN BEER KABUSHIKI KAISHA , KAKITANI, Makoto , UMEMOTO, Naoyuki , ISHIDA, Isao , YAMAOKA, Naoto
发明人： KIRIN BEER KABUSHIKI KAISHA
IPC分类号： A01H05/00
CPC分类号： C12N15/8282
摘要： A process for producing a plant resistant to pathogenic molds by integrating a DNA sequence coding for glucan elicitor receptors into plant chromosomes to effect expression; a plant resistant to pathogenic molds, which contains the DNA sequence coding for glucan elicitor receptors introduced thereinto and expressed therein; and the use thereof.
摘要翻译：通过将编码葡聚糖激发剂受体的DNA序列整合到植物染色体中以产生表达来生产对致病性霉菌有抗性的植物的方法; 一种抗病原菌的植物，其含有引入其中并在其中表达的编码葡聚糖激发剂受体的DNA序列; 及其用途。

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