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21. 发明申请

US20050049416A1 Synthesis 失效
标题翻译：合成
公开(公告)号：US20050049416A1
公开(公告)日：2005-03-03
申请号：US10884842
申请日：2004-07-02
申请人： Richard Palmer , Nicholas Meyers , John Knight
发明人： Richard Palmer , Nicholas Meyers , John Knight
IPC分类号： A61P1/00 , C07C231/12 , C07C233/54 , C07D471/08 , C07D453/04
CPC分类号： C07D471/08 , C07C231/12 , C07C233/54
摘要： The present invention provides an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride, compositions thereof, and intermediates thereto.
摘要翻译：本发明提供了制备[（±） - 内] -4-氨基-5-氯-2-甲氧基-N-（1-氮杂双环[3.3.1]壬-4-基）苯甲酰胺盐酸盐的改进方法，其组合物及其中间体。

22. 发明申请

US20050045344A1 Downhole tool and method 有权
标题翻译：井下工具及方法
公开(公告)号：US20050045344A1
公开(公告)日：2005-03-03
申请号：US10929345
申请日：2004-08-26
申请人： Simon Fraser , William Brown-Kerr , John Knight
发明人： Simon Fraser , William Brown-Kerr , John Knight
IPC分类号： E21B47/18 , E21B33/12
CPC分类号： E21B47/187
摘要： The invention relates to a downhole tool for generating a fluid pressure pulse, and to a method of generating a fluid pressure pulse downhole. In one embodiment of the invention, an improved downhole tool (10) and method for transmitting data signals from a downhole environment to surface is disclosed, the downhole tool (10) comprising a fluid actuated flow restrictor (22); a first fluid flow path (23) for flow of actuating fluid to actuate the flow restrictor (22); a second fluid flow path (25) for flow of actuating fluid to actuate the flow restrictor (22); and a control member (12) movable between a first closed position where the first fluid flow path (23) is closed and the second fluid flow path (25) is open, and a discrete second closed position where the first fluid flow path (23) is open and the second fluid flow path (25) is closed, for controlling actuation of the flow restrictor (22) to generate a fluid pressure pulse.
摘要翻译：本发明涉及一种用于产生流体压力脉冲的井下工具，以及一种产生井下流体压力脉冲的方法。在本发明的一个实施例中，公开了一种改进的井下工具（10）和用于将数据信号从井下环境传送到地面的方法，所述井下工具（10）包括流体致动的限流器（22）; 第一流体流动路径（23），用于致动流体以致动流量限制器（22）; 第二流体流路（25），用于致动流体以致动流量限制器（22）; 以及在第一流体流动路径（23）关闭的第一关闭位置和第二流体流路（25）之间可移动的控制构件（12）打开，以及离散的第二关闭位置，其中第一流体流路（23））打开并且关闭第二流体流路（25），用于控制限流器（22）的致动以产生流体压力脉冲。

