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21. 发明申请

US20050134377A1 Doherty amplifier 审中-公开
标题翻译：多赫蒂放大器
公开(公告)号：US20050134377A1
公开(公告)日：2005-06-23
申请号：US10745213
申请日：2003-12-23
申请人： Paul Dent
发明人： Paul Dent
IPC分类号： H03F1/02 , H03F3/68
CPC分类号： H03F1/0288
摘要： An efficient linear amplifier according to the present invention comprises a primary amplifier for providing power to a load and an auxiliary amplifier for generating an artificial reflection signal. The artificial reflection signal may have a predetermined phase difference as compared to the output signal supplied to the load. The amplifying circuit also includes a coupler connecting the primary amplifier to the load. The coupler includes a load port connected to the load, a primary port connected to an output of the primary amplifier, and an auxiliary port connected to an output of the auxiliary amplifier such that the artificial reflection signal changes an apparent impedance of the load as seen by the primary amplifier.
摘要翻译：根据本发明的有效线性放大器包括用于向负载提供电力的初级放大器和用于产生人造反射信号的辅助放大器。与提供给负载的输出信号相比，人造反射信号可以具有预定的相位差。放大电路还包括将初级放大器连接到负载的耦合器。耦合器包括连接到负载的负载端口，连接到主放大器的输出的主端口和连接到辅助放大器的输出的辅助端口，使得人造反射信号改变负载的视在阻抗，如图所示由主放大器。

22. 发明申请

US20050004007A1 Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitiors and cellular differentiation agents 审中-公开
标题翻译：通过共同施用细胞周期蛋白依赖性激酶抑制剂和细胞分化剂促进癌细胞凋亡
公开(公告)号：US20050004007A1
公开(公告)日：2005-01-06
申请号：US10363540
申请日：2001-09-07
申请人： Steven Grant , Paul Dent , Roberto Rosato , Leanne Cartee
发明人： Steven Grant , Paul Dent , Roberto Rosato , Leanne Cartee
IPC分类号： A61K31/19 , A61K31/353 , A61K31/59 , A61K38/12
CPC分类号： A61K31/353 , A61K31/19 , A61K31/59 , A61K38/12 , A61K2300/00
摘要： The invention provides compositions and methods for promoting apoptosis of cancer cells, and methods for treating cancer. The compositions comprise cyclin dependent kinase inhibitor and an agent that induces cellular differentiation. The methods of promoting apoptosis of cancer cells involve the co-administration to the cancer cells of a cyclin dependent kinase inhibitor and an agent that induces cell differentiation. The method for treating cancer involves the co-administration of a cyclin dependent kinase inhibitor and an agent that induces cellular differentiation to a patient. Examples of cyclin dependent kinase inhibitors include histone deacetylase inhibitors, protein kinase C activators, retinoids, and Vitamin D3.
摘要翻译：本发明提供了促进癌细胞凋亡的组合物和方法，以及治疗癌症的方法。组合物包含细胞周期蛋白依赖性激酶抑制剂和诱导细胞分化的药剂。促进癌细胞凋亡的方法涉及对细胞周期蛋白依赖性激酶抑制剂和诱导细胞分化的药物的癌细胞的共同给药。用于治疗癌症的方法涉及细胞周期蛋白依赖性激酶抑制剂和诱导细胞分化给患者的药剂的共同给药。细胞周期蛋白依赖性激酶抑制剂的实例包括组蛋白去乙酰化酶抑制剂，蛋白激酶C激活剂，类视色素和维生素D3。

