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21. 发明申请

US20090022746A1 Complexes for transferring nucleic acids into cells 审中-公开
标题翻译：用于将核酸转运到细胞中的复合物
公开(公告)号：US20090022746A1
公开(公告)日：2009-01-22
申请号：US11821070
申请日：2007-06-21
申请人： Joachim Simon , Martin Vollmer , Ulrich Betz , Philip Scuderi
发明人： Joachim Simon , Martin Vollmer , Ulrich Betz , Philip Scuderi
IPC分类号： A61K39/00 , C12N5/10 , A61K31/7088 , A61K48/00 , A61P37/04
CPC分类号： C12N15/87 , A61K47/59 , A61K47/645 , C08G73/0206 , C08G73/0233
摘要： The invention relates to complexes of cationic polymers and nucleic acids, to the use of such complexes for introducing nucleic acids into cells and organisms, to the use of the complexes as pharmaceuticals, and to novel polymers which can be used to prepare the complexes.
摘要翻译：本发明涉及阳离子聚合物和核酸的复合物，使用这种复合物将核酸引入细胞和生物体，将复合物用作药物，以及可用于制备复合物的新型聚合物。

22. 发明授权

US07371463B2 Sol-gel coating from water-soluble oxalamides 有权
标题翻译：溶胶 - 凝胶涂层从水溶性草酰胺
公开(公告)号：US07371463B2
公开(公告)日：2008-05-13
申请号：US11058339
申请日：2005-02-15
申请人： Burkhard Köhler , Harald Kraus , Joachim Simon
发明人： Burkhard Köhler , Harald Kraus , Joachim Simon
IPC分类号： B32B25/20
CPC分类号： C08K5/5455 , Y10T428/31663
摘要： Coating compositions for producing sol-gel coatings that include: a) one or more alkoxysilyl-containing oxalamides of the general formula (II), where R″ is hydrogen or an organic C1-C10 radical, R′ radicals are organic, optionally oxygen-attached C1-C10 radicals, R is an oxygen-attached radical optionally containing one or more ether groups and having 1 to 30 carbon atoms and n is an integer between 0 and 2, b) optionally further crosslinkers, c) one or more catalysts and d) water. The sol-gel coatings are produced by a method that includes combining a silica sol and one or more alkoxysilyl-containing oxalamides. The sol-gel coatings obtained from the above-described coating compositions can be used to coat substrates.
摘要翻译：用于生产溶胶 - 凝胶涂层的涂料组合物，其包括：a）一种或多种通式（II）的含烷氧基甲硅烷基的草酰胺，其中R“为氢或有机C 1 -C 3 R 10自由基是有机的，任选地与氧连接的C 1 -C 10基团，R是含氧的基团，任选地含有一个或多个更多的醚基团并且具有1至30个碳原子，n是0和2之间的整数，b）任选地进一步的交联剂，c）一种或多种催化剂和d）水。溶胶 - 凝胶涂层通过包括将硅溶胶与一种或多种含有烷氧基甲硅烷基的草酰胺结合的方法制备。由上述涂料组合物获得的溶胶 - 凝胶涂层可用于涂覆基材。

23. 发明授权

US07253252B2 Water-soluble aspartate 失效
标题翻译：水溶性天冬氨酸
公开(公告)号：US07253252B2
公开(公告)日：2007-08-07
申请号：US11178708
申请日：2005-07-11
申请人： Burkhard Köhler , Meike Niesten , Joachim Simon , Christian Wamprecht
发明人： Burkhard Köhler , Meike Niesten , Joachim Simon , Christian Wamprecht
IPC分类号： C08G69/10
CPC分类号： C07C229/24 , C08G18/3821 , C09D175/02
摘要： The present invention relates to new water-soluble polyaspartic esters and also to their use in aqueous coating compositions.
摘要翻译：本发明涉及新的水溶性聚天冬氨酸酯，也涉及它们在水性涂料组合物中的用途。

