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21. 发明申请

US20090204025A1 Method and apparatus for an improved sample capture device 有权
标题翻译：用于改进的采样装置的方法和装置
公开(公告)号：US20090204025A1
公开(公告)日：2009-08-13
申请号：US10574242
申请日：2004-09-29
申请人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Weigl
发明人： Travis Marsot , Paul Lum , Don Alden , James Ross , Ron L. Bardell , Bernhard Weigl
IPC分类号： A61B5/00 , G06G7/58
CPC分类号： A61B5/14865 , A61B5/1411 , A61B5/14532 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150358 , A61B5/150427 , A61B5/150503 , A61B5/150572 , A61B5/15107 , A61B5/15121 , A61B5/15146 , A61B5/15153 , A61B5/15161 , A61B5/15176 , A61B5/157 , A61B5/6848 , A61B2560/0223
摘要： A body fluid sampling device is provided. A mesh may be used to guide blood or fluid to travel directly from the wound to an analyte detecting port on the cartridge. Thus the volume of blood or body fluid produced at the wound site irregardless of its droplet geometry can be reliable and substantially completely transported to the analyte detecting member for measurement.
摘要翻译：提供体液取样装置。可以使用网格来引导血液或流体直接从伤口行进到药筒上的分析物检测端口。因此，在伤口部位产生的血液或体液的体积无论其液滴几何形状如何都可以是可靠的并且基本上完全输送到分析物检测构件以进行测量。

22. 发明申请

US20090201955A1 ILLUMINATION APPARATUS AND METHOD FOR CONTROLLING ENERGY OF A LASER SOURCE 有权
标题翻译：照明设备和控制激光源能量的方法
公开(公告)号：US20090201955A1
公开(公告)日：2009-08-13
申请号：US12027442
申请日：2008-02-07
申请人： Bernhard Weigl , Rick Sandstrom
发明人： Bernhard Weigl , Rick Sandstrom
IPC分类号： H01S3/13
CPC分类号： G02B27/0927 , B23K26/0626 , B23K26/0738 , B23K26/705 , H01S3/1305
摘要： The disclosure relates to an illuminating apparatus for illuminating a sample on a work stage, optionally with a relatively narrow illuminating line of relatively controlled energy, as well as methods for controlling energy of a laser source when illuminating a sample on a work stage with a relatively narrow illuminating line.
摘要翻译：本公开涉及一种用于照亮工作台上的样品的照明装置，可选地具有相对受控能量的相对狭窄的照明线，以及用于在相对于相对受控的能量照射工作台上照射样品时控制激光源的能量的方法狭窄的照明线。

23. 发明申请

US20050179996A1 Attenuating filter for ultraviolet light 失效
标题翻译：紫外线衰减滤光片
公开(公告)号：US20050179996A1
公开(公告)日：2005-08-18
申请号：US10998050
申请日：2004-11-29
申请人： Bernhard Weigl , Hans-Jochen Paul , Eric Eva
发明人： Bernhard Weigl , Hans-Jochen Paul , Eric Eva
IPC分类号： G02B5/22 , C03C17/34 , G02B1/11 , G02B5/20 , G02B5/08
CPC分类号： G02B5/208
摘要： An attenuating filter provides a prescribed attenuation of the intensity of transmitted, short-wavelength, ultraviolet light, in particular, at wavelengths below 200 nm, that is governed by a predefinable spatial distribution of its spectral transmittance. The filter has a transparent substrate (3), e.g. fabricated from crystalline calcium fluoride. A filter coating (5) fabricated from a dielectric material that absorbs over a predefined wavelength range is applied to at least one surface (4) of the substrate. In the case of operating wavelengths of about 193 nm, the filter coating consists largely of tantalum pentoxide. Filters of the type, which may be inexpensively fabricated with high yields, are noted for their high abilities to withstand laser radiation and may be effectively antireflection coated employing simply designed antireflection coatings.
摘要翻译：衰减滤波器提供了发射的，短波长的紫外光的强度的规定衰减，特别是在200nm以下的波长处，其受其光谱透射率的预定义空间分布的约束。滤光器具有透明基板（3），例如由结晶氟化钙制成。由吸收预定波长范围的介电材料制成的过滤器涂层（5）被施加到衬底的至少一个表面（4）。在工作波长约193nm的情况下，过滤器涂层主要由五氧化二钽组成。由于它们能承受激光辐射的高能力并且可以使用简单设计的抗反射涂层可以有效地防反射，因此注意到可以以高产率廉价地制造的类型的过滤器。

24. 发明申请

US20050106066A1 Microfluidic devices for fluid manipulation and analysis 有权
标题翻译：用于流体操纵和分析的微流体装置
公开(公告)号：US20050106066A1
公开(公告)日：2005-05-19
申请号：US10870717
申请日：2004-06-17
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey Houkal , Christy Lancaster , C. Battrell , Bernhard Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey Houkal , Christy Lancaster , C. Battrell , Bernhard Weigl
IPC分类号： B01F5/04 , B01F5/06 , B01F13/00 , B01L3/00 , F04B43/04 , F16K15/18
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译：本发明涉及用于操纵和分析流体样品的微流体装置和方法。所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。