23. 发明授权

US06532290B1 Authentication methods 有权
公开(公告)号：US06532290B1
公开(公告)日：2003-03-11
申请号：US09258414
申请日：1999-02-26
申请人： Paul Dent
发明人： Paul Dent
IPC分类号： H04K100
CPC分类号： H04W12/06 , H04L9/3273 , H04L63/0428 , H04L63/0869 , H04L2209/80
摘要： In one way to improve the security of bilateral authentication procedures while keeping transmission overhead to a minimum, a first party wishing to initiate communications with a second party generates a random number having a first number of digits. The first party the enciphers the random number using a secret ciphering key to obtain an enciphered version of the random number that has a second number of digits greater or equal to the first number. A third number of selected digits of the enciphered random number are then transmitted to the second party, where the third number is less than the first number. The second party receives the digits transmitted from the first party and expands the third number of digits in a pre-agreed manner to obtain the second number of digits. The second party then deciphers the second number digits using the second party's secret key to obtain the first number of digits, which is not equal to the original random number chosen by the first party. The so-obtained first number of digits is then used by the second party as a ciphering key to encipher the second party's secret key thereby obtaining an enciphered key containing the second number of digits. A fourth number of digits less than the second number are then selected by the second party and transmitted to the first party. The first party also expands the third number of digits it transmitted to the first party in the same pre-agreed manner to obtain the second number of digits and then deciphers this so-obtained second number of digits using its secret key to obtain a first number of digits once more. The first party then selects from these a fourth number of digits less than the second number in the same manner as the second party, and compares the selected fourth number of selected digits with the fourth number of digits received from the second party. If a match is detected, the first party has verified that the second party possesses the same secret key as itself. The roles may be reversed to allow the second party to verify the identity of the first party, either by repeating the above procedure starting with a new random number chosen by the second party, or else continuing to derive a number of digits to be returned from the first party to the second party based on the digits received from the second party and the first party's secret key.

24. 发明授权

US6147107A Specific inhibition of the P42/44 mitogen activated protein (map) kinase cascade sensitizes tumor cells 失效
标题翻译： P42 / 44丝裂原活化蛋白（图）激酶级联的特异性抑制对肿瘤细胞敏感
公开(公告)号：US6147107A
公开(公告)日：2000-11-14
申请号：US203342
申请日：1998-12-20
申请人： Paul Dent , Steven Grant , W. David Jarvis
发明人： Paul Dent , Steven Grant , W. David Jarvis
IPC分类号： A61K31/166 , A61K31/275 , A61K31/337 , A61K31/352 , A01N43/02 , A61K31/335
CPC分类号： A61K31/352 , A61K31/166 , A61K31/275 , A61K31/337
摘要： Mammaliam cancer cells are effectively killed when treated with a lethal agent (e.g. radiation or chemotherapeutic agents) in combination with an inhibitor specific for the p42/44 MAP kinase cascade "proper".
摘要翻译：当用致死剂（例如辐射或化学治疗剂）与对p42 / 44MIC激酶级联“适当”特异的抑制剂组合时，哺乳动物细胞癌细胞被有效地杀死。

25. 发明申请

US20120131348A1 METHOD FOR SIGNING DOCUMENTS USING A PC AND A PERSONAL TERMINAL DEVICE 审中-公开
标题翻译：使用PC和个人终端设备来签名文件的方法
公开(公告)号：US20120131348A1
公开(公告)日：2012-05-24
申请号：US13363690
申请日：2012-02-01
申请人： Janez Skubic , Paul Dent , Ben Smeets , Stefan Andersson , Mikael Nilsson , Helena Lindskog
发明人： Janez Skubic , Paul Dent , Ben Smeets , Stefan Andersson , Mikael Nilsson , Helena Lindskog
IPC分类号： H04L9/00
CPC分类号： H04L9/3236 , H04L9/3247 , H04L63/08 , H04L63/12 , H04L63/123 , H04L67/04 , H04L69/329 , H04L2209/56 , H04L2209/80
摘要： A method for obtaining a digital signature is disclosed. Upon receipt of request for a digital signature within a customer computer, a Mobile electronic transaction proxy within the customer PC notifies a web browser of the request for the digital signature and assists in obtaining a digital signature on a data string included within the request. After the digital signature is obtained, the data string along with an appended digital signature is transmitted back to a requesting party.
摘要翻译：公开了一种获取数字签名的方法。在客户计算机中接收到数字签名的请求之后，客户PC内的移动电子交易代理通知网络浏览器对数字签名的请求，并协助获取包含在请求内的数据串的数字签名。在获得数字签名之后，将数据串与附加的数字签名一起发送回请求方。