23. 发明授权

US06442608B1 Distributed database system with authoritative node 有权
标题翻译：具有权威节点的分布式数据库系统
公开(公告)号：US06442608B1
公开(公告)日：2002-08-27
申请号：US09231929
申请日：1999-01-14
申请人： John Knight , Thomas Anthony Roden , Darrell Myers Shively, II , Pauline Chen , Kavita Shekhar Patil , Sonny Bui
发明人： John Knight , Thomas Anthony Roden , Darrell Myers Shively, II , Pauline Chen , Kavita Shekhar Patil , Sonny Bui
IPC分类号： G06F15173
CPC分类号： H04L63/10
摘要： An authorizing apparatus for use with a client that connects to a first server in a network is described. The authorizing apparatus includes a second server that authorizes session requests of the client for the first server. A plurality of records of resource allocation data is coupled with the second server. Each record indicates whether a session may be established between the client and the first server. Coupled to the second server is information that associates an entity that includes and is associated with one or more clients, and information that associates the second server to a third server that is authoritative for the second server and the associated clients. Means are provided for receiving a request to establish a session between the client and the first server and for determining, at the second server, based on one of the records that is associated with the client, whether the session may be established when the client is associated with the entity. Also provided are means for informing the first server that the session is authorized only when the second server determines from the one of the records that the session may be established. Although the first, second and third servers have been described as separate servers the functions performed by two or more of the servers may actually be combined in a single server unit.
摘要翻译：描述了一种与连接到网络中的第一服务器的客户端一起使用的授权装置。授权装置包括授权客户端针对第一服务器的会话请求的第二服务器。资源分配数据的多个记录与第二服务器耦合。每个记录指示是否可以在客户端和第一个服务器之间建立会话。耦合到第二服务器的是将包括并与一个或多个客户端相关联的实体关联的信息，以及将第二服务器与对于第二服务器和相关联的客户端具有权威性的第三服务器相关联的信息。提供了用于接收在客户端和第一服务器之间建立会话的请求的装置，并且用于在第二服务器处，基于与客户端相关联的记录中的一个来确定该会话是否可以在客户端是与实体相关联。还提供了用于通知第一服务器仅当第二服务器从记录中的一个确定会话可被建立时才允许该会话被授权的装置。虽然第一，第二和第三服务器已经被描述为单独的服务器，但是由两台或多台服务器执行的功能实际上可以组合在单个服务器单元中。

24. 发明授权

US06359146B1 Process for the production of R-(+)-6-carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole 有权
标题翻译：制备R - （+） - 6-甲酰氨基-3-N-甲基氨基-1,2,3,4-四氢咔唑的方法
公开(公告)号：US06359146B1
公开(公告)日：2002-03-19
申请号：US09689661
申请日：2000-10-13
申请人： Ian Brackenridge , Caroline McGee , Steven McIntyre , John Knight , David Hartley
发明人： Ian Brackenridge , Caroline McGee , Steven McIntyre , John Knight , David Hartley
IPC分类号： C07D20984
CPC分类号： C07D209/88 , C07B2200/07
摘要： The present invention relates to a novel process for the preparation of R-(+)-6-carboxamido-3-N-methylamino-1,2,3,4-tetrahydrocarbazole. The process comprises resolving an enantiomeric mixture of a compound of formula (I):
摘要翻译：本发明涉及制备R - （+） - 6-甲酰氨基-3-N-甲基氨基-1,2,3,4-四氢咔唑的新方法。该方法包括拆分式（I）化合物的对映体混合物：

25. 发明授权

US5925624A 2,6-Di (substitutedamino) purine ribonucleoside analogues and administration to treat respiratory inflammation 失效
标题翻译： 2,6-Di（取代氨基）嘌呤核糖核苷类似物并给予治疗呼吸道炎症
公开(公告)号：US5925624A
公开(公告)日：1999-07-20
申请号：US446727
申请日：1995-09-18
申请人： Michael Gregson , Barry Edward Ayres, deceased , George Blanch Ewan , Frank Ellis , John Knight
发明人： Michael Gregson , Barry Edward Ayres, deceased , George Blanch Ewan , Frank Ellis , John Knight
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P1/00 , A61P9/00 , A61P11/00 , A61P29/00 , A61P35/04 , A61P37/00 , A61P37/06 , A61P37/08 , C07H19/16 , C07H19/167
CPC分类号： C07H19/16 , C07H19/167
摘要： The present invention relates to 2,6-diaminopurine-.beta.-D-ribofuranuronamide derivatives of the following formula (I). These compounds and their salts and solvates are useful as anti-inflammatory agents, particularly in the treatment of patients with inflammatory conditions who are susceptible to leukocyte-induced tissue damage. ##STR1##
摘要翻译： PCT No.PCT / EP94 / 00145 Sec。 371 1995年9月18日第 102（e）1995年9月18日PCT PCT 1994年1月18日PCT公布。公开号WO94 / 17090 日期：1994年8月4日本发明涉及下式（I）的2,6-二氨基嘌呤-β-D-呋喃核糖酰胺衍生物。这些化合物及其盐和溶剂化物可用作抗炎剂，特别是用于治疗易受白细胞诱导的组织损伤的炎性病症的患者。