24. 发明授权

US07057003B2 Reactive systems, their preparation and their use 有权
标题翻译：反应性体系，它们的制备和使用
公开(公告)号：US07057003B2
公开(公告)日：2006-06-06
申请号：US10738742
申请日：2003-12-17
申请人： Kamelia Detig-Karlou , Joachim Simon , Michael Mager , Thomas Stingl , Christoph Gürtler , Michael Schelhaas
发明人： Kamelia Detig-Karlou , Joachim Simon , Michael Mager , Thomas Stingl , Christoph Gürtler , Michael Schelhaas
IPC分类号： C08G18/80
CPC分类号： C08G18/4866 , C08G18/10 , C08G18/12 , Y10T428/31551 , C08G18/64 , C08G18/2895
摘要： The invention relates to novel blocked polyurethane prepolymers, to a process for their preparation, to reactive systems prepared therefrom that cure at room temperature, and to their use.
摘要翻译：本发明涉及新的封端聚氨酯预聚物，其制备方法，由其制备的反应体系，其在室温下固化及其用途。

25. 发明授权

US06992186B2 Process for preparing low-monomer-content TDI trimers 有权
标题翻译：制备低单体含量TDI三聚体的方法
公开(公告)号：US06992186B2
公开(公告)日：2006-01-31
申请号：US10610294
申请日：2003-06-30
申请人： Martin Brahm , Oswald Wilmes , Joachim Simon
发明人： Martin Brahm , Oswald Wilmes , Joachim Simon
IPC分类号： C07D251/34
CPC分类号： C08G18/022 , C08G18/1841 , C08G18/792
摘要： The invention relates to a novel process for preparing low-monomer-content trimers based on 2,4- and/or 2,6-diisocyanatotoluene (TDI). A catalytic trimerization is carried out in a mixture of from 20 to 80% by weight of a diisocyanate component containing at least 80% by weight of 2,4- and/or 2,6-diisocyanatotoluene, from 20 to 80% by weight of solvent, and 0–20% by weight of an alcohol component, and also phenolic catalysts containing dialkylamino-methyl groups. In the course of ongoing trimerization, in one or more steps, additional monomeric 2,v4-diisocyanatotoluene is metered in.
摘要翻译：本发明涉及一种基于2,4-和/或2,6-二异氰酸基甲苯（TDI）制备低单体含量三聚体的新方法。催化三聚在20至80重量％的二异氰酸酯组分的混合物中进行，所述二异氰酸酯组分含有至少80重量％的2,4-和/或2,6-二异氰酸基甲苯，20至80重量％溶剂和0-20重量％的醇组分，以及含有二烷基氨基 - 甲基的酚催化剂。在持续三聚过程中，在一个或多个步骤中，计量加入另外的单体2，v4-二异氰酸基甲苯。

26. 发明申请

US20050222367A1 Polyether allophanates stable towards discolouration 有权
标题翻译：聚醚脲基甲酸酯对变色稳定
公开(公告)号：US20050222367A1
公开(公告)日：2005-10-06
申请号：US11087994
申请日：2005-03-23
申请人： Michael Mager , Joachim Simon , Malte Homann
发明人： Michael Mager , Joachim Simon , Malte Homann
IPC分类号： C08G18/10 , C08G18/22 , C08G18/48 , C08G18/78 , C08G18/28
CPC分类号： C08G18/4866 , C08G18/222 , C08G18/7837
摘要： A process for preparing polyisocyanate prepolymers containing allophanate structural units that includes reacting a) one or more polyisocyanates with b) one or more polyetherpolyols containing less than or equal to 0.02 milliequivalent of unsaturated end groups per gram of polyol and having a polydispersity of from 1.0 to 1.5 and/or an OH functionality of greater than or equal to 1.9 to provide an NCO-functional polyurethane prepolymer containing urethane groups that are partly or fully allophanatized by further reaction with c) polyisocyanates, which may be different from those from a), and d) catalysts and optionally adding e) acidic additives before, during and/or after the allophanatization. The polyisocyanate prepolymers can be used to produce coatings, adhesive bonds and/or seals. The coatings include one or more of the polyisocyanate prepolymers, and at least one diol or polyol and/or at least one linear and/or cyclic, aliphatic, araliphatic and/or aromatic diamine or polyamine.
摘要翻译：一种制备含有脲基甲酸酯结构单元的多异氰酸酯预聚物的方法，包括使a）一种或多种多异氰酸酯与b）一种或多种含有少于或等于0.02毫当量的不饱和端基/克多元醇的聚醚多元醇，其多分散性为1.0〜 1.5和/或OH官能度大于或等于1.9，以提供含有氨基甲酸酯基团的NCO官能聚氨酯预聚物，所述聚氨酯预聚物通过与c）不同的多异氰酸酯进一步反应而部分或完全醛化， d）催化剂，并任选地加入e）酸性添加剂在醛化之前，期间和/或之后。多异氰酸酯预聚物可用于生产涂料，粘合剂粘合剂和/或密封件。涂层包括一种或多种多异氰酸酯预聚物，和至少一种二醇或多元醇和/或至少一种直链和/或环状脂族，芳脂族和/或芳族二胺或多胺。