26. 发明申请

US20080139457A1 Therapeutic compositions comprising chorionic gonadotropins and HMG CoA reductase inhibitors 审中-公开
标题翻译：包含绒毛膜促性腺激素和HMG CoA还原酶抑制剂的治疗组合物
公开(公告)号：US20080139457A1
公开(公告)日：2008-06-12
申请号：US11521213
申请日：2006-09-14
申请人： Paul Dent
发明人： Paul Dent
IPC分类号： A61K38/24 , A61P35/00
CPC分类号： A61K45/06 , A61K31/401 , A61K2300/00
摘要： The invention provides improved methods and compositions for the treatment of cancer in a subject comprising administering to said subject a therapeutically effective amount of a composition comprising a chorionic gonadotropin or a therapeutically active fragment or analogue thereof in combination with an HMG CoA reductase inhibitor. The compositions and methods may also comprise geranylgeranyltransferase inhibitors (GGTI) and farnesyltransferase inhibitors (FTI) instead of or in addition to the HMG CoA reductase inhibitors of the invention.
摘要翻译：本发明提供用于治疗受试者癌症的改进方法和组合物，其包括向所述受试者施用治疗有效量的组合物，所述组合物包含绒毛膜促性腺激素或其治疗活性片段或类似物与HMG CoA还原酶抑制剂的组合。组合物和方法还可以包含香叶基香叶基转移酶抑制剂（GGTI）和法呢基转移酶抑制剂（FTI），代替或补充本发明的HMG CoA还原酶抑制剂。

27. 发明申请

US20070204033A1 Methods and systems to detect abuse of network services 审中-公开
标题翻译：检测网络服务滥用的方法和系统
公开(公告)号：US20070204033A1
公开(公告)日：2007-08-30
申请号：US11361931
申请日：2006-02-24
申请人： James Bookbinder , Christopher Smith , Paul Dent
发明人： James Bookbinder , Christopher Smith , Paul Dent
IPC分类号： G06F15/173
CPC分类号： G06Q10/10
摘要： Methods, apparatus, and systems to detect abuse of network services are disclosed. An example method involves obtaining network service activity information associated with a plurality of network service accounts, comparing via a fraud detection system the network service activity information with a term of a service agreement of a service provider, and identifying abusive activity based on the comparison.
摘要翻译：公开了检测网络服务滥用的方法，装置和系统。示例性方法包括获得与多个网络服务帐户相关联的网络服务活动信息，通过欺诈检测系统将网络服务活动信息与服务提供商的服务协议的术语进行比较，以及基于比较来识别滥用活动。

28. 发明授权

US07245602B2 System and method for anonymous Bluetooth devices 有权
标题翻译：匿名蓝牙设备的系统和方法
公开(公告)号：US07245602B2
公开(公告)日：2007-07-17
申请号：US09802095
申请日：2001-03-07
申请人： Janez Skubic , Paul Dent , Nils Rydbeck , Christian Gehrman
发明人： Janez Skubic , Paul Dent , Nils Rydbeck , Christian Gehrman
IPC分类号： H04Q7/24
CPC分类号： H04L63/0407 , H04L29/12254 , H04L29/12273 , H04L29/1232 , H04L61/2038 , H04L61/2053 , H04L61/2092 , H04W8/26 , H04W12/02 , H04W84/18
摘要： A method and apparatus for enabling anonymous communications from a first Bluetooth device to a second Bluetooth device is disclosed wherein a temporary identification number associated with the first Bluetooth device is obtained and used in transmissions from the first Bluetooth device to the second Bluetooth device. A temporary identification number provides no clear indication of the particular Bluetooth communications device transmitting messages.
摘要翻译：公开了一种用于实现从第一蓝牙设备到第二蓝牙设备的匿名通信的方法和设备，其中获得与第一蓝牙设备相关联的临时识别号码并用于从第一蓝牙设备到第二蓝牙设备的传输。临时标识号码不提供特定蓝牙通信设备传输消息的明确指示。