26. 发明授权

US08178594B2 Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications 有权
公开(公告)号：US08178594B2
公开(公告)日：2012-05-15
申请号：US12967581
申请日：2010-12-14
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
IPC分类号： C08F10/02
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

27. 发明授权

US08129440B2 Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications 有权
标题翻译：用于医疗器械应用的抗氧化稳定的交联超高分子量聚乙烯
公开(公告)号：US08129440B2
公开(公告)日：2012-03-06
申请号：US12579094
申请日：2009-10-14
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
IPC分类号： C08F10/02
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译：在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。在一个示例性实施方案中，抗氧化剂是生育酚。在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。然后将所得产物进行交联照射。在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。

28. 发明申请

US20110133371A1 ANTIOXIDANT STABILIZED CROSSLINKED ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE FOR MEDICAL DEVICE APPLICATIONS 有权
公开(公告)号：US20110133371A1
公开(公告)日：2011-06-09
申请号：US12967581
申请日：2010-12-14
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
IPC分类号： B29C67/24 , B29C43/00 , B29C45/00 , B29C47/00 , B29C49/00 , C08J3/28
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

29. 发明申请

US20110035496A1 AUTOMATIC HARDWARE FAILURE DETECTION AND RECOVERY FOR DISTRIBUTED MAX SESSIONS SERVER 有权
标题翻译：自动硬件故障检测和恢复分布式最大会话服务器
公开(公告)号：US20110035496A1
公开(公告)日：2011-02-10
申请号：US12907900
申请日：2010-10-19
申请人： Darrell Myers Shively, II , John Knight , Kavita Shekhar Patil , Pauline Chen Boyd , Sonny Bui , Thomas Anthony Roden
发明人： Darrell Myers Shively, II , John Knight , Kavita Shekhar Patil , Pauline Chen Boyd , Sonny Bui , Thomas Anthony Roden
IPC分类号： G06F15/16
CPC分类号： G06F11/0751 , G06F11/0709 , H04L43/16 , H04L63/0892 , H04L67/14 , H04L69/40
摘要： A Max Sessions Server (MSS) automatically detects hardware and communications failures. Upon detection, counters are adjusted accordingly to maintain an accurate count of users or groups of users on a system. A database of unique identifiers for each connection is maintained, where the unique identifier is a concatenation of a Network Access Server (NAS) and the connection's incoming NAS node number. If a user requests permission to log into the system, the MSS first checks the database to determine if the unique identifier is already logged in. If so, then a hardware or communications failure has occurred and the MSS must make the appropriate adjustments to the database and counter.
摘要翻译：最大会话服务器（MSS）自动检测硬件和通信故障。检测后，相应地调整计数器，以便在系统上维持用户或用户组的准确计数。维护每个连接的唯一标识符的数据库，其中唯一标识符是网络访问服务器（NAS）和连接的传入NAS节点号码的级联。如果用户请求登录系统的权限，则MSS首先检查数据库以确定唯一标识符是否已经登录。如果是，则发生硬件或通信故障，并且MSS必须对数据库进行适当的调整和柜台。

30. 发明申请

US20100029858A1 ANTIOXIDANT STABILIZED CROSSLINKED ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE FOR MEDICAL DEVICE APPLICATIONS 有权
标题翻译：用于医疗器械应用的抗氧化稳定交联超高分子量聚乙烯
公开(公告)号：US20100029858A1
公开(公告)日：2010-02-04
申请号：US12579094
申请日：2009-10-14
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
IPC分类号： C08F10/02
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译：在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。在一个示例性实施方案中，抗氧化剂是生育酚。在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。然后将所得产物进行交联照射。在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。

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