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21. 发明授权

US06395514B1 Polynucleotides encoding chemokine&agr;-5 有权
标题翻译：编码趋化因子-5的多核苷酸
公开(公告)号：US06395514B1
公开(公告)日：2002-05-28
申请号：US09195106
申请日：1998-11-18
申请人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
发明人： Ying-Fei Wei , Yi Li , Jian Ni , Craig A. Rosen , Steven M. Ruben
IPC分类号： C12N510
CPC分类号： C07K14/521 , A61K38/00 , C07K14/522 , C07K2319/00 , C12N2799/026 , Y02A50/423 , Y10T436/143333
摘要： The present invention relates to a novel CK&agr;-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CK&agr;-5 protein. CK&agr;-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CK&agr;-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译：本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。还提供了CKalpha-5多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

22. 发明授权

US06261801B1 Nucleic acids encoding tumor necrosis factor receptor 5 失效
标题翻译：编码肿瘤坏死因子受体5的核酸
公开(公告)号：US06261801B1
公开(公告)日：2001-07-17
申请号：US09006353
申请日：1998-01-13
申请人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M. Ruben
发明人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M. Ruben
IPC分类号： C12P2102
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5”, and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

23. 发明授权

US07511017B2 Methods of treatment with TNFR5 失效
标题翻译： TNFR5治疗方法
公开(公告)号：US07511017B2
公开(公告)日：2009-03-31
申请号：US11182946
申请日：2005-07-18
申请人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
发明人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
IPC分类号： A61K38/16 , A61K38/00 , C07K14/435 , C07K14/00
CPC分类号： A61K31/522 , A61K31/66 , A61K39/395 , A61K45/06 , A61K48/00 , A61K2039/505 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C12N2799/026 , A61K2300/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

24. 发明授权

US07049402B2 Tumor necrosis factor receptor-5 失效
标题翻译：肿瘤坏死因子受体-5
公开(公告)号：US07049402B2
公开(公告)日：2006-05-23
申请号：US09826212
申请日：2001-04-05
申请人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M Ruben
发明人： Ying-Fei Wei , Reiner Gentz , Jian Ni , Steven M Ruben
IPC分类号： C07K14/00
CPC分类号： C07K14/70578 , A61K48/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

25. 发明授权

US06455040B1 Tumor necrosis factor receptor 5 失效
标题翻译：肿瘤坏死因子受体5
公开(公告)号：US06455040B1
公开(公告)日：2002-09-24
申请号：US09573986
申请日：2000-05-18
申请人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
发明人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
IPC分类号： A61K39395
CPC分类号： A61K31/522 , A61K31/66 , A61K39/395 , A61K45/06 , A61K48/00 , A61K2039/505 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C12N2799/026 , A61K2300/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same as well as anti-TRID antibodies. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译：本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。还提供了TRID多肽，载体，宿主细胞以及用于产生它们的重组方法以及抗TRID抗体也是如此。本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。还提供了利用这种组合物的诊断和治疗方法。

26. 发明申请

US20060099622A1 12 human secreted proteins 有权
公开(公告)号：US20060099622A1
公开(公告)日：2006-05-11
申请号：US11246999
申请日：2005-10-11
申请人： Jian Ni , Paul Young , Joseph Kenny , Henrik Olsen , Paul Moore , Ying-Fei Wei , John Greene , Steven Ruben , Ding Liu , Paul Crocker
发明人： Jian Ni , Paul Young , Joseph Kenny , Henrik Olsen , Paul Moore , Ying-Fei Wei , John Greene , Steven Ruben , Ding Liu , Paul Crocker
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00 , C07K14/47
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

27. 发明授权

US07232667B2 Keratinocyte growth factor-2 polynucleotides 有权
标题翻译：角质形成细胞生长因子-2多核苷酸
公开(公告)号：US07232667B2
公开(公告)日：2007-06-19
申请号：US10733311
申请日：2003-12-12
申请人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
发明人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
IPC分类号： C12N1/21 , C12N5/10 , C12N15/12 , C12N15/63 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

28. 发明授权

US06916786B2 Keratinocyte growth factor-2 失效
公开(公告)号：US06916786B2
公开(公告)日：2005-07-12
申请号：US10075446
申请日：2002-02-15
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N1/20 , C12N5/10
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

29. 发明授权

US6077692A Keratinocyte growth factor-2 失效
公开(公告)号：US6077692A
公开(公告)日：2000-06-20
申请号：US23082
申请日：1998-02-13
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N15/63
CPC分类号： C07H21/00 , C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

30. 发明申请

US20090305991A1 33 Human Secreted Proteins 审中-公开
标题翻译： 33人类分泌蛋白
公开(公告)号：US20090305991A1
公开(公告)日：2009-12-10
申请号：US12538668
申请日：2009-08-10
申请人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
发明人： Daniel R. Soppet , Paul A. Moore , Yanggu Shi , Steven M. Ruben , Craig A. Rosen , David W. LaFleur , Henrik Olsen , Reinhard Ebner , Kimberly Florence , Paul Young , George Komatsoulis , Jian Ni
IPC分类号： A61K38/16 , C12N15/11 , C12N15/00 , C12N15/87 , C12N5/06 , C12N1/21 , C07K14/435 , C07K16/18 , C12P21/02 , C12Q1/68 , C12Q1/02 , G01N33/566
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention relates to 33 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及33种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

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