25. 发明申请

US20050013732A1 Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing 有权
标题翻译：用于流体微流控操作，扩增和分析的方法和系统，例如细菌测定和抗球蛋白测试
公开(公告)号：US20050013732A1
公开(公告)日：2005-01-20
申请号：US10762586
申请日：2004-01-21
申请人： C. Battrell , Mingchao Shen , Bernhard Weigl , Jeffrey Houkal , Christy Lancaster , Wayne Breidford
发明人： C. Battrell , Mingchao Shen , Bernhard Weigl , Jeffrey Houkal , Christy Lancaster , Wayne Breidford
IPC分类号： B01F5/04 , B01F5/06 , B01F13/00 , B01L3/00 , F04B43/04 , C12Q1/68
CPC分类号： F04B43/043 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0487 , B01L2400/0633 , C12Q1/686 , Y10T436/107497 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , C12Q2565/625 , C12Q2565/629
摘要： A microfluidic system for isolation and amplification of DNA or RNA from aqueous solutions and detection of the DNA or RNA on a lateral flow detection strip, including a disposable microfluidic card for use in analysis of bacteria in platelets and an analysis of sexually transmitted diseases (STD) in urine. The card will include an embedded membrane that filters out cells and cellular debris. Any biological debris on the membrane will be lysed and the DNA or RNA amplified via PCR amplification protocol, including appropriate reagents and thermal cycling conditions. The amplified DNA or RNA are transferred to a lateral flow detection strip for a visual diagnostic read out. An alternate embodiment includes a microfluidic card for use in typing antiglobulin assays.
摘要翻译：一种用于从水溶液中分离和扩增DNA或RNA的微流体系统，并检测侧流检测条上的DNA或RNA，包括用于血小板中细菌分析的一次性微流控卡和性传播疾病分析（STD ）在尿液。该卡将包括一个过滤掉细胞和细胞碎片的嵌入膜。膜上的任何生物碎片将被裂解，并通过PCR扩增方案扩增DNA或RNA，包括适当的试剂和热循环条件。将扩增的DNA或RNA转移到侧向流动检测条中以进行视觉诊断读出。替代实施方案包括用于分选抗球蛋白测定的微流控卡。

26. 发明授权

US6159739A Device and method for 3-dimensional alignment of particles in microfabricated flow channels 失效
标题翻译：在微细流动通道中颗粒的三维排列的装置和方法
公开(公告)号：US6159739A
公开(公告)日：2000-12-12
申请号：US823747
申请日：1997-03-26
申请人： Bernhard Weigl , Paul Yager , James P. Brody
发明人： Bernhard Weigl , Paul Yager , James P. Brody
IPC分类号： G01N15/14 , G01N37/00 , G01N35/08
CPC分类号： G01N15/1404 , Y10S366/03 , Y10T436/117497 , Y10T436/118339
摘要： The present invention provides a sheath flow module made from a first plate of material having formed therein a laminar fluid flow channel; at least two inlets, each inlet joining the laminar flow channel at a junction, the first inlet junction being wider than the second inlet junction, and an outlet from the flow channel. A second plate, e.g. a transparent cover plate, seals the module and allows for optical measurements. A first inlet allows for introduction of a first fluid into the flow channel. The first fluid is the sheath fluid. A second inlet allows for introduction of a second fluid into the sheath fluid while it is flowing through the flow channel. The second fluid is the center fluid. Because the second inlet junction is narrower than the first inlet junction, the center fluid becomes surrounded on both sides by the sheath fluid. After all fluids have been introduced and sheath flow has been achieved, the depth of the flow channel can be decreased, leading to vertical hydrodynamic focusing. Optionally, the width of the flow channel can be decreased, leading to horizontal hydrodynamic focusing. The decrease in depth and width can be gradual or abrupt. The device of the present invention can function in two modes, the sheath flow mode and the particle injector mode, depending on the relative densities of the sheath fluid, the center fluid, and any particles in either fluid.
摘要翻译：本发明提供了一种由第一板材料制成的鞘流模块，其中形成有层流流体通道; 至少两个入口，每个入口在接合处连接层流通道，第一入口接合部比第二入口接合部宽，以及来自流动通道的出口。第二板，例如透明的盖板，密封模块并允许进行光学测量。第一入口允许将第一流体引入流动通道。第一种液体是鞘液。第二入口允许在鞘流体流过流动通道时将第二流体引入鞘液中。第二种液体是中心流体。因为第二入口接合点比第一入口接合点窄，所以中心流体在两侧被护套液体包围。在所有流体已经被引入并且鞘流已经实现之后，可以减小流动通道的深度，导致垂直的流体动力学聚焦。可选地，可以减小流动通道的宽度，导致水平的流体动力学聚焦。深度和宽度的减小可以是渐进的或突然的。本发明的装置可以根据鞘液，中心流体和任一液体中的任何颗粒的相对密度，以鞘流模式和颗粒注射模式两种模式起作用。

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