27. 发明授权

US06936678B2 Process for preparing low-monomer-content TDI trimers 有权
标题翻译：制备低单体含量TDI三聚体的方法
公开(公告)号：US06936678B2
公开(公告)日：2005-08-30
申请号：US10610231
申请日：2003-06-30
申请人： Martin Brahm , Joachim Simon , Oswald Wilmes , Jürgen Walloschek
发明人： Martin Brahm , Joachim Simon , Oswald Wilmes , Jürgen Walloschek
IPC分类号： C07D251/32 , C08G18/00 , C08G18/02 , C08G18/18 , C08G18/79
CPC分类号： C08G18/794 , C08G18/022 , C08G18/1841
摘要： The invention relates to a novel process for preparing low-monomer-content trimers based on 2,4- and 2,6-diisocyanatotoluene (TDI) and to the use thereof in coatings. The trimers are produced from a mixture of from 20 to 80% by weight of diisocyanate component containing at least 80% by weight of 2,4- and/or 2,6-diisocyanatotoluene and from 20 to 80% by weight of solvents and/or diluents and also phenolic catalysts containing dialkylaminomethyl groups.
摘要翻译：本发明涉及一种基于2,4-和2,6-二异氰酸根合甲苯（TDI）制备低单体含量三聚物及其在涂料中的应用的新方法。三聚物由20至80重量％的含有至少80重量％的2,4-和/或2,6-二异氰酸基甲苯的二异氰酸酯组分和20至80重量％的溶剂和/ 或稀释剂以及含有二烷基氨基甲基的酚类催化剂。

28. 发明授权

US06723333B1 Moulded bodies made of thermoplastic polyurethane containing an active substance 失效
标题翻译：由含有活性物质的热塑性聚氨酯制成的模制体
公开(公告)号：US06723333B1
公开(公告)日：2004-04-20
申请号：US09646339
申请日：2000-09-15
申请人： Reinhard Albers , Ralf Dujardin , Heinz Pudleiner , Joachim Simon , Günther Eberz , Wolfgang Kreiss , Christina Krasemann-Sharma
发明人： Reinhard Albers , Ralf Dujardin , Heinz Pudleiner , Joachim Simon , Günther Eberz , Wolfgang Kreiss , Christina Krasemann-Sharma
IPC分类号： A61L2900
CPC分类号： C08G18/12 , A61L29/06 , A61L29/16 , A61L2300/406 , C08G18/6674 , C08K5/0058 , C08L75/04 , C08G18/3234
摘要： The invention provides moulded items made from thermoplastic polyurethanes (TPUs), in particular medical articles such as central venous catheters which contain a homogeneous distribution of antibiotic substances, a process for the preparation thereof and preparation of the active substance-containing TPUs.
摘要翻译：本发明提供由热塑性聚氨酯（TPU）制成的模制品，特别是包含抗生素物质的均匀分布的中心静脉导管的医疗制品，其制备方法和含活性物质的TPU的制备。