29. 发明申请

US20060110376A1 MDA-7 and free radicals in the treatment of cancer 审中-公开
标题翻译： MDA-7和自由基治疗癌症
公开(公告)号：US20060110376A1
公开(公告)日：2006-05-25
申请号：US11158743
申请日：2005-06-22
申请人： Paul Fisher , Rahul Gopalkrishnan , Irina Lebedeva , Steven Grant , Adly Yacoub , Paul Dent
发明人： Paul Fisher , Rahul Gopalkrishnan , Irina Lebedeva , Steven Grant , Adly Yacoub , Paul Dent
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/00 , C07K14/47 , C07K2319/23 , C12N2710/10343 , C12N2810/00
摘要： The present invention relates to methods of treating a cancer in a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. The present invention further relates to methods of inhibiting proliferation or promoting death in a cancer cell of a subject comprising generating within one or more cancer cells of a subject an effective amount of MDA-7 and an effective amount of one or more free radicals. Generation of an effective amount of MDA-7 can occur by administering to the cancer cell an effective amount of an mda-7 nucleic acid, MDA-7 protein, functional equivalents of either of these molecules, by upregulation of the endogenous mda-7 gene, or by stabilization of the mda-7 mRNA. Generation of one or more free radicals in a cancer cell can occur by exposing the cancer cell to an effective amount of ionizing radiation, a free radical, a generator of a free radical, a ROS, a generator of a ROS, or a disruptor of mitochondrial membrane potential.
摘要翻译：本发明涉及治疗受试者的癌症的方法，包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。本发明还涉及在受试者的癌细胞中抑制增殖或促进死亡的方法，包括在受试者的一个或多个癌细胞内产生有效量的MDA-7和有效量的一种或多种自由基。有效量的MDA-7的产生可通过向癌细胞施用有效量的mda-7核酸，MDA-7蛋白，这些分子的功能等同物，通过上调内源性mda-7基因，或通过稳定mda-7mRNA。通过将癌细胞暴露于有效量的电离辐射，自由基，自由基的发生剂，ROS，ROS的产生剂或破坏剂的破坏剂，可以发生癌细胞中的一种或多种自由基的产生线粒体膜电位。

30. 发明申请

US20050046507A1 Pseudo-polar modulation for radio transmitters 有权
标题翻译：无线电发射机的伪极坐标调制
公开(公告)号：US20050046507A1
公开(公告)日：2005-03-03
申请号：US10639164
申请日：2003-08-11
申请人： Paul Dent
发明人： Paul Dent
IPC分类号： H03C3/40 , H03C5/00 , H03C3/00
CPC分类号： H03C5/00 , H03C3/40
摘要： Methods of modulating a radio transmitter. An amplitude modulation signal is generated based on in-phase (I) and quadrature (Q) components of an information signal, and so that it has a reduced predetermined characteristic compared to the magnitude of the I and Q components of the information signal. A complex signal is formed that has substantially the same phase angle variation as the I and Q components of the information signal so that the product of the complex signal and the amplitude modulation signal is substantially equal to the information signal.
摘要翻译：调制无线电发射机的方法。基于信息信号的同相（I）和正交（Q）分量产生幅度调制信号，并且与信息信号的I和Q分量的幅度相比，其具有减小的预定特性。形成具有与信息信号的I和Q分量基本相同的相位角变化的复信号，使得复信号和幅度调制信号的乘积基本上等于信息信号。

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