29. 发明授权

US5910612A Preparation of anhydrous 2-amino-1-methoxypropane 失效
标题翻译：无水2-氨基-1-甲氧基丙烷的制备
公开(公告)号：US5910612A
公开(公告)日：1999-06-08
申请号：US82543
申请日：1998-05-21
申请人： Joachim Simon , Andreas Henne , Heinz Lingk
发明人： Joachim Simon , Andreas Henne , Heinz Lingk
IPC分类号： C07C213/02 , C07C213/10 , C07C217/08 , C07C209/02
CPC分类号： C07C213/02 , C07C213/10
摘要： The process for preparing anhydrous 2-amino-1-methoxypropane proceeds by(a) admixing a 2-amino-1-methoxypropane-containing water-containing reaction mixture, obtainable from the reaction of 1-methoxy-2-propanol with ammonia on a catalyst, with sodium hydroxide solution, forming an aqueous phase containing sodium hydroxide solution and a 2-amino-1-methoxypropane-containing phase,(b) separating off the 2-amino-1-methoxypropane-containing phase from the aqueous phase and(c) distilling the 2-amino-1-methoxypropane-containing phase, an azeotrope of water and 2-amino-1-methoxypropane, which is recycled to step (a) or (b), first being produced and anhydrous 2-amino-1-methoxypropane then being produced.
摘要翻译：制备无水2-氨基-1-甲氧基丙烷的方法是：（a）将可从1-甲氧基-2-丙醇反应得到的含2-氨基-1-甲氧基丙烷的含水反应混合物与氨混合，催化剂，用氢氧化钠溶液，形成含有氢氧化钠溶液和含2-氨基-1-甲氧基丙烷的相的水相，（b）从水相中分离出含2-氨基-1-甲氧基丙烷的相和（ c）蒸馏出含有2-氨基-1-甲氧基丙烷的相，再循环至步骤（a）或（b）的水和2-氨基-1-甲氧基丙烷的共沸物，首先制得无水2-氨基-1-甲氧基丙烷，然后生产1-甲氧基丙烷。

30. 发明授权

US07393465B2 Hydrophobic polyols of low viscosity 失效
标题翻译：疏水性低粘度多元醇
公开(公告)号：US07393465B2
公开(公告)日：2008-07-01
申请号：US11065101
申请日：2005-02-24
申请人： Meike Niesten , Jack Reese , Joachim Simon , Gerhard Ruttmann
发明人： Meike Niesten , Jack Reese , Joachim Simon , Gerhard Ruttmann
IPC分类号： C08G18/28
CPC分类号： C08G18/283 , C08G18/4879 , C08G65/2606 , C08G2150/90 , C09D175/04 , Y10T428/31551
摘要： A process for preparing hydrophobic polyols that includes reacting A) a mixture having an OH content of from 180 to 300 mg KOH/g, a viscosity at 23° C. of from 5000 to 20 000 mPas and an OH functionality of from 2.8 to 4.5 including from 5 to 20 wt. % of 3-pentadecadienylphenol, from 5 to 10 wt. % of 3-pentadecadienyl-recorcinol and from 1 to 5 wt. % of 2-methyl 3-pentadecadienylrecorcinol; with B) alkylene oxides (AO) with addition of the AO monomers onto the AO-reactive groups of component A); the ratio of the amounts of A) to B) being from 1:9 to 9:1; where the hydrophobic polyols have an OH number of from 140 to 220 mg KOH/g and a viscosity at 23° C. of from 1000 to 4000 mPas. The hydrophobic polyols can be used in polyurethane systems, in coatings, adhesive bonds, sealants or moulding compounds, which can be used to coat substrates.
摘要翻译：一种制备疏水性多元醇的方法，其包括使A）OH含量为180-300mg KOH / g，23℃下的粘度为5000至20000mPas，OH官能度为2.8至4.5的混合物包括5至20wt。％的3-十五碳二烯基苯酚，5至10wt。％的3-十五碳二烯基 - 间苯二酚和1至5wt。％的2-甲基3-十五碳二烯基抗坏血酸; 与B）氧化烯（AO），并将AO单体加入组分A）的AO反应性基团上; A）与B）的比例为1:9至9:1; 其中疏水多元醇的OH值为140-220mg KOH / g，在23℃下的粘度为1000-4000mPas。疏水多元醇可用于聚氨酯体系，涂料，粘合剂粘合剂，密封剂或模塑料中，可用于涂覆基材。

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